Hiroshi Saeki
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View article: Two distinct polymorphisms in the basic region of Meq protein of marek’s disease virus alter pathological progression and clinical manifestations
Two distinct polymorphisms in the basic region of Meq protein of marek’s disease virus alter pathological progression and clinical manifestations Open
Background Marek’s disease virus (MDV) causes Marek’s disease (MD) in chickens, which is characterized by malignant lymphomas and neurological disorders. Although MD is currently controlled using live vaccines, the virulence of field strai…
View article: Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria
Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria Open
The large intestine has a dense milieu of indigenous bacteria, generating a complex ecosystem with crosstalk between individual bacteria and host cells. In vitro host cell modeling and bacterial interactions at the anaerobic interphase hav…
View article: Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus
Amino Acid Polymorphisms in the Basic Region of Meq of Vaccine Strain CVI988 Drastically Diminish the Virulence of Marek’s Disease Virus Open
Marek’s disease virus (MDV) is the etiological agent of Marek’s disease (MD), a lymphoproliferative disorder in chickens. Polymorphisms in the MDV-encoded oncoprotein Meq are shared among field strains and correlate with their virulence. T…
View article: Colorectal cancer cell line-derived organoid model with stem cell properties captures the regrowing state of residual cancer cells after neoadjuvant chemotherapy
Colorectal cancer cell line-derived organoid model with stem cell properties captures the regrowing state of residual cancer cells after neoadjuvant chemotherapy Open
The effectiveness of colorectal cancer (CRC) therapy is limited owing to the absence of treatments targeting drug-tolerant residual cancer cells. Although neoadjuvant therapy is effective, pathological examination of residual tumors has re…
View article: Benefit of laparoscopic two-team transanal beyond total mesorectal excision for advanced and recurrent rectal cancer with invasion: a retrospective study compared with conventional laparoscopic approach
Benefit of laparoscopic two-team transanal beyond total mesorectal excision for advanced and recurrent rectal cancer with invasion: a retrospective study compared with conventional laparoscopic approach Open
Laparoscopic two-team transanal approach offers better short-term outcomes than the conventional approach in highly selected patients.
View article: Programmed Cell Death-1 Expression in T-Cell Subsets in Chickens Infected with Marek’s Disease Virus
Programmed Cell Death-1 Expression in T-Cell Subsets in Chickens Infected with Marek’s Disease Virus Open
Marek’s disease virus (MDV) causes Marek’s disease (MD) in chickens, characterized by malignant lymphomas and immunosuppression. Sporadic MD outbreaks continue to occur even among vaccinated flocks in certain regions due to the increased v…
View article: Comprehensive genetic analysis of poorly differentiated gastric cancer in young females
Comprehensive genetic analysis of poorly differentiated gastric cancer in young females Open
Aim The reasons behind the high prevalence of poorly differentiated gastric cancer in young females remain unclear. Therefore, this study aimed to conduct a comprehensive genetic analysis to investigate the factors responsible for the high…
View article: A case of gastric glomus tumor with metachronous liver metastasis after laparoscopic partial gastrectomy
A case of gastric glomus tumor with metachronous liver metastasis after laparoscopic partial gastrectomy Open
View article: Salvage esophagectomy for unresectable locally advanced esophageal squamous cell carcinoma: Significant or not?
Salvage esophagectomy for unresectable locally advanced esophageal squamous cell carcinoma: Significant or not? Open
We reviewed the current status and perspectives on salvage esophagectomy for initially unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in the era of minimally invasive surgery and immunotherapy. Although the standar…
View article: Robotic Esophageal Cancer Surgery for Both Cure and Safety
Robotic Esophageal Cancer Surgery for Both Cure and Safety Open
View article: T-cell invigoration to cell-free DNA ratio associated with anti-PD-1 response in gastric or gastro-esophageal junction adenocarcinoma: VOYAGER trial
T-cell invigoration to cell-free DNA ratio associated with anti-PD-1 response in gastric or gastro-esophageal junction adenocarcinoma: VOYAGER trial Open
Background: Previous melanoma research suggests that host immune status and tumor burden impact anti-programmed cell death protein 1 (PD-1) therapy efficacy, favoring patients with low tumor burden and minimal T-cell exhaustion. Patients a…
View article: Evaluation of preoperative visceral fat area / psoas muscle area ratio and prognosis in patients with colorectal cancer
Evaluation of preoperative visceral fat area / psoas muscle area ratio and prognosis in patients with colorectal cancer Open
Background Recent research has focused on the prognostic relevance of preoperative sarcopenia and sarcopenic obesity in various cancers. In this study we investigated the relationship between visceral fat area (VFA), psoas muscle area (PMA…
View article: 「如何に教育的な査読によりいい論文を作り出すか？」を企画して
「如何に教育的な査読によりいい論文を作り出すか？」を企画して Open
View article: Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteria
Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteria Open
The large intestine has a dense milieu of indigenous bacteria, generating a complex ecosystem with crosstalk between individual bacteria and host cells. In vitro host cell modeling and bacterial interactions at the anaerobic interphase hav…
View article: Reply to: "Predictive Role of Age-Adjusted Charlson Comorbidity Index for Long-Term Survival in Surgical Esophageal Cancer Patients," by Yuan, Yong et al.
Reply to: "Predictive Role of Age-Adjusted Charlson Comorbidity Index for Long-Term Survival in Surgical Esophageal Cancer Patients," by Yuan, Yong et al. Open
View article: Squamous cell carcinoma of the anus successfully treated with multidisciplinary therapy for metachronous metastatic and local recurrences after DCF chemotherapy: a case report
Squamous cell carcinoma of the anus successfully treated with multidisciplinary therapy for metachronous metastatic and local recurrences after DCF chemotherapy: a case report Open
View article: Impact of the endoscopic surgical skill qualification system on conversion to laparotomy after low anterior resection for rectal cancer in Japan (a secondary analysis of the EnSSURE study)
Impact of the endoscopic surgical skill qualification system on conversion to laparotomy after low anterior resection for rectal cancer in Japan (a secondary analysis of the EnSSURE study) Open
View article: Retrograde drainage for duodenal stump leakage using ileal decompression tube guided by double-balloon endoscopy: a novel case report
Retrograde drainage for duodenal stump leakage using ileal decompression tube guided by double-balloon endoscopy: a novel case report Open
View article: HLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis
HLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis Open
Human leukocyte antigen class I (HLA-I) is considered a genetic pathogen for ulcerative colitis (UC). This study aimed to investigate the significance of DNA damage and HLA-I expression in infiltrating immune cells and immune checkpoint pr…
View article: Significance of Lipopolysaccharides in Gastric Cancer and Their Potential as a Biomarker for Nivolumab Sensitivity
Significance of Lipopolysaccharides in Gastric Cancer and Their Potential as a Biomarker for Nivolumab Sensitivity Open
Lipopolysaccharides are a type of polysaccharide mainly present in the bacterial outer membrane of Gram-negative bacteria. Recent studies have revealed that lipopolysaccharides contribute to the immune response of the host by functioning a…
View article: Phase II clinical trial to study the safety and efficacy of combined S-1 + oxaliplatin therapy as neoadjuvant chemotherapy for locally advanced gastric cancer in older patients
Phase II clinical trial to study the safety and efficacy of combined S-1 + oxaliplatin therapy as neoadjuvant chemotherapy for locally advanced gastric cancer in older patients Open
Background Gastrectomy with D2 dissection and adjuvant chemotherapy is the standard treatment for locally advanced gastric cancer (LAGC) in Asia. However, administering chemotherapy with sufficient intensity after gastrectomy is challengin…
View article: Significance of Lipopolysaccharides in Gastric Cancer and their Potential as a Biomarker for Nivolumab Sensitivity
Significance of Lipopolysaccharides in Gastric Cancer and their Potential as a Biomarker for Nivolumab Sensitivity Open
Lipopolysaccharides are a type of polysaccharide mainly present in the bacterial outer membrane of Gram-negative bacteria. Recent studies have revealed that lipopolysaccharides contribute to the immune response of the host by functioning a…
View article: Pathophysiologic Contributions of Visceral Adiposity to Left Ventricular Diastolic Dysfunction
Pathophysiologic Contributions of Visceral Adiposity to Left Ventricular Diastolic Dysfunction Open
Background: Visceral fat produces inflammatory cytokines and may play a major role in heart failure with preserved ejection fraction (HFpEF). However, little data exist regarding how qualitative and quantitative abnormalities of visceral f…
View article: Sigmoid colon schwannoma difficult to distinguish from peritoneal dissemination 13 years after pancreatic neuroendocrine tumor surgery
Sigmoid colon schwannoma difficult to distinguish from peritoneal dissemination 13 years after pancreatic neuroendocrine tumor surgery Open
Background Schwannoma, which clinicians sometimes struggle to diagnose, is a tumor arising from Schwann cells of peripheral nerves, often in the soft tissues and rarely in the gastrointestinal tract. Pancreatic neuroendocrine tumor (PNET) …
View article: Phase II Clinical Trial to Study the Safety and Efficacy of Combined S-1 + Oxaliplatin Therapy as Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer in Older Patients
Phase II Clinical Trial to Study the Safety and Efficacy of Combined S-1 + Oxaliplatin Therapy as Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer in Older Patients Open
Background : Gastrectomy with D2 dissection and adjuvant chemotherapy is the standard treatment for locally advanced gastric cancer (LAGC) in Asia. However, administering chemotherapy with sufficient intensity after gastrectomy is challeng…
View article: Surgical techniques and stoma-related complications associated with emergency stoma creation
Surgical techniques and stoma-related complications associated with emergency stoma creation Open
Background Determination of risk factors for stoma-related complications associated with emergency stoma creation may impact reducing complications and improving the quality of life of ostomy patients; however, there are few reports on sto…
View article: Data from Trifluridine Induces p53-Dependent Sustained G<sub>2</sub> Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks
Data from Trifluridine Induces p53-Dependent Sustained G<sub>2</sub> Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks Open
Trifluridine (FTD) is a key component of the novel oral antitumor drug TAS-102, which consists of FTD and a thymidine phosphorylase inhibitor. Like 5-fluoro-2′-deoxyuridine (FdUrd), a deoxynucleoside form of 5-fluorouracil metabolite, FTD …
View article: Data from The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis
Data from The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis Open
Platinum-based chemotherapeutic drugs are widely used as components of combination chemotherapy in the treatment of cancer. One such drug, oxaliplatin, exerts a synergistic effect against advanced colorectal cancer in combination with 5-fl…
View article: Association of High LAT1 Expression with Poor Prognosis and Recurrence in Colorectal Cancer Patients Treated with Oxaliplatin-Based Adjuvant Chemotherapy
Association of High LAT1 Expression with Poor Prognosis and Recurrence in Colorectal Cancer Patients Treated with Oxaliplatin-Based Adjuvant Chemotherapy Open
The mammalian target of rapamycin (mTOR) is often activated in several cancers. We focused on two mTOR regulatory mechanisms: oxaliplatin-induced mTOR signaling and L-type amino acid transporter 1 (LAT1)-induced mTOR activation. High LAT1 …
View article: Gangrenous ischemic colitis localized to the cecum: a case report
Gangrenous ischemic colitis localized to the cecum: a case report Open
Background Ischemic colitis affects the left colon in elderly individuals and localization on the right side, especially in the cecum, is rare. We report a case of gangrenous ischemic colitis localized in the cecum of a patient undergoing …