Hiromichi Ito
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View article: Current Status and Future Perspectives of Superior Mesenteric Artery Dissection in Robotic Pancreaticoduodenectomy: A Scoping Review of Technical Variations in the Robotic Era
Current Status and Future Perspectives of Superior Mesenteric Artery Dissection in Robotic Pancreaticoduodenectomy: A Scoping Review of Technical Variations in the Robotic Era Open
Background: Dissection around the superior mesenteric artery (SMA) is a key step for local clearance of periampullary cancers in pancreaticoduodenectomy (PD). Since the 2000s, SMA-first approaches have gained popularity in open surgery to …
View article: Efficacy of preoperative endoscopic nasobiliary drainage tube placement for liver cancer adjacent to the hepatic hilum
Efficacy of preoperative endoscopic nasobiliary drainage tube placement for liver cancer adjacent to the hepatic hilum Open
Preoperative ENBD tube placement is a safe, collaborative endoscopic-surgical technique that facilitates optimal liver preservation and acceptable local control for liver cancer adjacent to the hepatic hilum.
View article: Comparable impact of lymph node metastases in <scp>T2</scp> gallbladder cancer on postoperative prognosis irrespective of the extent of the metastases: A retrospective analysis
Comparable impact of lymph node metastases in <span>T2</span> gallbladder cancer on postoperative prognosis irrespective of the extent of the metastases: A retrospective analysis Open
Background Lymph node metastases beyond the hepatoduodenal ligament are sometimes encountered in locally limited T2 gallbladder cancer (GBCA). However, the incidence and impact on prognosis remain unclear. Methods This was a retrospective …
View article: Western and Eastern experience in treating perihilar cholangiocarcinoma: retrospective bi-centre study
Western and Eastern experience in treating perihilar cholangiocarcinoma: retrospective bi-centre study Open
Background Resection outcomes for perihilar cholangiocarcinoma differ between Western and Eastern centres, but reasons behind these disparities remain unclear. This study aimed to compare current outcomes between a Western and an Eastern e…
View article: Arterial resection and divestment in pancreatic cancer surgery in the era of multidisciplinary treatment: decadal comparative study
Arterial resection and divestment in pancreatic cancer surgery in the era of multidisciplinary treatment: decadal comparative study Open
Background The aim of this study was to investigate the feasibility and effectiveness of pancreatectomy with arterial resection/divestment for pancreatic cancer with arterial involvement in the modern era of multidisciplinary treatment. Me…
View article: A left‐posterior approach to the superior mesenteric artery during robot‐assisted pancreaticoduodenectomy
A left‐posterior approach to the superior mesenteric artery during robot‐assisted pancreaticoduodenectomy Open
Background A complete dissection around the superior mesenteric artery (SMA) with artery‐first concept is crucial during pancreaticoduodenectomy for periampullary cancers. The left‐posterior (LP) approach to the SMA may be effective during…
View article: A Multimodal Approach Utilizing Balloon Occlusion for Postpancreatectomy Hemorrhage: A Case Report
A Multimodal Approach Utilizing Balloon Occlusion for Postpancreatectomy Hemorrhage: A Case Report Open
This case underscores the efficacy of a multidisciplinary approach in managing delayed PPH in hemodynamically stable patients. Comprehensive angiographic assessment, combined with temporary CHA balloon occlusion for bleeding control and me…
View article: A Robotic Pancreaticoduodenectomy Case Involving a Meandering Main Pancreatic Duct Coursing Posterior to a Replaced Common Hepatic Artery and in Front of the Portal Vein
A Robotic Pancreaticoduodenectomy Case Involving a Meandering Main Pancreatic Duct Coursing Posterior to a Replaced Common Hepatic Artery and in Front of the Portal Vein Open
This is the first report of the rCHA surrounded by pancreatic parenchyma and MMPD running behind the rCHA and in front of the portal vein.
View article: Surgical Resection of a Solitary Metachronous Retrocaval Lymph Node Metastasis above the Renal Vein from Rectal Cancer
Surgical Resection of a Solitary Metachronous Retrocaval Lymph Node Metastasis above the Renal Vein from Rectal Cancer Open
This is the first report of a surgical resection of a retrocaval lymph node metastasis from CRC that invaded both the IVC wall and the liver.
View article: Impact of hepatospleno volume ratio on postoperative chronic liver failure after major hepatectomy for perihilar cholangiocarcinoma
Impact of hepatospleno volume ratio on postoperative chronic liver failure after major hepatectomy for perihilar cholangiocarcinoma Open
Aims The incidence of postoperative chronic liver failure (PCLF) after major hepatectomy for perihilar cholangiocarcinoma is relatively low, but it warrants careful attention. This study aimed to analyze the risk factors for PCLF, with a s…
View article: Unexpected postoperative liver failure in patients with splenomegaly induced by induction chemotherapy for colorectal liver metastases
Unexpected postoperative liver failure in patients with splenomegaly induced by induction chemotherapy for colorectal liver metastases Open
Purpose: With advances in chemotherapy, conversion surgery is often performed for initially unresectable colorectal cancer liver metastasis (CLM). However, unexpected postoperative liver failure (POLF) is sometimes associated with chemothe…
View article: Impact of sarcopenia on S1 adjuvant chemotherapy and prognosis in pancreatic cancer patients
Impact of sarcopenia on S1 adjuvant chemotherapy and prognosis in pancreatic cancer patients Open
Although the importance of adjuvant chemotherapy (AC) has been recognized in pancreatic cancer (PC) patients, there are few studies to address the underlying mechanisms of failure to complete AC. This study aims to investigate the relation…
View article: Supplementary Figure S3 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Supplementary Figure S3 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Open
Supplementary Figure S3. A cell growth assay of stable transfectants of MIAPaCa2 and Panc1 cells. MIAPaCa2PTK6 and Panc1PTK6 demonstrated the similar growth rates when they were cultured without chemotherapeutic agent compared to their con…
View article: Supplementary Figure S1 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Supplementary Figure S1 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Open
Supplementary Figure S1. (A) The PTK6 gene silencing by alternative siRNA targeting different sequences of PTK6. (B) Effect of PTK6 gene-silencing on cytotoxity of gemcitabine. Cancer cells were transfected either with siRNA targeting to P…
View article: Supplementary Figure S3 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Supplementary Figure S3 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Open
Supplementary Figure S3. A cell growth assay of stable transfectants of MIAPaCa2 and Panc1 cells. MIAPaCa2PTK6 and Panc1PTK6 demonstrated the similar growth rates when they were cultured without chemotherapeutic agent compared to their con…
View article: Supplementary Materials from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Supplementary Materials from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Open
Supplementary Materials. Figure legends for Supplementary Figures
View article: Data from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Data from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Open
Protein Tyrosine Kinase 6 (PTK6) is a non-receptor–type tyrosine kinase known to be expressed in various cancers, including pancreatic cancer. The role of PTK6 in cancer chemoresistance remains unclear. Therefore, it was hypothesized that …
View article: Supplementary Figure S2 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Supplementary Figure S2 from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer Open
Supplementary Figure S2. Effect of Caspase-8 gene silencing on PTK6 mediated apoptosis. Apoptotic markers at 96 hours after gemcitabine treatment were decreased by gene-silencing of Caspase-8 in Panc1PTK6.