Hironori Takagi
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View article: Exploring the Role of Rikkunshito for Chemotherapy‐Induced Anorexia ( <scp>RICH</scp> Trial): Insight From Plasma Metabolomics
Exploring the Role of Rikkunshito for Chemotherapy‐Induced Anorexia ( <span>RICH</span> Trial): Insight From Plasma Metabolomics Open
Aim Cisplatin is a key chemotherapeutic drug used for lung cancer therapy; however, it is known to induce gastrointestinal disorders. The aim of the present trial was to determine the efficacy of the Traditional Japanese (Kampo) Medicine r…
View article: A case of discordant histology and expression of programmed death ligand 1 between primary tumor and brain metastases in adenosquamous carcinoma of the lung
A case of discordant histology and expression of programmed death ligand 1 between primary tumor and brain metastases in adenosquamous carcinoma of the lung Open
A patient presented with vomiting and gait disturbance. Investigation revealed a single cerebellar tumor and another tumor in the upper lobe of the left lung. Based on the severe vomiting and gait disturbance, we removed the cerebellar tum…
View article: A Case of Lung Adenocarcinoma with Epipharyngeal Metastasis During Chemotherapy
A Case of Lung Adenocarcinoma with Epipharyngeal Metastasis During Chemotherapy Open
背景．肺癌の咽頭転移は極めて稀である．症例．60歳代男性．右肺腺癌（pT2aNxM1a stage IVA）に対してcisplatin＋pemetrexed＋bevacizumabによる化学療法を6コース施行し，維持療法pemetrexed＋bevacizumabを1 0コース施行後に右頚部腫脹および鼻閉感が出現した．造影C Tにて頚部リンパ節の腫大を認め，鼻咽頭ファイバーでは，上咽頭に腫瘤性病変を認めた．頚部リンパ節および上咽頭腫瘤性病変の生検を施行し，組織学的に肺腺癌の…
View article: Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers
Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers Open
Lung cancer is the leading cause of cancer-related deaths worldwide. The standard of care for advanced non-small-cell lung cancer (NSCLC) without driver-gene mutations is a combination of an anti-PD-1/PD-L1 antibody and chemotherapy, or an…
View article: Ectopic adrenocorticotropic hormone‐secreting carcinoid with solitary cryptococcosis in the lungs
Ectopic adrenocorticotropic hormone‐secreting carcinoid with solitary cryptococcosis in the lungs Open
Background Carcinoid tumors can on rare occasions ectopically produce adrenocorticotropic hormone (ACTH), causing Cushing's syndrome, and patients could become immunocompromised. Care must therefore be taken regarding infectious complicati…
View article: Large cell neuroendocrine carcinoma of the lung controlled for 4 years by a single administration of pembrolizumab: A case report
Large cell neuroendocrine carcinoma of the lung controlled for 4 years by a single administration of pembrolizumab: A case report Open
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly progressive tumor with a poor prognosis. Although immune checkpoint inhibitors have been approved for treatment of both small cell and non–small cell lung cancers…
View article: Efficacy of Immune-checkpoint Inhibitors as the Peri-operative Treatment for Resectable Non-small-cell Lung Cancer
Efficacy of Immune-checkpoint Inhibitors as the Peri-operative Treatment for Resectable Non-small-cell Lung Cancer Open
免疫チェックポイント阻害薬（ICIs）の登場によって進行再発非小細胞肺癌（NSCLC）の治療法は大きく変化した．IV期NSCLCにおいてはドライバー遺伝子を有さないNSCLCが主な適応とされているが，1次治療から2次治療以降にわたるまでICIs単独療法と殺細胞性薬物療法との併用療法も含めて，幅広く使われるようになった．近年ではICIsの2剤併用療法も使用可能となっている．一方で切除不能III期局所進行肺癌では放射線化学療法後の維持療法としての有効性も示され，実臨床で使用可能…
View article: CTLA-4 Expression in Tumor-infiltrating Lymphocytes Is Irrelevant to PD-L1 Expression in NSCLC
CTLA-4 Expression in Tumor-infiltrating Lymphocytes Is Irrelevant to PD-L1 Expression in NSCLC Open
The proportions of CTLA-4+ regulatory T cells to CD8 T cells and CTLA-4+ cells in CD8 T cells were irrelevant to the PD-L1 TPS in NSCLC patients.
View article: A patient with <scp>ALK</scp>‐positive lung adenocarcinoma who survived alectinib‐refractory postoperative recurrence for 4 years by switching to ceritinib
A patient with <span>ALK</span>‐positive lung adenocarcinoma who survived alectinib‐refractory postoperative recurrence for 4 years by switching to ceritinib Open
Echinoderm microtubule‐associated protein‐like 4‐anaplastic lymphoma kinase (EML4‐ALK) rearrangements are found in ~ 5% of patients with non‐small cell lung cancer (NSCLC). Several tyrosine kinase inhibitors (TKIs) have been developed for …
View article: Pulmonary large cell carcinoma, highly positive for <scp>PD‐L1</scp>, shows marked response to pembrolizumab: A case report
Pulmonary large cell carcinoma, highly positive for <span>PD‐L1</span>, shows marked response to pembrolizumab: A case report Open
Pulmonary large cell carcinoma (LCC) is classified as a poorly defined entity among non‐small cell lung cancers (NSCLCs). At present, there are no effective anticancer drugs, such as molecular targeted drugs, for LCC, and it has been repor…
View article: Our experience of lung resection in patients who decline blood transfusion for religious reasons
Our experience of lung resection in patients who decline blood transfusion for religious reasons Open
Objective Surgical treatment for patients who refuse blood transfusion due to religious beliefs is an important issue related to medical safety. Few reports have examined pulmonary surgery for these patients, and we analyzed clinical chara…
View article: Tumor β‑catenin expression is associated with immune evasion in non‑small cell lung cancer with high tumor mutation burden
Tumor β‑catenin expression is associated with immune evasion in non‑small cell lung cancer with high tumor mutation burden Open
β-catenin expression by tumor cells suppressed dendritic cell recruitment to the tumor microenvironment in a melanoma model, resulting in fewer tumor-infiltrating lymphocytes. Immunohistochemistry was used in the present study to examine t…
View article: Genetic alterations in epidermal growth factor receptor‑tyrosine kinase inhibitor‑na�ve non‑small cell lung carcinoma
Genetic alterations in epidermal growth factor receptor‑tyrosine kinase inhibitor‑na�ve non‑small cell lung carcinoma Open
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majorit…
View article: A Case of Sclerosing Thymoma with Myasthenia Gravis
A Case of Sclerosing Thymoma with Myasthenia Gravis Open
背景．胸腺腫は縦隔腫瘍全体の約20％を占め，最も頻度が高い．硬化性胸腺腫は，1994年にKuoによって初めて報告された比較的稀な胸腺腫の一亜型である．症例．症例は67歳男性．重症筋無力症の診断でステロイドパルス療法，免疫グロブリン大量療法を行った．胸部CT検査にて前縦隔に38 mmの軟部陰影が認められ胸腺腫が疑われたため，拡大胸腺腫摘出術を行った．病理学的所見で著しく硝子化した線維組織を認め，硬化性胸腺腫type B1，正岡分類I期，pT1N0M0，stage Iと診断した…
View article: Comparison of surgical outcomes after pneumonectomy and pulmonary function-preserving surgery for non-small cell lung cancer
Comparison of surgical outcomes after pneumonectomy and pulmonary function-preserving surgery for non-small cell lung cancer Open
The short-term results were better in Group PS than PN. However, the long-term results in both groups were similar. Other causes of death influenced OS in both groups; this result might have been affected by the surgical procedures.
View article: Thermal Decomposition of Printed Circuit Board in the Presence of Zinc Oxide under Inert and Oxidative Atmosphere: Emission Behavior of Inorganic Brominated Compounds
Thermal Decomposition of Printed Circuit Board in the Presence of Zinc Oxide under Inert and Oxidative Atmosphere: Emission Behavior of Inorganic Brominated Compounds Open
Thermal degradation of a FR-4 type printed circuit board, PCB, containing brominated flame retardant has been studied both in inert and oxidative atmosphere for the emission control of harmful brominated compounds. The presence of oxygen i…
View article: Repairability of skeletal alterations induced by sodium valproate in rats
Repairability of skeletal alterations induced by sodium valproate in rats Open
The present study aimed at examining postnatal repairability of sodium valproate‐induced skeletal alterations in rats. Sodium valproate (400 mg/kg) or the vehicle (distilled water) was orally administrated to pregnant Sprague‐Dawley rats f…
View article: Family with sequence similarity 83, member�B is a predictor of poor prognosis and a potential therapeutic target for lung adenocarcinoma expressing wild‑type epidermal growth factor receptor
Family with sequence similarity 83, member�B is a predictor of poor prognosis and a potential therapeutic target for lung adenocarcinoma expressing wild‑type epidermal growth factor receptor Open
Lung adenocarcinoma (ADC) patients with tumors that harbor no targetable driver gene mutation, such as epidermal growth factor receptor (EGFR) gene mutations, have unfavorable prognosis, and thus, novel therapeutic targets are required. Fa…
View article: The efficacy of the Kampo medicine rikkunshito for chemotherapy-induced anorexia (RICH trial): study protocol for a randomized controlled trial
The efficacy of the Kampo medicine rikkunshito for chemotherapy-induced anorexia (RICH trial): study protocol for a randomized controlled trial Open
Japan Pharmaceutical Information Center Clinical Trials Information (JAPIC CTI), trial registration: JAPIC CTI-142747 . Registered on 15 December 2014; the RICH trial.
View article: Serum Nitric Oxide as a Predictive Biomarker for Bevacizumab in Non-small Cell Lung Cancer Patients
Serum Nitric Oxide as a Predictive Biomarker for Bevacizumab in Non-small Cell Lung Cancer Patients Open
Serum nitric oxide levels could be a predictive biomarker for response to bevacizumab in NSCLC patients.