Explanipedia

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells Open

Ryuichi Murakami, Norihito Hayatsu, Takahisa Miyao, Zhi Liu, S. Shibata , et al. · 2025

SUMMARY Mechanisms by which diverse transcription factors (TFs) shape the heterogeneous transcriptional and epigenetic landscape of regulatory T (Treg) cells remain poorly understood. By investigating interactions between BATF and Foxp3 TF…

F-Trap Pyrene Ox: A Reagent Peak-Free Fluorescence Derivatization Reagent for Amine Analysis Open

Kenichiro Todoroki, Tomohiko Mikawa, K. KUSUDA, Hidemichi Etoh, Miki Itoyama , et al. · 2025

Role of PRC2 in the stochastic expression of Aire target genes and development of mimetic cells in the thymus Open

Minoru Matsumoto, Miyuki Yoshida, Takeshi Oya, Koichi Tsuneyama, Mitsuru Matsumoto , et al. · 2025

The transcriptional targets of Aire and the mechanisms controlling their expression in medullary thymic epithelial cells (mTECs) need to be clarified to understand Aire’s tolerogenic function. By using a multi-omics single-cell approach co…

Identification of a novel enhancer essential for Satb1 expression in T H 2 cells and activated ILC2s Open

Aneela Nomura, Tetsuro Kobayashi, Wooseok Seo, Michiko Ohno-Oishi, Kiyokazu Kakugawa , et al. · 2023

The genome organizer, special AT-rich binding protein-1 (SATB1), functions to globally regulate gene networks during primary T cell development and plays a pivotal role in lineage specification in CD4 + helper-, CD8 + cytotoxic-, and FOXP3…

Revisiting Aire and tissue-restricted antigens at single-cell resolution Open

Minoru Matsumoto, Hideyuki Yoshida, Koichi Tsuneyama, Takeshi Oya, Mitsuru Matsumoto · 2023

The thymus is a highly specialized organ that plays an indispensable role in the establishment of self-tolerance, a process characterized by the “education” of developing T-cells. To provide competent T-cells tolerant to self-antigens, med…

TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy Open

Toshiki Yamada, Megumi Tatematsu, Shunsuke Takasuga, Akane Fuchimukai, Kenki Yamagata , et al. · 2023

While group-2 innate lymphoid cells (ILC2s) are highly proliferative in allergic inflammation, the removal of overactivated ILC2s in allergic diseases has not been investigated. We previously showed that chronic airway allergy induces “exh…

Identification of a novel enhancer essential forSatb1expression in TH2 cells and activated ILC2s Open

Aneela Nomura, Michiko Ohno-Oishi, Tetsuro Kobayashi, Wooseok Seo, Kiyokazu Kakugawa , et al. · 2023

The genome organizer, special AT-rich binding protein-1 (SATB1) functions to globally regulate gene networks during primary T cells development and plays a pivotal role in lineage-specification in CD4 + helper-, CD8 + cytotoxic- and FOXP3 …

Simultaneous and Selective Quantification of Polycarboxylic Acids in Fruits and Fruit Juices by Combining Triphenylpyridinium Derivatization and Weak Cation Exchange with Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry Open

Shimba Kawasue, Yohei Sakaguchi, Kento Sonogi, Takahisa Shigematsu, Nao Ando , et al. · 2023

Dispensable Role of Aire in CD11c+ Conventional Dendritic Cells for Antigen Presentation and Shaping the Transcriptome Open

Ryuichiro Miyazawa, Jun-ichi Nagao, Ken-ichi Arita-Morioka, Minoru Matsumoto, Junko Morimoto , et al. · 2023

Aire, the defect of which is responsible for the development of autoimmunity, is predominantly expressed in medullary thymic epithelial cells, and it controls a wide variety of genes, including those of tissue-restricted Ags, for establish…

Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity Open

Junko Morimoto, Minoru Matsumoto, Ryuichiro Miyazawa, Hideyuki Yoshida, Koichi Tsuneyama , et al. · 2022

Impaired production of thymic regulatory T cells (Tregs) is implicated in the development of Aire-dependent autoimmunity. Because Tregs require agonistic T cell receptor stimuli by self-antigens to develop, reduced expression of self-antig…

A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach Open

Daisuke Douchi, Akihiro Yamamura, Junichi Matsuo, Jung-Won Lee, Napat Nuttonmanit , et al. · 2022

RUNX3^R122C missense mutation is associated with the continuous cycling of isthmus stem/progenitor cells, maturation arrest, and development of a precancerous state. This work highlights the importance of RUNX3 in the prevention …

Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens Open

Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Kazuyoshi Hosomichi, Nobuko Akiyama , et al. · 2021

The deficiency of Aire, a transcriptional regulator whose defect results in the development of autoimmunity, is associated with reduced expression of tissue-restricted self-Ags (TRAs) in medullary thymic epithelial cells (mTECs). Although …

A microRNA expression and regulatory element activity atlas of the mouse immune system Open

Samuel A. Rose, Aleksandra Wroblewska, Maxime Dhainaut, Hideyuki Yoshida, Jonathan M. Shaffer , et al. · 2021

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments Open

Ricardo Grieshaber‐Bouyer, Felix A. Radtke, Pierre Cunin, Giuseppina Stifano, Anaïs Levescot , et al. · 2021

Sensing of Acetylcholine-Related Compounds Using Cation-Selective Electrodes Open

Kenichiro Todoroki, Kaori YOSHIZATO, Hideyuki Yoshida, Masatoshi Yamaguchi, Hitoshi Nohta · 2021

Acetylcholine (ACh), a cholinergic neurotransmitter, has been widely analyzed by HPLC-electrochemical detection and other methods. However, these method are not durable because it uses a column immobilized with enzymes, such as ACh esteras…

Sensitive and Selective LC Determination of 5-Hydroxyindoles Through Online Electrochemical Fluorescence Derivatization Using Benzylamine Open

Kenichiro Todoroki, Masaki Nakano, Hideyuki Yoshida, Hitoshi Nohta, Masatoshi Yamaguchi · 2021

In this paper we describe a highly sensitive and selective LC method for the determination of 5-hydroxyindoles (serotonin, N-acetylserotonin, 5-hydroxyindole-3-acetamide, 5-hydroxytryptophan, 5-hydroxyindole-3-acetic acid, and 5-hydroxytry…

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes Open

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz , et al. · 2021

A Case of Squamous Cell Carcinoma of the Breast with Low-Grade Adenosquamous Carcinoma Open

Nozomi Kashu, Shoji Oura, Hideyuki Yoshida, Eisei Nishino, Shinichiro Makimoto · 2020

A 68-year-old woman with a breast mass was referred to our hospital. Imaging studies showed an oval well-defined mass, 1.3 cm in size, in her left lower outer quadrant of the breast. Core needle biopsy with immunohistochemical staining sho…

Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells Open

Mari Tenno, Alicia Y. W. Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo , et al. · 2019

Acquired immune responses are initiated by activation of CD4 + helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). DCs instruct Th-cell polarization program into specific effector Th subset, wh…

ImmGen report: sexual dimorphism in the immune system transcriptome Open

Shani T. Gal-Oz, Bárbara Maier, Hideyuki Yoshida, Kumba Seddu, Nitzan Elbaz , et al. · 2019

Fluorous Derivatization Method for Selective Analysis of Curcumin with Liquid Chromatography-Tandem Mass Spectrometry Open

Shimba Kawasue, Yohei Sakaguchi, Ena Yano, Tadashi Hayama, Reiko Koga , et al. · 2019

Curcumin has been shown to be pharmacologically active in the prevention and treatment of various human diseases. In this study, we developed a fluorous derivatization method for selective analysis of curcumin with liquid chromatography (L…

Multi-Dimensional HPLC Analysis of Metabolic Related Chiral Amino Acids -Method Development and Biological/Clinical Applications- Open

Reiko Koga, Hideyuki Yoshida, Hitoshi Nohta, Kenji Hamase · 2019

The existence of D-amino acids in mammals has been increasingly reported, and clarified that D and L enantiomers have different biological functions, distributions and metabolic pathways. Some D-amino acids were also reported to have a cor…

The cis-Regulatory Atlas of the Mouse Immune System Open

Hideyuki Yoshida, Caleb A. Lareau, Ricardo N. Ramírez, Samuel A. Rose, Bárbara Maier , et al. · 2019

Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10e Open

Hiromitsu Shirahashi, Eisuke Toriihara, Yoshihito Suenaga, Hideyuki Yoshida, Kensuke Akaogi , et al. · 2019

The design, synthesis, and biological evaluation of novel 3-aryl-indazole derivatives as peripherally selective pan-Trk inhibitors are described. Three strategies were used to obtain a potent compound exhibiting low central nervous system …

Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7–Null Mouse Cornea Open

Stacy L. Littlechild, Robert D. Young, Bruce Caterson, Hideyuki Yoshida, Maya Yamazaki , et al. · 2018

Addition of N-acetylglucosamine via β3GnT7 to KS glycosaminoglycans is necessary for their biosynthesis. Without β3GnT7, murine corneal stromas lack KS and appear to compensate for this loss with upregulation of chondroitinase ABC-sensitiv…

Assessment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-Depleted Conditions Using Intracellular and Extracellular Amino Acid Metabolomics Open

Ryoko Tomita, Kenichiro Todoroki, Tadashi Hayama, Hideyuki Yoshida, Toshihiro Fujioka , et al. · 2018

Previously, we developed a method to evaluate states of cells treated with anticancer drugs via the comprehensive analysis of amino acids, termed amino acid metabolomics. In the present study, we evaluated the effects of the anticancer dru…

Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development Open

Yusuke Fujikawa, Hideyuki Yoshida, Tadashi Inoue, Tetsuya Ohbayashi, Kazuo Noda , et al. · 2017

Microfibrils are exracellular matrix components necessary for elastic fiber assembly and for suspending lenses. We previously reported that latent TGF-β binding protein 2 (LTBP-2), a microfibril-associated protein, is required for forming …

Multi-Perfluoroalkyl Derivatization of Polyamines for Selective Liquid Chromatography-Tandem Mass Spectrometric Analysis Utilizing Fluorous Affinity Open

Tadashi Hayama, Erina Tamashima, Hideyuki Yoshida, Masatoshi Yamaguchi, Hitoshi Nohta · 2017

A novel derivatization method for the selective and sensitive liquid chromatography (LC)-tandem mass spectrometric (MS/MS) analysis of polyamines (putrescine, cadaverine, spermidine, and spermine) was developed. In this study, to utilize t…

Network pharmacology of JAK inhibitors Open

Devapregasan Moodley, Hideyuki Yoshida, Sara Mostafavi, Natasha Asinovski, Adriana Ortiz-Lopez , et al. · 2016

Significance JAK kinase inhibitors (JAKis) have advanced options for treatment of autoimmune diseases. Because JAKs are signaling hubs for several cytokine receptors, JAKis’ overall impact on the immune system and how they actually improve…

Selective HPLC Analysis of Polycylic Aromatic Hydrocarbons Using Exciplex Fluorescence Phenomenon Open

Kenichiro Todoroki, Keiko YANAGO, Hideyuki Yoshida, Hitoshi Nohta, Masatoshi Yamaguchi · 2016

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