Hiroyuki Saito
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View article: Can DNN models simulate appearance variations of #TheDress?
Can DNN models simulate appearance variations of #TheDress? Open
The color appearance of #TheDress image varies across individuals. The color of pixels in the image distributes mostly in blue-achromatic-yellow color direction, and so are the perceived color variations. One of the potential causes is dif…
View article: The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation
The structural characteristics of cellular phospholipid acyl chains required for ABCA1-mediated HDL formation Open
View article: Epidermal Growth Factor Receptor (EGFR) Downregulation by Cetuximab in Salivary Duct Carcinoma: A Case Report
Epidermal Growth Factor Receptor (EGFR) Downregulation by Cetuximab in Salivary Duct Carcinoma: A Case Report Open
View article: Amyloid-forming property of the N-terminal 1−70 residues of human apolipoprotein A-IV
Amyloid-forming property of the N-terminal 1−70 residues of human apolipoprotein A-IV Open
Apolipoprotein A-IV (apoA-IV), the largest member of the exchangeable apolipoprotein family, is a common constituent of amyloid deposits in renal and cardiac amyloidosis. In this study, we characterized the aggregation propensity of the ap…
View article: A Case of Type 2 Diabetes with Ipragliflozin Administration Developing Euglycemic Diabetic Ketoacidosis Due to Reduced Food Intake Following Colonoscopy
A Case of Type 2 Diabetes with Ipragliflozin Administration Developing Euglycemic Diabetic Ketoacidosis Due to Reduced Food Intake Following Colonoscopy Open
症例は80歳,女性.2型糖尿病に罹患しており,イプラグリフロジンを内服していた.X-7日に大腸内視鏡検査を施行された後,気分不良のため食事が減少していた.X日に腹痛と繰り返す嘔吐の為,救急搬送された.身体診察と胸腹部単純CTでは腹痛,嘔吐の原因疾患はなく,血液ガス検査ではアニオンギャップ開大性代謝性アシドーシスを示した.血中ケトンは上昇しており,血糖値は182 mg/dLであった.イプラグリフロジンによる正常血糖糖尿病性ケトアシドーシス(以下euDKA)と診断し同薬を中止し…
View article: Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons
Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons Open
We have successfully proven that intracerebral inoculated α-synuclein PFFs are propagated and incorporated from the host into grafted SNCA-/- hiPSC-derived mDA neurons. Our results contribute toward the basic understandin…
View article: Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I
Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I Open
Deposition and accumulation of amyloid fibrils is a hallmark of a group of diseases called amyloidosis and neurodegenerative disorders. Although polypeptides potentially have a fibril-forming propensity, native proteins have evolved into p…
View article: Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability
Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability Open
Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide …
View article: Amyloidogenic 60–71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects
Amyloidogenic 60–71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects Open
The N-terminal fragment of apolipoprotein A-I (apoA-I), comprising residues 1–83, contains three segments prone to aggregation: residues 14–22, 53–58, and 67–72. We previously demonstrated that residues 14–22 are critical in apoA-I fibril …
View article: Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability
Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability Open
Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide.…
View article: Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein Open
Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein, comprises positively charged N-terminal, hydropho…
View article: Plantainoside B in <i>Bacopa monniera</i> Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ
Plantainoside B in <i>Bacopa monniera</i> Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ Open
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by dementia. The most characteristic pathological changes in AD brain include extracellular amyloid-β (Aβ) accumulation and neuronal loss. Particularly, chol…
View article: Suppression of hydrogen entry by separation of load support point and hydrogen generation point
Suppression of hydrogen entry by separation of load support point and hydrogen generation point Open
Hydrogen embrittlement of metals is a phenomenon in which hydrogen entry into a material, such as steel, reduces its fracture strength and ductility. It is known that the hydrogen embrittlement susceptibility of high strength steels increa…
View article: Histological evaluation of the propagation of α-synuclein into grafted human induced pluripotent stem cell-derived neurons
Histological evaluation of the propagation of α-synuclein into grafted human induced pluripotent stem cell-derived neurons Open
Clinical trials of cell transplantation therapy using fetal mesencephalic tissue provided a proof-of-concept for regenerative therapy for the patients with Parkinson's disease. Postmortem studies of the patients who received fetal grafts r…
View article: Lipid Membrane Interaction Regulates Structure and Function of Apolipoproteins
Lipid Membrane Interaction Regulates Structure and Function of Apolipoproteins Open
Exchangeable apolipoproteins such as apoA–I and apoE function in lipid transport as structural components of lipoprotein particles, cofactors for enzyme, and ligands for cell–surface receptors. Both apoA–I and apoE contain amphipathic α– h…
View article: Effect of moderate-intensity treadmill exercise under different ambient temperatures on peripheral circulatory responses in young healthy adults
Effect of moderate-intensity treadmill exercise under different ambient temperatures on peripheral circulatory responses in young healthy adults Open
Exercise training has the potential for inducing enhancements in peripheral circulation, which can play important preventive and therapeutic roles in peripheral circulatory diseases. However, the relevant published studies show conflicting…
View article: Characterization of a Human Sapovirus Genotype GII.3 Strain Generated by a Reverse Genetics System: VP2 Is a Minor Structural Protein of the Virion
Characterization of a Human Sapovirus Genotype GII.3 Strain Generated by a Reverse Genetics System: VP2 Is a Minor Structural Protein of the Virion Open
We devised a reverse genetics system to generate an infectious human sapovirus (HuSaV) GII.3 virus. Capped/uncapped full-length RNAs derived from HuSaV GII.3 AK11 strain generated by in vitro transcription were used to transfect HuTu80 hum…
View article: Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations
Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations Open
View article: Design and Synthesis of 6‐<i>O</i>‐Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid β Aggregation
Design and Synthesis of 6‐<i>O</i>‐Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid β Aggregation Open
Dysregulation of amyloidogenic proteins and their abnormal processing and deposition in tissues cause systemic and localized amyloidosis. Formation of amyloid β (Aβ) fibrils that deposit as amyloid plaques in Alzheimer's disease (AD) brain…
View article: Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein Open
View article: Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E-derived arginine-rich amphipathic α-helical peptides
Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E-derived arginine-rich amphipathic α-helical peptides Open
View article: INPUT Team Description Paper in 2022
INPUT Team Description Paper in 2022 Open
INPUT is a team participating in the RoboCup Soccer Small League (SSL). It aims to show the world the technological capabilities of the Nagaoka region of Niigata Prefecture, which is where the team members are from. For this purpose, we ar…
View article: Kinetic and Thermodynamic Analyses of Aggregation and Fibril Formation of Amyloidogenic Proteins
Kinetic and Thermodynamic Analyses of Aggregation and Fibril Formation of Amyloidogenic Proteins Open
アミロイドーシス変異アポA-Iやパーキンソン病αシヌクレインのアミロイド線維化反応に対して，核形成－自己触媒線維伸長モデルに基づく速度論的解析ならびに核形成と線維伸長速度定数の温度変動解析を行うことで，これらアミロイドタンパク質の凝集・線維化過程の熱力学的特性を明らかにした著者らの研究を紹介する．
View article: A Human Intestinal Cell Line Suitable for the Propagation of Human Parechovirus Type 1 to 6 with a Clear Cytopathic Effect
A Human Intestinal Cell Line Suitable for the Propagation of Human Parechovirus Type 1 to 6 with a Clear Cytopathic Effect Open
Human parechoviruses (HPeVs) are being increasingly recognized as pathogens that cause mild-to-life-threatening diseases in children and adults. Recently, nucleic acid detection has become the mainstream method for pathogen detection. Howe…
View article: Near field EVM estimation in OTA test
Near field EVM estimation in OTA test Open
The EVM (Error Vector Magnitude) measurement is mandatory for radio equipment test. Signals transmitted from multiple antennas give high EVM value due to the phase difference in near field OTA (Over The Air) test. To overcome this difficul…
View article: IODP Expedition 314, Hole C0006B - Well Logging Data
IODP Expedition 314, Hole C0006B - Well Logging Data Open
Logging data are measurements of physical properties of the formation surrounding a borehole, acquired in situ after completion of coring (wireline logging) or during drilling (Logging-While-Drilling, LWD). The range of data (resistivity, …
View article: IODP Expedition 314, Hole C0006B - Well Logging Data
IODP Expedition 314, Hole C0006B - Well Logging Data Open
Logging data are measurements of physical properties of the formation surrounding a borehole, acquired in situ after completion of coring (wireline logging) or during drilling (Logging-While-Drilling, LWD). The range of data (resistivity, …
View article: Cell-to-cell transmission of p53 aggregates: a novel player in oncology?
Cell-to-cell transmission of p53 aggregates: a novel player in oncology? Open
The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear. Our recent study revealed that sulfated…
View article: Effects of Familial Mutation and C-Terminal Truncation on Nucleation and Fibril Elongation of α-Synuclein
Effects of Familial Mutation and C-Terminal Truncation on Nucleation and Fibril Elongation of α-Synuclein Open
View article: Mechanisms of Aggregation and Amyloid Fibril Formation of Apolipoproteins on Lipid Membranes
Mechanisms of Aggregation and Amyloid Fibril Formation of Apolipoproteins on Lipid Membranes Open
Lipid membranes are known to influence the folding, aggregation, and fibril formation of a variety of amyloidogenic proteins. In some natively unstructured amylodogenic proteins such as α– synuclein and islet amyloid peptide, the formation…