Hiromu Suzuki
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View article: Pan-Cancer Analysis Reveals AEBP1-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness
Pan-Cancer Analysis Reveals AEBP1-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness Open
Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that promote cancer progression and immune evasion. Adipocyte enhancer-binding protein 1 gene (AEBP1), which encodes aortic carboxypeptidase-like pr…
View article: DOT1L inhibition exerts the anti-tumor effect by activating interferon signaling in breast cancer cells
DOT1L inhibition exerts the anti-tumor effect by activating interferon signaling in breast cancer cells Open
Background DOT1L, a histone H3 lysine 79 (H3K79) methyltransferase, is a potential therapeutic target in various malignancies. In the present study, we aimed to clarify the anti-tumor effect of DOT1L inhibition in breast cancer. Methods Es…
View article: <p class="MDPI12titleori1" style="mso-line-height-alt: 14.0pt;"><span style="mso-bidi-font-size: 18.0pt; mso-ligatures: standardcontextual;">Pan-Cancer Analysis Reveals <em style="mso-bidi-font-style: normal;">AEBP1</em>-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness
<span>Pan-Cancer Analysis Reveals <em>AEBP1</em>-Collagen Co-Expression and Its Potential Role in CAF-Mediated Tumor Stiffness Open
Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment that promote cancer progression and immune evasion. Adipocyte enhancer-binding protein 1 gene (AEBP1), which encodes aortic carboxypeptidase-like pr…
View article: DOT1L inhibition exerts anti-tumor effects by activating interferon signaling in breast cancer cells
DOT1L inhibition exerts anti-tumor effects by activating interferon signaling in breast cancer cells Open
Background DOT1L, a histone H3 lysine 79 (H3K79) methyltransferase, is a potential therapeutic target in various malignancies. In the present study, we aimed to clarify the antitumor effect of DOT1L inhibition in breast cancer. Methods Est…
View article: DOT1L inhibition reprograms innate immunity to potentiate immunomodulatory drug responses in multiple myeloma
DOT1L inhibition reprograms innate immunity to potentiate immunomodulatory drug responses in multiple myeloma Open
Immunomodulatory drugs (IMiDs), such as lenalidomide, are a cornerstone of multiple myeloma (MM) treatment; however, their efficacy remains suboptimal. We previously reported that inhibition of DOT1L, a histone H3 lysine 79 methyltransfera…
View article: Analytical and Real‐World Clinical Characterization of S2,3PSA% Test in MRI Fusion Targeted Prostate Biopsy Population
Analytical and Real‐World Clinical Characterization of S2,3PSA% Test in MRI Fusion Targeted Prostate Biopsy Population Open
Background The α2,3‐sialyl N ‐glycosylated free prostate‐specific antigen ratio (S2,3PSA%) was approved in Japan as a prostate cancer (PCa) diagnostic test. We evaluated the analytical characterization and real‐world diagnostic performance…
View article: Application of Single Cell Type-Derived Spheroids Generated by Using a Hanging Drop Culture Technique in Various In Vitro Disease Models: A Narrow Review
Application of Single Cell Type-Derived Spheroids Generated by Using a Hanging Drop Culture Technique in Various In Vitro Disease Models: A Narrow Review Open
Cell culture methods are indispensable strategies for studies in biological sciences and for drug discovery and testing. Most cell cultures have been developed using two-dimensional (2D) culture methods, but three-dimensional (3D) culture …
View article: The molecular profile of gastric intraepithelial foveolar type neoplasia based on somatic copy number alterations and multiple mutation analysis
The molecular profile of gastric intraepithelial foveolar type neoplasia based on somatic copy number alterations and multiple mutation analysis Open
View article: AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma
AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma Open
The tumor microenvironment plays a pivotal role in cancer development. We recently reported that in oral squamous cell carcinoma (OSCC), adipocyte enhancer-binding protein 1 (AEBP1) is abundantly expressed in cancer-associated fibroblasts …
View article: A genome‐wide study of gastric intramucosal neoplasia based on somatic copy number alterations, gene mutations, and <scp>mRNA</scp> expression patterns
A genome‐wide study of gastric intramucosal neoplasia based on somatic copy number alterations, gene mutations, and <span>mRNA</span> expression patterns Open
We performed comprehensive analyses of somatic copy number alterations (SCNAs) and gene expression profiles of gastric intramucosal neoplasia (IMN) using array‐based methods in 97 intestinal‐type IMNs, including 39 low‐grade dysplasias (LG…
View article: Inhibition of protein arginine methyltransferase 6 activates interferon signaling and induces the apoptosis of endometrial cancer cells via histone modification
Inhibition of protein arginine methyltransferase 6 activates interferon signaling and induces the apoptosis of endometrial cancer cells via histone modification Open
Histone modification, a major epigenetic mechanism regulating gene expression through chromatin remodeling, introduces dynamic changes in chromatin architecture. Protein arginine methyltransferase 6 (PRMT6) is overexpressed in various type…
View article: Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas
Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas Open
Background Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rare…
View article: Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts
Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts Open
The current study’s objective was to elucidate some currently unknown biological indicators to evaluate the biological nature of cancer-associated fibroblasts (CAFs). For this purpose, four different CAFs, CAFS1, CAFS2, SCC17F and MO-1000,…
View article: Supplementary Figure S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
Supplementary Figure S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors Open
Supplementary Figure S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
View article: Supplementary Table 3 from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer
Supplementary Table 3 from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer Open
XLS file - 78K, Genes hypermethylated in background gastric mucosae from patients with diffuse type GC
View article: Supplementary Table 4 from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer
Supplementary Table 4 from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer Open
XLS file - 80K, Genes commonly methylated in background gastric mucosa from patients with intestinal type GC or diffuse type GC
View article: Supplementary Table 4 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
Supplementary Table 4 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer Open
Supplementary Table 4. Relationship between TET1 methylation and Clinical features in CIMP-P CRCs (TCGA data set)
View article: Supplementary Fig. 2 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
Supplementary Fig. 2 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer Open
Supplementary Fig. 2. Genetic and epigenetic alterations in CIMP-P CRCs
View article: Supplementary Figure S1 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
Supplementary Figure S1 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors Open
Supplementary Figure S1 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
View article: Supplementary Figures 1 - 4 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer
Supplementary Figures 1 - 4 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer Open
Supplementary Figure S1 Receiver operating characteristic curve analysis of the respective marker genes. Supplementary Figure S2 Ages of CRC patients (upper) and non-CRC individuals (lower) with the indicated M-scores. Each dot represents …
View article: Supplementary Table 1 from AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis
Supplementary Table 1 from AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis Open
XLSX file - 108K, Genes which was increased by p53 more than 8-fold compared to LacZ.
View article: Data from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer
Data from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer Open
Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms. In this study, we assessed the feasibility of using DNA methylation detected in bowel lavage fluid (BLF) for colorectal cancer screening. A total of …
View article: Supplementary Table S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
Supplementary Table S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors Open
Supplementary Table S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
View article: Supplementary Figure legends from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
Supplementary Figure legends from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer Open
Supplementary Figure legends for Supplementary Fig.1 and Fig. 2
View article: Supplementary Figures 1 - 4 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer
Supplementary Figures 1 - 4 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer Open
Supplementary Figure S1 Receiver operating characteristic curve analysis of the respective marker genes. Supplementary Figure S2 Ages of CRC patients (upper) and non-CRC individuals (lower) with the indicated M-scores. Each dot represents …
View article: Supplementary Figure 1 from AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis
Supplementary Figure 1 from AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis Open
PDF file - 31K, The effect of AKR1B10 knockdown on the activity of caspases and the amount of cellular NADPH.
View article: Supplementary Table 2 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
Supplementary Table 2 from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer Open
Supplementary Table 2. Primer sets for pyrosequencing methylation analysis, mutation analysis, and RT-PCR
View article: Supplementary Figure Legends from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
Supplementary Figure Legends from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors Open
Supplementary Figure Legends from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
View article: Data from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer
Data from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer Open
Aberrant DNA methylation is implicated in the epigenetic field defect seen in gastric cancer. Our aim in this study was to identify predictive biomarkers by screening for DNA methylation in noncancerous background gastric mucosa from patie…
View article: Data from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
Data from Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer Open
Inactivation of methylcytosine dioxygenase, ten-eleven translocation (TET) is known to be associated with aberrant DNA methylation in cancers. Tumors with a CpG island methylator phenotype (CIMP), a distinct subgroup with extensive DNA met…