Hiroshi Kido
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View article: Triethylamine inhibits influenza A virus infection and growth via mechanisms independent of viral neuraminidase and RNA-dependent RNA polymerase
Triethylamine inhibits influenza A virus infection and growth via mechanisms independent of viral neuraminidase and RNA-dependent RNA polymerase Open
Triethylamine (Et 3 N) is a proton (H⁺) acceptor that is widely used in various industrial organic synthesis processes, including the production of pharmaceuticals, agrochemicals, and polymers. Inhalation of high Et 3 N concentrations can …
View article: Retraction Note: Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells
Retraction Note: Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells Open
View article: Correction: Taniuchi et al. The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy. Nutrients 2023, 15, 2770
Correction: Taniuchi et al. The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy. Nutrients 2023, 15, 2770 Open
The authors wish to make the following correction to this paper [...]
View article: Prediction of clinical outcome of egg allergy by measuring avidity of ovomucoid-specific IgE
Prediction of clinical outcome of egg allergy by measuring avidity of ovomucoid-specific IgE Open
View article: Avidity of specific IgE antibody may predict the development of hen's egg allergy in infants
Avidity of specific IgE antibody may predict the development of hen's egg allergy in infants Open
View article: Dual assessment of total binding and antigen avidity of specific IgE antibody better predicts outcomes of oral food challenge in children
Dual assessment of total binding and antigen avidity of specific IgE antibody better predicts outcomes of oral food challenge in children Open
View article: Bakuchiol targets mitochondrial proteins, prohibitins and voltage-dependent anion channels: New insights into developing antiviral agents
Bakuchiol targets mitochondrial proteins, prohibitins and voltage-dependent anion channels: New insights into developing antiviral agents Open
We previously reported that bakuchiol, a phenolic isoprenoid anticancer compound, and its analogs exert anti-influenza activity. However, the proteins targeted by bakuchiol remain unclear. Here, we investigated the chemical structures resp…
View article: A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction
A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction Open
Heart failure with reduced ejection fraction (HFrEF) is characterized not only by reduced left ventricular ejection fraction (EF) but is also combined with symptoms such as dyspnea, fatigue, and edema. Several pharmacological interventions…
View article: Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity
Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity Open
Conventional serum antibody titer, which expresses antibody level, does not provide antigen binding avidity of the variable region of the antibody, which is essential for the defense response to infection. Here, we quantified anti-SARS-CoV…
View article: Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers
Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers Open
Importance Egg introduction in infants at age 4 to 6 months is associated with a lower risk of immunoglobulin E–mediated egg allergy (EA). However, whether their risk of EA at age 12 months is affected by maternal intake of eggs at birth i…
View article: Anti-influenza Activity of Povidone-Iodine-Integrated Materials
Anti-influenza Activity of Povidone-Iodine-Integrated Materials Open
Personal protective equipment (PPE), including medical masks, should be worn for preventing the transmission of respiratory pathogens via infective droplets and aerosols. In medical masks, the key layer is the filter layer, and the melt-bl…
View article: The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy
The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy Open
To increase the prediction accuracy of positive oral food challenge (OFC) outcomes during stepwise slow oral immunotherapy (SS-OIT) in children with a hen’s egg (HE) allergy, we evaluated the predictive value of the combination of antigen-…
View article: The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy
The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy Open
To increase the prediction accuracy of positive oral food challenge (OFC) outcome during stepwise slow oral immunotherapy (SS-OIT) in children with hen’s egg (HE) allergy, we evaluated the predictive value of the combination of antig…
View article: The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge Test during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy
The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge Test during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy Open
To increase the prediction accuracy of positive oral food challenge (OFC) outcome during stepwise slow oral immunotherapy (SS-OIT) in children with hen’s egg (HE) allergy, we evaluated the predictive value of the combination of antigen-spe…
View article: The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy
The Combination of Binding-Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcome of Oral Food Challenge during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy Open
To increase the prediction accuracy of positive oral food challenge (OFC) outcome during stepwise slow oral immunotherapy (SS-OIT) in children with hen’s egg (HE) allergy, we evaluated the predictive value of the combination of antig…
View article: A Murine Model of Food Allergy by Epicutaneous Adjuvant-Free Allergen Sensitization Followed by Oral Allergen Challenge Combined with Aspirin for Enhanced Detection of Hypersensitivity Manifestations and Immunotherapy Monitoring
A Murine Model of Food Allergy by Epicutaneous Adjuvant-Free Allergen Sensitization Followed by Oral Allergen Challenge Combined with Aspirin for Enhanced Detection of Hypersensitivity Manifestations and Immunotherapy Monitoring Open
Food allergy is one of the major existing health problems, but no effective treatment is available. In the current work, a murine model that closely mimics pathogenesis of human food allergy and its quantifiable diagnostic parameter design…
View article: Anti-Influenza Virus-Specific Nasal Secretory IgA and Serum IgG Titers in a Japanese Adult Population and their Changes after Subcutaneous Vaccination
Anti-Influenza Virus-Specific Nasal Secretory IgA and Serum IgG Titers in a Japanese Adult Population and their Changes after Subcutaneous Vaccination Open
インフルエンザウイルスに対するヒトの粘膜免疫と全身免疫を検討した. 155名の健常成人を対象に, 鼻腔分泌液中のインフルエンザウイルス特異的 IgA 抗体と血液中のインフルエンザウイルス特異的 IgG 抗体の抗体価を測定したところ, 鼻腔の抗体保有率は約70%で, 血液中の抗体保有率はほぼ100%だった. インフルエンザワクチンが鼻腔および血液中の抗体価に及ぼす影響を調査するため, 初回の検体採取直後にワクチン接種し, その1カ月後に改めて検体採取して抗体価の変動を調査した…
View article: Neonatal antigen-specific IgE measured by a highly sensitive method and its relationship to food allergy during infancy
Neonatal antigen-specific IgE measured by a highly sensitive method and its relationship to food allergy during infancy Open
【背景】胎内感作の意義はいまだ明らかでない．【目的】新生児血中抗原特異的IgEを高感度測定法により測定し，乳児期の感作および食物アレルギー（FA）発症との関係を明らかにすること．【方法】125名の出生コホート研究を行った．新生児血中抗原特異的IgEを高性能蛋白チップにより測定し，6，12か月時に児のプリックテスト（SPT）を，0，1，6，12か月時に保護者へのアンケート調査を行った．【結果】125例の新生児血のうち，84％で何らかの抗原特異的IgEが検出され，約50％で卵白…
View article: A Double-Blind, Randomized, Placebo-Controlled Trial of Heat-Killed Pediococcus acidilactici K15 for Prevention of Respiratory Tract Infections among Preschool Children
A Double-Blind, Randomized, Placebo-Controlled Trial of Heat-Killed Pediococcus acidilactici K15 for Prevention of Respiratory Tract Infections among Preschool Children Open
Although some probiotic bacteria have been reported to prevent infections in children, there are few well-designed double-blind studies. Here we evaluated the effects of a probiotic strain of lactic acid bacteria (LAB), Pediococcus acidila…
View article: Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells
Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells Open
A class of glycoproteins such as carcinoembryonic antigen (CEA)/CEA-related cell adhesion molecule 1(CEACAM1), CD26 (DPPIV), and mac-2 binding protein (Mac-2BP) harbor tumor-associated glycans in colorectal cancer. In this study, we identi…
View article: Is Avidity Of Ovomucoid-specific IgE Predictable For Immediate Allergic Reaction To Egg In Children With Low Levels Of sIgE ?
Is Avidity Of Ovomucoid-specific IgE Predictable For Immediate Allergic Reaction To Egg In Children With Low Levels Of sIgE ? Open
View article: Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus–infected mice
Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 feeding enhances humoral immune responses, which are suppressed by the antiviral neuraminidase inhibitor oseltamivir in influenza A virus–infected mice Open
Antiviral neuraminidase inhibitors, such as oseltamivir, zanamivir, and peramivir, are widely used for treatment of influenza virus infection. We reported previously that oseltamivir inhibits the viral growth cycle, ameliorates symptoms, a…
View article: Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice
Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice Open
We reported previously that a synthetic mucosal adjuvant SF-10, which mimics human pulmonary surfactant, delivers antigen to mucosal dendritic cells in the nasal cavity and promotes induction of humoral and cellular immunity. The aim of th…
View article: Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)—protocol for a randomized controlled trial
Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)—protocol for a randomized controlled trial Open
This is a novel pragmatic RCT study to examine the efficacy of early aggressive treatment for atopic dermatitis to prevent later food allergy. If our hypothesis is correct, we hope that such a strategy might impact on disease prevention in…
View article: Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase <scp>II</scp> variant
Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase <span>II</span> variant Open
Aim In serious heatstroke, elevated body temperature (>40°C) is considered the main cause of illness. Mitochondrial carnitine palmitoyltransferase II ( CPT II ) plays an important role in adenosine triphosphate ( ATP ) generation from long…
View article: Correction to: IL-1b is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle
Correction to: IL-1b is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle Open
View article: Author Correction: Oral immunotherapy combined with omalizumab for high–risk cow’s milk allergy: a randomized controlled trial
Author Correction: Oral immunotherapy combined with omalizumab for high–risk cow’s milk allergy: a randomized controlled trial Open
View article: Prion protein protects mice from lethal infection with influenza A viruses
Prion protein protects mice from lethal infection with influenza A viruses Open
The cellular prion protein, designated PrPC, is a membrane glycoprotein expressed abundantly in brains and to a lesser extent in other tissues. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in p…
View article: Adjuvanting influenza hemagglutinin vaccine with a human pulmonary surfactant-mimicking synthetic compound SF-10 induces local and systemic cell-mediated immunity in mice
Adjuvanting influenza hemagglutinin vaccine with a human pulmonary surfactant-mimicking synthetic compound SF-10 induces local and systemic cell-mediated immunity in mice Open
We reported previously that intranasal instillation of a synthetic human pulmonary surfactant with a carboxy vinyl polymer as a viscosity improver, named SF-10, shows potent adjuvanticity for humoral immunity in mice and cynomolgus monkeys…
View article: Oral immunotherapy combined with omalizumab for high–risk cow’s milk allergy: a randomized controlled trial
Oral immunotherapy combined with omalizumab for high–risk cow’s milk allergy: a randomized controlled trial Open