Hiroshi Shimada
YOU?
Author Swipe
View article: Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction
Normalization of trophoblast mTOR signaling rescues impaired function in primary human trophoblast cells isolated from pregnancies complicated by fetal growth restriction Open
Fetal growth restriction (FGR) is associated with inhibition of placental mTOR signaling and amino acid transport. mTOR is a positive regulator of amino acid transport mediated by controlling the plasma membrane trafficking of SNAT2, a Sys…
View article: Machine Learning-Based Clustering Using a 12-Lead Electrocardiogram in Patients With a Implantable Cardioverter Defibrillator to Identify Future Ventricular Arrhythmia
Machine Learning-Based Clustering Using a 12-Lead Electrocardiogram in Patients With a Implantable Cardioverter Defibrillator to Identify Future Ventricular Arrhythmia Open
We highlight the potential of ML-based clustering using 12-lead ECGs to help in the risk stratification of ventricular arrhythmia. Future research in a larger multicenter setting may provide further insights and refine ICD indications.
View article: The roles of tight junction protein cingulin in human endometrioid endometrial cancer
The roles of tight junction protein cingulin in human endometrioid endometrial cancer Open
The bicellular tight junction molecule cingulin (CGN) binds to microtubules in centrosomes. Furthermore, CGN contributes to the tricellular tight junction (tTJ) proteins lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin (TRIC…
View article: The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line
The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line Open
It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhi…
View article: Risk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning
Risk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning Open
We aimed to develop machine learning-based predictive models for identifying inappropriate implantable cardioverter-defibrillator (ICD) therapy. Our study included 182 consecutive cases (average age 62.2 ± 4.5 years, 169 men) and employed …
View article: Clustering by artificial intelligence for multi-vessel coronary artery disease on electrocardiography gated single photon emission computed tomography
Clustering by artificial intelligence for multi-vessel coronary artery disease on electrocardiography gated single photon emission computed tomography Open
Backgrounds Diagnosis of multi-vessel coronary artery disease (MVD) on single photon emission computed tomography (SPECT) is recognized to be difficult. We tried to classify patients who were suspected coronary artery stenosis by artificia…
View article: Diagnostic performance of machine learning on 12-lead electrocardiogram for predicting multi-vessel coronary vasospastic angina
Diagnostic performance of machine learning on 12-lead electrocardiogram for predicting multi-vessel coronary vasospastic angina Open
Background Multi-vessel coronary vasospastic angina (multi-VSA) is life-threatening disease. However, 12-leads electrocardiogram (ECG) in no chest symptom period was considered to have no predictive value for the multi-VSA. We tried to pre…
View article: Risk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning
Risk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning Open
Background Inappropriate shock from implantable cardioverter-defibrillators (ICDs) undermines quality of life and increases all-cause mortality risk. Various predictors of inappropriate ICD shock have also been indicated in previous studie…
View article: Data from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
Data from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process Open
Purpose: A positive response to gefitinib in non–small cell lung cancer (NSCLC) has been correlated to mutations in epidermal growth factor receptor (EGFR) gene. Previous reports have been based mainly on diagnostic screening by seq…
View article: Supplementary Figures S1-S2 from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
Supplementary Figures S1-S2 from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process Open
Supplementary Figures S1-S2 from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
View article: Data from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
Data from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process Open
Purpose: A positive response to gefitinib in non–small cell lung cancer (NSCLC) has been correlated to mutations in epidermal growth factor receptor (EGFR) gene. Previous reports have been based mainly on diagnostic screening by seq…
View article: Supplementary Figures S1-S2 from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
Supplementary Figures S1-S2 from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process Open
Supplementary Figures S1-S2 from Rapid Detection of Epidermal Growth Factor Receptor Mutations in Lung Cancer by the SMart-Amplification Process
View article: LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer
LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer Open
Lipolysis-stimulated lipoprotein receptor (LSR), a lipid metabolism-related factor localized in tricellular tight junctions (tTJs), plays an important role in maintaining the epithelial barrier. LSR is highly expressed in well-differentiat…
View article: A case of inappropriate pacing due to intermittent His bundle capture and the post–atrial pacing ventricular blanking period of managed ventricular pacing
A case of inappropriate pacing due to intermittent His bundle capture and the post–atrial pacing ventricular blanking period of managed ventricular pacing Open
View article: Role of the Intramural Vascular Network of the Extrahepatic Bile Duct for the Blood Circulation in the Recipient Extrahepatic Bile Duct Used for Duct-to-Duct-Biliary-Anastomosis in Living Donor Liver Transplantation
Role of the Intramural Vascular Network of the Extrahepatic Bile Duct for the Blood Circulation in the Recipient Extrahepatic Bile Duct Used for Duct-to-Duct-Biliary-Anastomosis in Living Donor Liver Transplantation Open
Graphical Abstract
View article: The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma
The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma Open
Tight junction proteins play roles beyond permeability barriers functions and control cell proliferation and differentiation. The relation between tight junctions and the signal transduction pathways affects cell growth, invasion and migra…
View article: Analysis of the diagnostic capabilities of urinary neutrophil gelatinase‐associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission
Analysis of the diagnostic capabilities of urinary neutrophil gelatinase‐associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission Open
Background Acute kidney injury (AKI) is a disease that negatively affects patient prognosis and requires early diagnosis and treatment. Biomarkers that predict AKI are needed for early diagnosis of this disease. Methods We compared the AKI…
View article: The comparison of the chronic-phase vascular healing between bioabsorbable and durable polymer drug eluting stent by using optical coherence tomography
The comparison of the chronic-phase vascular healing between bioabsorbable and durable polymer drug eluting stent by using optical coherence tomography Open
Background Bioabsorbable polymer drug eluting stents (BP-DESs) were designed to reduce a vascular inflammatory reaction compared to durable polymer drug eluting stents (DP-DESs). However, few studies have compared vascular responses to BP-…
View article: Prediction for cardiac prognosis in patients with congestive heart failure by machine learning on dual-isotope myocardial semiconductor SPECT
Prediction for cardiac prognosis in patients with congestive heart failure by machine learning on dual-isotope myocardial semiconductor SPECT Open
Background Dual-isotope (low doze 201TlCl and 123I-β-methyl-P-iodophenyl-pentadecanoic acid (BMIPP)) single photon emission computed tomography (SPECT) is utilized to estimate myocardial damage in patients with congestive heart failure (CH…
View article: Optical coherence tomography and coronary angioscopy assessment of healed vulnerable plaque components in patients with coronary artery lesions undergoing elective percutaneous coronary intervention
Optical coherence tomography and coronary angioscopy assessment of healed vulnerable plaque components in patients with coronary artery lesions undergoing elective percutaneous coronary intervention Open
Background Many vulnerable plaques would progress without clinical events and might result in healed plaques (HPs). Histopathological or intracoronary image assessment of HPs has been reported. However, the morphological characteristics of…
View article: Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1
Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1 Open
Angulin-1/LSR is a tricellular tight junction molecule, that plays an important role in maintaining the epithelial and endothelial barriers. The actin cytoskeleton at tricellular contacts also contributes to the maintenance of the epitheli…
View article: Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells
Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells Open
Epithelial integrity and barrier function are maintained during cytokinesis in vertebrate epithelial tissues. The changes in localization and the roles of tricellular tight junction molecule lipolysis-stimulated lipoprotein receptor (LSR) …
View article: P4727T-wave amplitude in aVR for left ventricular dyssynchrony in patients with complete left bundle branch block
P4727T-wave amplitude in aVR for left ventricular dyssynchrony in patients with complete left bundle branch block Open
Chronic heart failure -Diagnostic methods 985 over LV EF<30% (c2 = 13.7;p=0.05) and demographic and clinical parameters (c2 = 11.9) at incremental stepwise Cox analysis.Conclusions: In patients with chronic HFrEF, the results of this study…
View article: P2760Prognostic value of left ventricular contractile entropy for the presence of chronic total occlusion in coronary artery disease
P2760Prognostic value of left ventricular contractile entropy for the presence of chronic total occlusion in coronary artery disease Open
View article: A case of scar-related ventricular tachycardia demonstrating termination with nonglobal capture at the site of concealed entrainment with dual slow conduction pathways
A case of scar-related ventricular tachycardia demonstrating termination with nonglobal capture at the site of concealed entrainment with dual slow conduction pathways Open
Critical isthmus sites of the ventricular tachycardia (VT) circuit are recognized by entrainment with concealed fusion and a postpacing interval that approximates the cycle length. The stimulus-QRS (S-QRS) interval indicates the conduction…
View article: Immunohistochemical Comparison of Malignancy Between Radial Invasion and Mucosal Extension in Hilar Cholangiocarcinoma
Immunohistochemical Comparison of Malignancy Between Radial Invasion and Mucosal Extension in Hilar Cholangiocarcinoma Open
Removal of as many RI cells as possible should be a priority in resection of HCCA, followed by removal of ME cells. E-Cadherin appears to be associated with recurrence of HCCA.
View article: Downregulation of lipolysis‑stimulated lipoprotein receptor promotes cell invasion via claudin‑1‑mediated matrix metalloproteinases in human endometrial cancer
Downregulation of lipolysis‑stimulated lipoprotein receptor promotes cell invasion via claudin‑1‑mediated matrix metalloproteinases in human endometrial cancer Open
Lipolysis-stimulated lipoprotein receptor (LSR) is a novel molecule present at tricellular contacts which recruits tricellulin (TRIC), a molecular component of tricellular tight junctions (tTJs). LSR and TRIC are colocalized with the bicel…
View article: P1458Prognostic value of T wave axis deviation for left ventricular dysfunction in patients with complete left bundle branch block
P1458Prognostic value of T wave axis deviation for left ventricular dysfunction in patients with complete left bundle branch block Open
Purpose: To describe the differences between sub-acute and late onset cardiotoxicity in regard to LVEF recovery as well as all-cause mortality.Methods: Our analysis comprised of 91oncologic patients diagnosed between 1998 and 2016 as cardi…
View article: P881Diagnostic performance of T-axis deviation on 12-leads electrocardiography for myocardial ischemia: Analysis by semiconductor SPECT
P881Diagnostic performance of T-axis deviation on 12-leads electrocardiography for myocardial ischemia: Analysis by semiconductor SPECT Open
View article: Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer
Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer Open
Lipolysis-stimulated lipoprotein receptor (LSR) is a unique molecule of tricellular contacts of normal and cancer cells. We investigated how the loss of LSR induced cell migration, invasion and proliferation in endometrial cancer cell line…