Hirobumi Suzuki
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View article: Engineered single chain variable fragments (scFvs) with improved pH-dependent kinetics for use in continuous biosensor applications.
Engineered single chain variable fragments (scFvs) with improved pH-dependent kinetics for use in continuous biosensor applications. Open
One challenge in the continuous monitoring of insulin lies with the unavailability of a high-affinity biological recognition element (BRE) with kinetic parameters sufficient to track fluctuating concentrations of insulin in vivo. An…
View article: Development of DNA aptamers universally bound to single-chain fragment variables and their applications in bioprocess monitoring
Development of DNA aptamers universally bound to single-chain fragment variables and their applications in bioprocess monitoring Open
Single-chain fragment variables (scFvs), composed of variable heavy and light chains joined together by a peptide linker, can be produced using a cost-effective bacterial expression system, making them promising candidates for pharmaceutic…
View article: Genome assembly of Genji firefly (<i>Nipponoluciola cruciata</i>) reveals novel luciferase-like luminescent proteins without peroxisome targeting signal
Genome assembly of Genji firefly (<i>Nipponoluciola cruciata</i>) reveals novel luciferase-like luminescent proteins without peroxisome targeting signal Open
The Genji firefly, Nipponoluciola cruciata, is an aquatic firefly endemic to Japan, inhabiting a wide area of the Japanese archipelago. The luminescence of fireflies is a scientifically interesting phenomenon, and many studies have evaluat…
View article: Usefulness of capsule endoscopy for small intestinal obstruction: a dual-center prospective observational study
Usefulness of capsule endoscopy for small intestinal obstruction: a dual-center prospective observational study Open
Aim: To evaluate whether capsule endoscopy can identify causes of small intestinal obstruction and determine the appropriate patient population for capsule endoscopy. Methods: In this prospective observational study, we performed a tag-les…
View article: A new genus for two species of Japanese fireflies having aquatic larvae (Coleoptera, Lampyridae) and a definition of Luciola s. str.
A new genus for two species of Japanese fireflies having aquatic larvae (Coleoptera, Lampyridae) and a definition of Luciola s. str. Open
A new genus Nipponoluciola Ballantyne, Kawashima, Jusoh & Suzuki is proposed and described from males, females and larvae for two species of Japanese fireflies (Coleoptera, Lampyridae, Luciolinae) which have aquatic larvae. The famous Genj…
View article: Acute Hepatitis E Virus Infection Transmitted through Platelet Transfusion for Aplastic Anemia
Acute Hepatitis E Virus Infection Transmitted through Platelet Transfusion for Aplastic Anemia Open
62歳男性．再生不良性貧血に対して赤血球・血小板輸血依存状態であった．発熱と倦怠感，急激な肝逸脱酵素上昇にて入院し，急性E型肝炎と診断された．その後の検査で感染経路は，入院42日前に行っていた血小板輸血であることが判明した．
View article: A new genus for two species of Japanese fireflies having aquatic larvae (Coleoptera, Lampyridae) and a definition of Luciola s. str.
A new genus for two species of Japanese fireflies having aquatic larvae (Coleoptera, Lampyridae) and a definition of Luciola s. str. Open
This dataset contains the digitized treatments in Plazi based on the original journal article Ballantyne, Lesley, Kawashima, Itsuro, Jusoh, Wan F. A., Suzuki, Hirobumi (2022): A new genus for two species of Japanese fireflies having aquati…
View article: Imaging Promoter Assay of Adenylyl Cyclase A Gene in <i>Dictyostelium discoideum</i> during Fruiting Body Formation by Dual-Color Bioluminescence Microscopy
Imaging Promoter Assay of Adenylyl Cyclase A Gene in <i>Dictyostelium discoideum</i> during Fruiting Body Formation by Dual-Color Bioluminescence Microscopy Open
Cyclic adenosine monophosphate (cAMP), which is derived from adenosine triphosphate through adenylyl cyclase A (acaA), acts as an intracellular secondary messenger and an extracellular chemotactic substance in important biological processe…
View article: Acute Liver Failure Due to Hypereosinophilic Syndrome Accompanied by Duodenal Perforation
Acute Liver Failure Due to Hypereosinophilic Syndrome Accompanied by Duodenal Perforation Open
A 78-year-old woman presenting with severe acute liver failure was admitted to our hospital. On screening for the etiology of acute liver failure, it was diagnosed as being due to idiopathic hypereosinophilic syndrome (eosinophil count rep…
View article: Duodenal adenocarcinoma of the gastric phenotype treated by endoscopic submucosal dissection (ESD): a case report
Duodenal adenocarcinoma of the gastric phenotype treated by endoscopic submucosal dissection (ESD): a case report Open
A 59-year-old woman underwent esophagogastroduodenoscopy as a health check-up, which revealed a submucosal tumor-like lesion with a central recess, measuring 20 mm in diameter, on the opposite side of the major duodenal papilla. A biopsy s…
View article: Cloning and mutagenetic modification of the firefly luciferase gene and its use for bioluminescence microscopy of engrailed expression during Drosophila metamorphosis
Cloning and mutagenetic modification of the firefly luciferase gene and its use for bioluminescence microscopy of engrailed expression during Drosophila metamorphosis Open
View article: Evaluation of the population structure and phylogeography of the Japanese Genji firefly, Luciola cruciata, at the nuclear DNA level using RAD-Seq analysis
Evaluation of the population structure and phylogeography of the Japanese Genji firefly, Luciola cruciata, at the nuclear DNA level using RAD-Seq analysis Open
View article: Ecological and Histological Notes on the Luminous Springtail,<i>Lobella</i>sp. (Collembola: Neanuridae), Discovered in Tokyo, Japan
Ecological and Histological Notes on the Luminous Springtail,<i>Lobella</i>sp. (Collembola: Neanuridae), Discovered in Tokyo, Japan Open
Some species of springtail (Collembola) are luminous, but it is not known whether light emitted by springtail is due to self-luminescence, feeding on luminous fungi, or accidental infection by luminous bacteria. To address this question, w…
View article: Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy
Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy Open
View article: S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS
S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS Open
Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action (MOA) of current antipsychotics with dopamine D2 receptor antagonism. Phosphodiesterase 10A (PDE10A) inhibitor…
View article: Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents
Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents Open
Activation of indirect pathway medium spiny neurons ( MSN s) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D 2 receptor antagonism. TAK ‐063 [1‐[2‐fluoro‐4‐(1H‐pyrazol‐1‐yl)ph…
View article: Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study
Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study Open
The colorectal cancer mortality of patients who received colonoscopy without colorectal cancer diagnosis decreased significantly compared with that of individuals in the general population. These results were compatible even in patients wi…
View article: Evaluation of chemical chaperones based on the monitoring of Bip promoter activity and visualization of extracellular vesicles by real‐time bioluminescence imaging
Evaluation of chemical chaperones based on the monitoring of Bip promoter activity and visualization of extracellular vesicles by real‐time bioluminescence imaging Open
It is known that endoplasmic reticulum (ER) stress in cells and extracellular vesicles (EVs) plays a significant role in cancer cells, therefore the evaluation of compounds that can regulate ER stress and EV secretion would be a suitable s…
View article: Bioluminescence Microscopy: Design and Applications
Bioluminescence Microscopy: Design and Applications Open
Bioluminescence imaging by microscopy is performed using an ultra-low-light imaging camera. Although imaging devices such as sensor and camera have been greatly improved over time, such improvements have not been attained commercially whic…
View article: <scp>T</scp>i<scp>LIA</scp>: a software package for image analysis of firefly flash patterns
<span>T</span>i<span>LIA</span>: a software package for image analysis of firefly flash patterns Open
As flash signaling patterns of fireflies are species specific, signal‐pattern analysis is important for understanding this system of communication. Here, we present time‐lapse image analysis ( T i LIA ), a free open‐source software package…
View article: TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms
TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms Open
View article: Monitoring Bip promoter activation during cancer cell growth by bioluminescence imaging at the single-cell level
Monitoring Bip promoter activation during cancer cell growth by bioluminescence imaging at the single-cell level Open
View article: Efficacy of repeat review with flexible spectral imaging color enhancement in patients with no findings by capsule endoscopy
Efficacy of repeat review with flexible spectral imaging color enhancement in patients with no findings by capsule endoscopy Open
F1 detected incremental significant findings in a small percentage of patients with no findings in the standard review mode. In addition, F1 showed many false-positive findings. The incremental effect of a repeated review by F1 in patients…
View article: Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress
Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress Open
View article: Risk factors for small bowel angioectasia: The impact of visceral fat accumulation
Risk factors for small bowel angioectasia: The impact of visceral fat accumulation Open
VFA is positively associated with the prevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB.
View article: Combining fluorescence and bioluminescence microscopy
Combining fluorescence and bioluminescence microscopy Open
Bioluminescence microscopy has revealed that gene expression in individual cells can respond differently to the same stimulus. To understand this phenomenon, it is important to sequentially observe the series of events from cellular signal…
View article: Monitoring of Bip promoter activation during cancer cell growth by bioluminescence imaging technique at single cell level
Monitoring of Bip promoter activation during cancer cell growth by bioluminescence imaging technique at single cell level Open
Cancer cells require the regulation of organelle-specific unfolded protein responses, such as endoplasmic reticulum (ER) stress, because of their increased metabolic activity during rapid proliferation and cell growth, which are executed t…