Hironobu Osaki
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View article: Descending projections from the insular cortex to the lateral parabrachial nucleus facilitate nocifensive behaviors in rats
Descending projections from the insular cortex to the lateral parabrachial nucleus facilitate nocifensive behaviors in rats Open
The lateral parabrachial nucleus (LPBN) receives orofacial nociceptive inputs from the trigeminal spinal subnucleus caudalis and transmits them to higher brain regions, including the central amygdala (CeA), intralaminar thalamic nucleus, a…
View article: Effective training procedure for a simultaneous bimanual movement task in head-fixed mice
Effective training procedure for a simultaneous bimanual movement task in head-fixed mice Open
Bimanual movements consist of simultaneous and nonsimultaneous movements. The neural mechanisms of unimanual and nonsimultaneous bimanual movements have been explored in rodent studies through electrophysiological recordings and calcium im…
View article: Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks
Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks Open
Inherent capacity to flexibly reorganize after injury is a hallmark of brain networks, and recent studies suggest that functional consequences of focal damage are strongly influenced by the network’s non-random connectivity. Although many …
View article: Regulation of nociception by long-term potentiation of inhibitory postsynaptic currents from insular cortical parvalbumin-immunopositive neurons to pyramidal neurons
Regulation of nociception by long-term potentiation of inhibitory postsynaptic currents from insular cortical parvalbumin-immunopositive neurons to pyramidal neurons Open
The insular cortex (IC) processes various sensory information, including nociception, from the trigeminal region. Repetitive nociceptive inputs from the orofacial area induce plastic changes in the IC. Parvalbumin-immunopositive neurons (P…
View article: Recent advances and applications of human brain models
Recent advances and applications of human brain models Open
Recent advances in human pluripotent stem cell (hPSC) technologies have prompted the emergence of new research fields and applications for human neurons and brain organoids. Brain organoids have gained attention as an in vitro model system…
View article: Role of the medial agranular cortex in unilateral spatial neglect
Role of the medial agranular cortex in unilateral spatial neglect Open
Unilateral spatial neglect (USN) results from impaired attentional networks and can affect various sensory modalities, such as visual and somatosensory. The rodent medial agranular cortex (AGm), located in the medial part of the forebrain …
View article: ISPH with a Geometric Multigrid Preconditioning Solver using Background Cells in GPU environment
ISPH with a Geometric Multigrid Preconditioning Solver using Background Cells in GPU environment Open
Incompressible fluid analysis using the ISPH or MPS methods requires the solution of the pressure Poisson equation, which takes up most of the overall computation time. In addition, the iteration number for solving pressure Poisson equatio…
View article: Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex
Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex Open
View article: Facial nerve regeneration with bioabsorbable collagen conduits filled with collagen filaments: An experimental study
Facial nerve regeneration with bioabsorbable collagen conduits filled with collagen filaments: An experimental study Open
View article: FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes
FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes Open
Abnormalities in GABAergic inhibitory circuits have been implicated in the aetiology of autism spectrum disorder (ASD). ASD is caused by genetic and environmental factors. Several genes have been associated with syndromic forms of ASD, inc…
View article: Distinct nociresponsive region in mouse primary somatosensory cortex
Distinct nociresponsive region in mouse primary somatosensory cortex Open
Nociception, somatic discriminative aspects of pain, is represented in the primary somatosensory cortex (S1), as is touch, but the separation and the interaction of the two modalities within S1 remain unclear. Here, we show the spatially-d…
View article: Corrigendum to “Dedifferentiated fat cells in polyglycolic acid-collagen nerve conduits promote rat facial nerve regeneration” [Regen Ther 11 (2019) 240–248]
Corrigendum to “Dedifferentiated fat cells in polyglycolic acid-collagen nerve conduits promote rat facial nerve regeneration” [Regen Ther 11 (2019) 240–248] Open
View article: Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations
Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations Open
Peripheral nerve injury induces functional and structural remodeling of neural circuits along the somatosensory pathways, forming the basis for somatotopic reorganization and ectopic sensations, such as referred phantom pain. However, the …
View article: Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction
Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction Open
Primary motor cortex (M1) infarctions sometimes cause sensory impairment. Because sensory signals play a vital role in motor control, sensory impairment compromises the recovery and rehabilitation of motor disability. However, the neural m…
View article: 緊張性GABA作動性阻害は体性感覚視床および異所性感覚における神経損傷誘発求心性リモデリングに必須である【JST・京大機械翻訳】
緊張性GABA作動性阻害は体性感覚視床および異所性感覚における神経損傷誘発求心性リモデリングに必須である【JST・京大機械翻訳】 Open
View article: Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex
Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex Open
Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural pla…
View article: Author response: Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex
Author response: Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex Open
View article: Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction
Layer-specific sensory processing impairment in the primary somatosensory cortex after motor cortex infarction Open
Primary motor cortex (M1) infarction occasionally causes sensory impairment. Because sensory signal plays an important role in motor control, sensory impairment compromises recovery and rehabilitation from motor disability. Despite the imp…
View article: Dedifferentiated fat cells in polyglycolic acid-collagen nerve conduits promote rat facial nerve regeneration
Dedifferentiated fat cells in polyglycolic acid-collagen nerve conduits promote rat facial nerve regeneration Open
DFAT cell-filled PGA conduits were found to promote nerve regeneration in an experimental rat facial nerve defect model.
View article: Axonal supercharged interpositional jump‐graft with a hybrid artificial nerve conduit containing adipose‐derived stem cells in facial nerve paresis rat model
Axonal supercharged interpositional jump‐graft with a hybrid artificial nerve conduit containing adipose‐derived stem cells in facial nerve paresis rat model Open
Purpose Interpositional jump‐graft (IPJG) technique with the hypoglossal nerve for supercharging can be applied in a facial nerve paresis case. In IPJG, an autologous nerve is required, and the donor site morbidity is unavoidable. Biodegra…
View article: Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task
Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task Open
View article: A method package for electrophysiological evaluation of reconstructed or regenerated facial nerves in rodents
A method package for electrophysiological evaluation of reconstructed or regenerated facial nerves in rodents Open
View article: Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice as a Neural Basis of Somatotopic Reorganization in the Brain and Ectopic Mechanical Hypersensitivity after Peripheral Sensory Nerve Injury
Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice as a Neural Basis of Somatotopic Reorganization in the Brain and Ectopic Mechanical Hypersensitivity after Peripheral Sensory Nerve Injury Open
Plastic changes in the CNS in response to peripheral sensory nerve injury are a series of complex processes, ranging from local circuit remodeling to somatotopic reorganization. However, the link between circuit remodeling and somatotopic …
View article: The dysgranular area of somatosensory cortex represents nociceptive information
The dysgranular area of somatosensory cortex represents nociceptive information Open
View article: Assembly of GABAergic circuitry by FoxG1, a gene associated with neurodevelopmental disorders
Assembly of GABAergic circuitry by FoxG1, a gene associated with neurodevelopmental disorders Open
View article: Large-scale somatotopic reorganization with afferent fiber remodeling in the mice whisker sensory thalamus after peripheral sensory nerve injury
Large-scale somatotopic reorganization with afferent fiber remodeling in the mice whisker sensory thalamus after peripheral sensory nerve injury Open