Hilmar P. Sigurdsson
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View article: Feasibility, safety and efficacy of multi-dose vagus nerve stimulation in Parkinson’s disease: a double-blind, randomised sham-controlled proof-of-concept study
Feasibility, safety and efficacy of multi-dose vagus nerve stimulation in Parkinson’s disease: a double-blind, randomised sham-controlled proof-of-concept study Open
Background Gait and cognitive impairments are hallmark features of Parkinson's disease (PD) that significantly impact quality of life. These deficits arise from both dopaminergic and non-dopaminergic mechanisms, including cholinergic dysfu…
View article: Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia
Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia Open
Neuropsychiatric symptoms (NPS) are prevalent, emerge early, and are associated with poorer outcomes in Lewy body dementia (LBD). Research suggests NPS may reflect LBD-related dysfunction in distributed neuronal networks. This study invest…
View article: Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy
Locus coeruleus neuromelanin, cognitive dysfunction, and brain metabolism in multiple system atrophy Open
Background Cognitive dysfunction is increasingly recognized in multiple system atrophy (MSA). Locus coeruleus (LC) integrity is associated with cognitive performance both in healthy controls (HC) and neurodegenerative conditions such as Pa…
View article: Cerebellum and basal ganglia connectivity in isolated REM sleep behaviour disorder and Parkinson’s disease: an exploratory study
Cerebellum and basal ganglia connectivity in isolated REM sleep behaviour disorder and Parkinson’s disease: an exploratory study Open
REM sleep behaviour disorder (RBD) is a parasomnia characterised by dream-enacting behaviour with loss of muscle atonia during REM sleep and is a prodromal feature of α-synucleinopathies like Parkinson’s disease, dementia with Lewy bodies,…
View article: Developing a novel dual-injection FDG-PET imaging methodology to study the functional neuroanatomy of gait
Developing a novel dual-injection FDG-PET imaging methodology to study the functional neuroanatomy of gait Open
Gait is an excellent indicator of physical, emotional, and mental health. Previous studies have shown that gait impairments in ageing are common, but the neural basis of these impairments are unclear. Existing methodologies are suboptimal …
View article: Brain Network Connectivity Underlying Neuropsychiatric Symptoms in Prodromal Lewy Body Dementia
Brain Network Connectivity Underlying Neuropsychiatric Symptoms in Prodromal Lewy Body Dementia Open
View article: Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson’s: a study protocol
Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson’s: a study protocol Open
Background Parkinson’s disease (PD) is the fastest growing neurological condition worldwide. Recent theories suggest that symptoms of PD may arise due to spread of Lewy-body pathology where the process begins in the gut and propagate trans…
View article: Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson’s disease
Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson’s disease Open
Free-water imaging can predict and monitor dopamine system degeneration in people with Parkinson’s disease. It can also enhance the sensitivity of traditional diffusion tensor imaging (DTI) metrics for indexing neurodegeneration. However, …
View article: Gait‐Related Metabolic Covariance Networks at Rest in Parkinson's Disease
Gait‐Related Metabolic Covariance Networks at Rest in Parkinson's Disease Open
Background Gait impairments are characteristic motor manifestations and significant predictors of poor quality of life in Parkinson's disease (PD). Neuroimaging biomarkers for gait impairments in PD could facilitate effective interventions…
View article: Noninvasive vagus nerve stimulation in Parkinson’s disease: current status and future prospects
Noninvasive vagus nerve stimulation in Parkinson’s disease: current status and future prospects Open
Evidence of nVNS as a novel therapeutic to improve gait in PD is preliminary, but early signs indicate the possibility that nVNS may be useful to target dopa-resistant gait characteristics in early PD. The evidence for nVNS as a therapeuti…
View article: The role of the cingulate cortex in the generation of motor tics and the experience of the premonitory urge‐to‐tic in Tourette syndrome
The role of the cingulate cortex in the generation of motor tics and the experience of the premonitory urge‐to‐tic in Tourette syndrome Open
Tourette syndrome (TS) is a neurological disorder of childhood onset that is characterized by the occurrence of motor and vocal tics. TS is associated with cortical‐striatal‐thalamic‐cortical circuit [CSTC] dysfunction and hyper‐excitabili…
View article: Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS
Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS Open
View article: Entraining Movement-Related Brain Oscillations to Suppress Tics in Tourette Syndrome
Entraining Movement-Related Brain Oscillations to Suppress Tics in Tourette Syndrome Open
View article: A feasibility study for somatomotor cortical mapping in Tourette syndrome using neuronavigated transcranial magnetic stimulation
A feasibility study for somatomotor cortical mapping in Tourette syndrome using neuronavigated transcranial magnetic stimulation Open
View article: Somatomotor cortical representations are predicted by levels of short-interval intracortical inhibition
Somatomotor cortical representations are predicted by levels of short-interval intracortical inhibition Open
Transcranial magnetic stimulation (TMS) can be used to probe for the location of cortical somatomotor representations in humans. These somatomotor representations are dynamic and are perturbed following motor training, systematic intervent…
View article: The role of the cingulate cortex in the generation of motor tics and the experience of the premonitory urge-to-tic in Tourette syndrome
The role of the cingulate cortex in the generation of motor tics and the experience of the premonitory urge-to-tic in Tourette syndrome Open
Tourette syndrome (TS) is a neurological disorder of childhood onset that is characterised by the occurrence of motor and vocal tics. TS is associated with cortical-striatal-thalamic-cortical circuit [CSTC] dysfunction and hyper-excitabili…
View article: The role of the insula in the generation of motor tics and the experience of the premonitory urge-to-tic in Tourette syndrome
The role of the insula in the generation of motor tics and the experience of the premonitory urge-to-tic in Tourette syndrome Open
View article: Alterations in cerebellar grey matter structure and covariance networks in young people with Tourette syndrome
Alterations in cerebellar grey matter structure and covariance networks in young people with Tourette syndrome Open
Tourette syndrome (TS) is a childhood-onset neurological disorder characterised by the occurrence of motor and vocal tics and the presence of premonitory sensory/urge phenomena. Functional neuroimaging studies in humans, and experimental i…
View article: Entraining Movement-Related Brain Oscillations Using Peripheral Nerve Stimulation: Potential Clinical Application for Suppressing Tics and the Urge-to-Tic in Tourette Syndrome
Entraining Movement-Related Brain Oscillations Using Peripheral Nerve Stimulation: Potential Clinical Application for Suppressing Tics and the Urge-to-Tic in Tourette Syndrome Open
View article: Alterations in the microstructure of white matter in children and adolescents with Tourette syndrome measured using tract-based spatial statistics and probabilistic tractography
Alterations in the microstructure of white matter in children and adolescents with Tourette syndrome measured using tract-based spatial statistics and probabilistic tractography Open
View article: Activation induced changes in GABA: Functional MRS at 7 T with MEGA-sLASER
Activation induced changes in GABA: Functional MRS at 7 T with MEGA-sLASER Open
View article: Comparing GABA-dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-high-field MRI
Comparing GABA-dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-high-field MRI Open