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View article: Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells
Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells Open
Environmental chemicals are known risk factors for adverse pregnancy outcomes. However, the effects of environmentally relevant concentrations of chemical mixtures are less studied. This study investigated the effects of a mixture containi…
View article: Foodweb dynamics affect arsenic speciation and bioaccumulation in lakes affected by gold mines
Foodweb dynamics affect arsenic speciation and bioaccumulation in lakes affected by gold mines Open
We investigated the bioaccumulation patterns of arsenic species in freshwater food webs from three lakes near historical mining operations in the Northwest Territories, Canada. Two of these lakes (Long Lake and Lower Martin Lake) were loca…
View article: Re-thinking the link between exposure to mercury and blood pressure
Re-thinking the link between exposure to mercury and blood pressure Open
Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which is a significant contributor to the total global disease burden. Environmental chemicals, including mercury (Hg), may contribute to hypertension…
View article: Nurturing sustainable small-scale fisheries to strengthen food sovereignty in Qikiqtarjuaq, Nunavut, Canada
Nurturing sustainable small-scale fisheries to strengthen food sovereignty in Qikiqtarjuaq, Nunavut, Canada Open
For generations, Inuit in Nunavut have relied on small-scale fisheries as a foundation for food security, cultural identity, and economic resilience. However, systemic barriers, such as the high cost of living, limited infrastructure, clim…
View article: Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis
Reduction of Glyoxalase 1 Expression Links Fetal Methylmercury Exposure to Autism Spectrum Disorder Pathogenesis Open
Glyoxalase 1 (Glo1) is an essential enzyme to detoxify methylglyoxal (MGO), a cytotoxic byproduct of glycolysis. Accumulating studies have shown an important role of Glo1 in regulating cortical development and neurogenesis, potentially con…
View article: Omega-3 world map: 2024 update
Omega-3 world map: 2024 update Open
In 2016, the first worldwide n3 PUFA status map was published using the Omega-3 Index (O3I) as standard biomarker. The O3I is defined as the percentage of EPA + DHA in red blood cell (RBC) membrane FAs. The purpose of the present study was…
View article: Exploring practices, challenges, and priorities for human health and ecological risk assessments in Indigenous communities in Canada
Exploring practices, challenges, and priorities for human health and ecological risk assessments in Indigenous communities in Canada Open
Indigenous peoples in Canada are disproportionately exposed to environmental contaminants and may face elevated health risks related to their unique cultural, spiritual, and economic relationships with the land, including the use of tradit…
View article: Blood lead levels in the general population and vulnerable sub-populations and related risk factors for lead exposure in Canada
Blood lead levels in the general population and vulnerable sub-populations and related risk factors for lead exposure in Canada Open
Lead is an environmental contaminant that is considered a major public health concern due to its effects on various body systems, such as the neurological, cardiovascular, immune and renal systems. Scientific evidence indicates that health…
View article: Single-cell profiling of brain pericyte heterogeneity following ischemic stroke unveils distinct pericyte subtype-targeted neural reprogramming potential and its underlying mechanisms
Single-cell profiling of brain pericyte heterogeneity following ischemic stroke unveils distinct pericyte subtype-targeted neural reprogramming potential and its underlying mechanisms Open
Rationale: Brain pericytes can acquire multipotency to produce multi-lineage cells following injury. However, pericytes are a heterogenous population and it remains unknown whether there are different potencies from different subsets of pe…
View article: Potential impacts of reduced seafood consumption on myocardial infarction among coastal First Nations in British Columbia, Canada
Potential impacts of reduced seafood consumption on myocardial infarction among coastal First Nations in British Columbia, Canada Open
The objective of this study is to examine the potential cardiovascular risk of climate-related declines in seafood consumption among First Nations in British Columbia by assessing the combined effects of reduced omega-3 fatty acids and mer…
View article: A One Health perspective on recreational fisheries
A One Health perspective on recreational fisheries Open
Recreational fisheries involve an intimate connection between people, individual fish, and the environment. Recreational fishers and their health crucially depend on healthy fish and ecosystems. Similarly, fish and ecosystems can be impact…
View article: Identification of Chinese dietary patterns and their relationships with health outcomes: a systematic review and meta-analysis
Identification of Chinese dietary patterns and their relationships with health outcomes: a systematic review and meta-analysis Open
Objective: China has been undergoing a rapid nutrition transition in the past few decades. This review aims to characterise commonly reported dietary patterns in Chinese populations and their associations with health outcomes. Design: We s…
View article: Characterizing variability in total mercury hair:blood ratio in the general Canadian population
Characterizing variability in total mercury hair:blood ratio in the general Canadian population Open
The mean hair:blood THg ratio among Canadians generally exceeded the default ratio of 250:1. Higher ratios were observed in certain subgroups, such as seafood consumers, and shellfish consumption was the most important variable associated …
View article: Prenatal low-dose methylmercury exposure causes premature neuronal differentiation and autism-like behaviors in a rodent model
Prenatal low-dose methylmercury exposure causes premature neuronal differentiation and autism-like behaviors in a rodent model Open
Aberrant neurodevelopment is a core deficit of autism spectrum disorder (ASD). Here we ask whether a non-genetic factor, prenatal exposure to the environmental pollutant methylmercury (MeHg), is a contributing factor in ASD onset. We showe…
View article: Structure and function of the western Baffin Bay coastal and shelf ecosystem
Structure and function of the western Baffin Bay coastal and shelf ecosystem Open
Arctic marine species, from benthos to fish and mammals, are essential for food security and sovereignty of Inuit people. Inuit food security is dependent on the availability, accessibility, quality, and sustainability of country food reso…
View article: Associations between extreme precipitation, drinking water, and protozoan acute gastrointestinal illnesses in four North American Great Lakes cities (2009–2014)
Associations between extreme precipitation, drinking water, and protozoan acute gastrointestinal illnesses in four North American Great Lakes cities (2009–2014) Open
Climate change is already impacting the North American Great Lakes ecosystem and understanding the relationship between climate events and public health, such as waterborne acute gastrointestinal illnesses (AGIs), can help inform needed ad…
View article: Interplay of Obesity, Ethanol, and Contaminant Mixture on Clinical Profiles of Cardiovascular and Metabolic Diseases: Evidence from an Animal Study
Interplay of Obesity, Ethanol, and Contaminant Mixture on Clinical Profiles of Cardiovascular and Metabolic Diseases: Evidence from an Animal Study Open
Obesity, ethanol, and contaminants are known risk factors of cardiovascular and metabolic diseases (CMD). However, their interplay on clinical profiles of these diseases remains unclear, and thus were investigated in this study. Male lean …
View article: Opposing trends in fisheries portfolio diversity at harvester and community scales signal opportunities for adaptation
Opposing trends in fisheries portfolio diversity at harvester and community scales signal opportunities for adaptation Open
Understanding mechanisms that promote social-ecological resilience can inform future adaptation strategies. Among seafood dependent communities, these can be illuminated by assessing change among fisheries portfolios. Here, in collaboratio…
View article: Correction: Yuan et al. Sub-Micromolar Methylmercury Exposure Promotes Premature Differentiation of Murine Embryonic Neural Precursor at the Expense of Their Proliferation. Toxics 2018, 6, 61
Correction: Yuan et al. Sub-Micromolar Methylmercury Exposure Promotes Premature Differentiation of Murine Embryonic Neural Precursor at the Expense of Their Proliferation. Toxics 2018, 6, 61 Open
In the original article [...]
View article: Development of an optimal grocery list based on actual intake from a cross-sectional study of First Nations adults in Ontario, Canada
Development of an optimal grocery list based on actual intake from a cross-sectional study of First Nations adults in Ontario, Canada Open
A multi-stage sampling strategy selected 1387 on-reserve First Nations adults in Ontario. Foods from a 24-hour dietary recall were assigned to the 100 most common food groups for men and women. Nutrients from market foods (MF) and traditio…
View article: Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells
Characterizing the Low-Dose Effects of Methylmercury on the Early Stages of Embryo Development Using Cultured Human Embryonic Stem Cells Open
These results revealed that under the selection pressure of exposure to low doses of MeHg, some hESCs underwent apoptosis, whereas others adapted and survived with enhanced self-renewal gene expression and specific morphological phenotypes…
View article: Associations of health status and diabetes among First Nations Peoples living on-reserve in Canada
Associations of health status and diabetes among First Nations Peoples living on-reserve in Canada Open
Objective Our objective is to describe self-reported health status, prevalence of diabetes and obesity and their associations in participants from the First Nations Food, Nutrition and Environment Study (FNFNES) in order to identify possib…