Hiroyuki Hashimoto
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View article: Elucidating the antioxidative mechanisms by blending rice bran oil with canola oil at ambient temperature
Elucidating the antioxidative mechanisms by blending rice bran oil with canola oil at ambient temperature Open
Oil blending is a useful way to modify the unique properties of vegetable oils such as oxidative stability. Rice bran oil (RBO) has excellent oxidative stability due to its fatty acid (FA) composition with relatively more saturated FA and …
View article: Personalized prediction model generated with machine learning for kidney function one year after living kidney donation
Personalized prediction model generated with machine learning for kidney function one year after living kidney donation Open
View article: Personalized Prediction Model Generated with Machine Learning for Kidney Function One Year After Living Kidney Donation
Personalized Prediction Model Generated with Machine Learning for Kidney Function One Year After Living Kidney Donation Open
Living kidney donors typically experience approximately a 30% reduction in kidney function after donation, although the degree of reduction varies among individuals. This study aimed to develop a machine learning (ML) model to predict seru…
View article: Recent Findings on the Molecular Species of γ-Oryzanol
Recent Findings on the Molecular Species of γ-Oryzanol Open
View article: Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats
Rice endosperm and bran proteins ameliorate diabetic osteoporosis in Zucker Diabetic Fatty rats Open
We investigated whether rice protein ameliorates the osteoporosis associated with type 2 diabetes in Zucker diabetic fatty rats. Diets containing rice endosperm protein, rice bran protein, or casein were fed for 10 weeks. The rats exhibite…
View article: Clinical significance of cerebrospinal fluid presepsin as adjunctive biomarker for postneurosurgical meningitis: A single-center prospective observational study
Clinical significance of cerebrospinal fluid presepsin as adjunctive biomarker for postneurosurgical meningitis: A single-center prospective observational study Open
Background: Postneurosurgical meningitis (PNM) is a serious complication in neurocritical care patients, leading to clinical deterioration and worsening outcomes. Accurate diagnosis of PNM is often difficult due to the lack of definitive d…
View article: Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study
Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study Open
Background Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) a…
View article: Pharmacological profile of upacicalcet, a novel positive allosteric modulator of calcium-sensing receptor, in vitro and in vivo
Pharmacological profile of upacicalcet, a novel positive allosteric modulator of calcium-sensing receptor, in vitro and in vivo Open
Upacicalcet (formerly SK-1403/AJT240) is a novel non-peptide calcimimetic agent that acts as a calcium-sensing receptor (CaSR) agonist for the treatment of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). We compared u…
View article: A Case of Cutaneous Carcinosarcoma Composed of Basal Cell Carcinoma and Squamous Cell Carcinoma with Sarcomatoid Change
A Case of Cutaneous Carcinosarcoma Composed of Basal Cell Carcinoma and Squamous Cell Carcinoma with Sarcomatoid Change Open
基底細胞癌（basal cell carcinoma, BCC）と有棘細胞癌（squamous cell carcinoma, SCC）に肉腫様変化を示したcarcinosarcoma（癌肉腫）の 1 例を報告する。77 歳，女性。鼻背部の腫瘤を主訴に受診し，生検にて異型表皮細胞，異型紡錘形細胞が認められ，上皮系，間葉系の悪性腫瘍が疑われ切除術が行われた。全切除標本で病変の基部の一端に基底細胞様細胞が胞巣を形成する部分と，異型表皮細胞が増殖する部分があり，各々 BCC，SC…
View article: Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study
Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study Open
Background Limited data exist on the prognostic factors for patients with ischemic stroke and active cancer. Methods and Results We conducted a prospective, multicenter, observational study in Japan, including patients with acute ischemic …
View article: Predictors of survival in patients with ischemic stroke and active cancer: A prospective, multicenter, observational study
Predictors of survival in patients with ischemic stroke and active cancer: A prospective, multicenter, observational study Open
Background Patients with ischemic stroke and active cancer have a poor prognosis; however, supporting evidence remains limited. Methods We conducted a prospective, multicenter, observational study in Japan including patients with acute isc…
View article: Diagnostic Accuracy of the Combination of Cerebrospinal fluid and blood Presepsin for Postoperative Meningitis after Neurosurgery: Single-Center Prospective Observational Cohort Study
Diagnostic Accuracy of the Combination of Cerebrospinal fluid and blood Presepsin for Postoperative Meningitis after Neurosurgery: Single-Center Prospective Observational Cohort Study Open
Objective: Post-neurosurgical meningitis (PNM) is a serious complication in neurocritical care patients, leading to clinical deterioration and worsening outcomes. Accurate diagnosis of PNM is often difficult due to the lack of a definitive…
View article: Case Report : Rete Middle Cerebral Artery
Case Report : Rete Middle Cerebral Artery Open
中大脳動脈 (middle cerebral artery : MCA) で網目状の血管網を形成し, MCA近位に狭窄・閉塞がみられるrete MCAは比較的まれなMCAのvariantとされている. 今回rete MCAと思われる3症例を経験した. 1例は脳出血で発症し開頭血腫除去術が施行された. 2例はMRIで偶発的に発見され, うち1例はM2で網状血管を形成していた. 2例とも各種検査を施行し, 外科的治療介入せずに経過観察の方針となった. Rete MCAはもやもや…
View article: Secondary Contamination by Wheat Allergens across Cooking Bowls through the Use of Sponge Scourers
Secondary Contamination by Wheat Allergens across Cooking Bowls through the Use of Sponge Scourers Open
After washing the cooking utensils used to prepare liquid batter, flour may remain in the scrubbing sponge. Secondary contamination of cooking devices with wheat allergens is a concern if such scrubbing sponges are used to clean other equi…
View article: Scald Burns While Bathing Among Elderly People in Japan
Scald Burns While Bathing Among Elderly People in Japan Open
View article: Radiation dose for 320‐row dose‐modulated dynamic coronary CT angiography
Radiation dose for 320‐row dose‐modulated dynamic coronary CT angiography Open
Objectives The area detector 320‐row CT scanner, which can cover the whole heart in one rotation, can aid in reducing radiation exposure during electrocardiography (ECG)‐gated coronary CT angiography (CCTA). Recently, researchers have prop…
View article: Endovascular Thrombectomy for Acute Ischemic Stroke in Cancer Patients: Report of Three Cases
Endovascular Thrombectomy for Acute Ischemic Stroke in Cancer Patients: Report of Three Cases Open
We report three cancer patients who underwent mechanical thrombectomy for acute ischemic stroke. Although we achieved successful recanalization in all cases, two patients died within three months. The other patient improved after thrombect…
View article: A Case of Subarachnoid Hemorrhage Due to Ruptured Lateral Spinal Artery Aneurysm
A Case of Subarachnoid Hemorrhage Due to Ruptured Lateral Spinal Artery Aneurysm Open
The lateral spinal arteries (LSA) serve as an important collateral pathway when there is occlusion of the vertebral artery (VA) or posterior inferior cerebellar artery (PICA). We report a case of subarachnoid hemorrhage (SAH) due to a rupt…
View article: Locking versus nonlocking superior plate fixations for displaced midshaft clavicle fractures: A prospective randomized trial comparing clinical and radiografic results
Locking versus nonlocking superior plate fixations for displaced midshaft clavicle fractures: A prospective randomized trial comparing clinical and radiografic results Open
Therapeutic, level I.
View article: Rice bran protein ameliorates diabetes, reduces fatty liver, and has renoprotective effects in Zucker Diabetic Fatty rats
Rice bran protein ameliorates diabetes, reduces fatty liver, and has renoprotective effects in Zucker Diabetic Fatty rats Open
View article: Author Correction: Definitive evidence of the presence of 24-methylenecycloartanyl ferulate and 24-methylenecycloartanyl caffeate in barley
Author Correction: Definitive evidence of the presence of 24-methylenecycloartanyl ferulate and 24-methylenecycloartanyl caffeate in barley Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Statistical analysis of anti‐mamushi venom serum injection time and clinical course
Statistical analysis of anti‐mamushi venom serum injection time and clinical course Open
Aim Early injection of anti‐mamushi venom serum (antiserum) is believed to be effective for the treatment of patients with mamushi bites. However, there is no firm information that indicates the time range constituting “early” injection. W…
View article: Solitary subungual neurofibroma with glomus tumor-like appearance: a case report
Solitary subungual neurofibroma with glomus tumor-like appearance: a case report Open
We present a case of subungual neurofibroma which clinically presented a glomus tumor-like appearance. Six months after surgical resection, no clinical recurrence or pain was reported. We herein report the difficulty of its preoperative di…
View article: P1.09-15 Hybrid Organoid Reveals That Podoplanin-Positive Cancer-Associated Fibroblasts Enhance Proliferation of Lung Cancer Cell
P1.09-15 Hybrid Organoid Reveals That Podoplanin-Positive Cancer-Associated Fibroblasts Enhance Proliferation of Lung Cancer Cell Open
View article: Definitive evidence of the presence of 24-methylenecycloartanyl ferulate and 24-methylenecycloartanyl caffeate in barley
Definitive evidence of the presence of 24-methylenecycloartanyl ferulate and 24-methylenecycloartanyl caffeate in barley Open
View article: Safety and effectiveness of reduced-dose apixaban in Japanese patients with nonvalvular atrial fibrillation in clinical practice: A sub-analysis of the STANDARD study
Safety and effectiveness of reduced-dose apixaban in Japanese patients with nonvalvular atrial fibrillation in clinical practice: A sub-analysis of the STANDARD study Open
View article: Comparison of Blood Profiles of γ-Oryzanol and Ferulic Acid in Rats after Oral Intake of γ-Oryzanol
Comparison of Blood Profiles of γ-Oryzanol and Ferulic Acid in Rats after Oral Intake of γ-Oryzanol Open
γ-Oryzanol (OZ), a bioactive phytochemical abundant in cereals such as rice, has been reported to be mainly hydrolyzed to ferulic acid (FA) in the body. Meanwhile, in our previous study, we revealed that a part of OZ is absorbed into the b…
View article: Safety and effectiveness of apixaban in Japanese patients with nonvalvular atrial fibrillation in clinical practice: A regulatory postmarketing surveillance, the <scp>STANDARD</scp> study
Safety and effectiveness of apixaban in Japanese patients with nonvalvular atrial fibrillation in clinical practice: A regulatory postmarketing surveillance, the <span>STANDARD</span> study Open
Background Apixaban, a non‐vitamin K oral anticoagulant ( NOAC ), was approved in Japan in 2012 for the prevention of thromboembolic events in patients with nonvalvular atrial fibrillation ( NVAF ). However, the safety and effectiveness of…
View article: Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol
Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol Open
γ-Oryzanol (OZ), abundant in rice bran oil, has gained attention due to its physiological activities (e.g., lipid-lowering effects). However, the absorption and metabolism of orally ingested OZ have not yet been fully elucidated. In this s…
View article: A Case of Barely Diagnosed Multiple Subcutaneous Abscesses Caused by <i>Mycobacterium chelonae</i> Intection
A Case of Barely Diagnosed Multiple Subcutaneous Abscesses Caused by <i>Mycobacterium chelonae</i> Intection Open
68 歳，女性。慢性腎不全，肝硬変あり。3 月頃より両側手背，右足背に皮下膿瘍が多発し，他科で加療されたが軽快せず 7 月に皮膚科に紹介された。病理組織で深在性真菌症あるいは非結核性抗酸菌症が疑われた。β-D グルカンの高値を認め膿から真菌が検出されたため，深在性真菌症による多発膿瘍と診断し抗真菌剤で加療したところ，β-D グルカンは正常化したが皮疹は緩徐に増悪した。細菌培養を反復した結果，一般細菌用培地と Sabouraud ブドウ糖寒天培地で手背の膿から Mycobac…