Hiroshi Endoh
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View article: Highly selective SGLT2 inhibitors suppress glucose uptake in alpha-TC1 cells, while glucagon secretion is not affected
Highly selective SGLT2 inhibitors suppress glucose uptake in alpha-TC1 cells, while glucagon secretion is not affected Open
The existence of sodium-glucose cotransporter 2 (SGLT2) in pancreatic alpha cells and its potential roles in glucagon secretion remain controversial, despite its well-established function in renal glucose reabsorption. While some studies s…
View article: Impact on outcomes of measuring lactates prior to ICU in unselected heterogeneous critically ill patients: A propensity score analysis
Impact on outcomes of measuring lactates prior to ICU in unselected heterogeneous critically ill patients: A propensity score analysis Open
Background Elevated blood lactate levels were reported as effective predictors of clinical outcome and mortality in ICU. However, there have been no studies simply comparing the timing of measuring lactates before vs. after ICU admission. …
View article: Prognosis improvement effects of physician staffed helicopter emergency medical service on cerebral infarction patients: registry based prospective observational study
Prognosis improvement effects of physician staffed helicopter emergency medical service on cerebral infarction patients: registry based prospective observational study Open
Purpose This study clarifies the effectiveness of helicopter emergency medical service, widely known as “Doctor-Heli” (DH) in Japan, and its impact on the neurological outcome of cerebral infarction patients. Materials and methods Out of 4…
View article: Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study
Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study Open
View article: Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study
Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study Open
Objective: Acute mental stress (MS) increases arm blood pressure (BP); however, it remains unclear whether the stress-induced pressor response is also seen in other vessels. The present study aimed to examine the impact of acute MS on ankl…
View article: Child-rearing Assistance Enhances Physical Activity and Health-related Quality of Life among Japanese Grandmothers
Child-rearing Assistance Enhances Physical Activity and Health-related Quality of Life among Japanese Grandmothers Open
Appropriate physical activity (PA) enhances health-related quality of life (HRQOL) in the elderly. However, few studies have focused on the physical activity required during grandparenting activities. We investigated the levels of PA and H…
View article: Study of factors related to social and emotional skills in early childhood in Japan
Study of factors related to social and emotional skills in early childhood in Japan Open
Background There are numerous reports that social and emotional skills in early childhood have profound influence on lifelong health. The aim of this research is to determine the relation between the lifestyle and the social and emotional …
View article: Lactate indices as predictors of in-hospital mortality or 90-day survival after admission to an intensive care unit in unselected critically ill patients
Lactate indices as predictors of in-hospital mortality or 90-day survival after admission to an intensive care unit in unselected critically ill patients Open
These data indicate that the maximal arterial lactate concentration at T24 is a robust predictor of in-hospital mortality as well as 90-day survival in unselected ICU patients with predictive ability as comparable with APACHE III score.
View article: A case of diffuse alveolar hemorrhage following synthetic cathinone inhalation
A case of diffuse alveolar hemorrhage following synthetic cathinone inhalation Open
View article: Early prognostication of neurological outcome by heart rate variability in adult patients with out-of-hospital sudden cardiac arrest
Early prognostication of neurological outcome by heart rate variability in adult patients with out-of-hospital sudden cardiac arrest Open
Background Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family’s intention. Thus, accurat…
View article: Aortoesophageal Fistula after Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury
Aortoesophageal Fistula after Thoracic Endovascular Aortic Repair for Blunt Thoracic Aortic Injury Open
Although thoracic endovascular aortic repair (TEVAR) has grown to become the standard of care to treat blunt thoracic aortic injury (BTAI), the long-term effects of TEVAR are still unclear. We here present a 72-year-old man with BTAI due t…
View article: Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis
Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis Open
Our results show that SMI measurement at ICU admission is a valid predictive factor for ICU-AW progression in septic patients.
View article: Accidental falls related to clearing heavy snow on rooftops in a rural heavy snow area in Japan
Accidental falls related to clearing heavy snow on rooftops in a rural heavy snow area in Japan Open
Aim The purpose of this study is to describe our experience with patients who fell from rooftops while clearing snow. The falls occurred in rural areas that receive heavy snowfall and are undergoing depopulation and an increasing proportio…
View article: A protein-protein interaction in magnetosomes: TPR protein MamA interacts with an Mms6 protein
A protein-protein interaction in magnetosomes: TPR protein MamA interacts with an Mms6 protein Open
Magnetosomes are membrane-enveloped bacterial organelles containing nano-sized magnetic particles, and function as a cellular magnetic sensor, which assist the cells to navigate and swim along the geomagnetic field. Localized with each mag…
View article: Effect of the Early Introduction of Mild Mobilization Performed by Nurses on the Recovery of Patients in the Intensive Care Unit
Effect of the Early Introduction of Mild Mobilization Performed by Nurses on the Recovery of Patients in the Intensive Care Unit Open
Rationale: Recent studies have reported the effectiveness of the early introduction of rehabilitation for preventing muscle weakness in patients in the intensive care unit (ICU). The early introduction of full-scale rehabilitation by a phy…
View article: Randomized, double-blind, placebo-controlled, crossover study to evaluate the effects of beta-1,3/1,6 glucan on stress associated with daily lifestyle in healthy subjects
Randomized, double-blind, placebo-controlled, crossover study to evaluate the effects of beta-1,3/1,6 glucan on stress associated with daily lifestyle in healthy subjects Open
Background: Fatigue is attributable to physical and psychological stress. Fatigue is also a common symptom which occurs in both sick and healthy individuals. Although its mechanism of cause is complex, fatigue from stress is known to affec…