Hilary B. Whitlatch
YOU?
Author Swipe
View article: SUN-523 A Case of Sudden Onset Diabetic Ketoacidosis in Pregnancy
SUN-523 A Case of Sudden Onset Diabetic Ketoacidosis in Pregnancy Open
Disclosure: N. Sherani: None. N. Kolta: None. D.G. Varghese: None. H.B. Whitlatch: None. R. Malek: None. Background: Development of fulminant diabetes during pregnancy, albeit a rare occurrence, has been documented in the literature. This …
View article: SUN-522 Use of U500 Along with Lispro Insulin in Pregnancy with Extreme Insulin Resistance
SUN-522 Use of U500 Along with Lispro Insulin in Pregnancy with Extreme Insulin Resistance Open
Disclosure: D.G. Varghese: None. N. Sherani: None. N. Kolta: None. R. Malek: None. H.B. Whitlatch: None. Background: Pregnancy can cause extreme insulin resistance. Successful diabetes management in pregnant patients with high insulin requ…
View article: Exonic Variation and Its Clinical Impact in 7221 Old Order Amish
Exonic Variation and Its Clinical Impact in 7221 Old Order Amish Open
The Amish of Lancaster County, PA has been the focus of genetic studies for many years due to its demographic history and unique genetic makeup that includes a historical bottleneck event and subsequent genetic drift, resulting in a marked…
View article: Evaluating Hyperparathyroidism in Simultaneous Pancreas‐Kidney Transplant Recipients: A Single‐Center Experience
Evaluating Hyperparathyroidism in Simultaneous Pancreas‐Kidney Transplant Recipients: A Single‐Center Experience Open
Introduction Cardiovascular disease remains the primary cause of mortality after kidney transplantation. Hyperparathyroidism (HPT) may contribute to the accelerated progression of coronary artery disease (CAD) and peripheral artery disease…
View article: Randomized evaluation of the loss‐of‐function carboxylesterase 1 (<i>CES1</i>) <scp>G143E</scp> variant on clopidogrel and ticagrelor pharmacodynamics
Randomized evaluation of the loss‐of‐function carboxylesterase 1 (<i>CES1</i>) <span>G143E</span> variant on clopidogrel and ticagrelor pharmacodynamics Open
Antiplatelet therapy with a P2Y 12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers …
View article: 6652 Precision Diagnostic Approaches for Assessing Clinical Vitamin D Status
6652 Precision Diagnostic Approaches for Assessing Clinical Vitamin D Status Open
Disclosure: Z. Shahidzadeh Yazdi: None. E.A. Streeten: None. H.B. Whitlatch: Grant Recipient; Self; Regeneron Pharmaceuticals. M.E. Montasser: Grant Recipient; Self; Regeneron Pharmaceuticals. A.L. Beitelshees: None. S.I. Taylor: Consultin…
View article: 7325 Adjuvant Denosumab Therapy For Adult-Onset Central Giant Cell Granuloma
7325 Adjuvant Denosumab Therapy For Adult-Onset Central Giant Cell Granuloma Open
Disclosure: S. Khalid: None. H. Whitlatch: None. Introduction: Central giant cell granulomas (CGCG) are rare, expansile non-neoplastic bone lesions involving the mandible or maxilla. These lesions consist of a mix of mononuclear and multin…
View article: Starvation Ketoacidosis in Pregnancy: An Unusual Presentation and Brief Literature Review
Starvation Ketoacidosis in Pregnancy: An Unusual Presentation and Brief Literature Review Open
Starvation ketoacidosis in pregnant patients is a rare but life-threatening condition that requires prompt diagnosis and timely treatment. A 35-year-old pregnant woman at 33 weeks’ gestation was admitted for abdominal pain with poor oral i…
View article: Value of Vitamin D Metabolite Ratios in 3 Patients as Diagnostic Criteria to Assess Vitamin D Status
Value of Vitamin D Metabolite Ratios in 3 Patients as Diagnostic Criteria to Assess Vitamin D Status Open
Although clinical guidelines recommend measuring total plasma 25-hydroxyvitamin D (25[OH]D) to assess vitamin D (VitD) status, this index does not account for 3-fold inter-individual variation in VitD binding protein (VDBP) level. We prese…
View article: Acute pharmacodynamic responses to sitagliptin: Drug‐induced increase in early insulin secretion in oral glucose tolerance test
Acute pharmacodynamic responses to sitagliptin: Drug‐induced increase in early insulin secretion in oral glucose tolerance test Open
DPP4 inhibitors are widely prescribed as treatments for type 2 diabetes. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses. Sitagliptin (…
View article: THU397 Homeostatic Regulation Of 1,25-dihydroxyvitamin D: Critical Role Of 24-hydroxylation (CYP24A1)
THU397 Homeostatic Regulation Of 1,25-dihydroxyvitamin D: Critical Role Of 24-hydroxylation (CYP24A1) Open
Disclosure: Z. Shahidzadeh Yazdi: None. E.A. Streeten: Grant Recipient; Self; Regeneron Pharmaceuticals. H.B. Whitlatch: Grant Recipient; Self; Regeneron Pharmaceuticals. M.E. Montasser: Grant Recipient; Self; Regeneron Pharmaceuticals. A.…
View article: SAT245 Hips Don’t Lie: A Case Of Peri-Prosthetic Pseudotumor Leading To Hypercalcemia After Total Hip Replacement.
SAT245 Hips Don’t Lie: A Case Of Peri-Prosthetic Pseudotumor Leading To Hypercalcemia After Total Hip Replacement. Open
Disclosure: F. Sotomayor: None. H. Whitlatch: None. Background: Peri-prosthetic pseudotumors are well described, yet rare complications of total hip replacement. They can present as destructive or granulomatous lesions. We present the firs…
View article: Acute pharmacodynamic responses to sitagliptin: Drug-induced increase in early insulin secretion in oral glucose tolerance test
Acute pharmacodynamic responses to sitagliptin: Drug-induced increase in early insulin secretion in oral glucose tolerance test Open
Aim DPP4 inhibitors are widely prescribed as treatments for type 2 diabetes. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses. Methods S…
View article: Vitamin D Deficiency Increases Vulnerability to Canagliflozin-induced Adverse Effects on 1,25-Dihydroxyvitamin D and PTH
Vitamin D Deficiency Increases Vulnerability to Canagliflozin-induced Adverse Effects on 1,25-Dihydroxyvitamin D and PTH Open
Context Canagliflozin has been reported to increase the risk of bone fracture—possibly mediated by decreasing 1,25-dihydroxyvitamin D (1,25(OH)2D) and increasing parathyroid hormone (PTH). Objective This work investigated whether baseline …
View article: Pharmacogenetics of sodium‐glucose co‐transporter‐2 inhibitors: Validation of a sex‐agnostic pharmacodynamic biomarker
Pharmacogenetics of sodium‐glucose co‐transporter‐2 inhibitors: Validation of a sex‐agnostic pharmacodynamic biomarker Open
Aim To validate pharmacodynamic responses to sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors and test for association with genetic variants in SLC5A4 , SLC5A9 , and SLC2A9 . Methods Canagliflozin (300 mg), a SGLT2 inhibitor, was adminis…
View article: Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism
Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism Open
Context The body has evolved homeostatic mechanisms to maintain free levels of Ca +2 and 1,25-dihydroxyvitamin D [1,25(OH) 2 D] within narrow physiological ranges. Clinical guidelines emphasize important contributions of PTH in maintaining…
View article: Acute pharmacodynamic responses to exenatide: Drug‐induced increases in insulin secretion and glucose effectiveness
Acute pharmacodynamic responses to exenatide: Drug‐induced increases in insulin secretion and glucose effectiveness Open
Aim Glucagon‐like peptide‐1 receptor agonists provide multiple benefits to patients with type 2 diabetes, including improved glycaemic control, weight loss and decreased risk of major adverse cardiovascular events. Because drug responses v…
View article: Vitamin D deficiency increases vulnerability to canagliflozin-induced adverse effects on 1,25-dihydroxyvitamin D and PTH
Vitamin D deficiency increases vulnerability to canagliflozin-induced adverse effects on 1,25-dihydroxyvitamin D and PTH Open
Context. Canagliflozin has been reported to increase the risk of bone fracture – possibly mediated by decreasing 1,25-dihydroxyvitamin D [1,25(OH) 2 D] and increasing PTH. Objective. To investigate whether baseline vitamin D (VitD) deficie…
View article: Decoding Hypertension Through Primary Aldosteronism
Decoding Hypertension Through Primary Aldosteronism Open
rimary aldosteronism (PA) is one of the most common causes of secondary hypertension.It is usually caused by idiopathic adrenal hyperplasia or aldosterone-producing adenomas (APAs), and it is a particularly morbid form of secondary hyperte…
View article: Acute pharmacodynamic responses to exenatide: Drug-induced increases in insulin secretion and glucose effectiveness
Acute pharmacodynamic responses to exenatide: Drug-induced increases in insulin secretion and glucose effectiveness Open
Background GLP1R agonists provide multiple benefits to patients with type 2 diabetes – including improved glycemic control, weight loss, and decreased risk of major adverse cardiovascular events. Because drug responses vary among individua…
View article: Pharmacogenetics of SGLT2 Inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker
Pharmacogenetics of SGLT2 Inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker Open
Aim SGLT2 inhibitors provide multiple benefits to patients with type 2 diabetes – including improved glycemic control and decreased risks of cardiorenal disease. Because drug responses vary among individuals, we initiated investigations to…
View article: PSUN253 Cocaine Use Resulting in Inadvertent Sulfonylurea Overdose
PSUN253 Cocaine Use Resulting in Inadvertent Sulfonylurea Overdose Open
Introduction Most street cocaine is cut with other substances to increase drug volume. Often, cutting agents are used that change or intensify the effects of the drug. We present a case in which sulfonylurea-laced cocaine resulted in life-…
View article: PSAT282 A Case of Papillary Thyroid Cancer in a Thyroglossal Duct Cyst
PSAT282 A Case of Papillary Thyroid Cancer in a Thyroglossal Duct Cyst Open
Background Thyroglossal duct cysts (TGDC) are common congenital neck anomalies. They persist through adulthood in 7% of the general population. Associated malignancy is rare, occurring in <1% of cases. Over 90% of such malignancies are …
View article: ODP125 Soft Bones in Crohn's: Tumor-induced osteomalacia and inflammatory bowel disease
ODP125 Soft Bones in Crohn's: Tumor-induced osteomalacia and inflammatory bowel disease Open
Introduction Bone loss is common in patients with inflammatory bowel disease (IBD) and is usually attributed to Vitamin D malabsorption, treatment with glucocorticoids or chronic inflammation. We report a case of bone loss, hypophosphatemi…
View article: MON-500 A Case of Tumor-Induced Osteomalacia Caused by Metastatic Prostate Cancer
MON-500 A Case of Tumor-Induced Osteomalacia Caused by Metastatic Prostate Cancer Open
Background: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia due to renal phosphate wasting. An overproduction of the phosphatonin fibroblast growth factor 23 (FGF-23) has been imp…
View article: MON-327 A Case of Parathyroid Carcinoma in a Patient with Late Stage Chronic Kidney Disease
MON-327 A Case of Parathyroid Carcinoma in a Patient with Late Stage Chronic Kidney Disease Open
Introduction: Parathyroid carcinoma (PC) is rare, representing 0.3-5% of primary hyperparathyroidism cases. Its pathophysiology is incompletely understood. Established predisposing factors are lacking, with the exception of known genetic m…
View article: Unusual case of anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis and autoimmune polyglandular syndrome (APS)
Unusual case of anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis and autoimmune polyglandular syndrome (APS) Open
Anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis is a novel disease discovered within the past 10 years. It is an autoimmune disease (AD) that has been associated with other ADs, such as Graves’ disease. However, association wi…