Hind Muteb Albadrani
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View article: Telomeres, Telomerase, and Curcumin: A New Frontier in Cancer Therapy: A Narrative Review
Telomeres, Telomerase, and Curcumin: A New Frontier in Cancer Therapy: A Narrative Review Open
Telomeres, which serve as protective ends on chromosomes, and telomerase, the enzyme that preserves telomere length, play crucial roles in ensuring genomic stability and delaying cellular aging. Dysregulation of these proteins is a key cha…
View article: Involvement of MEF-2 and Apo-1/Fas in the Modulatory Mechanism of Liposomal Curcumin Against Cardiac Hypoxia
Involvement of MEF-2 and Apo-1/Fas in the Modulatory Mechanism of Liposomal Curcumin Against Cardiac Hypoxia Open
Background/Objectives Hypoxia is a severe pathological complication associated with many disorders, as oxygen insufficiency could decline normal cellular homeostasis. Hypoxia causes alteration of the coronary blood flow and reduction of th…
View article: Differential expression of ABO in normal and tumor tissues: Implications for cancer biology and prognosis
Differential expression of ABO in normal and tumor tissues: Implications for cancer biology and prognosis Open
View article: In-vitro enzyme inhibition, kinetics, molecular docking and dynamics simulation approaches to decoding the mechanism of Ficus virens in cholinesterase inhibition
In-vitro enzyme inhibition, kinetics, molecular docking and dynamics simulation approaches to decoding the mechanism of Ficus virens in cholinesterase inhibition Open
In the current study, we investigate the bioactive potentials and mode of action of Ficus virens bark (FVB) extract against cholinesterase enzymes, via in-vitro cell-free cholinesterase inhibition kinetics, molecular docking, ADMET and dyn…
View article: Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease
Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease Open
Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising a…
View article: A protein–miRNA biomic analysis approach to explore neuroprotective potential of nobiletin in human neural progenitor cells (hNPCs)
A protein–miRNA biomic analysis approach to explore neuroprotective potential of nobiletin in human neural progenitor cells (hNPCs) Open
Chemical-induced neurotoxicity is increasingly recognized to accelerate the development of neurodegenerative disorders (NDs), which pose an increasing health burden to society. Attempts are being made to develop drugs that can cross the bl…
View article: A molecular informatics and <i>in-vitro</i> approach to evaluate the HMG-CoA reductase inhibitory efficacy of monoterpenes, carvacrol and geraniol
A molecular informatics and <i>in-vitro</i> approach to evaluate the HMG-CoA reductase inhibitory efficacy of monoterpenes, carvacrol and geraniol Open
Currently, statins, the β-hydroxy-β-methyl-glutaryl-CoA reductase (HMG-R) inhibitors, are widely used to lower cholesterol, nevertheless, they have several side effects. Consequently, the present study is designed to unravel the cardioprot…
View article: Pharmacophore-Based Screening, Molecular Docking, and Dynamic Simulation of Fungal Metabolites as Inhibitors of Multi-Targets in Neurodegenerative Disorders
Pharmacophore-Based Screening, Molecular Docking, and Dynamic Simulation of Fungal Metabolites as Inhibitors of Multi-Targets in Neurodegenerative Disorders Open
Neurodegenerative disorders, such as Alzheimer’s disease (AD), negatively affect the economic and psychological system. For AD, there is still a lack of disease-altering treatments and promising cures due to its complex pathophysiology. In…
View article: Multitargeted Virtual Screening and Molecular Simulation of Natural Product-like Compounds against GSK3β, NMDA-Receptor, and BACE-1 for the Management of Alzheimer’s Disease
Multitargeted Virtual Screening and Molecular Simulation of Natural Product-like Compounds against GSK3β, NMDA-Receptor, and BACE-1 for the Management of Alzheimer’s Disease Open
The complexity of Alzheimer’s disease (AD) and several side effects of currently available medication inclined us to search for a novel natural cure by targeting multiple key regulatory proteins. We initially virtually screened the natural…
View article: Valorization of Adhatoda vasica leaves: Extraction, in vitro analyses and in silico approaches
Valorization of Adhatoda vasica leaves: Extraction, in vitro analyses and in silico approaches Open
Adhatoda vasica (also called Vasaka) is a traditional medicinal herb used traditionally for the relief of cough, asthma, nasal congestion, bronchial inflammation, upper respiratory infections, bleeding disorders, skin diseases, leprosy, tu…
View article: Antibacterial efficacy of synthesized silver nanoparticles of Microbacterium proteolyticum LA2(R) and Streptomyces rochei LA2(O) against biofilm forming meningitis causing microbes
Antibacterial efficacy of synthesized silver nanoparticles of Microbacterium proteolyticum LA2(R) and Streptomyces rochei LA2(O) against biofilm forming meningitis causing microbes Open
View article: Homology Modelling, Molecular Docking and Molecular Dynamics Simulation Studies of CALMH1 against Secondary Metabolites of Bauhinia variegata to Treat Alzheimer’s Disease
Homology Modelling, Molecular Docking and Molecular Dynamics Simulation Studies of CALMH1 against Secondary Metabolites of Bauhinia variegata to Treat Alzheimer’s Disease Open
Calcium homeostasis modulator 1 (CALHM1) is a protein responsible for causing Alzheimer’s disease. In the absence of an experimentally designed protein molecule, homology modelling was performed. Through homology modelling, different CALHM…