Hirotaka Imai
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View article: Lipid Peroxidation Induced Novel Cell Death (Ferroptosis and Lipoxytosis)
Lipid Peroxidation Induced Novel Cell Death (Ferroptosis and Lipoxytosis) Open
View article: Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration
Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration Open
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse mode…
View article: Oxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis
Oxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis Open
Ferroptosis is a type of nonapoptotic cell death that is characteristically caused by phospholipid peroxidation promoted by radical reactions involving iron. Researchers have identified many of the protein factors that are encoded by genes…
View article: Retinal Pigment Epithelium-Specific Ablation of GPx4 in Adult Mice Recapitulates Key Features of Geographic Atrophy in Age-Related Macular Degeneration
Retinal Pigment Epithelium-Specific Ablation of GPx4 in Adult Mice Recapitulates Key Features of Geographic Atrophy in Age-Related Macular Degeneration Open
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse mode…
View article: Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A
Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A Open
Background Ferroptosis, an iron‐dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition‐driven necrosis, which is inhibited by cyc…
View article: Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation
Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation Open
Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme that reduces phospholipid hydroperoxide. Studies have reported that the loss of GPx4 activity through anticancer drugs leads to ferroptosis, an iron-dependent lipid peroxidation-indu…
View article: Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity Open
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View article: New Discoveries from the Search for Food Components Targeting the Treatment of Mouse Models of Lipid Oxidation-Dependent Heart Failure
New Discoveries from the Search for Food Components Targeting the Treatment of Mouse Models of Lipid Oxidation-Dependent Heart Failure Open
GPx4 is an enzyme that reduces oxidized phospholipids in a glutathione-dependent manner. GPx4 is also a regulator of lipid oxidation-dependent cell death ferroptosis (iron-dependent) and lipoxytosis (iron-independent), which have recently …
View article: Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis Open
Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-induced cardiomyopathy (DIC). Mitochondria-dependent ferroptosis, which is triggered by iron overload and excessive lipid peroxidation, plays a …
View article: Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury Open
View article: Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice
Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice Open
View article: Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity Open
Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis. However, t…
View article: Inhibition of lipid peroxidation during the reproductive period extends the lifespan of <i>Caenorhabditis elegans</i>
Inhibition of lipid peroxidation during the reproductive period extends the lifespan of <i>Caenorhabditis elegans</i> Open
Glutathione peroxidase 4 (GPx4) is a unique antioxidant enzyme that directly reduces the phospholipid hydroperoxides (PLOOH) generated in biomembranes using glutathione as the reductant. We have previously reported that the Caenorhabdit…
View article: Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease
Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease Open
Currently approved therapies for age-related macular degeneration (AMD) are inhibitors against vascular endothelial growth factor (VEGF), which is a major contributor to the pathogenesis of neovascular AMD (nAMD). Intravitreal injections o…
View article: Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis Open
View article: Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis
Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis Open
Nonalcoholic steatohepatitis (NASH) is a metabolic liver disease that progresses from simple steatosis to the disease state of inflammation and fibrosis. Previous studies suggest that apoptosis and necroptosis may contribute to the pathoge…
View article: High‐level expression of STING restricts susceptibility to HBV by mediating type III IFN induction
High‐level expression of STING restricts susceptibility to HBV by mediating type III IFN induction Open
Hepatitis B virus (HBV) is a hepatotropic DNA virus causing hepatic diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. To study HBV, human hepatoma HepG2 cells are currently used as an HBV infectious cell cu…
View article: Secreted <scp>d</scp>‐aspartate oxidase functions in <i>C. elegans</i> reproduction and development
Secreted <span>d</span>‐aspartate oxidase functions in <i>C. elegans</i> reproduction and development Open
d ‐Aspartate oxidase ( DDO ) is a degradative enzyme that acts stereospecifically on free acidic D‐amino acids such as d ‐aspartate and d ‐glutamate. d ‐Aspartate plays an important role in regulating neurotransmission, developmental proce…
View article: High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction
High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction Open
Hepatitis B virus (HBV) is a hepatotropic DNA virus causing hepatic diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. To study HBV, human hepatoma HepG2 cells are currently used as an HBV infectious cell cu…
View article: Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010
Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010 Open
Influenza viruses exist in each host as a collection of genetically diverse variants, which might enhance their adaptive potential. To assess the genetic and functional diversity of highly pathogenic avian influenza A(H5N1) viruses within …
View article: <scp>ULBP</scp>1 is induced by hepatitis C virus infection and is the target of the <scp>NK</scp> cell‐mediated innate immune response in human hepatocytes
<span>ULBP</span>1 is induced by hepatitis C virus infection and is the target of the <span>NK</span> cell‐mediated innate immune response in human hepatocytes Open
Natural killer ( NK ) cells through their NK group 2 member D ( NKG 2D) receptors recognize NKG 2D ligands such as UL 16‐binding proteins ( ULBP s) on virus‐infected cells and subsequently trigger the host innate immune response. In the pr…
View article: Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging
Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging Open
View article: Hydrogen peroxide produced by superoxide dismutase SOD-2 activates sperm in Caenorhabditis elegans
Hydrogen peroxide produced by superoxide dismutase SOD-2 activates sperm in Caenorhabditis elegans Open
Superoxide dismutase (SOD) is a ubiquitous antioxidant enzyme that catalytically converts the superoxide radical to hydrogen peroxide (H2O2). In mammals, high SOD activity is detectable in sperm and seminal plasma, an…
View article: Memory CTLs in the lung vasculature, parenchyma and airways following IN vaccination with ADJ-OVA.
Memory CTLs in the lung vasculature, parenchyma and airways following IN vaccination with ADJ-OVA. Open
Thy1.1+ve naïve OT-I TCR transgenic CD8 T cells were adoptively transferred into C57BL/6 mice. Twenty-four hours after cell transfer, mice were vaccinated with ADJ-OVA by the SQ or IN routes. Three weeks after the first vaccinat…
View article: Intranasal Adjuplex Administration Rapidly Alters Inflammatory Cell Populations in Bronchoalveoloar Lavage Fluid and Lung Tissue.
Intranasal Adjuplex Administration Rapidly Alters Inflammatory Cell Populations in Bronchoalveoloar Lavage Fluid and Lung Tissue. Open
Mice were vaccinated by IN inoculation of 50 μl PBS with and without 10% ADJ, and the bronchoalveolar lavage (BAL) fluid and lung were collected 24 hours later and analyzed by flow cytometry. Absolute cell counts in BAL and lung were not s…
View article: Effect of Vaccination Route and the Dose of Adjuplex and OVA on the Magnitude of CD8 T-cell Responses.
Effect of Vaccination Route and the Dose of Adjuplex and OVA on the Magnitude of CD8 T-cell Responses. Open
(A) Intramuscular and subcutaneous vaccination with increasing doses of Adjuplex generate comparable primary CTL responses. WT C57BL/6 mice were vaccinated by intramuscular or subcutaneous injection of 10 μg ovalbumin in PBS alone o…
View article: Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines
Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines Open
CD8+ cytotoxic T lymphocytes (CTLs) are critical for clearing many viral infections, and protective CTL memory can be induced by vaccination with attenuated viruses and vectors. Non-replicating vaccines are typically potentiated by the add…
View article: Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition
Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition Open
Oxidative stress is implicated in the pathologies of vascular endothelial cells. However, the importance of specific antioxidant enzymes in vascular endothelial cells is not fully understood. The purpose of this study was to elucidate the …
View article: Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells
Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells Open
Oxidative stress is involved in the pathologies of corneal epithelial cells. However, the importance of specific antioxidant enzymes in corneal epithelial cells is not fully understood. The purpose of this study is to elucidate the role of…
View article: Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia
Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia Open
Histopathology and IMS can provide comprehensive and complementary information on cell death mechanisms in the hippocampal CA1 after global ischemia. IMS provided novel data on molecular changes in phospholipids immediately after TGI. Incr…