Hiroyuki Asama
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View article: Effectiveness of Gel‐immersion Endoscopic Injection Sclerotherapy Under Texture and Color Enhancement Imaging for Esophageal Varices: A Comparison of Variceal Visibility Under Gel With White Light Imaging
Effectiveness of Gel‐immersion Endoscopic Injection Sclerotherapy Under Texture and Color Enhancement Imaging for Esophageal Varices: A Comparison of Variceal Visibility Under Gel With White Light Imaging Open
Objective Gel‐immersion endoscopic injection sclerotherapy (GI‐EIS) addresses the technical challenges in intravariceal injection for esophageal varices (EVs). However, gel accumulation may obscure the variceal morphology. Thus, we develop…
View article: Factors Associated with the Detection of Actionable Genomic Alterations Using Liquid Biopsy in Biliary Tract Cancer
Factors Associated with the Detection of Actionable Genomic Alterations Using Liquid Biopsy in Biliary Tract Cancer Open
Background: Blood-based comprehensive genomic profiling (CGP), a form of liquid biopsy, is often used for biliary tract cancer (BTC) when tissue-based CGP (tissue CGP) is unavailable, despite lower detection rates. This study explored fact…
View article: Combination chemotherapy for older patients with unresectable biliary tract cancer: a prospective observational study using propensity-score matched analysis (JON2104-B)
Combination chemotherapy for older patients with unresectable biliary tract cancer: a prospective observational study using propensity-score matched analysis (JON2104-B) Open
Background Systemic chemotherapy with gemcitabine plus S-1 (GEM + S-1), GEM + CDDP plus S-1 (GEM + CDDP + S-1), or gemcitabine plus cisplatin (GEM + CDDP) is standard treatment for advanced biliary tract cancer (aBTC). We aimed to evaluate…
View article: A Systemic Review and Meta-analysis of the Incidence Rate of Interstitial Lung Disease in Patients with Unresectable Pancreatic Cancer Treated with Gemcitabine and Nab-paclitaxel Combination Therapy in the Japanese Population
A Systemic Review and Meta-analysis of the Incidence Rate of Interstitial Lung Disease in Patients with Unresectable Pancreatic Cancer Treated with Gemcitabine and Nab-paclitaxel Combination Therapy in the Japanese Population Open
Objective Drug-induced interstitial lung disease (DI-ILD) is an adverse effect of the combination of gemcitabine and nab-paclitaxel (GnP) treatment that has raised concerns because the incidence rate of DI-ILD in the real world is higher t…
View article: Selection methods for endoscopic ultrasound‑guided biliary drainage cases that are appropriate for beginners
Selection methods for endoscopic ultrasound‑guided biliary drainage cases that are appropriate for beginners Open
Endoscopic ultrasound-guided biliary drainage (EUS-BD) is performed as a second drainage method when endoscopic retrograde cholangiopancreatography-guided biliary drainage fails. There are several severe adverse events in EUS-BD, and avoid…
View article: A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model Open
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to estab…
View article: Impact of COVID-19 pandemic on unresectable pancreatic cancer: a regional cohort study in Japan
Impact of COVID-19 pandemic on unresectable pancreatic cancer: a regional cohort study in Japan Open
We did not observe a negative impact on the prognosis of patients with unresectable PDAC throughout the COVID-19 pandemic.
View article: Single pancreatic and multiple hepatic metastases developing 6 years after left hemicolectomy for colon cancer: A case report
Single pancreatic and multiple hepatic metastases developing 6 years after left hemicolectomy for colon cancer: A case report Open
A 50-year-old woman presented with a pancreatic tumor and multiple hepatic tumors identified via computed tomography (CT). The patient had undergone surgical resection for colon cancer 6 years earlier, followed by resection of a metastatic…
View article: Development of a prediction system for KRAS mutation detection via circulating tumour DNA analysis among patients with unresectable pancreatic cancer
Development of a prediction system for KRAS mutation detection via circulating tumour DNA analysis among patients with unresectable pancreatic cancer Open
Background Pancreatic cancer (PC) is an aggressive malignancy with a poor prognosis and limited treatment options. Advances in molecular profiling and liquid biopsy, specifically the detection of circulating tumour DNA (ctDNA), offer new a…
View article: A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model Open
Background Post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establ…
View article: A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model Open
Background Post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establ…
View article: A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model Open
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to estab…
View article: A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model Open
Background Post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establ…
View article: Visibility of esophageal squamous cell carcinoma under iodine staining on texture and color enhancement imaging
Visibility of esophageal squamous cell carcinoma under iodine staining on texture and color enhancement imaging Open
Objective Iodine staining on white light imaging (WLI) is the gold standard for detecting and demarcating esophageal squamous cell carcinoma (ESCC). We examined the effects of texture and color enhancement imaging (TXI) on improving the en…
View article: Clinical benefit of subsequent chemotherapy after drug-induced interstitial lung disease in pancreatic cancer patients: a multicenter retrospective study from Japan
Clinical benefit of subsequent chemotherapy after drug-induced interstitial lung disease in pancreatic cancer patients: a multicenter retrospective study from Japan Open
Purpose Drug-induced interstitial lung disease (ILD) is not a rare adverse event in the current chemotherapy strategy for pancreatic ductal adenocarcinoma (PDAC). Thus, we aimed to find the optimal management for PDAC patients with a histo…
View article: Comparison of time to recurrent biliary obstruction between plastic stents and metallic stents for endoscopic ultrasound‑guided biliary drainage
Comparison of time to recurrent biliary obstruction between plastic stents and metallic stents for endoscopic ultrasound‑guided biliary drainage Open
Endoscopic ultrasound-guided biliary drainage (EUS-BD) may prevent stent placement at the bile duct stricture. Therefore, whether a plastic stent (PS) or metallic stent (MS) should be used for EUS-BD remains to be undetermined. The present…
View article: A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer
A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer Open
Background/Aims: Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable…
View article: Screening for hilar biliary invasion in ampullary cancer patients
Screening for hilar biliary invasion in ampullary cancer patients Open
Although some false-positive results were obtained with each method, the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results was useful for diagnosing hilar biliary invasion of ampullary cancer. Howev…
View article: Prognostic significance of sarcopenia as determined by bioelectrical impedance analysis in patients with advanced pancreatic cancer receiving gemcitabine plus nab‑paclitaxel: A retrospective study
Prognostic significance of sarcopenia as determined by bioelectrical impedance analysis in patients with advanced pancreatic cancer receiving gemcitabine plus nab‑paclitaxel: A retrospective study Open
Sarcopenia often affects patients with various types of cancer, and has been reported to affect patient prognosis and therapeutic effects. However, to the best of our knowledge, there are no reports on the relationship between gemcitabine …
View article: Biliary metal stents should be placed near the hilar duct in distal malignant biliary stricture patients
Biliary metal stents should be placed near the hilar duct in distal malignant biliary stricture patients Open
A longer patency period was achieved by positioning the SEMS near the biliary hilar duct.
View article: Efficacy of a novel large-cell Niti-S stent with a slim delivery system for hilar biliary obstruction: a preliminary study
Efficacy of a novel large-cell Niti-S stent with a slim delivery system for hilar biliary obstruction: a preliminary study Open
Placing multiple USEMSs in patients with a past history of abdominal surgery or in reintervention is difficult. Although difficult cases were included in this study, stent-in-stent placement with the novel Niti-S large-cell SR slim deliver…
View article: Drug treatment for chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer
Drug treatment for chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer Open
Pancreatic cancer (PC) is a lethal disease where most tumors are too advanced at diagnosis for resection, leaving chemotherapy as the mainstay of treatment. Although the prognosis of unresectable PC is poor, it has been dramatically improv…
View article: Modified FOLFIRINOX versus sequential chemotherapy (FOLFIRI/FOLFOX) as a second‐line treatment regimen for unresectable pancreatic cancer: A real‐world analysis
Modified FOLFIRINOX versus sequential chemotherapy (FOLFIRI/FOLFOX) as a second‐line treatment regimen for unresectable pancreatic cancer: A real‐world analysis Open
Background Although second‐line treatment for pancreatic cancer has been proven to have survival benefit, it is not clear which is the most preferred regimen. This study compared the efficacy and safety of modified FOLFIRINOX (mFOLFIRINOX)…
View article: Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer
Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer Open
The duodenal microbiota may be useful for PB Ca screening.
View article: Efficacy of a Novel Large-cell Niti-S stent with a Slim Delivery System for Hilar Biliary Obstruction: A Preliminary Study
Efficacy of a Novel Large-cell Niti-S stent with a Slim Delivery System for Hilar Biliary Obstruction: A Preliminary Study Open
Background: The large-cell Niti-S stent is useful for multiple stenting in malignant hilar biliary obstruction (MHBO) patients. Recently, a novel uncovered self-expandable metallic stent (USEMS) (a large-cell Niti-S slim-delivery stent) wa…