Himansha Singh
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View article: Drug‐dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from <i>Streptococcus pneumoniae</i>
Drug‐dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from <i>Streptococcus pneumoniae</i> Open
The bacterial heterodimeric ATP‐binding cassette (ABC) multidrug exporter PatAB has a critical role in conferring antibiotic resistance in multidrug‐resistant infections by Streptococcus pneumoniae . As with other heterodimeric ABC exporte…
View article: Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent Open
View article: Research data supporting "Energetics of lipid transport by the ABC transporter MsbA is lipid dependent"
Research data supporting "Energetics of lipid transport by the ABC transporter MsbA is lipid dependent" Open
The ABC multidrug exporter MsbA mediates the translocation of lipopolysaccharides and phospholipids across the plasma membrane in Gram-negative bacteria. Although MsbA is structurally well characterised, the energetic requirements of lipid…
View article: Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae
Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae Open
View article: Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP
Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP Open
View article: Research data supporting 'Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP'
Research data supporting 'Complexities of a protonatable substrate in measurements of Hoechst 33342 transport by multidrug transporter LmrP' Open
Multidrug transporters can confer drug resistance on cells by extruding structurally unrelated compounds from the cellular interior. In transport assays, Hoechst 33342 (referred to as Hoechst) is a commonly used substrate, the fluorescence…
View article: Energy coupling in ABC exporters
Energy coupling in ABC exporters Open
View article: Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force
Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force Open
Researchers study how different forms of metabolic energy are coupled to drug extrusion by an ATP-binding cassette transporter.
View article: Research data supporting the publication "Powering the ABC multidrug exporter LmrA: how nucleotides embrace the ion-motive force" by Agboh et al.
Research data supporting the publication "Powering the ABC multidrug exporter LmrA: how nucleotides embrace the ion-motive force" by Agboh et al. Open
View article: On the mechanisms of transport and energy coupling in ABC exporters
On the mechanisms of transport and energy coupling in ABC exporters Open
The rapid emergence of multidrug resistant bacterial strains represents a major global healthcare issue. Amongst five known classes of membrane transporters, which play a huge role in multidrug efflux, primary-active ATP-binding cassette (…
View article: Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions
Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions Open
View article: Research data supporting “Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions”
Research data supporting “Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions” Open
The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents. These transporters reduce intracellular drug concentrations to…
View article: ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled
ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled Open
View article: Research Data Supporting "ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled"
Research Data Supporting "ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled" Open
ATP-binding cassette transporters mediate the transbilayer movement of a vast number of substrates in or out of cells in organisms ranging from bacteria to humans. Current alternating access models for ABC exporters including the multidrug…