Hiroki Ohya
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View article: Pharmacist Awareness, Knowledge, and Clinical Engagement of Medication-Related Osteonecrosis of the Jaw: A Survey From a Designated Community Cancer Care Hospital
Pharmacist Awareness, Knowledge, and Clinical Engagement of Medication-Related Osteonecrosis of the Jaw: A Survey From a Designated Community Cancer Care Hospital Open
Introduction Medication-related osteonecrosis of the jaw (MRONJ) is a clinically challenging condition; however, the actual practice and interprofessional engagement of pharmacists regarding MRONJ remain undetermined. We assessed the aware…
View article: A multicenter randomized controlled trial evaluating the effect of the use of an anti‐adhesion barrier for diverting ileostomy on the multidimensional workload in minimally invasive surgery for rectal cancer (<scp>YCOG</scp> 2005: The <scp>ADOBARRIER</scp> study)
A multicenter randomized controlled trial evaluating the effect of the use of an anti‐adhesion barrier for diverting ileostomy on the multidimensional workload in minimally invasive surgery for rectal cancer (<span>YCOG</span> 2005: The <span>ADOBARRIER</span> study) Open
Aim The purpose of this study was to assess whether the use of spray‐type anti‐adhesion material during diverting ileostomy construction could reduce the surgeon's multidimensional workload, the degree of adhesion, and the operation time i…
View article: Novel machine‐learning model for predicting lymph node metastasis in resectable pancreatic ductal adenocarcinoma
Novel machine‐learning model for predicting lymph node metastasis in resectable pancreatic ductal adenocarcinoma Open
Aim Lymph node metastasis is an adverse prognostic factor in pancreatic ductal adenocarcinoma. However, it remains a challenge to predict lymph node metastasis using preoperative imaging alone. We used machine learning (combining preoperat…
View article: Effects of neoadjuvant chemotherapy for patients with obstructive colon cancer: A multicenter propensity score‐matched analysis (<scp>YCOG2101</scp>)
Effects of neoadjuvant chemotherapy for patients with obstructive colon cancer: A multicenter propensity score‐matched analysis (<span>YCOG2101</span>) Open
Aim Obstructive colon cancer is locally advanced colon cancer with poor prognosis. However, the effect of neoadjuvant chemotherapy (NAC) on obstructive colon cancer remains unclear. Therefore, this study aimed to investigate the safety and…
View article: A Case of Low-grade Appendiceal Mucinous Neoplasm with Intussusception Resected by Laparoscopic Assisted Surgery
A Case of Low-grade Appendiceal Mucinous Neoplasm with Intussusception Resected by Laparoscopic Assisted Surgery Open
症例は26歳，男性．腹痛が増悪し，嘔気を伴ったため当院受診となった．腹部造影CTでは，虫垂から連続する径35mm大の嚢胞性腫瘍を先進部とする上行結腸重積を認めた．虫垂腫瘍，腸重積と判断し，診断と治療を目的に腹腔鏡補助下に手術を施行した．虫垂先端部は軽度腫大を認め，虫垂根部が上行結腸内に重積をしている所見を認め，腹腔鏡補助下盲腸部分切除術，腸重積症整復術を施行した．病理診断は，低異型度虫垂粘液性腫瘍（LAMN）であった．LAMNは大腸癌取り扱い規約第8版において，新たに分類さ…
View article: A Case of Emergency Loop Ileostomy and Trans Artificial Anal Decompression Tube for Obstructive Splenic Flexure Colon Cancer: A Case Report
A Case of Emergency Loop Ileostomy and Trans Artificial Anal Decompression Tube for Obstructive Splenic Flexure Colon Cancer: A Case Report Open
右側結腸の著明な拡張を伴う閉塞性脾彎曲部横行結腸癌に対して，緊急腹腔鏡補助下双孔式回腸人工肛門造設術+経人工肛門的減圧チューブを施行し有用であった症例を経験したので文献的考察を加え報告する．症例は83歳男性．便潜血反応陽性を契機に診断された横行結腸癌に対して手術を予定していた．術前検査で著明な右側結腸の拡張を認め，腹痛を伴っていたため閉塞性横行結腸癌と診断した．緊急双孔式回腸人工肛門造設術および経人工肛門的減圧チューブ留置による口側腸管の減圧処置を施行後，待機的に減圧術後1…
View article: Comparison of the continuation and discontinuation of perioperative antiplatelet therapy in laparoscopic surgery for colorectal cancer: A retrospective, multicenter, observational study (YCOG 1603)
Comparison of the continuation and discontinuation of perioperative antiplatelet therapy in laparoscopic surgery for colorectal cancer: A retrospective, multicenter, observational study (YCOG 1603) Open
Aim The present study aimed to examine the effect of continuing antiplatelet therapy in the perioperative period for patients undergoing laparoscopic resection for colorectal cancer who had received preoperative antiplatelet therapy. Metho…
View article: The comparison of health‐related quality of life and patient satisfaction between single‐incision and multiport laparoscopic colectomy for cancer: A sub‐study of a randomized, prospective clinical trial
The comparison of health‐related quality of life and patient satisfaction between single‐incision and multiport laparoscopic colectomy for cancer: A sub‐study of a randomized, prospective clinical trial Open
Aim The present study clarified the effect on the health‐related quality of life and patient satisfaction of single‐incision laparoscopic colectomy compared with multiport laparoscopic colectomy for colorectal cancer. Methods We conducted …
View article: A Case of Advanced Cancer of the Gastric Antrum in which Total Gastrectomy was Avoided by Intraoperative Assessment of Perfusion in the Remnant Stomach by Indocyanine Green Fluorography
A Case of Advanced Cancer of the Gastric Antrum in which Total Gastrectomy was Avoided by Intraoperative Assessment of Perfusion in the Remnant Stomach by Indocyanine Green Fluorography Open
症例は78歳，男性．心窩部不快感を主訴に前医で施行された上部消化管内視鏡検査で胃癌の診断となり，手術目的に当科を紹介受診した．胃幽門前庭部に3型病変を認め，生検でadenocarcinoma（tub2）と診断した．幽門前庭部進行胃癌の診断で，幽門側胃切除術（以下，DG）の方針としたが，膵尾部への直接浸潤を伴う下行結腸癌穿孔に対する開腹結腸左半切除+膵尾部脾臓合併切除術（以下，DP）術の既往があり，脾動脈，短胃動脈切離後であったため，残胃虚血が危惧された．術中，血管処理後にi…
View article: A Case Report of Resection of Liver Tumor Considerd to Have Developed from Metastases of Pancreatic Gastrinoma 13 Years after Primary Resection
A Case Report of Resection of Liver Tumor Considerd to Have Developed from Metastases of Pancreatic Gastrinoma 13 Years after Primary Resection Open
症例は76歳，男性．2005年8月の検診にて膵腫瘍を指摘され来院．当院にて膵尾部腫瘍に対して膵体尾部切除，脾摘術を施行．病理の結果はガストリノーマ（2017年WHO分類ではPanNET G2）の診断．外来にて経過観察中に，CTで低吸収域を示す腫瘤を認め肝S4転移と診断し，2008年1月に肝S4部分切除術を施行した．病理結果はガストリノーマ肝転移（PanNET G1）の診断．その後10年間再発なく経過していた．突然の腹痛にて来院し，単純CTにて肝に低濃度腫瘤を認めたため，ガス…
View article: Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients
Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients Open
MicroRNAs (miRs) have been shown to negatively regulate gene expression by binding to mRNAs, and they play an important role in various physiological processes and malignancies. A previous study identified mature miR-126-3p as an onco-micr…
View article: Regorafenib Is Transported by the Organic Anion Transporter 1B1 and the Multidrug Resistance Protein 2
Regorafenib Is Transported by the Organic Anion Transporter 1B1 and the Multidrug Resistance Protein 2 Open
Regorafenib is a small molecule inhibitor of tyrosine kinases, and has been shown to improve the outcomes of patients with advanced colorectal cancer and advanced gastrointestinal stromal tumors. The transport profiles of regorafenib by va…