Hiroko Kunitake
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Salivary oxytocin and anxiety in older adults during the COVID-19 pandemic: A cross-sectional study Open
Among older women in rural Japan, elevated oxytocin was linked with higher anxiety levels, suggesting that oxytocin may amplify anxiety under threat. This highlights oxytocin's complex role in stress responses and warrants further study to…
Does rTMS modulate phenotype of microglia in patients with treatment-resistant depression? A transcriptome analysis using iMG cells Open
Background The neuroinflammatory hypothesis has been proposed as the pathophysiology of depression, and microglia are suggested to have crucial roles by modulating neuroinflammatory responses in patients with depression. We have originally…
Differential Effects of Electroconvulsive Therapy on Patients with Schizophrenia Versus Depressive Disorder: Clinical Distinction Between Antipsychotic and Antidepressant Effects of Electroconvulsive Therapy Open
Objective: Electroconvulsive therapy (ECT) is utilized for treating psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD). We aimed to compare pre- and post-ECT treatment outcomes be…
Differential Effects of Electroconvulsive Therapy (ECT) on Patients with Schizophrenia Versus Depressive Disorder: Clinical Distinction Between Antipsychotic and Antidepressant Effects of ECT Open
Electroconvulsive therapy (ECT) is utilized for treating psychiatric disorders such as schizo-phrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD). To assess the comparative clinical efficacy and acceptability of ECT, …
View article: Intraoperative Frontal Electroencephalogram Alpha Power Is Associated with Postoperative Mortality and Other Adverse Outcomes
Intraoperative Frontal Electroencephalogram Alpha Power Is Associated with Postoperative Mortality and Other Adverse Outcomes Open
Background: With estimated global postoperative mortality rates at 1% to 4% leading to approximately 3 million to 12 million deaths per year, an urgent need exists for reliable measures of perioperative risk. Existing approaches suffer fro…
Association depressive symptoms with memory function and social capital before and during COVID‐19 in community‐dwelling older adults in rural Japan: A retrospective study with a longitudinal data Open
Objectives This study aimed to investigate the impact of memory function and social capital on depressive symptoms during the COVID‐19 pandemic among older adults in rural Japan. Methods A retrospective study with longitudinal data was con…
View article: Data from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Data from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Purpose:Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require tumor sequencing to identify tum…
View article: Supplementary Figures from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Supplementary Figures from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Supplementary Figures
View article: Data from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Data from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Purpose:Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require tumor sequencing to identify tum…
View article: Supplementary Tables from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Supplementary Tables from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Supplementary Tables
View article: Supplementary Tables from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Supplementary Tables from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Supplementary Tables
View article: Supplementary Figures from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Supplementary Figures from Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Supplementary Figures
Serum soluble triggering receptor expressed on myeloid cells‐2 was not altered by <span>rTMS</span> in patients with treatment‐resistant depression Open
Aim Repetitive transcranial magnetic stimulation (rTMS) is one of the most effective and minimally invasive treatments for treatment‐resistant depression (TRD). However, the mechanism underlying the therapeutic effects of rTMS in patients …
View article: Spatially organized multicellular immune hubs in human colorectal cancer
Spatially organized multicellular immune hubs in human colorectal cancer Open
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we tr…
Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer Open
Purpose: Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery can identify patients with minimal residual disease (MRD) who will ultimately recur. Most ctDNA MRD assays require tumor sequencing to identify tu…
The Use of Single-agent Versus Multiple-agent Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Rectal Cancer Open
Purpose: The use of concurrent chemoradiotherapy is frequently recommended in the treatment of locally advanced rectal cancer however the ideal chemotherapy regimen remains unknown and there is variability in chemotherapy agents used among…
View article: Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer Open
Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we tr…
Is Microsatellite Status Associated With Prognosis in Stage II Colon Cancer With High-Risk Features? Open
BACKGROUND: The influence of microsatellite instability on prognosis in high-risk stage II colon cancer is unknown. OBJECTIVE: This study aimed to investigate the relationship between microsatellite instability and overall survival in high…
Care of the Geriatric Colorectal Surgical Patient and Framework for Creating a Geriatric Program: A Compendium From the 2019 American Society of Colon and Rectal Surgeons Annual Meeting Open
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