Explanipedia

Oligo DNA-based quantum dot (QD) single-particle tracking for multicolor single-molecule imaging Open

Shigeo Sakuragi, Naoki Kato, Tomoya Uchida, Takashi Katagiri, Masaya Enomoto , et al. · 2025

Quantum dot single-particle tracking (QD-SPT), a powerful tool for analyzing membrane domains that are critical to various cellular processes, is widely used in membrane molecular dynamics research. QDs, which possess both a broad excitati…

MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis Open

M Itsuno, Hirokazu Tanabe, Etsuko Sano, Takashi Sasaki, C Oyama , et al. · 2024

Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool Open

Shigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Toshiki Takahashi , et al. · 2024

Tauopathy is a spectrum of diseases characterized by fibrillary tau aggregate formation in neurons and glial cells in the brain. Tau aggregation originates in the brainstem and entorhinal cortex and then spreads throughout the brain in Alz…

Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer’s disease Open

Sopak Supakul, Rei Murakami, C Oyama, Tomoko Shindo, Yuki Hatakeyama , et al. · 2024

Background The development of induced pluripotent stem cells (iPSCs) technology has enabled human cellular disease modeling for inaccessible cell types, such as neural cells in the brain. However, many of the iPSC-derived disease models es…

Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool Open

Shigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Toshiki Takahashi , et al. · 2024

Tauopathy is a spectrum of diseases characterized by fibrillary tau aggregate formation in neurons and glial cells in the brain. Tau aggregation originates in the brainstem and entorhinal cortex and then spreads throughout the brain in Alz…

Application of single-molecule analysis to singularity phenomenon of cells Open

Michio Hiroshima, Hiroko Bannai, Gen Matsumoto, Masahiro Ueda · 2024

Single-molecule imaging in living cells is an effective tool for elucidating the mechanisms of cellular phenomena at the molecular level. However, the analysis was not designed for throughput and requires high expertise, preventing it from…

Research on the molecular mechanism of singularity phenomenon in neurological disorders Open

Hiroko Bannai, Akihiko Takashima, Yoshiyuki Soeda, Hideaki� Yoshimura, Gen Matsumoto , et al. · 2024

In Alzheimer's disease (AD), toxic oligomers of tau proteins originate from a small number of cells deep inside the brain and propagate to other regions of the brain, ultimately causing cell death in up to 50% of neurons in the cerebral co…

Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils Open

Yoshiyuki Soeda, Hideaki� Yoshimura, Hiroko Bannai, Riki Koike, Isshin Shiiba , et al. · 2023

Summary Intracellular tau aggregation requires a local protein concentration increase, referred to as "droplets". However, the cellular mechanism for droplet formation is poorly understood. Here, we expressed OptoTau, a P301L mutant tau fu…

Report on the Symposium in the Science Council of Japan Open

Hiroko Bannai · 2023

Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils Open

Yoshiyuki Soeda, Hideaki� Yoshimura, Hiroko Bannai, Riki Koike, Akihiko Takashima · 2023

Editorial: Neuroscience and Neurotechnology of Neuronal Cell Surface Molecules in Neural Circuits Open

Masahito Yamagata, Hiroko Bannai · 2021

EDITORIAL article Front. Neural Circuits, 23 June 2021 | https://doi.org/10.3389/fncir.2021.703300

Expansion and Diversification of Research in Biophysics Open

Mariko Okada, Kouhei Tsumoto, Takeharu Nagai, Hiroyuki Noji, Hiroko Bannai , et al. · 2021

Inhibitory synaptic transmission tuned by Ca2+ and glutamate through the control of GABAAR lateral diffusion dynamics Open

Hiroko Bannai, Fumihiro Niwa, Shigeo Sakuragi, Katsuhiko Mikoshiba · 2020

The GABAergic synapses, a primary inhibitory synapse in the mammalian brain, is important for the normal development of brain circuits, and for the regulation of the excitation‐inhibition balance critical for brain function from the develo…

Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators Open

Hiroko Bannai, Matsumi Hirose, Fumihiro Niwa, Katsuhiko Mikoshiba · 2019

Calcium ion (Ca²⁺) is a universal intracellular messenger molecule that drives multiple signaling pathways, leading to diverse biological outputs. The coordination of two Ca²⁺ signal sources-"Ca²⁺ influx" f…

IP 3 R-SOC協調系による星状細胞カルシウムシグナリングの誘発 Open

Shigeo Sakuragi, Fumihiro Niwa, Yoichi Oda, Hiroko Bannai, Katsuhiko Mikoshiba · 2017

Induction of astroglial Ca2 signaling by IP3R-SOC coordinated system Open

Sakuragi Shigeo, Fumihiro Niwa, Yoichi Oda, Hiroko Bannai, Katsuhiko Mikoshiba · 2017

Stabilization of GABAAR synaptic structure by IP3-induced calcium release Open

Fumihiro Niwa, Hiroko Bannai, Katsuhiko Mikoshiba · 2016

細胞膜の構成要素である脂質・タンパク質は流体としての性質を持ち，側方拡散運動により自由に動く．自由拡散運動により脂質・タンパク質は均一に分布すると予想されるが，実際の細胞膜では膜分子の分布は一様ではない．シナプス後膜には神経伝達物質受容体が高密度で局在し，効率の良い神経伝達を可能にしている．いかにして神経細胞は，自由拡散運動に逆らって受容体の密度勾配を形成・維持し，シナプス伝達の制御を行っているのか？我々は，ほ乳類の中枢神経系のGABA作動性シナプスに注目し，「量子ドット…

Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium Open

Hiroko Bannai, Fumihiro Niwa, Mark W. Sherwood, Amulya Nidhi Shrivastava, Misa Arizono , et al. · 2015

GABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits. The structure and function of GABAergic synapses are sensitive to destabilization by impinging…

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