Hiroaki Onda
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View article: Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies
Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies Open
Deficit of oxygen and nutrients in the tumor microenvironment (TME) triggers abnormal angiogenesis that produces dysfunctional and leaky blood vessels, which fail to adequately perfuse tumor tissues. Resulting hypoxia, exacerbation of meta…
View article: Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism
Fustin suppressed melanoma cell growth via cAMP/PKA-dependent mechanism Open
Melanoma, a cancer arising from melanocytes, requires a novel treatment strategy because of the ineffectiveness of conventional therapies in certain patients. Fustin is a flavanonol found in young fustic (Cotinus coggygria). However, littl…
View article: Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse
Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse Open
Mouse Genome Informatics (MGI) is a federation of expertly curated information resources designed to support experimental and computational investigations into genetic and genomic aspects of human biology and disease using the laboratory m…
View article: Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1
Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1 Open
Lung fibrosis, including idiopathic pulmonary fibrosis, is an intractable disease accompanied by an irreversible dysfunction in the respiratory system. Its pathogenesis involves the transforming growth factorβ (TGFβ)-induced overproduction…
View article: Mouse Genome Database (MGD): Knowledgebase for mouse–human comparative biology
Mouse Genome Database (MGD): Knowledgebase for mouse–human comparative biology Open
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism knowledgebase for the laboratory mouse, a widely used animal model for comparative studies of the genetic and genomic basis for human health an…
View article: Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression Open
Kumazoe, M., M. Yamashita, Y. Nakamura, K. Takamatsu, J. Bae, S. Yamashita, S. Yamada, H. Onda, T. Nojiri, K. Kangawa, and H. Tachibana. 2017. Green tea polyphenol EGCG upregulates Tollip expression by suppressing Elf-1 expression. J. Immu…