Hirohisa Chiyoda
YOU?
Author Swipe
View article: Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Patched regulates lipid homeostasis by controlling cellular cholesterol levels Open
Hedgehog (Hh) signaling is essential during development and in organ physiology. In the canonical pathway, Hh binding to Patched (PTCH) relieves the inhibition of Smoothened (SMO). Yet, PTCH may also perform SMO-independent functions. Whil…
View article: Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis
Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis Open
Spatiotemporal restriction of signaling plays a critical role in animal development and tissue homeostasis. All stem and progenitor cells in newly hatched C . elegans larvae are quiescent and capable of suspending their development until s…
View article: Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Patched regulates lipid homeostasis by controlling cellular cholesterol levels Open
Hedgehog (Hh) signaling is essential during development and in organ physiology. In the canonical pathway, Hh binding to Patched (PTCH) relieves the inhibition of Smoothened (SMO). Yet, PTCH may also perform SMO-independent functions. Whil…