Hiroshi Fujii
YOU?
Author Swipe
View article: Serotype distribution among adults with community-acquired pneumococcal pneumonia in Japan between 2019 and 2022: A multicenter observational study
Serotype distribution among adults with community-acquired pneumococcal pneumonia in Japan between 2019 and 2022: A multicenter observational study Open
Streptococcus pneumoniae is a leading cause of community-acquired pneumonia (CAP) in adults. With the introduction of pneumococcal conjugate vaccines (PCVs) into pediatric national immunization programs, the serotype distribution of…
View article: Clinical Images: Multiple blisters on the upper and lower extremities in granulomatosis with polyangiitis
Clinical Images: Multiple blisters on the upper and lower extremities in granulomatosis with polyangiitis Open
View article: Rheumatoid factor or interleukin-6 receptor inhibition predicts the long-term effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: A two-center retrospective study
Rheumatoid factor or interleukin-6 receptor inhibition predicts the long-term effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: A two-center retrospective study Open
Objectives To assess long-term retention rates associated with effectiveness of certolizumab pegol (CZP) and identify determinants of its effectiveness in patients with rheumatoid arthritis (RA). Methods This retrospective observational st…
View article: Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication
Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication Open
Mutations in the complement factor H ( CFH ) gene are associated with complement dysregulation and the development of atypical hemolytic uremic syndrome (aHUS). Several fusion genes that result from genomic structural variation in the CFH …
View article: Potassium balance in paddy fields under conventional rice straw recycling versus cow dung compost application in mixed crop–livestock systems in Japan
Potassium balance in paddy fields under conventional rice straw recycling versus cow dung compost application in mixed crop–livestock systems in Japan Open
Potassium (K) fertilizer consumption in rice production has increased in developing countries where negative K balance was observed, but it has recently decreased in Japan. This situation raises a question of how K fertilization is managed…
View article: Granulomatosis with polyangiitis following Pfizer-BioNTech COVID-19 vaccination
Granulomatosis with polyangiitis following Pfizer-BioNTech COVID-19 vaccination Open
We report the first case of proteinase 3-antineutrophil cytoplasmic antibody-positive granulomatosis with polyangiitis (GPA) with predominant ears, nose, and throat manifestations following coronavirus disease 2019 (COVID-19) vaccination. …
View article: Sjögren’s Syndrome Presenting with Temporary Hemiplegia Mimicking Transient Ischemic Attack
Sjögren’s Syndrome Presenting with Temporary Hemiplegia Mimicking Transient Ischemic Attack Open
Sjögren's syndrome manifests with a wide variety of neurologic symptoms. This case report presents a 53-year-old woman with Sjögren's syndrome associated with temporal hemiplegia, which was suspected to be a transient ischemic attack. Afte…
View article: On-farm assessment of the phosphorus balance of paddy soil fertilized with cow dung compost in mixed crop–livestock systems and with rice straw in conventional practice in Yamagata, Japan
On-farm assessment of the phosphorus balance of paddy soil fertilized with cow dung compost in mixed crop–livestock systems and with rice straw in conventional practice in Yamagata, Japan Open
Rice straw (RS) and cow dung compost (CDC) are good sources of phosphorus (P) to support rice production. Our previous research found that CDC application in mixed crop-livestock systems supplied more total P to the paddy soil than RS, but…
View article: On-farm assessment of the phosphorus balance of paddy soil fertilized with cow dung compost in mixed crop–livestock systems and with rice straw in conventional practice in Yamagata, Japan
On-farm assessment of the phosphorus balance of paddy soil fertilized with cow dung compost in mixed crop–livestock systems and with rice straw in conventional practice in Yamagata, Japan Open
Rice straw (RS) and cow dung compost (CDC) are good sources of phosphorus (P) to support rice production. Our previous research found that CDC application in mixed crop-livestock systems supplied more total P to the paddy soil than RS, but…
View article: Comparison of the nitrogen balance in paddy fields under conventional rice straw application versus cow dung compost application in mixed crop–livestock systems
Comparison of the nitrogen balance in paddy fields under conventional rice straw application versus cow dung compost application in mixed crop–livestock systems Open
In Japan, rice straw (RS) is commonly incorporated into the soil after harvest to maintain the fertility of paddy soil. However, in mixed crop–livestock systems, RS is collected to feed livestock and then cow dung compost (CDC) is applied …
View article: Identification and characterization of oligomeric proanthocyanidins with significant anti-cancer activity in adzuki beans (Vigna angularis)
Identification and characterization of oligomeric proanthocyanidins with significant anti-cancer activity in adzuki beans (Vigna angularis) Open
View article: Cover Feature: A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf (Chem. Eur. J. 59/2019)
Cover Feature: A Guanidyl‐Based Bivalent Peptidomimetic Inhibits K‐Ras Prenylation and Association with c‐Raf (Chem. Eur. J. 59/2019) Open
Hook to a hole: A cell-permeable bivalent inhibitor of protein prenyltransferases binds to the active pocket and delivers a small module compound onto an interface of protein–protein interactions with K-Ras, allowing inhibition of posttran…
View article: Isolation and characterization of a novel oligomeric proanthocyanidin with significant anti-cancer activities from grape stems (Vitis vinifera)
Isolation and characterization of a novel oligomeric proanthocyanidin with significant anti-cancer activities from grape stems (Vitis vinifera) Open
Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds were estimated as epigallocatech…
View article: アズキ(Vigna angularis)における有意な抗腫瘍活性を有するオリゴマープロアントシアニジンの同定と特性化【JST・京大機械翻訳】
アズキ(Vigna angularis)における有意な抗腫瘍活性を有するオリゴマープロアントシアニジンの同定と特性化【JST・京大機械翻訳】 Open
View article: Adzuki bean (<i>Vigna angularis</i>) extract reduces amyloid-β aggregation and delays cognitive impairment in <i>Drosophila</i> models of Alzheimer's disease
Adzuki bean (<i>Vigna angularis</i>) extract reduces amyloid-β aggregation and delays cognitive impairment in <i>Drosophila</i> models of Alzheimer's disease Open
The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer's disease and provide useful information for identifying novel prevention treatments for Alzheimer's disease.
View article: Evidence for the involvement of FXR signaling in ovarian granulosa cell function
Evidence for the involvement of FXR signaling in ovarian granulosa cell function Open
Farnesoid X receptor (FXR) is mainly present in enterohepatic tissues and regulates cholesterol, lipid, and glucose homeostasis in coordination with target genes such as SHP and FABP6. Although FXR has been revealed to be expressed in repr…
View article: A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells
A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells Open
Epidermal or cutaneous fatty acid-binding protein is an intracellular lipid-binding protein, also known as FABP5, and its expression level is closely related to cancer cell proliferation and metastatic activities in various types of carcin…
View article: Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts
Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts Open
View article: Additional file 5: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity
Additional file 5: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity Open
is a figure showing the effect of Bz treatment on serum uric acid, calcium, and phosphate. Mice aged 14Â weeks were injected with vehicle or Bz, twice on both day 1 and day 4 (14wk and 14wkBz, respectively). After the second Bz injection, …
View article: Additional file 3: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity
Additional file 3: of Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity Open
is a table presenting significantly increased or decreased genes among the proteasome ubiquitin pathway, GADD45 signaling, and DNA damage induced 14-3-3 signaling. The genes which were significantly increased with Bz treatment and belong t…
View article: Identification of Multiple Forms of RNA Transcripts Associated with Human-Specific Retrotransposed Gene Copies
Identification of Multiple Forms of RNA Transcripts Associated with Human-Specific Retrotransposed Gene Copies Open
The human genome contains thousands of retrocopies, mostly as processed pseudogenes, which were recently shown to be prevalently transcribed. In particular, those specifically acquired in the human lineage are able to modulate gene express…
View article: High expression of Fatty Acid‐Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells
High expression of Fatty Acid‐Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells Open
Fatty acid‐binding proteins ( FABP s) are responsible for binding and storing hydrophobic ligands such as long‐chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonst…
View article: Synthesis of Prodelphinidin Trimer Isolated from Cistus Albidus and its Growth Inhibitory Activity Against Human Prostate Cancer Cell Lines
Synthesis of Prodelphinidin Trimer Isolated from Cistus Albidus and its Growth Inhibitory Activity Against Human Prostate Cancer Cell Lines Open
First synthesis of prodelphinidin trimer (epigallocatechin-gallocatechin-catechin) isolated from Cistus albidus w a s accomplished from monomeric epigallocatechin electrophile and dimeric gallocatechin-catechin nucleophile.The condensation…
View article: Synthesis of Arecatannin A1 from Dimeric Epicatechin Electrophile
Synthesis of Arecatannin A1 from Dimeric Epicatechin Electrophile Open
Synthesis of arrecatannin A1 (1) was accomplished from dimeric epicatechin electrophile, which was prepared by Zn(OTf) 2 mediated self-condensation, and monomeric catechin nucleophile. The condensation was successfully worked using Yb(OTf)…
View article: Influence of Soil Properties on the Arsenate Immobilization by Magnesium Oxide
Influence of Soil Properties on the Arsenate Immobilization by Magnesium Oxide Open
Soil contamination and accompanied groundwater contamination by arsenic is a serious environmental problem worldwide. In this study, a series of experiments were performed to obtain the information on the influence of soil properties (arse…