Hiroshi Ide
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View article: Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization
Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization Open
Ionizing radiation induces various types of DNA damage, and the reparability and lethal effects of DNA damage differ depending on its spatial density. Elucidating the structure of radiation-induced clustered DNA damage and its repair proce…
View article: Changes in repair pathways of radiation-induced DNA double-strand breaks at the midblastula transition in <i>Xenopus</i> embryo
Changes in repair pathways of radiation-induced DNA double-strand breaks at the midblastula transition in <i>Xenopus</i> embryo Open
Ionizing radiation (IR) causes DNA damage, particularly DNA double-strand breaks (DSBs), which have significant implications for genome stability. The major pathways of repairing DSBs are homologous recombination (HR) and nonhomologous end…
View article: Molecular detection of antimicrobial resistance genes in multidrug-resistant Gram-negative bacteria isolated from clinical samples in two hospitals in Niger
Molecular detection of antimicrobial resistance genes in multidrug-resistant Gram-negative bacteria isolated from clinical samples in two hospitals in Niger Open
Background: According to the World Health Organization (WHO), bacterial resistance to antibiotics is a global public health challenge, which is also developing in Niger. The aim of this study was to determine the prevalence of antibiotic r…
View article: Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding Open
Topoisomerases are enzymes that relax DNA supercoiling during replication and transcription. Camptothecin, a topoisomerase 1 (TOP1) inhibitor, and its analogs trap TOP1 at the 3'-end of DNA as a DNA-bound intermediate, resulting in DNA dam…
View article: Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy
Formation of clustered DNA damage in vivo upon irradiation with ionizing radiation: Visualization and analysis with atomic force microscopy Open
Significance DNA damage causes loss of or alterations in genetic information, resulting in cell death or mutations. Ionizing radiations produce local, multiple DNA damage sites called clustered DNA damage. In this study, a complete protoco…
View article: Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells
Repair pathways for radiation DNA damage under normoxic and hypoxic conditions: Assessment with a panel of repair-deficient human TK6 cells Open
Various types of DNA lesions are produced when cells are exposed to ionizing radiation (IR). The type and yield of IR-induced DNA damage is influenced by the oxygen concentration. Thus, different DNA repair mechanisms may be involved in th…
View article: Molecular insights into the repair mechanism of enzymatic DNA-protein cross-link damage induced by a DNMT inhibitor.
Molecular insights into the repair mechanism of enzymatic DNA-protein cross-link damage induced by a DNMT inhibitor. Open
Background: DNA-protein cross-links (DPCs) are a special type of DNA damage that is formed when a protein that participates in DNA transactions is irreversibly and covalently linked to DNA bases.DPCs are formed after exposure to chemicals,…
View article: Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells
Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells Open
Proteins are covalently trapped on DNA to form DNA-protein cross-links (DPCs) when cells are exposed to DNA-damaging agents. Aldehyde compounds produce common types of DPCs that contain proteins in an undisrupted DNA strand. Tyrosyl-DNA ph…
View article: Direct observation of damage clustering in irradiated DNA with atomic force microscopy
Direct observation of damage clustering in irradiated DNA with atomic force microscopy Open
Ionizing radiation produces clustered DNA damage that contains two or more lesions in 10–20 bp. It is believed that the complexity of clustered damage (i.e., the number of lesions per damage site) is related to the biological severity of i…
View article: Role of DNA Polymerase κ in the Processing of DNA-protein Cross-link Damage Induced by 2ʹ-deoxy-5-azacytidine and Formaldehyde
Role of DNA Polymerase κ in the Processing of DNA-protein Cross-link Damage Induced by 2ʹ-deoxy-5-azacytidine and Formaldehyde Open
DNA molecule contains vital genetic information for nearly all living organisms and required for cell survival and function.Thus, it is very essential to keep genetic information intact.However, DNA undergoes several forms of DNA
View article: A general Mechanistic Model of Bromate Cytotoxicity Mediated by DNA Damage
A general Mechanistic Model of Bromate Cytotoxicity Mediated by DNA Damage Open
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View article: Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells
Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells Open
Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological studies have indicated that metformin exhibits anti-cancer activity. However, the molecular mechanisms underlying this activity currently remai…
View article: Establishment of expanded and streamlined pipeline of PITCh knock-in – a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO
Establishment of expanded and streamlined pipeline of PITCh knock-in – a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO Open
The emerging genome editing technology has enabled the creation of gene knock-in cells easily, efficiently, and rapidly, which has dramatically accelerated research in the field of mammalian functional genomics, including in humans. We rec…
View article: Restriction glycosylases: involvement of endonuclease activities in the restriction process
Restriction glycosylases: involvement of endonuclease activities in the restriction process Open
All restriction enzymes examined are phosphodiesterases generating 3΄-OH and 5΄-P ends, but one restriction enzyme (restriction glycosylase) excises unmethylated bases from its recognition sequence. Whether its restriction activity involve…