Hiroki Tojima
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View article: Employment Status of Patients With Liver Disease: A Nationwide Questionnaire Survey in Japan
Employment Status of Patients With Liver Disease: A Nationwide Questionnaire Survey in Japan Open
Aim Patients with chronic liver disease often experience significant physical, psychological, and financial burdens. These burdens result from repeated long‐term hospital visits or admissions caused by progression to decompensated cirrhosi…
View article: Current Status and Issues of Hepatitis B Reactivation in Gunma Prefecture
Current Status and Issues of Hepatitis B Reactivation in Gunma Prefecture Open
View article: Follow-up Survey on Hepatitis Virus Testing Among Ophthalmologists
Follow-up Survey on Hepatitis Virus Testing Among Ophthalmologists Open
View article: Association Between Liver Injury and Pneumonia in Patients Hospitalized with COVID-19, -With a Focus on Pregnant Women
Association Between Liver Injury and Pneumonia in Patients Hospitalized with COVID-19, -With a Focus on Pregnant Women Open
View article: Sodium-Glucose Cotransporter-Specific Substrate αMG Stimulates Endogenous Glucagon Secretion and Ameliorates Obesity-Associated Metabolic Disorders in Mice
Sodium-Glucose Cotransporter-Specific Substrate αMG Stimulates Endogenous Glucagon Secretion and Ameliorates Obesity-Associated Metabolic Disorders in Mice Open
View article: A Resected Case of Hepatic Angiomyolipoma with Tumor Hemorrhage and Undetectable Fat Causing Diagnostic Difficulty
A Resected Case of Hepatic Angiomyolipoma with Tumor Hemorrhage and Undetectable Fat Causing Diagnostic Difficulty Open
Hepatic AML may exhibit progressive growth despite lacking typical imaging features such as intratumoral fat or vascularity, making preoperative diagnosis difficult. In cases where malignancy cannot be ruled out, surgical resection should …
View article: Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study
Evaluation of the Efficacy of Lusutrombopag for Chronic Liver Disease Based on Pre‐Treatment Platelet Counts: A Retrospective Multicenter Study Open
Background Oral thrombopoietin receptor agonists are used to treat thrombocytopenia in patients with chronic liver disease who are scheduled for invasive procedures. The efficacy of lusutrombopag based on the pretreatment platelet count wa…
View article: The Treatment Effects of Percutaneous Drainage with or without Sclerotherapy for Symptomatic Liver Cysts
The Treatment Effects of Percutaneous Drainage with or without Sclerotherapy for Symptomatic Liver Cysts Open
Background: While the current guidelines recommend laparoscopic deroofing for symptomatic simple liver cysts, percutaneous drainage may serve as a less invasive alternative method. In this study, the treatment effects of percutaneous drain…
View article: Which nonhepatology departments are in urgent need of measures for treating patients positive for hepatitis virus?
Which nonhepatology departments are in urgent need of measures for treating patients positive for hepatitis virus? Open
In eight regional core centers for liver disease management, we evaluated the status of HBs antigen (HBsAg) and anti-hepatitis C virus antibody (anti-HCV) testing from 2016 to 2020. Among nonhepatology departments, ophthalmology had the hi…
View article: A case of unresectable combined hepatocellular and cholangiocarcinoma treated with atezolizumab plus bevacizumab
A case of unresectable combined hepatocellular and cholangiocarcinoma treated with atezolizumab plus bevacizumab Open
An 81‐year‐old man initially underwent right hepatic lobectomy for liver cancer and was pathologically diagnosed with combined hepatocellular and cholangiocarcinoma (CHC). At 13 months after resection, multiple lymph node metastases were o…
View article: A case of unresectable combined hepatocellular and cholangiocarcinoma treated with atezolizumab plus bevacizumab
A case of unresectable combined hepatocellular and cholangiocarcinoma treated with atezolizumab plus bevacizumab Open
An 81-year-old man initially underwent right hepatic lobectomy for liver cancer and was pathologically diagnosed with combined hepatocellular and cholangiocarcinoma (CHC). At 13 months after resection, multiple lymph node metastases were o…
View article: Adolescents with chronic hepatitis C might be good candidates for direct‐acting antiviral therapy
Adolescents with chronic hepatitis C might be good candidates for direct‐acting antiviral therapy Open
Three Japanese adolescents with chronic hepatitis C were treated by direct‐acting antivirals (DAAs). No adverse events or laboratory abnormalities were observed during and after DAA therapy, and a sustained virological response was achieve…
View article: Questionnaire survey on hepatitis virus tests among ophthalmologists in Japan
Questionnaire survey on hepatitis virus tests among ophthalmologists in Japan Open
We performed a questionnaire survey among ophthalmologists on how they handle the results of viral hepatitis tests. Of 307 responses (28.6% of sent questionnaires), 80.1% were analyzed, which were from the ophthalmologists who order viral …
View article: Follow-up after Direct-acting Antiviral Treatment for Chronic Hepatitis C Virus Infection: Most Patients Are Followed Appropriately
Follow-up after Direct-acting Antiviral Treatment for Chronic Hepatitis C Virus Infection: Most Patients Are Followed Appropriately Open
Objective Chronic hepatitis C virus (HCV) infection carries a residual risk of hepatocarcinogenesis even after viral elimination, so appropriate follow-up is necessary. The present study investigated the current hospital visits and hepatoc…
View article: Effect of 48‐week pemafibrate on non‐alcoholic fatty liver disease with hypertriglyceridemia, as evaluated by the <scp>FibroScan‐</scp>aspartate aminotransferase score
Effect of 48‐week pemafibrate on non‐alcoholic fatty liver disease with hypertriglyceridemia, as evaluated by the <span>FibroScan‐</span>aspartate aminotransferase score Open
Background and Aim This retrospective study investigated the effect of 48‐week pemafibrate therapy in non‐alcoholic fatty liver disease (NAFLD) with hypertriglyceridemia, as evaluated by the FibroScan‐aspartate aminotransferase (FAST) scor…
View article: Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals
Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals Open
Objectives The changes in portal hypertension after achieving a sustained viral response (SVR) by direct‐acting antivirals (DAAs) have not been fully elucidated. Consequently, noninvasive and inexpensive predictors need to be investigated.…
View article: Usefulness of FibroScan-AST (FAST) score in Japanese patients with non-alcoholic fatty liver disease: A single-center retrospective experience
Usefulness of FibroScan-AST (FAST) score in Japanese patients with non-alcoholic fatty liver disease: A single-center retrospective experience Open
活動性の炎症(NAS≥4)と進行した線維化(F≧2)を伴う非アルコール性脂肪肝炎(NASH)症例を,非侵襲的に同定する方法としてFibroScan-AST(FAST)スコアの有用性が近年報告された.これはASTとFibroScanで測定された肝硬度とCAPを用いて算出される.本研究では日本人におけるFASTスコアの有用性を後ろ向きに検討した.2018年4月から2020年3月まで当院で経皮的肝生検で非アルコール性脂肪性肝疾患と診断した34例を対象とした.FASTスコアが0.4…
View article: The first reported case of Noonan syndrome complicated with hepatocellular carcinoma
The first reported case of Noonan syndrome complicated with hepatocellular carcinoma Open
Noonan syndrome is a genetic multisystem disorder and is associated with mutation of genes encoding the proteins in the RAS‐MAPK pathway. We reported the first case of Noonan syndrome complicated with hepatocellular carcinoma.
View article: An Autopsy Case of Multicentric Castleman Disease Presenting with Severe Jaundice
An Autopsy Case of Multicentric Castleman Disease Presenting with Severe Jaundice Open
A 70-year-old man with multicentric Castleman disease (MCD) was admitted to our hospital with jaundice and ascites. Elevations in his bilirubin and interleukin-6 levels were noted, and computed tomography revealed hepatic atrophy and porta…
View article: Characteristics of liver injury in cases of COVID-19
Characteristics of liver injury in cases of COVID-19 Open
In novel coronavirus disease 2019 (COVID-19), liver injury was found at a high rate, and reports from outside Japan revealed that such injury was related to severity. We examined the characteristics of liver injury in 15 cases of COVID-19.…
View article: The first reported case of Noonan syndrome complicated with hepatocellular carcinoma.
The first reported case of Noonan syndrome complicated with hepatocellular carcinoma. Open
Noonan syndrome is a genetic multisystem disorder characterized by distinctive facial features, developmental delay, congenital heart disease, and other conditions. It is associated with mutation of genes encoding the proteins in the RAS-M…
View article: Impact of Pemafibrate in Patients with Hypertriglyceridemia and Metabolic Dysfunction-associated Fatty Liver Disease Pathologically Diagnosed with Non-alcoholic Steatohepatitis: A Retrospective, Single-arm Study
Impact of Pemafibrate in Patients with Hypertriglyceridemia and Metabolic Dysfunction-associated Fatty Liver Disease Pathologically Diagnosed with Non-alcoholic Steatohepatitis: A Retrospective, Single-arm Study Open
Objective The therapeutic effect of pemafibrate on metabolic dysfunction-associated fatty liver disease (MAFLD) remains unknown. This retrospective, single-arm study investigated the efficacy and safety of pemafibrate in MAFLD patients wit…
View article: Tolvaptan reduces the required amount of albumin infusion in patients with decompensated cirrhosis with uncontrolled ascites : a multicenter retrospective propensity score-matched cohort study
Tolvaptan reduces the required amount of albumin infusion in patients with decompensated cirrhosis with uncontrolled ascites : a multicenter retrospective propensity score-matched cohort study Open
Background : The aim of this retrospective study was to determine whether tolvaptan treatment reduces the amount of albumin administered, volume of ascites removed, and frequency of paracentesis procedures in patients with decompensated ci…
View article: A change in the timing for starting systemic therapies for hepatocellular carcinoma : the comparison of sorafenib and lenvatinib as the first-line treatment
A change in the timing for starting systemic therapies for hepatocellular carcinoma : the comparison of sorafenib and lenvatinib as the first-line treatment Open
Aim : The aim of this retrospective multicenter study was to evaluate the differences in the timing for starting systemic therapies as the first-line treatment for hepatocellular carcinoma (HCC). Methods : A total of 375 patients with HCC …
View article: Retroperitoneal hemorrhage of adrenal metastasis from hepatocellular carcinoma during lenvatinib treatment
Retroperitoneal hemorrhage of adrenal metastasis from hepatocellular carcinoma during lenvatinib treatment Open
症例は72歳女性．C型肝硬変を背景とする肝細胞癌，多発肺転移，右副腎転移に対してレンバチニブ8 mgで治療した．治療6週目のCTでは，SDと判断しレンバチニブ8 mgを継続した．治療10週目に有害事象によりレンバチニブを1週間休薬し，4 mgに減量して再開した．治療12週目のCTでは，PDと判断しレンバチニブを中止した．その2日後に突然の右季肋部痛と背部痛を訴え，右副腎転移巣破裂による後腹膜出血と診断し，緊急血管造影で右下横隔膜動脈を塞栓し止血を得た．後方視的に見直すと，治…
View article: Liver Function Changes in Patients with Hepatocellular Carcinoma Treated with Lenvatinib: Predictive Factors of Progression to Child-Pugh Class B, the Formation of Ascites and the Candidates for the Post-Progression Treatment
Liver Function Changes in Patients with Hepatocellular Carcinoma Treated with Lenvatinib: Predictive Factors of Progression to Child-Pugh Class B, the Formation of Ascites and the Candidates for the Post-Progression Treatment Open
The aim of this multicenter retrospective study was to assess the change in liver function in patients with hepatocellular carcinoma treated with lenvatinib. Among 139 consecutive patients receiving lenvatinib treatment between March 2018 …
View article: Characteristics of cases of hepatitis E in 2019 in Gunma prefecture: a small epidemic caused by the same subgenotype 3a strain
Characteristics of cases of hepatitis E in 2019 in Gunma prefecture: a small epidemic caused by the same subgenotype 3a strain Open
In 2019, the number of reported cases of hepatitis E in Gunma prefecture was 1.44 per 100,000 people, which was the highest in all of Japan. We examined the clinical characteristics of 20 cases of hepatitis E reported in 2019 and analyzed …
View article: Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling
Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling Open
Our study suggests that the liver steatosis-ameliorating effects of ipragliflozin in ob/ob mice may be mediated partly by hepatic SIRT1 signaling, possibly through the PGC-1α/PPARα-FGF21 pathway.
View article: Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling
Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling Open
View article: The Daclatasvir/Asunaprevir/Beclabuvir Combination Therapy for Chronic Hepatitis C Patients Experiencing Failure of IFN-Free DAA-Based Therapies
The Daclatasvir/Asunaprevir/Beclabuvir Combination Therapy for Chronic Hepatitis C Patients Experiencing Failure of IFN-Free DAA-Based Therapies Open
Background: Daclatasvir/asunaprevir/beclabuvir (DCV/ASV/BCV) combination therapy had been available for the treatment of chronic hepatitis C patients with genotype 1 (CHG1) in Japan. Our aim was to report the efficacy and safety of DCV/ASV…