Himanshu Nagar
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View article: Integrated histopathologic modeling of detailed tumor subtypes and actionable biomarkers
Integrated histopathologic modeling of detailed tumor subtypes and actionable biomarkers Open
Accurate cancer subtyping with accompanying molecular characterization is critical for precision oncology. While machine learning approaches have been applied to both digital pathology and cancer genomics, previous work has been limited in…
View article: Segmentation Regularized Training for Multi-Domain Deep Learning Registration applied to MR-Guided Prostate Cancer Radiotherapy
Segmentation Regularized Training for Multi-Domain Deep Learning Registration applied to MR-Guided Prostate Cancer Radiotherapy Open
Background: Accurate deformable image registration (DIR) is required for contour propagation and dose accumulation in MR-guided adaptive radiotherapy (MRgART). This study trained and evaluated a deep learning DIR method for domain invarian…
View article: Failed Loop Endobutton Acromioclavicular Joint Reconstruction Treated with Duo Figure of 8 FiberTape Augmented Autogenic Graft Wrapping Technique: A Case Report
Failed Loop Endobutton Acromioclavicular Joint Reconstruction Treated with Duo Figure of 8 FiberTape Augmented Autogenic Graft Wrapping Technique: A Case Report Open
Introduction: Acromioclavicular joint (ACJ) injuries are prevalent among young, active individuals and account for a significant proportion of shoulder girdle and collision sports injuries. The Rockwood classification system categorizes th…
View article: Trends in Active Surveillance for Men With Intermediate-Risk Prostate Cancer
Trends in Active Surveillance for Men With Intermediate-Risk Prostate Cancer Open
Importance Initial management of intermediate-risk prostate cancer is evolving, with no clear recommendation for treatment. Data on utilization of active surveillance for patients with newly diagnosed intermediate-risk prostate cancer may …
View article: Radiation therapy and IRreversible electroporation for intermediate risk prostate cancer (RTIRE)
Radiation therapy and IRreversible electroporation for intermediate risk prostate cancer (RTIRE) Open
Introduction Radiation Therapy and IRreversible Electroporation for Intermediate Risk Prostate Cancer (RTIRE) is a phase II clinical trial testing combination of radiation therapy and irreversible electroporation for intermediate risk pros…
View article: Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study
Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study Open
PURPOSE To characterize the relationship between Decipher genomic classifier scores and prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT)–based metastatic spread. MATERIALS AND METHODS We i…
View article: Reasons for Discordance between 68Ga-PSMA-PET and Magnetic Resonance Imaging in Men with Metastatic Prostate Cancer
Reasons for Discordance between 68Ga-PSMA-PET and Magnetic Resonance Imaging in Men with Metastatic Prostate Cancer Open
Background: PSMA PET has emerged as a “gold standard” imaging modality for assessing prostate cancer metastases. However, it is not universally available, and this limits its impact. In contrast, whole-body MRI is much more widely availabl…
View article: 166 Radiation Therapy and IRreversible Electroporation (RTIRE) for Intermediate Risk Prostate Cancer
166 Radiation Therapy and IRreversible Electroporation (RTIRE) for Intermediate Risk Prostate Cancer Open
OBJECTIVES/GOALS: Prostate cancer treatment is associated with significant genitourinary side effects. There is a critical need for treatment with decreased morbidity. We report the development of a novel treatment paradigm combining irrev…
View article: MR-LINAC, a New Partner in Radiation Oncology: Current Landscape
MR-LINAC, a New Partner in Radiation Oncology: Current Landscape Open
Technological advances in radiation oncology are oriented towards improving treatment precision and tumor control. Among these advances, magnetic-resonance-image-guided radiation therapy (MRgRT) stands out, with technological advances to d…
View article: Eligibility and Endpoints for Clinical Trials in Trimodality Therapy for Bladder Cancer.
Eligibility and Endpoints for Clinical Trials in Trimodality Therapy for Bladder Cancer. Open
The standardization of clinical trial design, eligibility criteria, and endpoints is essential for expediting progress in the field. Inclusivity, patient-centricity, and clinically meaningful endpoints will facilitate the analysis, compari…
View article: Differential Use of Radiotherapy Fractionation Regimens in Prostate Cancer
Differential Use of Radiotherapy Fractionation Regimens in Prostate Cancer Open
Importance Technical advances in treatment of prostate cancer and a better understanding of prostate cancer biology have allowed for hypofractionated treatment courses using a higher dose per fraction. Use of ultrahypofractionated stereota…
View article: Randomized phase II trial of MRI-guided salvage radiotherapy for prostate cancer in 4 weeks versus 2 weeks (SHORTER)
Randomized phase II trial of MRI-guided salvage radiotherapy for prostate cancer in 4 weeks versus 2 weeks (SHORTER) Open
Background Ultra-hypofractionated image-guided stereotactic body radiotherapy (SBRT) is increasingly used for definitive treatment of localized prostate cancer. Magnetic resonance imaging-guided radiotherapy (MRgRT) facilitates improved vi…
View article: Prostate cancer grade migration and facility-level treatment trends for grade group 1 disease
Prostate cancer grade migration and facility-level treatment trends for grade group 1 disease Open
Overdiagnosis and overtreatment of low-grade prostate cancer (PCa) reflect poor quality of care and prompted changes to guidelines over the past decade. We used the National Cancer Database to characterize Gleason Grade Group (GG)1 PCa dia…
View article: Use of focal radiotherapy boost for prostate cancer and perceived barriers toward its implementation: a survey
Use of focal radiotherapy boost for prostate cancer and perceived barriers toward its implementation: a survey Open
Background In a recent phase III randomized control trial (FLAME), delivering a focal radiotherapy (RT) boost to tumors visible on MRI was shown to improve outcomes for prostate cancer patients without increasing toxicity. The aim of this …
View article: MRI-LINAC: A transformative technology in radiation oncology
MRI-LINAC: A transformative technology in radiation oncology Open
Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery. Amongst the recent novel technologies, Magnetic Resonance Imaging …
View article: Patterns of utilization and clinical adoption of 0.35 Tesla MR-guided radiation therapy in the United States – Understanding the transition to adaptive, ultra-hypofractionated treatments
Patterns of utilization and clinical adoption of 0.35 Tesla MR-guided radiation therapy in the United States – Understanding the transition to adaptive, ultra-hypofractionated treatments Open
This is the first comprehensive study reporting patterns of utilization among early adopters of MRIdian in the US. Intrafraction MR image-guidance, advanced motion management, and increasing adoption of adaptive radiation therapy has led t…
View article: Adaptive magnetic resonance image guided radiation for intact localized prostate cancer how to optimally test a rapidly emerging technology
Adaptive magnetic resonance image guided radiation for intact localized prostate cancer how to optimally test a rapidly emerging technology Open
Introduction Prostate cancer is a common malignancy for which radiation therapy (RT) provides an excellent management option with high rates of control and low toxicity. Historically RT has been given with CT based image guidance. Recently…
View article: SPIN-02 LEVERAGING AN MRI-GUIDED LINEAR ACCELERATOR PLATFORM FOR POST-OPERATIVE STEREOTACTIC BODY RADIATION THERAPY (SBRT) OF SPINAL METASTASES
SPIN-02 LEVERAGING AN MRI-GUIDED LINEAR ACCELERATOR PLATFORM FOR POST-OPERATIVE STEREOTACTIC BODY RADIATION THERAPY (SBRT) OF SPINAL METASTASES Open
PURPOSE/OBJECTIVE(S) Post-operative spine SBRT presents unique clinical challenges. Spinal hardware produces CT and high-field strength MRI artifacts that obscure visualization of the spinal cord and unresected disease. Existing workflows …