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View article: Impact of renal mass biopsy on decision-making experience for clinical T1 renal masses
Impact of renal mass biopsy on decision-making experience for clinical T1 renal masses Open
Though renal mass biopsy did not significantly decrease decisional conflict in all patients, biopsy reduced decisional conflict in certain patient subsets, demonstrating the importance of further investigating how to better support patient…
View article: glmmPen: High Dimensional Penalized Generalized Linear Mixed Models.
glmmPen: High Dimensional Penalized Generalized Linear Mixed Models. Open
Generalized linear mixed models (GLMMs) are widely used in research for their ability to model correlated outcomes with non-Gaussian conditional distributions. The proper selection of fixed and random effects is a critical part of the mode…
View article: Efficient Computation of High‐Dimensional Penalized Piecewise Constant Hazard Random Effects Models
Efficient Computation of High‐Dimensional Penalized Piecewise Constant Hazard Random Effects Models Open
Identifying and characterizing relationships between treatments, exposures, or other covariates and time‐to‐event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi‐center clinical trial…
View article: Adjuvant chemotherapy in localized, resectable extremity and truncal soft tissue sarcoma and survival outcomes – A systematic review and meta‐analysis of randomized controlled trials
Adjuvant chemotherapy in localized, resectable extremity and truncal soft tissue sarcoma and survival outcomes – A systematic review and meta‐analysis of randomized controlled trials Open
Introduction The role of adjuvant chemotherapy in localized, resectable soft tissue sarcomas (STSs) remains controversial. Despite positive findings reported in previous meta‐analyses, the majority of randomized controlled trials (RCTs) fa…
View article: Efficient computation of high-dimensional penalized generalized linear mixed models by latent factor modeling of the random effects
Efficient computation of high-dimensional penalized generalized linear mixed models by latent factor modeling of the random effects Open
Modern biomedical datasets are increasingly high-dimensional and exhibit complex correlation structures. Generalized linear mixed models (GLMMs) have long been employed to account for such dependencies. However, proper specification of the…
View article: A phase II single‐arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects
A phase II single‐arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects Open
BACKGROUND: Cognitive difficulties have been described after chemotherapy for breast cancer, but there is no standard of care to improve cognitive outcomes in these patients. This trial examined the feasibility, tolerability, acceptability…
View article: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer Open
Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, ∼12% of all cases, are uniquely dependent on POU2F3 itsel…
View article: Neratinib and ado-trastuzumab emtansine for pretreated and untreated human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases: Translational Breast Cancer Research Consortium trial 022
Neratinib and ado-trastuzumab emtansine for pretreated and untreated human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases: Translational Breast Cancer Research Consortium trial 022 Open
We observed intracranial activity for neratinib plus T-DM1, including those with prior T-DM1 exposure, suggesting synergistic effects with neratinib. Our data provide additional evidence for neratinib-based combinations in patients with HE…
View article: Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas Open
Chimeric antigen receptor (CAR)-T cells targeting CD30 have demonstrated high response rates with durable remissions observed in a subset of patients with relapsed/refractory CD30+ hematologic malignancies, particularly classical Hodgkin l…
View article: Decisional Conflict Among Patients Newly Diagnosed With Clinical T1 Renal Masses: A Prospective Study
Decisional Conflict Among Patients Newly Diagnosed With Clinical T1 Renal Masses: A Prospective Study Open
In addition to patient and clinical factors, decision-making factors and patient-centered communication relate with decisional conflict, highlighting potential avenues to better support patient decision-making for clinical T1 renal masses.
View article: glmmPen: High Dimensional Penalized Generalized Linear Mixed Models
glmmPen: High Dimensional Penalized Generalized Linear Mixed Models Open
Generalized linear mixed models (GLMMs) are widely used in research for their ability to model correlated outcomes with non-Gaussian conditional distributions. The proper selection of fixed and random effects is a critical part of the mode…
View article: Trends in breast, colon, pancreatic, and uterine cancers in women during the COVID‐19 pandemic in North Carolina
Trends in breast, colon, pancreatic, and uterine cancers in women during the COVID‐19 pandemic in North Carolina Open
Importance The COVID‐19 pandemic led to reductions in primary care and cancer screening visits, which may delay detection of some cancers. The impact on incidence has not been fully quantified. We examined change in cancer incidence to det…
View article: Complete anatomic segmentectomy shows improved oncologic outcomes compared to incomplete anatomic segmentectomy
Complete anatomic segmentectomy shows improved oncologic outcomes compared to incomplete anatomic segmentectomy Open
OBJECTIVES To compare oncologic outcomes after segmentectomy with division of segmental bronchus, artery and vein (complete anatomic segmentectomy) versus segmentectomy with division of <3 segmental structures (incomplete anatomic segme…
View article: Efficient computation of high-dimensional penalized generalized linear mixed models by latent factor modeling of the random effects
Efficient computation of high-dimensional penalized generalized linear mixed models by latent factor modeling of the random effects Open
Modern biomedical datasets are increasingly high-dimensional and exhibit complex correlation structures. Generalized linear mixed models (GLMMs) have long been employed to account for such dependencies. However, proper specification of the…
View article: Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer Open
Small cell lung cancers (SCLC) are comprised of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLC, ∼12% of all cases, are uniquely dependent on POU2F3 itself…
View article: Home time among older adults with acute myeloid leukemia by therapy intensity
Home time among older adults with acute myeloid leukemia by therapy intensity Open
Not available.
View article: Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas
Patient-reported outcomes in CD30-directed CAR-T cells against relapsed/refractory CD30+ lymphomas Open
Chimeric antigen receptor (CAR)-T cells targeting CD30 have demonstrated high response rates with durable remissions observed in a subset of patients with relapsed/refractory CD30+ hematologic malignancies, particularly classical Hodgkin l…
View article: Physical activity maintenance among young adult cancer survivors in an <scp>mHealth</scp> intervention: Twelve‐month outcomes from the <scp>IMPACT</scp> randomized controlled trial
Physical activity maintenance among young adult cancer survivors in an <span>mHealth</span> intervention: Twelve‐month outcomes from the <span>IMPACT</span> randomized controlled trial Open
Background Most physical activity (PA) interventions in young adult cancer survivors (YACS) have focused on short‐term outcomes without evaluating longer‐term outcomes and PA maintenance. This study examined the effects of an mHealth PA in…
View article: glmmPen: High Dimensional Penalized Generalized Linear Mixed Models
glmmPen: High Dimensional Penalized Generalized Linear Mixed Models Open
Generalized linear mixed models (GLMMs) are widely used in research for their ability to model correlated outcomes with non-Gaussian conditional distributions. The proper selection of fixed and random effects is a critical part of the mode…
View article: Efficient Computation of High-Dimensional Penalized Generalized Linear Mixed Models by Latent Factor Modeling of the Random Effects
Efficient Computation of High-Dimensional Penalized Generalized Linear Mixed Models by Latent Factor Modeling of the Random Effects Open
Modern biomedical datasets are increasingly high dimensional and exhibit complex correlation structures. Generalized Linear Mixed Models (GLMMs) have long been employed to account for such dependencies. However, proper specification of the…
View article: Accelerated epigenetic aging and myopenia in young adult cancer survivors
Accelerated epigenetic aging and myopenia in young adult cancer survivors Open
Background Young adult cancer survivors experience early aging‐related morbidities and mortality. Biological aging biomarkers may identify at‐risk survivors and increase our understanding of mechanisms underlying this accelerated aging. Me…
View article: Exploring the Acceptability of Text Messages to Inform and Support Shared Decision-making for Colorectal Cancer Screening: Online Panel Survey
Exploring the Acceptability of Text Messages to Inform and Support Shared Decision-making for Colorectal Cancer Screening: Online Panel Survey Open
Background While online portals may be helpful to engage patients in shared decision-making at the time of cancer screening, because of known disparities in patient portal use, sole reliance on portals to support cancer screening decision-…
View article: Electronic Health Record Use and Perceptions among Urologic Surgeons
Electronic Health Record Use and Perceptions among Urologic Surgeons Open
Objective Electronic health records (EHRs) have become widely adopted with increasing emphasis on improving care delivery. Improvements in surgery may be limited by specialty-specific issues that impact EHR usability and engagement. Accord…
View article: A phase II single‐arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects
A phase II single‐arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects Open
Background Cognitive difficulties have been described after chemotherapy for breast cancer, but there is no standard of care to improve cognitive outcomes in these patients. This trial examined the feasibility, tolerability, acceptability,…
View article: Effect of an mHealth intervention on physical activity outcomes among young adult cancer survivors: The IMPACT randomized controlled trial
Effect of an mHealth intervention on physical activity outcomes among young adult cancer survivors: The IMPACT randomized controlled trial Open
Background Physical inactivity is common in young adult cancer survivors (YACS), but evidence regarding effects of physical activity (PA) interventions among YACS is limited. The IMproving Physical Activity after Cancer Treatment (IMPACT) …
View article: Physical Activity Intervention in Patients with Metastatic Breast Cancer During Active Treatment: Quality of Life and Function
Physical Activity Intervention in Patients with Metastatic Breast Cancer During Active Treatment: Quality of Life and Function Open
Background In this study, we explore recruitment, retention, and potential quality of life (QoL) and function benefits from a self-directed, home-based walking intervention in women during active treatment for metastatic breast cancer (MBC…