Explanipedia

Food‐Based Edible Wireless Sensing Device with Isotropic Electromagnetic Response for Gastrointestinal Monitoring Open

Ryosuke Matsuda, Shion Miura, Tetsuo Kan, Hiroaki Onoe · 2025

Small oral‐intake sensors are extremely effective in detecting diseases concerning the digestive system because those sensors enable remote monitoring of information in the body through oral intake. Conventional oral‐intake sensors contain…

Fabrication of a hydrogel-based microstrip patch antenna by laser-induced graphitization Open

Yuma Hattori, M. Kato, Hiroaki Onoe, Mitsuhiro Terakawa · 2025

Hydrogels have attracted attention as highly biocompatible supporting materials for wearable devices. An antenna is a key component for wireless transmission of information collected by the devices worn on the human body. Furthermore, inte…

M/G‐Ratio‐Tuned Calcium Alginate Hydrogel Microcarrier for Controlled Delivery of Adeno‐Associated Virus for Gene Therapy Open

Aiki Hioki, Shuhei Takatsuka, Yuta Kurashina, Hiroaki Onoe · 2025

This paper proposes the controlled release of adeno‐associated virus (AAV) by polymer mesh structures of alginate hydrogel microbeads (gel‐beads). The polymer mesh structure of alginate hydrogel can be controlled by adjusting the number of…

Bioengineered iPSC Vessels Recapitulate Human Vascular Physiological Function and Aging Phenotypes Open

Shun Itai, Ron Usami, Mayuko Korekata, Jumpei Muramatsu, Mikako Katagiri , et al. · 2025

Vascular aging contributes to multisystem diseases and limits health span. Although various animal models have contributed to aging research, their vasculatures poorly recapitulate human physiology. Even existing tissue-engineered blood ve…

Loss of angulin-1/LSR promotes vasculogenic mimicry and epithelial-mesenchymal transition in breast cancer Open

Yayoi Yoshioka, Chisato Nosaka, Tomokazu Ohishi, Minami Nakajima, Yumiko Ishikawa , et al. · 2025

Vasculogenic mimicry (VM) is a process by which tumor cells form vessel-like network to secure oxygen and nutrients essential for tumor growth. Intercellular junctions, including tight junctions, may play a critical role in this process, i…

Synthesis of Hydrogel Microparticles from Ultra‐High‐Viscosity Pre‐Gel Solution by Combining Centrifugal Force and Ultrasonic Vibration (Small 34/2025) Open

Yuki Bando, Ryota Kawamae, R. Konno, Hiroaki Onoe, Yoshiyuki Tagawa , et al. · 2025

Structural Color Polymer‐Based Colorimetric Sensor for Detecting Mechanical Stress in Lithium Batteries Separator Open

Satoshi Nishita, Hiroaki Onoe · 2025

Deformation of lithium batteries is known as a hazardous problem possibly leading to a fire or fuming, while deformation sensors are not attached to the batteries. The deformation comes from complex phenomena inside the batteries, resultin…

Soil moisture monitoring using sheet-type GHz metamaterial perfect absorber Open

F. Noto, Soma Sato, Hiroaki Onoe, Tetsuo Kan · 2025

In this study, we propose a sensor probe utilizing electromagnetic metamaterial perfect absorbers to enable the evaluation of soil properties. This device consists of periodically arrayed copper split-ring resonators (SRRs), a moisture-abs…

Hydrosilane‐Functionalized [2.2]Paracyclophane for Plasma‐Etch‐Resistant and Post‐Modifiable Poly(Para‐Xylylene) Open

Lukas Bichlmaier, Tetsuhiko Teshima, Arseni Kostenko, George Al Boustani, Rebecca Wilhelm , et al. · 2024

Poly(para‐xylylene)s (PPXs), or so‐called parylenes, have become a well‐established polymer class in the conformal coating industry. Due to their transparent nature, low electrical conductivity, and high biocompatibility, they are ideal ca…

Microdroplet fusion driving the mass formation of twisted bilayer molybdenum disulfide fragments via spontaneous liquid-liquid phase separation Open

Shotaro Yotsuya, Takahiko Endo, Yasumitsu Miyata, Limi Chen, Yoshifumi Oshima , et al. · 2024

The stacking of 2D materials has attracted attention from emergent properties by Moiré patterns, a degree of freedom that is artificially controlled. However, the current process of arranging Moiré patterns, which involves mechanically rep…

Maturation of Human iPSC‐Derived Cardiac Microfiber with Electrical Stimulation Device Open

Akari Masuda, Yuta Kurashina, Hidenori Tani, Y Soma, Jumpei Muramatsu , et al. · 2024

Here an electrical stimulation system is described for maturing microfiber‐shaped cardiac tissue (cardiac microfibers, CMFs). The system enables stable culturing of CMFs with electrical stimulation by placing the tissue between electrodes.…

Adeno‐Associated Virus‐Encapsulated Alginate Microspheres Loaded in Collagen Gel Carriers for Localized Gene Transfer Open

Yuta Kurashina, Sho Kurihara, Takeshi Kubota, Shuhei Takatsuka, Motoki Hirabayashi , et al. · 2024

This work reports localized in vivo gene transfer by biodegradation of the adeno‐associated virus‐encapsulating alginate microspheres (AAV‐AMs) loaded in collagen gel carriers. AAV‐AMs are centrifugally synthesized by ejecting a mixed pre‐…

Edible piezoelectric wireless capsule sensor for sensing gastric motility Open

Shion Miura, Tetsuo Kan, Hiroaki Onoe · 2024

Hydrogel on a split-ring resonator soil water content sensing using swelling characteristics Open

F. Noto, Soma Sato, Hiroaki Onoe, Tetsuo Kan · 2024

Macroscale Collagen‐Actomyosin Hybrid Actuator Built from Bioderived Materials (Adv. Funct. Mater. 51/2023) Open

Koki Yoshida, Kenjiro Kohno, Y. Hiratsuka, Hiroaki Onoe · 2023

Artificial Muscles In article number 2307766, Hiroaki Onoe and co-workers propose a macroscale collagen-actomyosin hybrid actuator built from bioderived materials inspired by a hierarchical structure of biological muscle. Collagen gel entr…

Hydrogel‐Sheathed hiPSC‐Derived Heart Microtissue Enables Anchor‐Free Contractile Force Measurement (Adv. Sci. 35/2023) Open

Yuta Kurashina, Keisuke Fukada, Shun Itai, Shuichi Akizuki, Ryo Sato , et al. · 2023

Anchor‐Free Contractile Force Measurement A hydrogel‐sheathed human induced pluripotent stem cell (hiPSC)‐derived heart microtissue (H3M) can provide an anchor‐free contractile force measurement platform in commonly used multi‐well plates.…

Spatiotemporal single-cell tracking analysis in 3D tissues to reveal heterogeneous cellular response to mechanical stimuli Open

Keitaro Kasahara, Jumpei Muramatsu, Yuta Kurashina, Shigenori Miura, Shogo MIYATA , et al. · 2023

Mechanical stimuli have been recognized as important for tissue maturation, homeostasis and constructing engineered three-dimensional (3D) tissues. However, we know little about the cellular mechanical response in tissues that could be con…

Macroscale Collagen‐Actomyosin Hybrid Actuator Built from Bioderived Materials Open

Koki Yoshida, Kenjiro Kohno, Y. Hiratsuka, Hiroaki Onoe · 2023

Biological muscles mainly consist of motor proteins that play essential roles and have a hierarchical structure covered with collagen that can transmit the tension to bones via tendons. The artificial reconstruction of motor proteins is hi…

Controlled release of adeno‐associated virus from alginate hydrogel microbeads with enhanced sensitivity to ultrasound Open

Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, Sho Kurihara, Motoki Hirabayashi , et al. · 2023

Adeno‐associated virus (AAV)‐based gene therapy holds promise as a fundamental treatment for genetic disorders. For clinical applications, it is necessary to control AAV release timing to avoid an immune response to AAV. Here we propose an…

Unusual selective monitoring of N,N-dimethylformamide in a two-dimensional layered field-effect transistor Open

Akito Fukui, Keigo Matsuyama, Hiroaki Onoe, Shun Itai, Hidekazu Ikeno , et al. · 2023

N,N-Dimethylformamide (DMF) is an essential solvent in industries and pharmaceutics. Its market size range was estimated to be 2 billion US dollars in 2022. Monitoring DMF in solution environments in real time is significant because of its…

A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Open

Teppei Komatsu, Hiroki Ohta, Naoki Takakura, Junichi Hata, Tomomichi Kitagawa , et al. · 2023

Background and Purpose The failure of neuroprotective treatment-related clinical trials, including stem cell therapies, may be partially due to a lack of suitable animal models. We have developed a stem cell-implantable radiopaque hydrogel…

Marangoni‐Propulsion Micro‐Robots Integrated with a Wireless Photonic Colloidal Crystal Hydrogel Sensor for Exploring the Aquatic Environment Open

Koki Yoshida, Hiroaki Onoe · 2022

Marangoni-Propulsion Micro-Robots In article number 2100248, Koki Yoshida and Hiroaki Onoe present Marangoni-propulsion micro-robots integrated with a visible photonic colloidal crystal hydrogel sensor. The micro-robots can autonomously pr…

Janus Hydrogel Microbeads for Glucose Sensing with pH Calibration Open

Maru Ando, Mio Tsuchiya, Shun Itai, Tomomi Murayama, Yuta Kurashina , et al. · 2021

We present fluorescent Janus hydrogel microbeads for continuous glucose sensing with pH calibration. The Janus hydrogel microbeads, that consist of fluorescent glucose and pH sensors, were fabricated with a UV-assisted centrifugal microflu…

Ultrasound-triggered on-demand drug delivery using hydrogel microbeads with release enhancer Open

Takeshi Kubota, Yuta Kurashina, JianYi Zhao, Keita Ando, Hiroaki Onoe · 2021

Ultrasound-triggered drug delivery has been widely researched for its potential to improve the therapeutic efficacy of drugs. This paper presents drug release using hydrogel microbeads with release enhancer for efficient ultrasound-trigger…

Simultaneous crosslinking induces macroscopically phase-separated microgel from a homogeneous mixture of multiple polymers Open

Yuta Kurashina, Mio Tsuchiya, Atsushi Sakai, Tomoki Maeda, Yun Jung Heo , et al. · 2021

Soft Spiral‐Shaped Microswimmers for Autonomous Swimming Control by Detecting Surrounding Environments Open

Koki Yoshida, Hiroaki Onoe · 2020

Microswimmers In article number 2000095, Hiroaki Onoe and Koki Yoshida achieve the fabrication of soft spiral-shaped microswimmers that can sense the external temperature and deform their spiral-shaped body in order to change propulsion ve…

Ethanol driven micro-robot Open

Koki Yoshida, Hiroaki Onoe · 2020

This paper describes the motion change of ethanol driven micro-robots by the stimuli-responsive hydrogel. The main components of micro-robot are thermal responsive hydrogel, silicone tube, and PDMS. The micro-robots are soaked in the ethan…

Biochemical microsensor array with structural color hydrogel for rapid target detection Open

Ryohei Ueno, Shota Yamawaki, Hiroaki Onoe · 2020

This paper describes a biochemical microsensor with arrayed structural color hydrogels enabling the rapid detection. We fabricated thermo-responsive structural color hydrogels composed of silica colloidal particles and N-isopropylacrylamid…

Microdot reflective channel display with color control by sub-pixel Open

Jumpei Muramatsu, Hiroaki Onoe · 2020

This paper describes the multi-color microfluidic display with sub-pixels, especially the design strategy of the display. Our display has four primary color sub-pixels in the single pixel, and shows various colors by patterning the ON/OFF …

Fabrication of Micro-Gel Beads Using Liquid Nitrogen in Centrifugal Microfluidic Device Open

Tomomi Murayama, Mio Tsuchiya, Koki Yoshida, Yuta Kurashina, Hiroaki Onoe · 2020

We propose centrifugal-based microfluidic device with a heating system for fabricating microgel beads that can be cross-linked by temperature change. Microgel beads can be fabricated by rapidly cooling agarose pre-gel droplets injected by …

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