Hillary F. Huber
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View article: Sexually dimorphic responses in androgen metabolism and signalling in the non-human primate placenta to moderate maternal undernutrition
Sexually dimorphic responses in androgen metabolism and signalling in the non-human primate placenta to moderate maternal undernutrition Open
Background Maternal nutrient restriction (MNR) can increase maternal androgen concentrations during pregnancy and cause placental dysfunction leading to reduced fetal growth, especially in males. Placental androgen metabolism, as well as d…
View article: Aging Leads to Altered Physiological Reactivity in Response to Repeated Social Separation Stress in a Nonhuman Primate Model
Aging Leads to Altered Physiological Reactivity in Response to Repeated Social Separation Stress in a Nonhuman Primate Model Open
Social relationships are critical for maintaining physical health and psychological wellbeing. Since nearly 1 in 4 adults aged 65 years or older are socially isolated, there is a strong need to understand how repeated social stress negativ…
View article: Comparative lifespan and healthspan of nonhuman primate species common to biomedical research
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research Open
View article: Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed Open
Mitochondria play a crucial role in brain aging due to their involvement in bioenergetics, neuroinflammation and brain steroid synthesis. Mitochondrial dysfunction is linked to age-related neurodegenerative diseases, including Alzheimer’s …
View article: Maternal obesogenic diet during pregnancy and its impact on fetal hepatic function in baboons
Maternal obesogenic diet during pregnancy and its impact on fetal hepatic function in baboons Open
Objective Maternal obesity (MO) increases the risk of later‐life liver disease in offspring, especially in males. This may be due to impaired cytochrome P450 (CYP) enzyme activity driven by an altered maternal‐fetal hormonal milieu. MO inc…
View article: Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway
Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway Open
Age is a prominent risk factor for cardiometabolic disease, often leading to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction exclusively resulting from physiologi…
View article: Comparative lifespan and healthspan of nonhuman primate species common to biomedical research
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research Open
There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed…
View article: Maternal high fat–high energy diet alters metabolic factors in the non‐human primate fetal heart
Maternal high fat–high energy diet alters metabolic factors in the non‐human primate fetal heart Open
The consumption of high fat–high energy diets (HF‐HEDs) continues to rise worldwide and parallels the rise in maternal obesity (MO) that predisposes offspring to cardiometabolic disorders. Although the underlying mechanisms are unclear, th…
View article: Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring
Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring Open
We previously demonstrated in baboons that maternal undernutrition (MUN), achieved by 70 % of control nutrition, impairs fetal liver function, but long-term changes associated with aging in this model remain unexplored. Here, we assessed c…
View article: Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons
Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons Open
View article: Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons
Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons Open
Biological resilience, broadly defined as ability to recover from acute challenge and return to homeostasis, is of growing importance to the biology of aging. At the cellular level, there is variability across tissue types in resilience an…
View article: Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course
Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course Open
View article: Alzheimer disease-like neuropathologic changes in a geriatric baboon (<i>Papio hamadryas</i>)
Alzheimer disease-like neuropathologic changes in a geriatric baboon (<i>Papio hamadryas</i>) Open
Our results suggest that more detailed, prospective, longitudinal studies are warranted utilizing this particular species to see if they represent a viable model for human brain aging.
View article: Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation Via Hexosamine Biosynthetic Pathway
Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation Via Hexosamine Biosynthetic Pathway Open
Age is a prominent risk factor for cardiometabolic disease, and often leads to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction resulting from physiological aging …
View article: Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course
Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course Open
Debate exists on life-course adrenocortical zonal function trajectories. Rapid, phasic blood steroid concentration changes, such as circadian rhythms and acute stress responses, complicate quantification. To avoid pitfalls and account for …
View article: Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders
Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders Open
View article: Multi-omics Analysis of Aging Liver Reveals Changes in Endoplasmic Stress and Degradation Pathways in Female Nonhuman Primates
Multi-omics Analysis of Aging Liver Reveals Changes in Endoplasmic Stress and Degradation Pathways in Female Nonhuman Primates Open
The liver is critical for functions that support metabolism, immunity, digestion, detoxification, and vitamin storage. Aging is associated with severity and poor prognosis of various liver diseases such as nonalcoholic fatty liver disease …
View article: Maternal obesity alters offspring liver and skeletal muscle metabolism in early <scp>post‐puberty</scp> despite maintaining a normal <scp>post‐weaning</scp> dietary lifestyle
Maternal obesity alters offspring liver and skeletal muscle metabolism in early <span>post‐puberty</span> despite maintaining a normal <span>post‐weaning</span> dietary lifestyle Open
Maternal obesity (MO) during pregnancy is linked to increased and premature risk of age‐related metabolic diseases in the offspring. However, the underlying molecular mechanisms still remain not fully understood. Using a well‐established n…
View article: Integrated Multi-Omics Analysis of Brain Aging in Female Nonhuman Primates Reveals Altered Signaling Pathways Relevant to Age-Related Disorders
Integrated Multi-Omics Analysis of Brain Aging in Female Nonhuman Primates Reveals Altered Signaling Pathways Relevant to Age-Related Disorders Open
The prefrontal cortex (PFC) has been implicated as a key brain region responsible for age-related cognitive decline. Little is known about aging-related molecular changes in PFC that may mediate these effects. To date, no studies have used…
View article: Summary and Assessment of Studies on Cardiac Aging in Nonhuman Primates
Summary and Assessment of Studies on Cardiac Aging in Nonhuman Primates Open
Nonhuman primates (NHP) are important translational models for cardiac aging. To assess progress in this research area and to provide a reference for other investigators, we identified papers indexed in PubMed to determine what species, ag…
View article: Walking speed declines with age in male and female baboons (<i>Papio sp</i>.): Confirmation of findings with sex as a biological variable
Walking speed declines with age in male and female baboons (<i>Papio sp</i>.): Confirmation of findings with sex as a biological variable Open
We measured walking speed in baboons (67 female, 36 male; 5–22 years) to develop regression formulas to predict biological age. The final model strongly predicted age from just speed and sex. Walking speed is a valuable baboon aging biomar…
View article: Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest
Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest Open
Microvascular health is a main determinant of coronary blood flow reserve and myocardial vascular resistance. Extracardiac capillary abnormality has been reported in subjects at increased coronary heart disease risk, such as prehypertensio…
View article: The nonhuman primate hypothalamo-pituitary-adrenal axis is an orchestrator of programming-aging interactions: role of nutrition
The nonhuman primate hypothalamo-pituitary-adrenal axis is an orchestrator of programming-aging interactions: role of nutrition Open
Developmental programming alters life-course multi-organ function and significantly affects life-course health. Recently, interest has developed in how programming may influence the rate of aging. This review describes interactions of nutr…
View article: LEFT VENTRICULAR REMODELING PROCEEDS FROM YOUNG ADULTHOOD INTO MIDLIFE IN INTRAUTERINE GROWTH RESTRICTION BABOONS
LEFT VENTRICULAR REMODELING PROCEEDS FROM YOUNG ADULTHOOD INTO MIDLIFE IN INTRAUTERINE GROWTH RESTRICTION BABOONS Open
Previous cross-sectional studies have shown young adult baboons (~5-6 y.o.), subjected to intrauterine growth restriction (IUGR) by maternal calorie restriction during pregnancy and lactation, exhibit ventricular remodeling with mildly imp…
View article: Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work
Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work Open
Nonhuman primate (NHP) studies are crucial to biomedical research. NHPs are the species most similar to humans in lifespan, body size, and hormonal profiles. Planning research requires statistical power evaluation, which is difficult to pe…
View article: Effect of maternal baboon (<i>Papio</i> sp.) dietary mismatch in pregnancy and lactation on post‐natal offspring early life phenotype
Effect of maternal baboon (<i>Papio</i> sp.) dietary mismatch in pregnancy and lactation on post‐natal offspring early life phenotype Open
Background Non‐human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 yea…
View article: Effect of maternal obesity on fetal and postnatal baboon (<i>Papio</i> species) early life phenotype
Effect of maternal obesity on fetal and postnatal baboon (<i>Papio</i> species) early life phenotype Open
Background Non‐human primate models of developmental programming by maternal obesity (MO) are needed for translation to human programming outcomes. We present baboon offspring (F1) morphometry, blood cortisol, and adrenocorticotropic hormo…
View article: Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons
Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons Open
Human studies show that obesity is associated with vitamin D insufficiency, which contributes to obesity-related disorders. Our aim was to elucidate the regulation of vitamin D during pregnancy and obesity in a nonhuman primate species. We…
View article: Ageing changes in biventricular cardiac function in male and female baboons (<i>Papio</i> spp.)
Ageing changes in biventricular cardiac function in male and female baboons (<i>Papio</i> spp.) Open
Key points Life course changes in cardiovascular function in a non‐human primate have been comprehensively characterized. Age‐related declines in normalized left ventricular stroke volume and cardiac output were found with corresponding de…
View article: Antenatal Synthetic Glucocorticoid Exposure at Human Therapeutic Equivalent Doses Predisposes Middle-Age Male Offspring Baboons to an Obese Phenotype That Emerges With Aging
Antenatal Synthetic Glucocorticoid Exposure at Human Therapeutic Equivalent Doses Predisposes Middle-Age Male Offspring Baboons to an Obese Phenotype That Emerges With Aging Open