Hiromitsu Toyoda
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View article: Efficacy and Safety of Mirogabalin as an Add-on to Nonsteroidal Anti-inflammatory Drugs for Neuropathic Pain Caused by Lumbar Disc Herniation: A Randomized Controlled Study (Miro-Hers)
Efficacy and Safety of Mirogabalin as an Add-on to Nonsteroidal Anti-inflammatory Drugs for Neuropathic Pain Caused by Lumbar Disc Herniation: A Randomized Controlled Study (Miro-Hers) Open
Japan Registry of Clinical Trials (jRCTs061220102, registered 27/February/2023, https://jrct.mhlw.go.jp/en-latest-detail/jRCTs061220102 ).
View article: Efficacy of Chemonucleolysis With Condoliase Versus Minimally Invasive Discectomy for Lumbar Disc Herniation: A Propensity Score-Matched Retrospective Cohort Study
Efficacy of Chemonucleolysis With Condoliase Versus Minimally Invasive Discectomy for Lumbar Disc Herniation: A Propensity Score-Matched Retrospective Cohort Study Open
Study Design Retrospective cohort study. Objective Condoliase is a chemonucleolysis for lumbar disc herniation (LDH) that enzymatically degrades herniated disc material with high specificity for chondroitin sulfate and hyaluronic acid. Few…
View article: Predicting osteoporosis-related complications in lumbar spine surgery using Hounsfield unit and vertebral bone quality scores: A 5-Year follow-up study with principal component analysis insights
Predicting osteoporosis-related complications in lumbar spine surgery using Hounsfield unit and vertebral bone quality scores: A 5-Year follow-up study with principal component analysis insights Open
This study demonstrated that both HU and VBQ scores effectively predicted postoperative osteoporosis-related complications, with no significant difference in predictive ability. Optimal cutoff values were identified at approximately ≤ 100 …
View article: A randomized controlled trial of mobile intervention using health support bubbles to prevent social frailty
A randomized controlled trial of mobile intervention using health support bubbles to prevent social frailty Open
View article: Deep learning algorithm for identifying osteopenia/osteoporosis using cervical radiography
Deep learning algorithm for identifying osteopenia/osteoporosis using cervical radiography Open
View article: 12. A multidisciplinary approach to social functioning might improve the surgical outcomes of patients with cervical myelopathy: comparisons of two prospective cohorts
12. A multidisciplinary approach to social functioning might improve the surgical outcomes of patients with cervical myelopathy: comparisons of two prospective cohorts Open
View article: 39. Does cervical paraspinal muscle degeneration influence quality of life after cervical spine surgery?
39. Does cervical paraspinal muscle degeneration influence quality of life after cervical spine surgery? Open
View article: Anti-Tumor Effect of Non-Thermal Atmospheric Pressure Plasma-Activated Medium on Synovial Sarcoma: An In Vitro and In Vivo Study
Anti-Tumor Effect of Non-Thermal Atmospheric Pressure Plasma-Activated Medium on Synovial Sarcoma: An In Vitro and In Vivo Study Open
Background/Objective: Anti-tumor effects of plasma-activated medium (PAM) were demonstrated using various malignant tumors. However, the anti-tumor effect of PAM on synovial sarcoma remains unclear. Therefore, we aimed to investigate the a…
View article: Impact of Antiplatelet Medication Continuation on Surgical Outcomes after Minimally Invasive Posterior Lumbar Decompression Surgery: Retrospective Cohort Study
Impact of Antiplatelet Medication Continuation on Surgical Outcomes after Minimally Invasive Posterior Lumbar Decompression Surgery: Retrospective Cohort Study Open
Study Design Retrospective cohort study. Objectives Spinal surgeons face a dilemma regarding the continuation or discontinuation of antiplatelet agents during the perioperative period. Guidelines recommend considering the balance between t…
View article: Osteoporosis assessment in lumbar spine surgery: A principal component analysis-based analysis of hounsfield unit values and vertebral bone quality scores
Osteoporosis assessment in lumbar spine surgery: A principal component analysis-based analysis of hounsfield unit values and vertebral bone quality scores Open
View article: Utility of ct hounsfield unit and mri vertebral bone quality score in assessing the risk of adjacent vertebral fracture following balloon kyphoplasty
Utility of ct hounsfield unit and mri vertebral bone quality score in assessing the risk of adjacent vertebral fracture following balloon kyphoplasty Open
View article: Fractures from same-level falls among workers in the transportation sector: a retrospective analysis of the national open database of occupational injuries in Japan
Fractures from same-level falls among workers in the transportation sector: a retrospective analysis of the national open database of occupational injuries in Japan Open
We investigated the occurrence of fractures caused by same-level falls resulting from occupational accidents in the transportation sector, utilizing data on occupational deaths and injuries (2012-2016) collected by Japan's Ministry of Heal…
View article: Correction: In vivo study on the repair of rat Achilles tendon injury treated with non-thermal atmospheric-pressure helium microplasma jet
Correction: In vivo study on the repair of rat Achilles tendon injury treated with non-thermal atmospheric-pressure helium microplasma jet Open
[This corrects the article DOI: 10.1371/journal.pone.0301216.].
View article: 13. Preoperative range of motion from neutral to extension position can be a predictive factor for loss of cervical lordosis after cervical laminoplasty.
13. Preoperative range of motion from neutral to extension position can be a predictive factor for loss of cervical lordosis after cervical laminoplasty. Open
View article: P91. Less-invasive decompression procedures can reduce risk of reoperation for lumbar spinal stenosis with diffuse idiopathic skeletal hyperostosis extended to the lumbar segment
P91. Less-invasive decompression procedures can reduce risk of reoperation for lumbar spinal stenosis with diffuse idiopathic skeletal hyperostosis extended to the lumbar segment Open
View article: 12. Residual paresthesia and satisfaction after surgery for cervical myelopathy
12. Residual paresthesia and satisfaction after surgery for cervical myelopathy Open
View article: Diagnosis and Treatment of Symptomatic Multiple Sacral Perineural Cysts-Technical Note
Diagnosis and Treatment of Symptomatic Multiple Sacral Perineural Cysts-Technical Note Open
This case series reports the diagnostic and surgical methods for multiple sacral perineural cysts and their outcomes. Delayed CT myelography is helpful in diagnosing symptomatic cysts. Moreover, all cysts with filling defect signs or delay…
View article: Analysis of Risk Factors for Postoperative Progressive Segment Degeneration at the Decompression and Non-decompression Segments after Minimally Invasive Lumbar Decompression Surgery: A 5-year Follow-up Study
Analysis of Risk Factors for Postoperative Progressive Segment Degeneration at the Decompression and Non-decompression Segments after Minimally Invasive Lumbar Decompression Surgery: A 5-year Follow-up Study Open
Even though PSD does not correlate with worsening symptoms, our study confirms that a higher degree of pre-existing disc degeneration is indicative of a higher PSD in 5 years.
View article: In vivo study on the repair of rat Achilles tendon injury treated with non-thermal atmospheric-pressure helium microplasma jet
In vivo study on the repair of rat Achilles tendon injury treated with non-thermal atmospheric-pressure helium microplasma jet Open
Non-thermal atmospheric-pressure plasma (NTAPP) has been widely studied for clinical applications, e.g., disinfection, wound healing, cancer therapy, hemostasis, and bone regeneration. It is being revealed that the physical and chemical ac…
View article: Fracture healing on non-union fracture model promoted by non-thermal atmospheric-pressure plasma
Fracture healing on non-union fracture model promoted by non-thermal atmospheric-pressure plasma Open
Non-thermal atmospheric-pressure plasma (NTAPP) is attracting widespread interest for use in medical applications. The tissue repair capacity of NTAPP has been reported in various fields; however, little is known about its effect on fractu…
View article: Minimum Clinically Important Difference of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for Patients with Lumbar Spine Disease Undergoing Posterior Surgery by Generation
Minimum Clinically Important Difference of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for Patients with Lumbar Spine Disease Undergoing Posterior Surgery by Generation Open
Focusing on achieving the ideal responsiveness of patient-reported outcomes across generations, MCIDs of the pain-related disorder and gait disturbance domains may be valuable for patients, regardless of age, when adopting the JOABPEQ for …
View article: Risks of fracture from same-level falls among workers in the transportation service: A cross-sectional study of the national open database of occupational injuries in Japan
Risks of fracture from same-level falls among workers in the transportation service: A cross-sectional study of the national open database of occupational injuries in Japan Open
Background: To prevent falls, individual worker factors and work environment factors should be considered. Purpose: This study aimed to determine the risks of fracture from same level falls for occupational accidents in the transport indus…
View article: Short-Term Risk Factors for Distal Junctional Kyphosis after Spinal Reconstruction Surgery in Patients with Osteoporotic Vertebrae
Short-Term Risk Factors for Distal Junctional Kyphosis after Spinal Reconstruction Surgery in Patients with Osteoporotic Vertebrae Open
Study Design: Level 3 retrospective cohort case-control study.Purpose: This study aimed to investigate the risk factors for distal junctional kyphosis (DJK) caused by osteoporotic vertebral fractures following spinal reconstruction surgery…
View article: Uso do painel molecular para o diagnóstico de infecções sexualmente transmissíveis
Uso do painel molecular para o diagnóstico de infecções sexualmente transmissíveis Open
Objetivo: Desde 1993, a Organização Mundial da Saúde introduziu o conceito de abordagem sindrômica para o manejo de pacientes com infecções sexualmente transmissíveis. Apesar da recomendação atual, vários artigos apontam para o fraco desem…
View article: Factors Predicting the Final Diagnosis in Image-Guided Percutaneous Needle Biopsy for Suspected Spinal Tumors
Factors Predicting the Final Diagnosis in Image-Guided Percutaneous Needle Biopsy for Suspected Spinal Tumors Open
In cases of suspected spinal tumors on imaging studies, a biopsy is often necessary for establishing the diagnosis. Predictive factors for tumors or malignancies may help in scheduling biopsies or avoiding unnecessary ones. However, there …
View article: Muscle strength rather than appendicular skeletal muscle mass might affect spinal sagittal alignment, low back pain, and health-related quality of life
Muscle strength rather than appendicular skeletal muscle mass might affect spinal sagittal alignment, low back pain, and health-related quality of life Open
Sarcopenia is defined as decreasing in muscle strength and mass, and dynapenia is defined as decreasing in muscle strength and maintained muscle mass. This study elucidated the prevalence and characteristics of sarcopenia and dynapenia and…
View article: Risk Factors for Poor Outcome after Palliative Surgery for Metastatic Spinal Tumors
Risk Factors for Poor Outcome after Palliative Surgery for Metastatic Spinal Tumors Open
Palliative surgery is performed to improve the quality of life of patients with spinal metastases. However, it is sometimes difficult to achieve the expected results because the patient’s condition, and risk factors related to poor outcome…
View article: Periostin increased by mechanical stress upregulates interleukin‐6 expression in the ligamentum flavum
Periostin increased by mechanical stress upregulates interleukin‐6 expression in the ligamentum flavum Open
Ligamentum flavum (LF) hypertrophy is a major cause of lumbar spinal canal stenosis. Although mechanical stress is thought to be a major factor involved in LF hypertrophy, the exact mechanism by which it causes hypertrophy has not yet been…
View article: Prevalence, risk factors, and potential symptoms of hyponatremia after spinal surgery in elderly patients
Prevalence, risk factors, and potential symptoms of hyponatremia after spinal surgery in elderly patients Open
View article: Change in Physical and Mental Quality-of-Life between the Short- and Mid-Term Periods after Cervical Laminoplasty for Cervical Spondylotic Myelopathy: A Retrospective Cohort Study with Minimum 5 Years Follow-up
Change in Physical and Mental Quality-of-Life between the Short- and Mid-Term Periods after Cervical Laminoplasty for Cervical Spondylotic Myelopathy: A Retrospective Cohort Study with Minimum 5 Years Follow-up Open
The mid-term surgical outcomes of cervical spondylotic myelopathy (CSM), evaluated using the cervical Japanese Orthopedic Association (cJOA) score, are reported to be satisfactory. However, there remains room for improvement in quality-of-…