Explanipedia

Comprehensive analysis of prognosis markers with molecular features derived from pan-cancer whole-genome sequences Open

Mamoru Kato, Jo Nishino, Momoko Nagai, Hirofumi Rokutan, Daichi Narushima , et al. · 2025

Successful treatment with bortezomib for refractory cryoglobulinemic vasculitis triggered by ischemic non-obstructive coronary artery disease Open

Yui Ohta, Takaaki Tsuchiya, Masatoshi Oka, Moriaki Tachibana, Yoshitaka Kondo , et al. · 2025

An Autopsy Case of Myotonic Dystrophy Type 1 With Pancreatic Intraductal Papillary Mucinous Neoplasm Open

Keisuke Nonaka, Akira Arakawa, Manato Hara, Akiko Komatsu, Takuya Nagasaka , et al. · 2024

Microbiome spectra and prevalent colibactin-associated mutational process in Japanese colorectal cancer Open

Tatsuhiro Shibata, Satoshi Shiba, Shinichi Yachida, Sayaka Mizutani, Yasushi Totoki , et al. · 2024

The recent rapid increase in colorectal cancer (CRC) cases, particularly among young patients, poses a significant public health concern in Japan and other countries. The association between the gut microbiota and CRC has been well establi…

Mixed adenoma-neuroendocrine tumor of the stomach: analysis of nine cases with literature review Open

Hirofumi Rokutan, Miyako Fukasawa-Hokazono, Yukio Hokazono, Tetsuo Ushiku · 2024

Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type Open

Hirofumi Rokutan, Yasuhito Arai, Akiko Kunita, Satoshi Yamasaki, Hiromi Nakamura , et al. · 2024

Very well-differentiated adenocarcinoma of intestinal type is a distinct subtype of gastric cancer characterized by anastomosing glands with a hand-in-hand pattern and low-grade cytologic atypia resembling intestinal metaplasia. This is a …

Comment on: “Senolytic Treatment Improve Small Intestine Regeneration in Aging” Open

Hirofumi Rokutan · 2024

Cancer of unknown primary histologically, genetically and spatially diagnosed as left ovary‑derived cancer: A case report Open

Harunori Honjoh, Ayumi Taguchi, Hirofumi Rokutan, Ayako Mori, Takahiro Ando , et al. · 2023

Cancer of unknown primary (CUP) is a heterogeneous syndrome of metastatic cancer in which the primary site cannot be determined even after a standard and comprehensive search. The present report describes a case in which the spatial distri…

Clinical utility of postablation liver tumor biopsy and possibility of gene mutation analysis Open

T. Nakatsuka, Hayato Nakagawa, Koji Uchino, Hirofumi Rokutan, Mariko Tanaka , et al. · 2023

Aim Radiofrequency ablation (RFA) is regarded as a first‐line treatment for hepatocellular carcinoma (HCC) at an early stage. When treated with RFA, tumor biopsy may not be performed due to the risk of neoplastic seeding. We previously rev…

COVID-19 Analysis in Tissue Samples Acquired by Minimally Invasive Autopsy in Out-of-Hospital Deaths with Postmortem Degeneration Open

Yuichiro Hirata, Yohsuke Makino, Shun Iida, Harutaka Katano, Sayaka Nagasawa , et al. · 2023

Minimally invasive autopsy (MIA) is an alternative to a full autopsy for the collection of tissue samples from patients' bodies using instruments such as a biopsy needle. MIA has been conducted in many cases of coronavirus disease 2019 (CO…

Oncogenic structural aberration landscape in gastric cancer genomes Open

Mihoko Saito-Adachi, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai , et al. · 2023

Structural variants (SVs) are responsible for driver events in gastric cancer (GC); however, their patterns and processes remain poorly understood. Here, we examine 170 GC whole genomes to unravel the oncogenic structural aberration landsc…

Supplementary Data from Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System Open