Haruhiko Maruyama
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View article: Transcriptome analysis reveals the gene expression changes in Strongyloides ratti tissue-migrating larvae
Transcriptome analysis reveals the gene expression changes in Strongyloides ratti tissue-migrating larvae Open
Strongyloides ratti is an intestinal nematode commonly found in rats. Unlike other Strongyloides species, the tissue-migrating third-stage larvae in S. ratti follow a unique route of invasion via the nasofrontal region before reaching the …
View article: Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice
Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice Open
Introduction Eimeria pragensis , an intestinal protozoa infecting mice, induces colitis and reduces goblet cell numbers in the large intestine. In the present study, we investigated the pathogenesis and the mechanisms underlying goblet cel…
View article: Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission
Detection and analysis of Serpin and RP26 specific antibodies for monitoring Schistosoma haematobium transmission Open
Background Schistosoma haematobium is the causative pathogen for urogenital schistosomiasis. To achieve progress towards schistosomiasis elimination, there is a critical need for developing highly sensitive and specific tools to monitor tr…
View article: A Case of Fasciolosis Reinfection in Japan
A Case of Fasciolosis Reinfection in Japan Open
Fasciolosis is a major cause of food-borne parasitic zoonosis. It primarily affects ruminants but also infects humans. Clinically, it is characterized by abnormal liver images with prominent eosinophilia. We herein report a 77-year-old Jap…
View article: Transcriptome Analysis Reveals the Gene Expression Changes in Strongyloides Ratti Tissue-Migrating Larvae
Transcriptome Analysis Reveals the Gene Expression Changes in Strongyloides Ratti Tissue-Migrating Larvae Open
View article: Four successive cases of human fasciolosis in Japan
Four successive cases of human fasciolosis in Japan Open
Fasciolosis is a food-borne parasitic disease, caused by the large liver fluke, Fasciola. Humans acquire infection by ingesting fresh or undercooked water plants, on which infective metacercaria encyst. In spite of the rarity of the diseas…
View article: <scp>ACVIM</scp> consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats
<span>ACVIM</span> consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats Open
Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment‐associated morbidity in both species. Im…
View article: Syntenic relationship of chromosomes in <i>Strongyloides</i> species and <i>Rhabditophanes diutinus</i> based on the chromosome-level genome assemblies
Syntenic relationship of chromosomes in <i>Strongyloides</i> species and <i>Rhabditophanes diutinus</i> based on the chromosome-level genome assemblies Open
The Strongyloides clade, to which the parasitic nematode genus Strongyloides belongs, contains taxa with diverse lifestyles, ranging from free-living to obligate vertebrate parasites. Reproductive strategies are also diverse in this group …
View article: <i>Paragonimus westermani</i> preadult fluke in a pulmonary necrotizing granulomatous lesion: A case associated with eating soy sauce‐marinated raw freshwater crab, “gejang”
<i>Paragonimus westermani</i> preadult fluke in a pulmonary necrotizing granulomatous lesion: A case associated with eating soy sauce‐marinated raw freshwater crab, “gejang” Open
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View article: Pneumothorax with Eosinophilia is an Important Diagnostic Clue for Distinguishing Paragonimiasis from Chronic Eosinophilic Pneumonia: A Case Report
Pneumothorax with Eosinophilia is an Important Diagnostic Clue for Distinguishing Paragonimiasis from Chronic Eosinophilic Pneumonia: A Case Report Open
The Paragonimus westermani infection is a parasitic foodborne infection that induces systemic symptoms with eosinophilia in humans. Here, we described pneumothorax in addition to pulmonary opacities with eosinophilia in a man with a…
View article: A Cluster of Paragonimiasis with Delayed Diagnosis Due to Difficulty Distinguishing Symptoms from Post-COVID-19 Respiratory Symptoms: A Report of Five Cases
A Cluster of Paragonimiasis with Delayed Diagnosis Due to Difficulty Distinguishing Symptoms from Post-COVID-19 Respiratory Symptoms: A Report of Five Cases Open
Paragonimiasis caused by trematodes belonging to the genus Paragonimus is often accompanied by chronic respiratory symptoms such as cough, the accumulation of sputum, hemoptysis, and chest pain. Prolonged symptoms, including respiratory sy…
View article: Posttreatment Positive Antibody Detection in a Case of Fascioliasis: A Case Report
Posttreatment Positive Antibody Detection in a Case of Fascioliasis: A Case Report Open
We report the case of a Vietnamese man in his twenties who presented with a few days' history mild fever and severe pain in the right hypochondrium. Laboratory findings showed elevated levels of the hepatobiliary enzymes and marked periphe…
View article: Supplementary Tables S1 to S3 from Syntenic relationship of chromosomes in <i>Strongyloides</i> species and <i>Rhabditophanes diutinus</i> based on the chromosome-level genome assemblies
Supplementary Tables S1 to S3 from Syntenic relationship of chromosomes in <i>Strongyloides</i> species and <i>Rhabditophanes diutinus</i> based on the chromosome-level genome assemblies Open
Strongyloides clade, to which the parasitic nematode genus Strongyloides belongs, contains taxa with diverse lifestyles, ranging from free-living to obligate vertebrate parasites. Reproductive strategies are also diverse in t…
View article: Supplementary Tables S1 to S3 from Syntenic relationship of chromosomes in <i>Strongyloides</i> species and <i>Rhabditophanes diutinus</i> based on the chromosome-level genome assemblies
Supplementary Tables S1 to S3 from Syntenic relationship of chromosomes in <i>Strongyloides</i> species and <i>Rhabditophanes diutinus</i> based on the chromosome-level genome assemblies Open
Strongyloides clade, to which the parasitic nematode genus Strongyloides belongs, contains taxa with diverse lifestyles, ranging from free-living to obligate vertebrate parasites. Reproductive strategies are also diverse in t…
View article: Strongyloidiasis in recently arrived captive-bred meerkats imported to Japan
Strongyloidiasis in recently arrived captive-bred meerkats imported to Japan Open
View article: Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration
Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration Open
Parasitic helminths can reside in humans owing to their ability to disrupt host protective immunity. Receptor for advanced glycation end products (RAGE), which is highly expressed in host skin, mediates inflammatory responses by regulating…
View article: Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation
Genome of the fatal tapeworm Sparganum proliferum uncovers mechanisms for cryptic life cycle and aberrant larval proliferation Open
View article: Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by <i>Ascaris suum</i>
Clinico-radiologic Characteristics of Pulmonary Visceral Larva Migrans Caused by <i>Ascaris suum</i> Open
Objective Visceral larva migrans (VLM) caused by Ascaris suum is a major health problem in pig farming regions. The clinical characteristics of pulmonary VLM caused by A. suum, however, are unclear. We assessed the clinico-radiologic featu…
View article: Primaquine plus clindamycin as a promising salvage therapy for Pneumocystis jirovecii pneumonia: A retrospective analysis in Japanese patients
Primaquine plus clindamycin as a promising salvage therapy for Pneumocystis jirovecii pneumonia: A retrospective analysis in Japanese patients Open
Treatment of intractable Pneumocystis jirovecii pneumonia (PCP) patients with primaquine (PQ) in combination with clindamycin (CLDM) was conducted by the Research Group on Chemotherapy of Tropical Diseases (RG-CTD), as a kind of compassion…
View article: Enzyme-linked immunosorbent assay (ELISA) using recombinant Fasciola cathepsin L1 for the diagnosis of human fasciolosis caused by Fasciola hepatica/gigantica hybrid type
Enzyme-linked immunosorbent assay (ELISA) using recombinant Fasciola cathepsin L1 for the diagnosis of human fasciolosis caused by Fasciola hepatica/gigantica hybrid type Open
Recombinant Fasciola cathepsin L-1 (rCatL1) was evaluated in enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of human fasciolosis in Japan. Quality characteristics of the test were accessed by receiver operating characteris…
View article: Abdominal paragonimiasis after consumption of wild boar meat
Abdominal paragonimiasis after consumption of wild boar meat Open
A 60-year-old man presented with a 10-day history of abdominal and back pain. Abdominal contrast-enhanced computed tomography showed an intraperitoneal abscess (Figure 1). Antibiotic therapy with flomoxef resulted in reduced size but not t…
View article: Application of a real-time PCR assay for the detection of <i>Ascaris suum</i> DNA in the liver of experimentally infected chickens
Application of a real-time PCR assay for the detection of <i>Ascaris suum</i> DNA in the liver of experimentally infected chickens Open
This study aimed to evaluate the sampling method for the detection of Ascaris suum larval DNA in chicken livers using real-time PCR. Chickens were inoculated with A. suum eggs of a single dose (Group A) or repeatedly low doses (Group B). W…
View article: An outbreak of Paragonimus westermani infection among Cambodian technical intern trainees in Japan, exhibiting various extrapulmonary lesions
An outbreak of Paragonimus westermani infection among Cambodian technical intern trainees in Japan, exhibiting various extrapulmonary lesions Open
We encountered an outbreak of paragonimiasis among Cambodian technical intern trainees (TITs) at a food-processing factory in Fukuoka, Japan. The patients were 20-28 years old, seven females and two males, who had been in Japan for one to …
View article: Meningitis patients with Angiostrongylus cantonensis may present without eosinophilia in the cerebrospinal fluid in northern Vietnam
Meningitis patients with Angiostrongylus cantonensis may present without eosinophilia in the cerebrospinal fluid in northern Vietnam Open
Background Eosinophilic meningitis (EM) is a rare clinical syndrome caused by both infectious and noninfectious diseases. In tropical pacific countries, Angiostrongylus cantonensis is the most common cause. However, the EM definition varie…
View article: Seroprevalence of toxoplasmosis among reproductive-aged women in Myanmar and evaluation of luciferase immunoprecipitation system assay
Seroprevalence of toxoplasmosis among reproductive-aged women in Myanmar and evaluation of luciferase immunoprecipitation system assay Open
View article: <i>Strongyloides stercoralis</i> colitis in a patient positive for human T-cell leukaemia virus with rheumatoid arthritis during an anti-rheumatic therapy: a case report
<i>Strongyloides stercoralis</i> colitis in a patient positive for human T-cell leukaemia virus with rheumatoid arthritis during an anti-rheumatic therapy: a case report Open
An elderly woman with rheumatoid arthritis (RA) presented with a chief complaint of abdominal pain and diarrhoea while undergoing treatment with low-dose corticosteroids and abatacept. Endoscopic and histopathological findings revealed man…
View article: Genome analysis of the fatal tapeworm<i>Sparganum proliferum</i>unravels the cryptic lifecycle and mechanisms underlying the aberrant larval proliferation
Genome analysis of the fatal tapeworm<i>Sparganum proliferum</i>unravels the cryptic lifecycle and mechanisms underlying the aberrant larval proliferation Open
Background The cryptic parasite Sparganum proliferum proliferates in humans and invades tissues and organs. Only scattered cases have been reported, but S. proliferum infection is always fatal. However, the S. proliferum phylogeny and life…
View article: Human proliferative sparganosis update
Human proliferative sparganosis update Open
Proliferative sparganosis is one of the most bizarre and mysterious parasitic diseases ever described. The causative parasite is Sparganum proliferum, which is a pseudophyllidean cestode distinct from Spirometra tapeworms. Here we overview…
View article: Improved 18S and 28S rDNA primer sets for NGS-based parasite detection
Improved 18S and 28S rDNA primer sets for NGS-based parasite detection Open
View article: Sequential Changes in the Host Gut Microbiota During Infection With the Intestinal Parasitic Nematode Strongyloides venezuelensis
Sequential Changes in the Host Gut Microbiota During Infection With the Intestinal Parasitic Nematode Strongyloides venezuelensis Open
Soil-transmitted helminths (STHs) are medically important parasites that infect 1. 5 billion humans globally, causing a substantial disease burden. These parasites infect the gastrointestinal tract (GIT) of their host where they co-exist a…