Explanipedia

A Japanese patient with hereditary spastic paraplegia with a rare KIF5A nonsense variant Open

Shiroh Miura, Shigeaki Suenaga, Hironobu Goto, Zhaonan Wang, Atsushi Makino , et al. · 2025

The Role of Serum Testosterone in the Pathogenesis and Treatment of Prostate Cancer: A Review Based on the Clinical Evidence Open

Xue Zhao, Shinichi Sakamoto, Yasutaka Yamada, Kodai Sato, Tomohiro Tamura , et al. · 2025

Serum testosterone plays a pivotal role in the pathogenesis and treatment of prostate cancer, influencing tumor growth and progression. This review synthesizes current clinical evidence on the dual role of serum testosterone as both a biom…

Predicting intraoperative transfusion volumes of blood products in cardiovascular surgery: a retrospective study Open

Hiroki Shibata · 2025

Time-dependent personalized prognostic analysis by machine learning in biochemical recurrence after radical prostatectomy: a retrospective cohort study Open

Kodai Sato, Shinichi Sakamoto, Shinpei Saito, Hiroki Shibata, Yasutaka Yamada , et al. · 2024

Our prognostic model analyzed the time-dependent relationship between the timing of recurrence and prognostic factors. Our study achieved personalized prognosis analysis and its rationale after radical prostatectomy by employing machine le…

Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks Open

Kie Ozaki, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa , et al. · 2024

Although previous studies have reported that pre-mRNA splicing factors (SFs) are involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), their exact role in promoting HR remains poorly understood. Here,…

Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy Open

Koichiro Kurokawa, Yasutaka Yamada, Shinichi Sakamoto, Takuro Horikoshi, Kodai Sato , et al. · 2024

The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate cancer (PCa). However, little i…

Effects of Sleep-Disordered Breathing on Daytime Brain Activity in Community-Dwelling Older Adults Open

Hiroki Shibata, Akiko Noda, Yuanjie Mao, Kunihiro Iwamoto, Masato Okuda , et al. · 2024

Introduction Sleep-disordered breathing (SDB) is associated with an increased risk of cardiovascular diseases. The present study aimed to examine the influence of SDB on daytime brain activity in the community-dwelling older adults. Materi…

Implications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy Open

Koichiro Kurokawa, Yasutaka Yamada, Shinichi Sakamoto, Takuro Horikoshi, Kodai Sato , et al. · 2024

The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate cancer (PCa). However, little i…

Episodic ataxia type 2 with a novel missense variant (Leu602Arg) in CACNA1A Open

Shiroh Miura, Emina Watanabe, Kensuke Senzaki, Shigeyoshi Hiruki, Sayaka Matsumoto , et al. · 2024

Autosomal dominant episodic ataxia type 2 (EA2) is caused by variants in CACNA1A . We examined a 20-year-old male with EA symptoms from a Japanese family with hereditary EA. Cerebellar atrophy was not evident, but single photon emission co…

Development of Behavior Analysis Code for MA Transmutation Nitride Fuel in Accelerator-Driven System Open

Hiroki Shibata, Hiroaki Saito, Hirokazu Hayashi, Masahide Takano · 2024

Partitioning and transmutation techniques for minor actinides have been developed to reduce the radiotoxicity and volume in high-level radioactive wastes. Minor actinide nitride fuel has been chosen as a candidate for the transmutation of …

A MULTI-INSTITUTIONAL SURVEY OF IMPLEMENTATION OF ELECTRONIC PATIENT IDENTIFICATION SYSTEMS FOR BLOOD COLLECTION AND ADMINISTRATION Open

Chiaki Yamada, Keiko Ishizuka, Akari Sugimura, Mitsuki Ohishi, Aoi Kuwahara , et al. · 2023

採血前や輸血前での患者照合システムの運用状況と，システムの院内採用後に発生した患者誤認のインシデントおよびアクシデントに関し，多施設アンケート調査を実施した．2020年10月から2022年3月までに26施設より調査票が提出された．採血前は15施設（58％），輸血前は25施設（96％）で患者照合システムが採用されていた．手術室，救急外来，血管造影室等では，システムが導入できていない施設が報告された．システム採用後のインシデントおよびアクシデントは12施設より70例が報告され，…

Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks Open

Motohiro Yamauchi, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa , et al. · 2023

Although previous studies have reported that pre-mRNA splicing factors (SFs) are involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), their exact role in promoting HR remains poorly understood. Here,…

A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs Open

Tomoyuki Abe, Hiroshi Sakagami, Shigeru Amano, SHIN UOTA, Kenjiro Bandow , et al. · 2023

Background. Many anti-cancer drugs used in clinical practice cause adverse events such as oral mucositis, neurotoxicity, and extravascular leakage. We have reported that two 3-styrylchromone derivatives, 7-methoxy-3-[(1E)-2-phenylethenyl]-…

A Comparative Study of Tumor-Specificity and Neurotoxicity Between 3-Styrylchromones and Anticancer Drugs Open

Tomoyuki Abe, Hiroshi Sakagami, Shigeru Amano, SHIN UOTA, Kenjiro Bandow , et al. · 2023

Background. Many anticancer drugs used in clinical practice cause adverse events such as oral mucositis, neurotoxicity, and extravascular leakage. We have reported that two 3-styrylchromone derivatives, 7-methoxy-3-[(1E)-2-phenylethenyl]-4…

Case report: Frontotemporal dementia and amyotrophic lateral sclerosis caused by a missense variant (p.Arg89Trp) in the valosin-containing protein gene Open

Shiroh Miura, Shigeyoshi Hiruki, Tomohisa Okada, Satoko Takei, Kensuke Senzaki , et al. · 2023

Frontotemporal dementia and/or amyotrophic lateral sclerosis 6, also known as amyotrophic lateral sclerosis 14, is an autosomal dominant, progressive neurodegenerative disorder caused by various mutations in the valosin-containing protein …

Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28 Open

Takuya Morikawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kosei Moriyama , et al. · 2023

Hereditary spastic paraplegia is a genetic neurological disorder characterized by spasticity of the lower limbs, and spastic paraplegia type 28 is one of its subtypes. Spastic paraplegia type 28 is a hereditary neurogenerative disorder wit…

Results of lifestyle modification promotion and reproductive/general health check for male partners of couples seeking conception Open

Akira Komiya, Mayuko Kato, Hiroki Shibata, Yusuke Imamura, Tomokazu Sazuka , et al. · 2023

Comorbidities and inappropriate lifestyle choices were common among men with infertility. The promotion of lifestyle modifications as part of male preconception care could improve semen quality without urologic intervention.

Hereditary Congenital Methemoglobinemia Diagnosed at the Age of 79 Years: A Case Report Open

Marohito Nakata, Naoko Yokota, Kazuhiko Tabata, Takuya Morikawa, Hiroki Shibata , et al. · 2023

Background: Cardiopulmonary disorders are the most common cause of central cyanosis, and methemoglobinemia is often overlooked in the differential diagnosis of patients with central cyanosis. In most cases, methemoglobinemia is acquired an…

A Japanese family with dystonia due to a pathogenic variant in SGCE Open

Takuya Morikawa, Shiroh Miura, Luoming Fan, Emina Watanabe, Ryuta Fujioka , et al. · 2022

One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study Open

Yuichi Matsuno, Takehiro Torisu, Junji Umeno, Hiroki Shibata, Atsushi Hirano , et al. · 2022

Background/Aims: Recent studies suggested a favorable effect of indigo naturalis (IN) in inducing remission for refractory ulcerative colitis (UC), however, the maintenance effect of IN for patients with UC remains unknown. Therefore, we c…

Active Expression of Genes for Protein Modification Enzymes in Habu Venom Glands Open

Akiko Isomoto, Eiichi Shoguchi, Kanako Hisata, Jun Inoue, Yinrui Sun , et al. · 2022

Genes encoding snake venom toxins have been studied extensively. However, genes involved in the modification and functioning of venom proteins are little known. Protobothrops is a genus of pit vipers, which are venomous and inhabit the Nan…

A novel 1-bp deletion variant in DAG1 in Japanese familial asymptomatic hyper-CK-emia Open

Luoming Fan, Shiroh Miura, Tomofumi Shimojo, Hirotoshi Sugino, Ryuta Fujioka , et al. · 2022

Ten years of Fukushima Dai-Ichi post-accident research on the degradation phenomenology of the BWR core components Open

Anton Pshenichnikov, Hiroki Shibata, Takuya Yamashita, Yuji Nagae, Masaki Kurata · 2021

The paper reviews the results of the JAEA and some International activities over the last ten years of research on the understanding of the core components melting and debris formation in boiling water reactors.

Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma Open

T Tanaka, Yuichi Matsuno, Takehiro Torisu, Hiroki Shibata, Atsushi Hirano , et al. · 2021

To investigate the mucosal microbiota in the stomach of patients with Helicobacter pylori -negative mucosa-associated lymphoid tissue (MALT) lymphoma by means of metagenomic analysis. Although some gastric MALT lymphomas are associated wit…

A Japanese hereditary spastic paraplegia family with a rare nonsynonymous variant in the SPAST gene Open

Takuya Morikawa, Shiroh Miura, Takahisa Tateishi, Kazuhito Noda, Hiroki Shibata · 2021

<i>Ddhd1</i> knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia Open

Takuya Morikawa, Hiroaki Ohishi, Kengo Kosaka, Tomofumi Shimojo, Akihiro Nagano , et al. · 2021

We have previously reported a novel homozygous 4-bp deletion in DDHD1 as the responsible variant for spastic paraplegia type 28 (SPG28; OMIM#609340). The variant causes a frameshift, resulting in a functionally null allele in the patient. …

Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations Open

Takashi Gakuhari, Shigeki Nakagome, Simon Rasmussen, Morten E. Allentoft, Takehiro Sato , et al. · 2020

Venomics Study of <i>Protobothrops flavoviridis</i> Snake: How Venom Proteins Have Evolved and Diversified? Open

Tomohisa Ogawa, Hiroki Shibata · 2020

Venomics projects have been conducted to disclose the divergent profiles and evolution of various venomous animals. Here, we describe the venomics project including genome and transcriptome of habu snake, leading to drug discovery. Venomic…

Discovery of the Gene Encoding a Novel Small Serum Protein (SSP) of Protobothrops flavoviridis and the Evolution of SSPs Open

Kento Inamaru, Ami Takeuchi, Marie Maeda, Hiroki Shibata, Yasuyuki Fukumaki , et al. · 2020

Small serum proteins (SSPs) are low-molecular-weight proteins in snake serum with affinities for various venom proteins. Five SSPs, PfSSP-1 through PfSSP-5, have been reported in Protobothrops flavoviridis (“habu”, Pf) serum so far. Recent…

The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins Open

Kushal Suryamohan, Sajesh P Krishnankutty, Joseph Guillory, Matthew Jevit, Markus Schröder , et al. · 2020

Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive characterization of toxin genes will facilitate development of effective humanized recombinant…

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