Hinrich Schulenburg
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View article: A novel mechanism of unstable heteroresistance via reversible ompP2 mutations in Haemophilus influenzae
A novel mechanism of unstable heteroresistance via reversible ompP2 mutations in Haemophilus influenzae Open
We discovered a novel mechanism of unstable heteroresistance in H. influenzae, mediated by reversible structural changes in the gene ompP2. Rapid phenotypic switching was induced by ceftriaxone exposure and likely reflects the mutational p…
View article: Investigating the consequences of the mating system for drug resistance evolution in <i>Caenorhabditis elegans</i>
Investigating the consequences of the mating system for drug resistance evolution in <i>Caenorhabditis elegans</i> Open
The rise of anthelmintic-resistant strains in livestock threatens both animal and human health. Understanding the factors influencing anthelmintic resistance is crucial to mitigate the threat posed by these parasites. Due to difficulties i…
View article: Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i>
Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i> Open
The evolution of antimicrobial-resistant pathogens poses a global health threat, and it is unclear if evolutionary trajectories to resistance lead to predictable phenotypes. We analyzed antimicrobial resistance (AMR) evolution in the human…
View article: Robust antibiotic sensitization of pathogenic <i>Pseudomonas aeruginosa</i> via negative hysteresis in the cell envelope
Robust antibiotic sensitization of pathogenic <i>Pseudomonas aeruginosa</i> via negative hysteresis in the cell envelope Open
Antibiotic combination in time and space is a key strategy to combat antimicrobial resistance. The success of such treatment designs requires their robust efficacy across treatment conditions and a pathogen’s genomic diversity. This study …
View article: A streamlined method to determine the antibiotic resistance of plaque-forming predatory bacteria
A streamlined method to determine the antibiotic resistance of plaque-forming predatory bacteria Open
Introduction Antimicrobial resistance (AMR) is a critical global health issue caused by antibiotic overuse, leading to the rise of multi-resistant pathogens such as in bacteria of the ESKAPE group. Alternative or combination therapies, inc…
View article: The Interaction Between the Nematode <i>Caenorhabditis elegans</i> and Its Coexisting Fungal Microbiome Member <i>Barnettozyma californica</i>
The Interaction Between the Nematode <i>Caenorhabditis elegans</i> and Its Coexisting Fungal Microbiome Member <i>Barnettozyma californica</i> Open
The nematode Caenorhabditis elegans is known to feed on and interact with bacteria in its environment and has become a model organism for microbiome studies. However, whether and how C. elegans interacts with co‐occurring fungi remains lar…
View article: Maintenance and loss of microbe-mediated protection in the absence of pathogens
Maintenance and loss of microbe-mediated protection in the absence of pathogens Open
Protective microbes are known for their service to hosts. While they allow hosts to survive infection, microbes, too, benefit from successful inhibition of incoming pathogens. Under constant pathogen exposure, protective symbionts should t…
View article: A novel mechanism of unstable heteroresistance via reversible ompP2 mutations in Haemophilus influenzae
A novel mechanism of unstable heteroresistance via reversible ompP2 mutations in Haemophilus influenzae Open
Heteroresistance, the presence of a resistant subpopulation within a predominantly susceptible bacterial isolate, is usually difficult to detect and may cause treatment failure. Mechanisms driving unstable heteroresistant phenotypes, which…
View article: How can we enable school students to learn and participate in science engagement initiatives? Roles and tasks of enablers
How can we enable school students to learn and participate in science engagement initiatives? Roles and tasks of enablers Open
Involving school students in authentic research beyond their school learning means creating participatory, out-of-school opportunities related to research processes, giving them a voice in the applied format of science engagement. Importan…
View article: Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans
Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans Open
View article: Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i>
Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i> Open
The evolution of antimicrobial resistant (AMR) pathogens poses a global health threat and it is unclear if evolutionary trajectories to resistance lead to predictable phenotypes. We analyzed AMR-evolution in the human pathogen Haemophilus …
View article: PelD is required downstream of c-di-GMP for host specialization of Pseudomonas lurida
PelD is required downstream of c-di-GMP for host specialization of Pseudomonas lurida Open
View article: pelD is required downstream of c-di-GMP for host specialization of Pseudomonas lurida
pelD is required downstream of c-di-GMP for host specialization of Pseudomonas lurida Open
Background The bacterial second messenger c-di-GMP is known to influence the formation of biofilms and thereby persistence of pathogenic and beneficial bacteria in hosts. A previous evolution experiment with Pseudomonas lurida MYb11, occas…
View article: The nematode<i>Caenorhabditis elegans</i>can benefit from its coexisting fungal microbiome member<i>Barnettozyma californica</i>
The nematode<i>Caenorhabditis elegans</i>can benefit from its coexisting fungal microbiome member<i>Barnettozyma californica</i> Open
The nematode Caenorhabditis elegans is known to feed on and interact with bacteria in its environment and has become a model organism for microbiome studies. However, whether and how C. elegans interacts with co-occurring fungi remains lar…
View article: Comparative analysis of novel <i>Pseudobdellovibrionaceae</i> genera and species yields insights into the genomics and evolution of bacterial predation mode
Comparative analysis of novel <i>Pseudobdellovibrionaceae</i> genera and species yields insights into the genomics and evolution of bacterial predation mode Open
Bacteria of the family Pseudobdellovibrionaceae belong to a group of bacteria that kill and feed on other bacteria. The diversity of predation strategies, habitats, and genome characteristics of these bacteria are largely unexplored, despi…
View article: Are we overlooking the obvious? Bacterial evolution is at the heart of antimicrobial resistance
Are we overlooking the obvious? Bacterial evolution is at the heart of antimicrobial resistance Open
View article: <i>Caenorhabditis</i> nematodes influence microbiome and metabolome characteristics of their natural apple substrates over time
<i>Caenorhabditis</i> nematodes influence microbiome and metabolome characteristics of their natural apple substrates over time Open
The microbiomes of host organisms and their direct source environments are closely linked and key for shaping microbial community dynamics. The relationship between these linked dynamics is largely unexplored because source substrates are …
View article: Role of microbial life history strategy in shaping the characteristics and evolution of host-microbiota interactions
Role of microbial life history strategy in shaping the characteristics and evolution of host-microbiota interactions Open
Many host-associated microbes are transmitted between individual hosts via the environment and, therefore, need to succeed both within a host and a connected environmental habitat. These microbes might invest differentially into the two ha…
View article: Evolution of ivermectin resistance in the nematode model<i>Caenorhabditis elegans</i>: critical influence of population size and unexpected cross-resistance to emodepside
Evolution of ivermectin resistance in the nematode model<i>Caenorhabditis elegans</i>: critical influence of population size and unexpected cross-resistance to emodepside Open
The emergence and spread of anthelmintic resistance represent a major challenge for treating parasitic nematodes, threatening mass-drug control programs in humans and zoonotic species. Currently, experimental evidence to understand the inf…
View article: Understanding Host-Microbiome Evolution through the Lens of Evolutionary Theory: New Tricks for Old Dogs
Understanding Host-Microbiome Evolution through the Lens of Evolutionary Theory: New Tricks for Old Dogs Open
All plants and animals are host to a community of microorganisms, their microbiomes, that have crucial influences on the life history and performance of their hosts. Despite the importance of such host-microbiome relationships, relatively …
View article: Investigating the consequences of the mating system for drug resistance evolution in <i>C. elegans</i>
Investigating the consequences of the mating system for drug resistance evolution in <i>C. elegans</i> Open
The rise of anthelmintic-resistant strains in livestock threatens both animal and human health. Understanding the factors influencing anthelmintic resistance is crucial to mitigate the threat posed by these parasites. Due to difficulties i…
View article: Variation in the response to antibiotics and life-history across the major <i>Pseudomonas aeruginosa</i> clone type (mPact) panel
Variation in the response to antibiotics and life-history across the major <i>Pseudomonas aeruginosa</i> clone type (mPact) panel Open
Pseudomonas aeruginosa is a ubiquitous, opportunistic human pathogen. Since it often expresses multidrug resistance, new treatment options are urgently required. Such new treatments are usually assessed with one of the canonical laboratory…
View article: Use of Viscous medium to study anthelmintic drug action in Caenorhabditis elegans
Use of Viscous medium to study anthelmintic drug action in Caenorhabditis elegans Open
Caenorhabditis elegans is an appealing tool for experimental evolution and for working with antiparasitic drugs, from understanding the molecular mechanisms of drug action and resistance to uncover new drug targets. We present a new method…
View article: Gut-associated functions are favored during microbiome assembly across a major part of <i>C. elegans</i> life
Gut-associated functions are favored during microbiome assembly across a major part of <i>C. elegans</i> life Open
The microbiome expresses a variety of functions that influence host biology. The range of functions depends on the microbiome’s composition, which can change during the host’s lifetime due to neutral assembly processes, host-mediated selec…
View article: The archaeome in metaorganism research, with a focus on marine models and their bacteria–archaea interactions
The archaeome in metaorganism research, with a focus on marine models and their bacteria–archaea interactions Open
Metaorganism research contributes substantially to our understanding of the interaction between microbes and their hosts, as well as their co-evolution. Most research is currently focused on the bacterial community, while archaea often rem…
View article: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in<i>C. elegans</i>
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in<i>C. elegans</i> Open
Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely u…
View article: Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans Open
Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely u…
View article: Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics
Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics Open
While numerous health-beneficial interactions between host and microbiota have been identified, there is still a lack of targeted approaches for modulating these interactions. Thus, we here identify precision prebiotics that specifically m…
View article: Variation in the response to antibiotics and life-history across the major<i>Pseudomonas aeruginosa</i>clone type (mPact) panel
Variation in the response to antibiotics and life-history across the major<i>Pseudomonas aeruginosa</i>clone type (mPact) panel Open
Pseudomonas aeruginosa is a ubiquitous, opportunistic human pathogen. Since it often expresses multidrug resistance, it is ranked by the World Health Organization among the top 3 high priority pathogens, for which new treatment options are…
View article: The intricate triangular interaction between protective microbe, pathogen and host determines fitness of the metaorganism
The intricate triangular interaction between protective microbe, pathogen and host determines fitness of the metaorganism Open
The microbiota shapes host biology in numerous ways. One example is protection against pathogens, which is likely critical for host fitness in consideration of the ubiquity of pathogens. The host itself can affect abundance of microbiota o…