Hiroyuki Ida
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View article: DOTA chelation through click chemistry enables favorable biodistribution of <sup>89</sup>Zr-radiolabeled antibodies: A comparison with DFO chelation
DOTA chelation through click chemistry enables favorable biodistribution of <sup>89</sup>Zr-radiolabeled antibodies: A comparison with DFO chelation Open
Currently, the DFO chelator is commonly used to conjugate monoclonal antibodies (mAbs) and 89 Zr, whereas the DOTA chelator is commonly used to conjugate mAbs and alpha- and beta-emitting metal radionuclides. However, if the degradation of…
View article: Re-Evaluations of Zr-DFO Complex Coordination Chemistry for the Estimation of Radiochemical Yields and Chelator-to-Antibody Ratios of 89Zr Immune-PET Tracers
Re-Evaluations of Zr-DFO Complex Coordination Chemistry for the Estimation of Radiochemical Yields and Chelator-to-Antibody Ratios of 89Zr Immune-PET Tracers Open
(1) Background: Deferoxamine B (DFO) is the most widely used chelator for labeling of zirconium-89 (89Zr) to monoclonal antibody (mAb). Despite the remarkable developments of the clinical 89Zr-immuno-PET, chemical species and stability con…
View article: Radiolabeling of PSMA-617 with <sup>89</sup>Zr: A Novel Use of DMSO for Radiochemical Yield Enhancement and Preliminary Small-Animal PET Results
Radiolabeling of PSMA-617 with <sup>89</sup>Zr: A Novel Use of DMSO for Radiochemical Yield Enhancement and Preliminary Small-Animal PET Results Open
Introduction Prostate-specific membrane antigen (PSMA)-targeted ligands, including PSMA-617, have been developed for theranostics of prostate cancer. 68 Ga-PSMA-617 is the de facto standard of PSMA Positron Emission Tomography (PET) for im…
View article: White Photoluminescence Properties of Carbon-Containing Porous Silica Synthesized from Denatured Collagen / Silica Composite
White Photoluminescence Properties of Carbon-Containing Porous Silica Synthesized from Denatured Collagen / Silica Composite Open
Recently, carbon-containing silica has attracted much attention due to its white photoluminescence property under UV light irradiation at room temperature. We have previously reported that microporous silica was successfully synthesized by…
View article: Synthesis of Porous Silica by Using Denatured Collagen as a Template
Synthesis of Porous Silica by Using Denatured Collagen as a Template Open
Porous silica was synthesized by using denatured collagen as a template. The shape, pore characteristics and synthesis mechanism for porous silica synthesized by using denatured collagen (DC-PS) was compared with that synthesized by using …