Hiroshi Maruta
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View article: Rapamycin <i>vs</i> TORin-1 or Gleevec <i>vs</i> Nilotinib: Simple chemical evolution that converts PAK1-blockers to TOR-blockers or <i>vice versa</i>?
Rapamycin <i>vs</i> TORin-1 or Gleevec <i>vs</i> Nilotinib: Simple chemical evolution that converts PAK1-blockers to TOR-blockers or <i>vice versa</i>? Open
Both PAK1 (RAC/CDC42-activating kinase 1) and TOR (Target of Rapamycin) are among the major oncogenic/ageing kinases. However, they play the opposite role in our immune system, namely immune system is suppressed by PAK1, while it requires …
View article: Study on Effect of Paraffin on Combined Deterioration Resistance of Freeze-Thaw Damage and Salt Damage
Study on Effect of Paraffin on Combined Deterioration Resistance of Freeze-Thaw Damage and Salt Damage Open
本研究では,各種固形パラフィンのうち,石油由来のものが凍結融解抵抗性の向上に有効であることを確認できたことから,その水和反応に及ぼす影響を確認し,施工工程により空気量が減少したことを想定したコンクリートにおいて,凍結融解抵抗性および凍害と塩害の複合劣化抵抗性における固形パラフィンの効果を検討した。検討の結果,石油由来の固形パラフィンの混和は,セメントの水和反応に影響を及ぼさないこと,塩化物イオン供給環境下においても凍結融解による相対動弾性係数の低下は認められないことを確認し…
View article: WITHDRAWN: Lactobacillus and other probiotic bacteria: Their anti-melanogenicity and longevity promoting activities are closely linked through the major ‘pathogenic’ kinase PAK1
WITHDRAWN: Lactobacillus and other probiotic bacteria: Their anti-melanogenicity and longevity promoting activities are closely linked through the major ‘pathogenic’ kinase PAK1 Open
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our…
View article: Probiotic microbes: Are their anti-melanogenicity and longevity promoting activities closely linked through the major "pathogenic" kinase PAK1?
Probiotic microbes: Are their anti-melanogenicity and longevity promoting activities closely linked through the major "pathogenic" kinase PAK1? Open
PAK1-deficient mutant of C. elegans lives 60% longer than the wild-type. Interestingly, PAK1-deficient mutant of melanocytes produces less melanin (only a half compared with the wild-type) in the presence of either serum (PDGF) or α-MSH (a…
View article: 1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice
1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice Open
More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a highly cell-permeab…
View article: Breakthrough: PAK1-dependent expression of PD-L1 (programmed death ligand)
Breakthrough: PAK1-dependent expression of PD-L1 (programmed death ligand) Open
The "Nobel-winning" monoclonal antibodies against programmed death ligand (PD-L1) or its receptor (PD-1) have been used clinically for immuno (check point) therapy of cancers such as melanomas and lung cancers, but not Gemcitabine (GEM)-re…
View article: Should Empyema Space Be Surgically Closed?: A Case Report of Pleural Irrigation with Electrolyzed Saline for Postoperative Empyema
Should Empyema Space Be Surgically Closed?: A Case Report of Pleural Irrigation with Electrolyzed Saline for Postoperative Empyema Open
Acute empyema without bronchofistulae is now a well controllable disease by intrapleural irrigation with electrolyzed saline (ES), current ultimate disinfectant for biological tissues. ES irrigation was applied to postoperative empyema of …
View article: 1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of <i>C. elegans</i> by down-regulating PAK1 at nM levels
1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of <i>C. elegans</i> by down-regulating PAK1 at nM levels Open
PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene. 15K is a highly cell-permeable 1,2,3-triazolyl ester of ketorolac that down-…
View article: PAK1-Blockers (Natural and Synthetic) that Promote the Longevity and HeatEndurance
PAK1-Blockers (Natural and Synthetic) that Promote the Longevity and HeatEndurance Open
In the past several distinct "ageing" genes have been identified in small animals such as Caenorhabditis (C.) elegans, Drosophila and mouse.Among them are PI-3 kinase (Age), TOR (Target of Rapamycin), PAK1 (RAC/ CDC42-activated kinase 1) a…
View article: Natural or Synthetic Anti-Melanogenic Compounds That Block the PDGFR-EGFR-PAK1-MITF-Tyrosinase Signaling Pathway
Natural or Synthetic Anti-Melanogenic Compounds That Block the PDGFR-EGFR-PAK1-MITF-Tyrosinase Signaling Pathway Open
Ota's nevus is a congenital benign oculo-dermal melanocytosis as a macular hyperpigmentation on the face. The color of lesion is mostly blotchy gray to blue or blue. Ota's nevus can cause emotional and psychological distress because the fa…
View article: Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum Open
Xeroderma pigmentosum (XP) is a genetic disease in which DNA repair mechanisms are impaired. Cisplatin (CDDP) exerts cytotoxic effects by forming mainly intrastrand DNA cross-links, and sensitivity to CDDP depends on the DNA repair system.…
View article: Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis <i>in ovo</i> (fertilized eggs) <i>via</i> their common PAK1-survivin/VEGF signaling pathway
Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis <i>in ovo</i> (fertilized eggs) <i>via</i> their common PAK1-survivin/VEGF signaling pathway Open
15 K is 1,2, 3-triazolyl ester of ketorolac, an old pain-killer, that blocks PAK1 by its R-form and inhibits COX-2 by its S-form. Mainly due to a robust increase in cell-permeability, 15K is over 500 times more potent than ketorolac in bot…
View article: 1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability
1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability Open
Artepillin C (ARC) and caffeic acid (CA) are among the major anti-cancer ingredients of propolis, and block the oncogenic/melanogenic/ageing kinase PAK1. However, mainly due to their COOH moiety, cell-permeability of these herbal compounds…
View article: Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 <i>in vitro </i>
Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 <i>in vitro </i> Open
A sulfated saponin called "Frondoside A" (FRA) from sea cucumber and ingredients from Okinawa propolis (OP) have been previously shown to suppress the PAK1-dependent growth of A549 lung cancer as well as pancreatic cancer cells. However, t…
View article: The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay
The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay Open
We previously demonstrated that the oncogenic kinase PAK4, which both melanomas and normal melanocytes express at a very high level, is essential for their melanogenesis. In the present study, using the highly sensitive "Macaroni-Western" …