Hirohito Ogawa
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View article: Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production
Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production Open
Human herpesvirus 6B (HHV-6B), a member of the Betaherpesvirinae subfamily, is a T-lymphotropic virus that causes exanthem subitum and has been implicated in neuroinflammatory conditions such as multiple sclerosis. The tegument proteins, w…
View article: Detection of alphacoronaviruses in Rhinolophus ferrumequinum in Ehime, Japan
Detection of alphacoronaviruses in Rhinolophus ferrumequinum in Ehime, Japan Open
Bats are suspected reservoirs for several emerging viruses, including coronaviruses. Here, we report the detection of coronaviruses in the insectivorous bat, Rhinolophus ferrumequinum, in Ehime Prefecture, located in Shikoku, the smallest …
View article: Suppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System
Suppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System Open
Borna disease virus (BoDV-1) is a bornavirus that infects the central nervous systems of various animal species, including humans, and causes fatal encephalitis. BoDV-1 also establishes persistent infection in neuronal cells and causes neu…
View article: Surveillance, Isolation, and Genetic Characterization of Bat Herpesviruses in Zambia
Surveillance, Isolation, and Genetic Characterization of Bat Herpesviruses in Zambia Open
Bats are of significant interest as reservoirs for various zoonotic viruses with high diversity. During the past two decades, many herpesviruses have been identified in various bats worldwide by genetic approaches, whereas there have been …
View article: Surveillance, Isolation, and Genetic Characterization of Bat Herpesviruses in Zambia
Surveillance, Isolation, and Genetic Characterization of Bat Herpesviruses in Zambia Open
Bats are of significant interest as reservoirs for various zoonotic viruses with high diversity. During the past two decades, many herpesviruses have been identified in various bats worldwide by genetic approaches, whereas there have been …
View article: Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B
Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B Open
Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitum. HHV-6B is present in a latent or persistent form after primary infection and is produced in the salivary glands or transmitted to this o…
View article: Detection of anti-ebolavirus antibodies in Ghanaian pigs
Detection of anti-ebolavirus antibodies in Ghanaian pigs Open
Some filoviruses such as ebolaviruses and marburgviruses, cause hemorrhagic fever in humans and nonhuman primates. Pigs are suggested to play a potential role in the filovirus ecology. We investigated the seroprevalence of filovirus infect…
View article: Receptor-Mediated Host Cell Preference of a Bat-Derived Filovirus, Lloviu Virus
Receptor-Mediated Host Cell Preference of a Bat-Derived Filovirus, Lloviu Virus Open
Lloviu virus (LLOV), a bat-derived filovirus that is phylogenetically distinct from human pathogenic filoviruses such as Ebola virus (EBOV) and Marburg virus (MARV), was discovered in Europe. However, since infectious LLOV has never been i…
View article: Comparative Analysis of Fecal Microbiota in Grasscutter (Thryonomys swinderianus) and Other Herbivorous Livestock in Ghana
Comparative Analysis of Fecal Microbiota in Grasscutter (Thryonomys swinderianus) and Other Herbivorous Livestock in Ghana Open
The grasscutter (also known as the greater cane rat; Thryonomys swinderianus) is a large rodent native to West Africa that is currently under domestication process for meat production. However, little is known about the physiology of this …
View article: Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism Open
Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. H…
View article: Detection of novel orthoreovirus genomes in shrew (<i>Crocidura hirta</i>) and fruit bat (<i>Rousettus aegyptiacus</i>)
Detection of novel orthoreovirus genomes in shrew (<i>Crocidura hirta</i>) and fruit bat (<i>Rousettus aegyptiacus</i>) Open
Orthoreoviruses have been indentified in several mammals, however, there is no information about orthoreoviruses in shrews. In this study, we screened wild animals in Zambia, including shrews, rodents, and bats for the detection of orthore…
View article: Marburgvirus in Egyptian Fruit Bats, Zambia
Marburgvirus in Egyptian Fruit Bats, Zambia Open
We detected Marburg virus genome in Egyptian fruit bats (Rousettus aegyptiacus) captured in Zambia in September 2018. The virus was closely related phylogenetically to the viruses that previously caused Marburg outbreaks in the Democratic …
View article: Risk assessment for hepatitis E virus infection from domestic pigs introduced into an experimental animal facility in a medical school
Risk assessment for hepatitis E virus infection from domestic pigs introduced into an experimental animal facility in a medical school Open
Hepatitis E virus (HEV) is known to cause zoonotic infections from pigs, wild boars and deer. Domestic pigs have been used as an experimental animal model in medical research and training; however, the risks of HEV infection from pigs duri…
View article: Loss of Bacitracin Resistance Due to a Large Genomic Deletion among <i>Bacillus anthracis</i> Strains
Loss of Bacitracin Resistance Due to a Large Genomic Deletion among <i>Bacillus anthracis</i> Strains Open
Anthrax is caused by Bacillus anthracis , an endospore-forming soil bacterium. The genetic diversity of B. anthracis is known to be low compared with that of Bacillus species. In this study, we performed whole-genome sequencing of Zambian …
View article: Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia
Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia Open
Bats are suspected to play important roles in the ecology of filoviruses, including ebolaviruses and marburgviruses. A cave-dwelling fruit bat, Rousettus aegyptiacus, has been shown to be a reservoir of marburgviruses. Using an enzyme-link…
View article: Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)
Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum) Open
Bats are important reservoirs for emerging zoonotic viruses. For extensive surveys of potential pathogens in straw-colored fruit bats (Eidolon helvum) in Zambia, a total of 107 spleen samples of E. helvum in 2006 were inoculated onto Vero …