Explanipedia

Exosomes and Biomimetic Nanoparticles: Natural Nanocarriers for Breast Cancer Open

Anshika Garg, Shailendra Kumar, Meddi Tharun, Sanjeev Sharma, Himanshu Narayan Singh , et al. · 2025

Breast cancer is one of the leading causes of cancer associated morbidity worldwide as conventional therapies are often limited by drug resistance and metastatic spread. These challenges observed with conventional therapies underscore the …

Harnessing Natural Product Compounds to Target Dormancy Survival Regulator (DosR) in Latent Tuberculosis Infection (LTBI): An In Silico Strategy Against Dormancy Open

Mandeep Chouhan, Mukesh Kumar, Vivek Dhar Dwivedi, Vivek K. Kashyap, Himanshu Narayan Singh , et al. · 2025

Dormancy occurs when Mycobacterium tuberculosis (Mtb) enters a non-replicating and metabolically inactive state in response to hostile environment. During this state, it is highly resistant to conventional antibiotics, which increase the u…

Extracellular vesicles in triple-negative breast cancer: current updates, challenges and future prospects Open

Prashant Tiwari, Anis Ahmad Chaudhary, Saurabh Gupta, Mandeep Chouhan, Himanshu Narayan Singh , et al. · 2025

Breast cancer (BC) remains a complex and widespread problem, affecting millions of women worldwide, Among the various subtypes of BC, triple-negative breast cancer (TNBC) is particularly challenging, representing approximately 20% of all B…

Molecular insights and RAPD profiling of bioactive compounds from Salacia oblonga wall: inhibition of mecA and beta-lactamase in drug-resistant Staphylococcus aureus Open

Anjaneyulu Musini, Himanshu Narayan Singh, P. Gnana Deepu, Kandula Priyanka, Archana Giri · 2025

Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes Open

Juliette Malfait, Jing Wan, Himanshu Narayan Singh, Charbel Souaid, Gaëlle Farah , et al. · 2024

Stress insults trigger the rapid and global reprogramming of gene transcription by coordinated recruitment of a limited number of key inducible transcription factors to cis-regulatory elements. Here, we performed a comprehensive analysis o…

Joubert syndrome: a rare cause of hypotonia with developmental delay Open

Himanshu Narayan Singh, Prasun Bhattacharjee, Pranay Trivedi, Keeranmayee Mishra, Ashwani Parashar · 2024

Joubert syndrome is a rare autosomal recessive disorder. It is characterized by congenital ataxia, hypotonia, developmental delay, and at least one of the following features: neonatal respiratory disturbances and abnormal eye movements; in…

Recombinant vaccines: Current updates and future prospects Open

Vivek Kumar, Anuj A. Verma, Riddhi Singh, Priyanshi Garg, Santosh Kumar Sharma , et al. · 2024

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of illnesses. The technology improved vaccine manufacturing, rendering it more efficient and economical. These vaccines have multiple adva…

Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies Open

Pritee Chunarkar Patil, Mohammed Kaleem, Richa Mishra, Subhasree Ray, Aftab Ahmad , et al. · 2024

Globally, malignancies cause one out of six mortalities, which is a serious health problem. Cancer therapy has always been challenging, apart from major advances in immunotherapies, stem cell transplantation, targeted therapies, hormonal t…

CRISPR/Cas9 as a therapeutic tool for triple negative breast cancer: from bench to clinics Open

Prashant Kumar Tiwari, Tin-Hsien Ko, Rajni Dubey, Mandeep Chouhan, Lung‐Wen Tsai , et al. · 2023

Clustered regularly interspaced short palindromic repeats (CRISPR) is a third-generation genome editing method that has revolutionized the world with its high throughput results. It has been used in the treatment of various biological dise…

SARS-CoV-2 Omicron Variant Genomic Sequences and Their Epidemiological Correlates Regarding the End of the Pandemic: In Silico Analysis Open

Ashutosh Kumar, Adil Asghar, Himanshu Narayan Singh, Muneeb A. Faiq, Sujeet Kumar , et al. · 2022

Background Emergence of the new SARS-CoV-2 variant B.1.1.529 worried health policy makers worldwide due to a large number of mutations in its genomic sequence, especially in the spike protein region. The World Health Organization (WHO) des…

Transcriptomic Profiling Unravels Novel Deregulated Gene Signatures Associated with Acute Myocardial Infarction: A Bioinformatics Approach Open

Sanjay Kumar, Chun-Ming Shih, Lung‐Wen Tsai, Rajni Dubey, Deepika Gupta , et al. · 2022

Acute myocardial infarction (AMI) is a severe disease with elevated morbidity and mortality rate worldwide. This is attributed to great losses of cardiomyocytes, which can trigger the alteration of gene expression patterns. Although severa…

Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema Open

Kavita Sharma, Aastha Mishra, Himanshu Narayan Singh, Tashi Thinlas, M. A. Qadar Pasha · 2022

Omicron variant, scripting the end of the pandemic: An in silico analysis of SARS-CoV-2 genomic sequences and their epidemiological correlates (Preprint) Open

Ashutosh Kumar, Adil Asghar, Himanshu Narayan Singh, Muneeb A. Faiq, Sujeet Kumar , et al. · 2022

BACKGROUND A newly emerged SARS-CoV-2 variant B.1.1.529 worried the health policy makers worldwide due to a large number of mutations in its genomic sequence, especially in the spike protein region. World Health Organization (WHO) designa…

CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope Open

Vamika Karn, Sandhya Sandhya, Wayne Hsu, Deepak Parashar, Himanshu Narayan Singh , et al. · 2022

Extracellular Vesicles and Their Significance in COVID-19 Open

Sanjay Kumar, Soumi Sadhu, Himanshu Narayan Singh, Navneet Kumar Dubey, Nikhil Kumar , et al. · 2022

Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis Open

Yashbir Singh, Naidu Subbarao, Abhinav Jaimini, Quincy A. Hathaway, Amina Kunovac , et al. · 2022

Breast cancer metastases are most commonly found in bone, an indication of poor prognosis. Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the et…

Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia Open

Lin Lin, Pugui Li, Xin Liu, Xiuyuan Xie, Liping Liu , et al. · 2022

Differential Transcriptome Profiling Unveils Novel Deregulated Gene Signatures Involved in Pathogenesis of Alzheimer’s Disease Open

Himanshu Narayan Singh, Vishnu Swarup, Navneet Kumar Dubey, Niraj Kumar Jha, Anjani Kumar Singh , et al. · 2022

Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by a progressive loss of cognitive functions at a higher level than normal aging. Although the apolipoprotein (APOE) gene is a major risk factor in developing A…

Mecanismos del COVID-19 en el cuerpo humano: Lo que sabemos hasta ahora Open

Ashutosh Kumar, Ravi Kant Narayan, Pranav Prasoon, Chiman Kumari, Gurjot Kaur , et al. · 2022

Ha transcurrido más de un año y medio desde el inicio de la pandemia debida a la enfermedad por coronavirus 2019 (COVID-19), y el mundo se esfuerza por contenerla. Al ser causada por un virus hasta ahora desconocido, en el periodo inicial …

An <i>in silico</i> analysis of early SARS-CoV-2 variant B.1.1.529 (Omicron) genomic sequences and their epidemiological correlates Open

Ashutosh Kumar, Adil Asghar, Himanshu Narayan Singh, Muneeb A. Faiq, Sujeet Kumar , et al. · 2021

Background A newly emerged SARS-CoV-2 variant B.1.1.529 has worried the health policy makers worldwide due to the presence of a large number of mutations in its genomic sequence, especially in the spike protein region. World Health Organiz…

Emerging SARS‐CoV‐2 variants can potentially break set epidemiological barriers in COVID‐19 Open

Ashutosh Kumar, Rakesh Parashar, Sujeet Kumar, Muneeb A. Faiq, Chiman Kumari , et al. · 2021

Young age, female sex, absence of comorbidities, and prior infection or vaccination are known epidemiological barriers for contracting the new infection and/or increased disease severity. Demographic trends from the recent coronavirus dise…

Epromoters function as a hub to recruit key transcription factors required for the inflammatory response Open

David Santiago‐Algarra, Charbel Souaid, Himanshu Narayan Singh, Lan T.M. Dao, Saadat Hussain , et al. · 2021

Genome-Wide Scanning of Potential Hotspots for Adenosine Methylation: A Potential Path to Neuronal Development Open

Sanjay Kumar, Lung‐Wen Tsai, Pavan Kumar, Rajni Dubey, Deepika Gupta , et al. · 2021

Methylation of adenosines at N6 position (m6A) is the most frequent internal modification in mRNAs of the human genome and attributable to diverse roles in physiological development, and pathophysiological processes. However, studies on th…

COVID-19 Mechanisms in the Human Body—What We Know So Far Open

Ashutosh Kumar, Ravi Kant Narayan, Pranav Prasoon, Chiman Kumari, Gurjot Kaur , et al. · 2021

More than one and a half years have elapsed since the commencement of the coronavirus disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused by a previously unknown virus, in the initial period, there had…

Current Trends and Future Prospects of Nanotechnology in Biofuel Production Open

Indrajeet Arya, Asha Poona, Pritam Kumar Dikshit, Soumya Pandit, Jatin Kumar , et al. · 2021

Biofuel is one of the best alternatives to petroleum-derived fuels globally especially in the current scenario, where fossil fuels are continuously depleting. Fossil-based fuels cause severe threats to the environment and human health by r…

A novel computational methodology for GWAS multi-locus analysis based on graph theory and machine learning Open

Subrata Saha, Himanshu Narayan Singh, Ahmed Soliman, Sanguthevar Rajasekaran · 2021

Background Current form of genome-wide association studies (GWAS) is inadequate to accurately explain the genetics of complex traits due to the lack of sufficient statistical power. It explores each variant individually, but current studie…

Extracellular Vesicle-Based Therapy for COVID-19: Promises, Challenges and Future Prospects Open

Vamika Karn, Shaista Ahmed, Lung‐Wen Tsai, Rajni Dubey, Shreesh Ojha , et al. · 2021

The COVID-19 pandemic has become a serious concern and has negatively impacted public health and the economy. It primarily targets the lungs, causing acute respiratory distress syndrome (ARDS); however, it may also lead to multiple organ f…

Emerging SARS-CoV-2 Variants Can Potentially Break Set Epidemiological Barriers in COVID-19 Open

Ashutosh Kumar, Rakesh Parashar, Muneeb A. Faiq, Sujeet Kumar, Chiman Kumari , et al. · 2021

Differentially Expressed Genes and Their Clinical Significance in Ischaemic Stroke: An In-Silico Study Open

Sandeep Appunni, Muni Rubens, Venkataraghavan Ramamoorthy, Hina Sharma, Anjani Kumar Singh , et al. · 2020

Background: Ischaemic stroke (IS), a multifactorial neurological disorder, is mediated by interplay between genes and the environment and, thus, blood-based IS biomarkers are of significant clinical value. Therefore, this study aimed to fi…

A novel ultrasound-guided pectoralis-intercostal rectus-sheath (PIRS) block for the management of chest wall analgesia after cardiac surgery: a prospective hospital-based cross-sectional control study Open

Mario Cibelli, John White, Himanshu Narayan Singh, Luigi Vivona, Seema Agarwal , et al. · 2020

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