Hilda Garay
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View article: In Vivo Evaluation of the Antitumor Peptide CIGB- 552: Antitumor Activity, Pharmacokinetics and Safety of the Subcutaneously Administered Peptide
In Vivo Evaluation of the Antitumor Peptide CIGB- 552: Antitumor Activity, Pharmacokinetics and Safety of the Subcutaneously Administered Peptide Open
Background/Objectives: The CIGB-552 peptide is a novel therapeutic alternative for the treatment of cancer. In this study, we aimed to determine the optimal formulation and route of administration for CIGB-552. Other objectives were to cha…
View article: Structural Characterization of the Dimers and Selective Synthesis of the Cyclic Analogues of the Antimicrobial Peptide Cm-p5
Structural Characterization of the Dimers and Selective Synthesis of the Cyclic Analogues of the Antimicrobial Peptide Cm-p5 Open
Background/Objectives: Cm-p5 and its cyclic monomeric and dimeric analogues are known for their antifungal, antibacterial, antiviral, and antibiofilm activities. Previously, our cyclization method produced a mixture of peptides that were d…
View article: Complementary Characterization and Selective Synthesis of Cyclic and Dimeric Analogues of the Antimicrobial Peptide Cm-p5
Complementary Characterization and Selective Synthesis of Cyclic and Dimeric Analogues of the Antimicrobial Peptide Cm-p5 Open
Cm-p5, as well as its cyclic monomer and dimeric analogues are known for their antifungal, antibacterial, antiviral, and antibiofilm activities. Previously, our cyclization method generated a mixture of peptides that were difficult to sepa…
View article: Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures Open
Purpose The next-generation anti-tumor drug peptide CIGB-300, developed by the Center for Genetic Engineering and Biotechnology (CIGB), targets casein kinase 2 (CK2) and its substrates, implicating significant therapeutic potential in canc…
View article: Characterization by LC-MS/MS of two conjugate vaccines using KLH as carrier protein
Characterization by LC-MS/MS of two conjugate vaccines using KLH as carrier protein Open
Keyhole limpet haemocyanins (KLH1 and KLH2) from Megathura crenulata, are large ( 3900 amino acids) multi-subunit oxygen-carrying metalloproteins, that are widely used as carrier proteins in conjugate vaccines and in immunotherapy. KLHs an…
View article: Stability in human serum and plasma of the HIV peptide drug candidate CIGB‐210 and improved variants
Stability in human serum and plasma of the HIV peptide drug candidate CIGB‐210 and improved variants Open
The peptide CIGB‐210 inhibits HIV replication, inducing a rearrangement of vimentin intermediate filaments. The assessment of the in vitro serum and plasma stability of this peptide is important to develop an optimal pharmacological formul…
View article: Diastereomers of the anticancer peptide CIGB-300 with altered b-turn structures
Diastereomers of the anticancer peptide CIGB-300 with altered b-turn structures Open
The next-generation anti-tumor drug peptide CIGB-300, developed by the Center for Genetic Engineering and Biotechnology (CIGB), targets casein kinase 2 (CK2) and its substrates, implicating significant therapeutic potential in cancer treat…
View article: Insights into the Adsorption Mechanisms of the Antimicrobial Peptide CIDEM-501 on Membrane Models
Insights into the Adsorption Mechanisms of the Antimicrobial Peptide CIDEM-501 on Membrane Models Open
CIDEM-501 is a hybrid antimicrobial peptide rationally designed based on the structure of panusin and panulirin template peptides. The new peptide exhibits significant antibacterial activity against multidrug-resistant pathogens (MIC = 2–4…
View article: Title: Synergic effects of anticancer peptide CIGB-552 and Cisplatin in lung cancer models
Title: Synergic effects of anticancer peptide CIGB-552 and Cisplatin in lung cancer models Open
Non-small cell lung cancer constitutes one the most frequent and lethal forms of the disease. The antitumor peptide CIGB-552 is a new targeted anticancer therapy which molecular mechanism is associated with the inhibition of the transcript…
View article: On the Utility of the Extracted Ion Chromatograms for Assigning the Conjugation Sites and Side Reactions in Bioconjugates Synthesized by the Maleimide-Thiol Chemistry
On the Utility of the Extracted Ion Chromatograms for Assigning the Conjugation Sites and Side Reactions in Bioconjugates Synthesized by the Maleimide-Thiol Chemistry Open
View article: On the utility of the extracted ion chromatograms for assigning the conjugation sites in bioconjugates synthesized by the maleimide-thiol chemistry
On the utility of the extracted ion chromatograms for assigning the conjugation sites in bioconjugates synthesized by the maleimide-thiol chemistry Open
Maleimide-thiol chemistry is widely used to synthesize antibody-drug conjugates and conjugate vaccines. The set of MS/MS spectra automatically assigned to proteolytic type 2 peptides with a thiosuccinimide linker and its stabilized product…
View article: On the utility of the extracted ion chromatograms for assigning the conjugation sites in bioconjugates synthesized by the maleimide-thiol chemistry
On the utility of the extracted ion chromatograms for assigning the conjugation sites in bioconjugates synthesized by the maleimide-thiol chemistry Open
Maleimide-thiol chemistry is widely used to synthesize antibody-drug conjugates and conjugate vaccines. The set of MS/MS spectra automatically assigned to proteolytic type 2 peptides with a thiosuccinimide linker and its stabilized product…
View article: Monoclonal antibody generated against Nile tilapia (Oreochromis niloticus) IgT heavy chain using a peptide-based strategy
Monoclonal antibody generated against Nile tilapia (Oreochromis niloticus) IgT heavy chain using a peptide-based strategy Open
View article: Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection
Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection Open
Current human immunodeficiency virus treatments need to be periodically administered lifelong. In this study we assess the effect of repeated doses of an anti-HIV peptide drug candidate in C57BL6 strain. Two schemes of up to 15 administrat…
View article: Evaluation of Cell-Penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination
Evaluation of Cell-Penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination Open
View article: Synthesis, LC-MS/MS analysis, and biological evaluation of two vaccine candidates against ticks based on the antigenic P0 peptide from R. sanguineus linked to the p64K carrier protein from Neisseria meningitidis
Synthesis, LC-MS/MS analysis, and biological evaluation of two vaccine candidates against ticks based on the antigenic P0 peptide from R. sanguineus linked to the p64K carrier protein from Neisseria meningitidis Open
A peptide from the P0 acidic ribosomal protein (pP0) of ticks conjugated to keyhole limpet hemocyanin from Megathura crenulata has shown to be effective against different tick species when used in host vaccination. Turning this peptide int…
View article: Evaluation of Cell-penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination
Evaluation of Cell-penetrating Peptides as Mucosal Immune Enhancers for Nasal Vaccination Open
Cell-penetrating peptides (CPPs) have been evaluated as enhancers in drug delivery, their addition in medical formulations favors absorption allowing obtaining the pharmacological effect with lower drug doses. In vaccine formulations their…
View article: A first‐in‐class, first‐in‐human, phase I trial of <scp>CIGB</scp>‐552, a synthetic peptide targeting <scp>COMMD1</scp> to inhibit the oncogenic activity of <scp>NF‐κB</scp> in patients with advanced solid tumors
A first‐in‐class, first‐in‐human, phase I trial of <span>CIGB</span>‐552, a synthetic peptide targeting <span>COMMD1</span> to inhibit the oncogenic activity of <span>NF‐κB</span> in patients with advanced solid tumors Open
CIGB‐552 is a synthetic peptide that interacts with COMMD1 and upregulates its protein levels. The objectives of this phase I study were safety, pharmacokinetic profile, evaluation of the lymphocytes CD4+ and CD8+ and preliminary activity …
View article: Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains
Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains Open
Cm-p5 is a snail-derived antimicrobial peptide, which demonstrated antifungal activity against the pathogenic strains of Candida albicans. Previously we synthetized a cyclic monomer as well as a parallel and an antiparallel dimer of Cm-p5 …
View article: Functional and Mass Spectrometric Evaluation of an Anti-Tick Antigen Based on the P0 Peptide Conjugated to Bm86 Protein
Functional and Mass Spectrometric Evaluation of an Anti-Tick Antigen Based on the P0 Peptide Conjugated to Bm86 Protein Open
A synthetic 20 amino acid peptide of the ribosomal protein P0 from ticks, when conjugated to keyhole limpet hemocyanin from Megathura crenulata and used as an immunogen against Rhipicephalus microplus and Rhipicephalus sanguineus s.l. spec…
View article: Anti-GnRH Neutralizing Antibodies Produce Testosterone Ablation and Tumor Shrinkage in Prostate Cancer Models
Anti-GnRH Neutralizing Antibodies Produce Testosterone Ablation and Tumor Shrinkage in Prostate Cancer Models Open
Background: Vaccines based on modified GnRH peptide variants can be an alternative treatment for advanced prostate cancer. However, the efficacy of the GnRH-based vaccine variants has been limited by their insufficient immunogenicity.
View article: Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity
Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity Open
Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized. The cyclic monomer showed an increased activity in vitro against Candida albicans and C…
View article: Identification of a new therapeutic target and a potential therapeutic candidate for the treatment of HIV infection
Identification of a new therapeutic target and a potential therapeutic candidate for the treatment of HIV infection Open
View article: The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5
The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5 Open
Diseases caused by bacterial and fungal pathogens are among the major health problems in the world. Newer antimicrobial therapies based on novel molecules urgently need to be developed, and this includes the antimicrobial peptides. In spit…
View article: Identification of Vimentin as a Potential Therapeutic Target against HIV Infection
Identification of Vimentin as a Potential Therapeutic Target against HIV Infection Open
A combination of antiviral drugs known as antiretroviral therapy (ART) has shown effectiveness against the human immunodeficiency virus (HIV). ART has markedly decreased mortality and morbidity among HIV-infected patients, having even redu…
View article: Gradual reduction of testosterone using a gonadotropin-releasing hormone vaccination delays castration resistance in a prostate cancer model
Gradual reduction of testosterone using a gonadotropin-releasing hormone vaccination delays castration resistance in a prostate cancer model Open
In a previous study aimed to design a novel prostate cancer vaccine, the authors of the present study demonstrated the advantage of combining the adjuvants Montanide ISA 51 with very small size proteoliposomes (VSSP) to promote a significa…
View article: Comparative proteomic analysis of growth hormone secretagogue A233 treatment of murine macrophage cells J774A.2 indicates it has a role in antiviral innate response
Comparative proteomic analysis of growth hormone secretagogue A233 treatment of murine macrophage cells J774A.2 indicates it has a role in antiviral innate response Open