Hiroyuki Sano
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View article: Comprehensive Pathological Image Segmentation via Teacher Aggregation for Tumor Microenvironment Analysis
Comprehensive Pathological Image Segmentation via Teacher Aggregation for Tumor Microenvironment Analysis Open
The tumor microenvironment (TME) plays a crucial role in cancer progression and treatment response, yet current methods for its comprehensive analysis in H&E-stained tissue slides face significant limitations in the diversity of tissue cel…
View article: <i>IL1RL1</i>variant may affect the response to type 2 biologics in patients with severe asthma
<i>IL1RL1</i>variant may affect the response to type 2 biologics in patients with severe asthma Open
Background Asthma is a heterogeneous disease with variable response to treatment. Genetic backgrounds are involved in the severity of type 2 asthma, but their effects on responses to biologics remain unknown. This study aimed to clarify th…
View article: An approach to MOFaxanes by threading ultralong polymers through metal–organic framework microcrystals
An approach to MOFaxanes by threading ultralong polymers through metal–organic framework microcrystals Open
View article: Re-Enlightenment of Fulminant Type 1 Diabetes under the COVID-19 Pandemic
Re-Enlightenment of Fulminant Type 1 Diabetes under the COVID-19 Pandemic Open
Fulminant type 1 diabetes (FT1D) is a subtype of type 1 diabetes (T1D) that is characterized by the rapid progression to diabetic ketoacidosis against the background of rapid and almost complete pancreatic islet destruction. The HbA1c leve…
View article: Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes
Decreased cognitive function is associated with preceding severe hypoglycemia and impaired blood glucose control in the elderly individuals with type 1 diabetes Open
View article: Research following genome‐wide association study focuses on the multifaceted nature of Src kinase‐associated phosphoprotein 2 in type 1 diabetes
Research following genome‐wide association study focuses on the multifaceted nature of Src kinase‐associated phosphoprotein 2 in type 1 diabetes Open
Rutsch et al. identified a patient with type 1 diabetes having a rare Src kinase-associated phosphoprotein 2 variant and investigated the details. As a result, they showed that rare Src kinase-associated phosphoprotein 2 c.475 G>A increase…
View article: Pulmonary Tumor Thrombotic Microangiopathy Caused by Recurrent Gastric Cancer 26 Years After Total Gastrectomy
Pulmonary Tumor Thrombotic Microangiopathy Caused by Recurrent Gastric Cancer 26 Years After Total Gastrectomy Open
Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cancer-related complication that induces pulmonary hypertension (PH). PTTM can be caused by recurrent cancer, with 12 years being the longest reported interval from primary cancer…
View article: Impact of Dapagliflozin on the Left Ventricular Diastolic Function in Diabetic Patients with Heart Failure Complicating Cardiovascular Risk Factors
Impact of Dapagliflozin on the Left Ventricular Diastolic Function in Diabetic Patients with Heart Failure Complicating Cardiovascular Risk Factors Open
Objective Our aim was to investigate the impact of the sodium glucose cotransporter type 2 (SGLT2) inhibitor on the left ventricular (LV) diastolic function in type 2 diabetes mellitus (T2DM) patients with chronic heart failure (HF) compli…
View article: Integrated backscatter-intravascular ultrasound and modification of plaque during excimer laser coronary angioplasty
Integrated backscatter-intravascular ultrasound and modification of plaque during excimer laser coronary angioplasty Open
This study aims to test the hypothesis that the effect of excimer laser coronary angioplasty (ELCA) not only vaporizes thrombi and their underlying coronary plaque, it also changes their quality. We performed a series of cross-sectional an…
View article: Association with Ambient Air Pollutants and School Absence Due to Sickness in Schoolchildren: A Case-Crossover Study in a Provincial Town of Japan
Association with Ambient Air Pollutants and School Absence Due to Sickness in Schoolchildren: A Case-Crossover Study in a Provincial Town of Japan Open
The effect of ambient air pollutants and Asian dust (AD) on absence from school due to sickness has not been well researched. By conducting a case-crossover study, this study investigated the influence of ambient air pollutants and desert …
View article: Analysis of Litz Wire Losses Using Homogenization-Based FEM
Analysis of Litz Wire Losses Using Homogenization-Based FEM Open
This article proposes a novel analysis method for the losses in a litz wire considering the circulating and eddy currents. In the proposed method, the macroscopic complex permeability is introduced to evaluate the eddy current loss owing t…
View article: impact of dapagliflozin on left ventricular diastolic function in diabetic patients with heart failure complicating cardiovascular risk factors
impact of dapagliflozin on left ventricular diastolic function in diabetic patients with heart failure complicating cardiovascular risk factors Open
Funding Acknowledgements Type of funding sources: None. Background Type 2 diabetes mellitus (T2DM) is a well-known risk factor for heart failure (HF), even in patients without a structural heart disease or a symptom of HF. Diabetes-related…
View article: Positive effect of dapagliflozin on left ventricular longitudinal function for type 2 diabetic mellitus patients with chronic heart failure
Positive effect of dapagliflozin on left ventricular longitudinal function for type 2 diabetic mellitus patients with chronic heart failure Open
View article: Development of a Sensor with a Lipid/Polymer Membrane Comprising Na+ Ionophores to Evaluate the Saltiness Enhancement Effect
Development of a Sensor with a Lipid/Polymer Membrane Comprising Na+ Ionophores to Evaluate the Saltiness Enhancement Effect Open
The saltiness enhancement effect is the effect whereby saltiness is enhanced by adding specific substances to salt (sodium chloride). Since this effect can be used in the development of salt-reduced foods, a method to objectively evaluate …
View article: Pancreatic β‐cells express major histocompatibility complex class II: Do diabetic β‐cells have the capacity of antigen‐presenting cells?
Pancreatic β‐cells express major histocompatibility complex class II: Do diabetic β‐cells have the capacity of antigen‐presenting cells? Open
Russell et al. showed that major histocompatibility complex class II is expressed in pancreatic β-cells by a highly accurate method called transcriptome analysis. Pancreatic β-cells might have the capacity as antigen-presenting cells.
View article: A Smartphone 3D Positioning Method using a Spinning Magnet Marker
A Smartphone 3D Positioning Method using a Spinning Magnet Marker Open
In recent years, the importance of location information has increased due to the popularization of terminals such as smartphones. Our purpose is to estimate the 3D position of smartphones within several centimeters. This location informati…
View article: Impact of dapagliflozin on left ventricular diastolic function of patients with type 2 diabetic mellitus with chronic heart failure
Impact of dapagliflozin on left ventricular diastolic function of patients with type 2 diabetic mellitus with chronic heart failure Open
View article: “Benifuuki” Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial
“Benifuuki” Extract Reduces Serum Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind Placebo-Controlled Randomized Trial Open
(1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O-methylated catechins in “Benifuuki” green tea are expected to reduce cholesterol levels, although there is limited research reg…
View article: Ozone augments interleukin-8 production induced by ambient particulate matter
Ozone augments interleukin-8 production induced by ambient particulate matter Open
View article: A Muscarinic Antagonist Reduces Airway Inflammation and Bronchoconstriction Induced by Ambient Particulate Matter in a Mouse Model of Asthma
A Muscarinic Antagonist Reduces Airway Inflammation and Bronchoconstriction Induced by Ambient Particulate Matter in a Mouse Model of Asthma Open
Ambient particulate matter (PM) can increase airway inflammation and induce bronchoconstriction in asthma. This study aimed to investigate the effect of tiotropium bromide, a long-acting muscarinic antagonist, on airway inflammation and br…
View article: Myeloid-specific<i>Acat1</i>ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity
Myeloid-specific<i>Acat1</i>ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity Open
Macrophages are phagocytes that play important roles in health and diseases. Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) converts cellular cholesterol to cholesteryl esters and is expressed in many cell types. Unlike global Acat1 knocko…
View article: Association of short‐term ozone exposure with pulmonary function and respiratory symptoms in schoolchildren:A panel study in a western Japanese city
Association of short‐term ozone exposure with pulmonary function and respiratory symptoms in schoolchildren:A panel study in a western Japanese city Open
The average annual ozone levels have been increasing in Japan, even though the high ozone levels have decreased in recent years. There is limited information on the relationship between ozone exposure, pulmonary function, and respiratory s…
View article: Impact of overweight on left ventricular function in type 2 diabetes mellitus
Impact of overweight on left ventricular function in type 2 diabetes mellitus Open
View article: Estimation of the effects of heavy Asian dust on respiratory function by definition type
Estimation of the effects of heavy Asian dust on respiratory function by definition type Open
The associations between heavy-AD and respiratory function differed between these definitions.
View article: Impact of glycemic variability on the levels of endothelial progenitor cells in patients with type 1 diabetes
Impact of glycemic variability on the levels of endothelial progenitor cells in patients with type 1 diabetes Open
View article: 1247The assessment of contractile reserve and diastolic reserve during non-invasive preload stress echocardiography contributes to the risk stratification for patients with heart failure
1247The assessment of contractile reserve and diastolic reserve during non-invasive preload stress echocardiography contributes to the risk stratification for patients with heart failure Open
Over a mean follow-up period of 80.4±6.1 months (6.7±0.5 years), 18 patients suffered NFMI and 28 died (18% hard events, annualized hard events 2.7%).Both MCE and SPECT indexes were significant predictors on univariate analysis (p=0.008 an…
View article: Association of Short-Term Exposure to Ambient Fine Particulate Matter with Skin Symptoms in Schoolchildren: A Panel Study in a Rural Area of Western Japan
Association of Short-Term Exposure to Ambient Fine Particulate Matter with Skin Symptoms in Schoolchildren: A Panel Study in a Rural Area of Western Japan Open
Numerous studies have unmasked the deleterious effects of particulate matter less than 2.5 μm (PM2.5) on health. However, epidemiologic evidence focusing on the effects of PM2.5 on skin health remains limited. An important aspect of Asian …
View article: A case of fatal heart and liver failure accompanied by thyroid storm treated with prompt plasma exchange
A case of fatal heart and liver failure accompanied by thyroid storm treated with prompt plasma exchange Open
View article: Risk Stratification of Future Left Ventricular Dysfunction for Patients with Indications for Right Ventricular Pacing due to Bradycardia
Risk Stratification of Future Left Ventricular Dysfunction for Patients with Indications for Right Ventricular Pacing due to Bradycardia Open
Although right ventricular (RV) pacing is the only effective treatment for patients with symptomatic bradycardia, it creates left ventricular (LV) dyssynchrony, which can induce LV dysfunction and heart failure. The current criterion for c…
View article: Effects of Asian Dust Particles on the Early-Stage Antigen-Induced Immune Response of Asthma in NC/Nga Mice
Effects of Asian Dust Particles on the Early-Stage Antigen-Induced Immune Response of Asthma in NC/Nga Mice Open
Asian dust (AD) can aggravate airway inflammation in asthma, but the association between AD and the development of asthma remains unclear. This study aimed to investigate the effects of AD on the early stage of antigen sensitization using …