Hiroyuki Nakayama
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View article: Cardiac Damage Stages and Clinical Outcomes in Patients With Severe Aortic Stenosis
Cardiac Damage Stages and Clinical Outcomes in Patients With Severe Aortic Stenosis Open
Cardiac damage staging is a useful tool for prognostic stratification in patients with severe AS, independent of gradient patterns, symptoms, and initial treatment strategies.
View article: Prognostic Value of the 6-Minute Walk Test in Patients With Severe Aortic Stenosis
Prognostic Value of the 6-Minute Walk Test in Patients With Severe Aortic Stenosis Open
The 6MWD is a reliable prognostic marker for patients with severe AS, regardless of initial treatment strategy.
View article: Fabrication of Bulk High-Temperature δ-MoC Phase by Mechanical Alloying and Subsequent Pulsed Current Sintering, and Investigation of Its Several Properties
Fabrication of Bulk High-Temperature δ-MoC Phase by Mechanical Alloying and Subsequent Pulsed Current Sintering, and Investigation of Its Several Properties Open
View article: Safety of Calcium Channel Blockers in Patients With Severe Aortic Stenosis and Hypertension
Safety of Calcium Channel Blockers in Patients With Severe Aortic Stenosis and Hypertension Open
Among patients with severe AS and hypertension, CCB was the most commonly prescribed antihypertensive agents, and antihypertensive therapy with CCB was associated with comparable clinical outcomes to antihypertensive therapy without CCB. S…
View article: Pre-constrain technique using the Gore Excluder Conformable endograft for abdominal aortic aneurysm with severely angulated proximal neck
Pre-constrain technique using the Gore Excluder Conformable endograft for abdominal aortic aneurysm with severely angulated proximal neck Open
View article: Concomitant Mitral Regurgitation in Severe Aortic Stenosis ― Insights From the CURRENT AS Registry-2 ―
Concomitant Mitral Regurgitation in Severe Aortic Stenosis ― Insights From the CURRENT AS Registry-2 ― Open
Moderate/severe MR was associated with a higher risk for death or HF hospitalization in the initial SAVR and conservative strategies, while the association was less pronounced in the initial TAVI strategy.
View article: Modification of the Viabahn Open Revascularization Technique for extensive internal iliac artery aneurysms
Modification of the Viabahn Open Revascularization Technique for extensive internal iliac artery aneurysms Open
We modified the Viabahn Open Revascularization Technique for managing extensive internal iliac artery aneurysms concomitant with aortoiliac aneurysms to facilitate the proximal suture with the exclusion of internal iliac artery aneurysms. …
View article: A case of infundibular cyst with neutrophil cannibalism by squamous cells in a dog
A case of infundibular cyst with neutrophil cannibalism by squamous cells in a dog Open
A 6-years and 6-months-old, neutered male mongrel dog had a skin mass between the left eye and nose. Fine needle aspiration biopsy of the mass revealed giant epithelial cells containing many neutrophils in the cytoplasm. The mass was excis…
View article: CORRIGENDUM: Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2
CORRIGENDUM: Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2 Open
Registry-2 InvestigatorsFigure.Study flowchart.AVR included both SAVR and TAVI.High-gradient AS was defined as Vmax >4.0 m/s or mean aortic PG >40 mmHg, whereas low-gradient AS was defined as Vmax ≤4.0 m/s and mean aortic PG ≤40 mmHg.AVA, …
View article: In-hospital outcomes after SAVR or TAVI in patients with severe aortic stenosis
In-hospital outcomes after SAVR or TAVI in patients with severe aortic stenosis Open
View article: A Case Report of Tyzzer’s Disease in Two Kittens in Japan
A Case Report of Tyzzer’s Disease in Two Kittens in Japan Open
Available within the full article
View article: Transcarotid Transcatheter Aortic Valve Replacement for Severe Aortic Valve Stenosis with Narrow Aortic Root and Shaggy Aorta: A Case Report
Transcarotid Transcatheter Aortic Valve Replacement for Severe Aortic Valve Stenosis with Narrow Aortic Root and Shaggy Aorta: A Case Report Open
Objective: Transcarotid access for transcatheter aortic valve replacement (TAVR) is a minimally invasive alternative approach if femoral access becomes unfavorable; however, it remains off-label use in Japan.
View article: Developing Multidisciplinary Management of Heart Failure in the Super-Aging Society of Japan
Developing Multidisciplinary Management of Heart Failure in the Super-Aging Society of Japan Open
The Japanese population is rapidly aging because of its long life expectancy and low birth rate; additionally, the number of patients with heart failure (HF) is increasing to the extent that HF is now considered a pandemic. According to a …
View article: Chronological transition of necropsy cases of animals in Tokyo, Japan
Chronological transition of necropsy cases of animals in Tokyo, Japan Open
There is no nationwide necropsy database of animals in Japan, and most of the records are available from the postwar period. To clarify the chronological transition of animal necropsy cases in Tokyo, Japan, the records accumulated in The U…
View article: Exercise echocardiography for a differential diagnosis in a patient with radiation-induced heart disease: A case report
Exercise echocardiography for a differential diagnosis in a patient with radiation-induced heart disease: A case report Open
Radiation therapy (RT) has improved the survival rates of patients with cancer, but which involves radiation-induced heart disease (RIHD). RIHD is complex and multifaceted, and RT-related valvular disease may be underestimated with transth…
View article: Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice
Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice Open
Neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include Alzheimer's disease and Pick's disease. Recent studies show that the intake of tryptophan-tyrosine (Trp-Tyr)-relate…
View article: Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2
Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2 Open
The CURRENT AS Registry-2 might be large and meticulous enough to determine the appropriate timing of intervention for patients with severe AS in contemporary clinical practice.
View article: Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload
Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload Open
Heart failure has high morbidity and mortality in the developed countries. Autophagy is important for the quality control of proteins and organelles in the heart. Rubicon (Run domain Beclin-1-interacting and cysteine-rich domain-containing…
View article: Histological and immunohistochemical features of cutaneous mast cell tumor in six captive four-toed hedgehogs (<i>Atelerix albiventris</i>)
Histological and immunohistochemical features of cutaneous mast cell tumor in six captive four-toed hedgehogs (<i>Atelerix albiventris</i>) Open
This report described the histopathological and immunohistochemical features of cutaneous mast cell tumor (MCT) in six hedgehogs. The hedgehogs presented single cutaneous mass with ulcer and crusting. Histologically, the neoplastic lesions…
View article: Adult-Onset Focal Nesidioblastosis With Nodular Formation Mimicking Insulinoma
Adult-Onset Focal Nesidioblastosis With Nodular Formation Mimicking Insulinoma Open
Nesidioblastosis is defined as the neoformation of the islets of Langerhans from the pancreatic ductal epithelium and is recognized as the most common cause of hyperinsulinemic hypoglycemia in infants. We herein report an extremely rare ca…
View article: The Effects of an Oral Nutritional Supplement with Whey Peptides and Branched-Chain Amino Acids for Cardiac Rehabilitation of Patients with Chronic Heart Failure
The Effects of an Oral Nutritional Supplement with Whey Peptides and Branched-Chain Amino Acids for Cardiac Rehabilitation of Patients with Chronic Heart Failure Open
The aim of the present study was to determine whether the addition of an oral nutritional supplement with whey peptides and branched-chain amino acids for cardiac rehabilitation improves cardiopulmonary function, skeletal muscle function, …
View article: β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline
β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline Open
With the rapid increase in aging populations worldwide, there has been an increase in demand for preventive and therapeutic measures for age-related cognitive decline and dementia. Epidemiological studies show that consumption of dairy pro…
View article: Safety of Intravenous Autologous Bone Marrow-Derived Mesenchymal Cell Transplantation in 5 Patients With Reduced Left Ventricular Ejection Fraction
Safety of Intravenous Autologous Bone Marrow-Derived Mesenchymal Cell Transplantation in 5 Patients With Reduced Left Ventricular Ejection Fraction Open
Background: Although intracardiac injection or intracoronary delivery of mesenchymal stem cells (MSCs) has been reported, there have been few studies on the intravenous injection of MSCs, particularly in Japan. Methods …
View article: Deposition of Phosphorylated α-Synuclein and Activation of GSK-3β and PP2A in the PS19 Mouse Model of Tauopathy
Deposition of Phosphorylated α-Synuclein and Activation of GSK-3β and PP2A in the PS19 Mouse Model of Tauopathy Open
The simultaneous accumulation of multiple pathological proteins, such as hyperphosphorylated tau (hp-tau) and phosphorylated α-synuclein (p-αSyn), has been reported in the brains of patients with various neurodegenerative diseases. We prev…
View article: A retrospective study (2006-2020) of cytology and biopsy findings in pet rabbits (Oryctolagus cuniculus), ferrets (Mustela putorius furo) and four-toed hedgehogs (Atelerix albiventris) seen at an exotic animal clinic in Tokyo, Japan
A retrospective study (2006-2020) of cytology and biopsy findings in pet rabbits (Oryctolagus cuniculus), ferrets (Mustela putorius furo) and four-toed hedgehogs (Atelerix albiventris) seen at an exotic animal clinic in Tokyo, Japan Open
Background: Rabbits, ferrets, and four-toed hedgehogs are popular exotic pets, but comprehensive epidemiological studies in these animals have been rarely conducted. The present study aims to clarify the incidence of neoplastic and non-neo…
View article: Neuronal Deposition of Amyloid-β Oligomers and Hyperphosphorylated Tau Is Closely Connected with Cognitive Dysfunction in Aged Dogs
Neuronal Deposition of Amyloid-β Oligomers and Hyperphosphorylated Tau Is Closely Connected with Cognitive Dysfunction in Aged Dogs Open
Background: Canine cognitive dysfunction (CCD) is a progressive syndrome recognized in mature to aged dogs with a variety of neuropathological changes similar to human Alzheimer’s disease (AD), for which it is thought to be a good natural …
View article: Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)
Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus) Open
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. The AD-related pathology has b…
View article: Pharmacology and Safety
Pharmacology and Safety Open
Propolis is a nature resinous mixture produced by honeybees that exhibit a wide range of biological functions.We previously reported that the propolis derived from Philippine endemic stingless bees (Tetragonula biroi, Friese) had anti-gast…
View article: Hop bitter acids containing a β-carbonyl moiety prevent inflammation-induced cognitive decline via the vagus nerve and noradrenergic system
Hop bitter acids containing a β-carbonyl moiety prevent inflammation-induced cognitive decline via the vagus nerve and noradrenergic system Open
The prevention of age-related cognitive decline and dementia is becoming a high priority because of the rapid growth of aging populations. We have previously shown that hop bitter acids such as iso-α-acids (IAAs) and matured hop bitter aci…
View article: Content
Content Open