Explanipedia

Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan Open

Keigo Mitsui, Masashi Ueno, Kazuo Ohtsuka, Takayuki Matsumoto, Tomohiro Kato , et al. · 2025

Background Owing to the rarity of metastatic tumors in the small bowel, their clinicopathological features, and prognostic factors remain poorly understood. This study aimed to clarify the clinicopathological features and factors associate…

Outcomes of Subsequent Endoscopic Resection for Rectal Neuroendocrine Tumors with Positive/Indeterminate Vertical Margins Open

Mitsunori Kusuhara, Masau Sekiguchi, Naoya Toyoshima, Hiroyuki Takamaru, Masayoshi Yamada , et al. · 2025

Time variation of lightning activity observed around the Nilgiri plateau with GRAPES-3 Open

B. Hariharan, S.K. Gupta, Y. Hayashi, P. Jagadeesan, A. Jain , et al. · 2025

Surveillance and Surgical Salvage Treatment for Endoscopically Removed T1 Colorectal Cancers Open

Hiroyuki Takamaru, Cynthia Tsay, Yutaka Saito · 2025

Endoscopic submucosal dissection (ESD) enables en-bloc resection of large lesions more than 20 mm in size. Therefore, the use of ESD has gained broader acceptance for clinical applications globally. Previous reports on long-term outcomes a…

The Efficacy of Texture and Color Enhancement Imaging Observation in the Detection of Colorectal Lesions: A Multicenter, Randomized Controlled Trial (deTXIon Study) Open

Naoya Toyoshima, Yasuhiko Mizuguchi, Hiroyuki Takamaru, Keiko Nakamura, Yasuo Kakugawa , et al. · 2025

This study did not demonstrate the superiority of TXI over WLI in detecting neoplastic lesions. However, TXI may be effective in detecting flat polyps. (Clinical trial registration: jRCT1032230089.).

Efficacy and safety of multi-loop traction device-assisted colorectal endoscopic submucosal dissection: Multicenter randomized clinical trial Open

Mamoru Ito, Yuko Miura, Yasuhiko Mizuguchi, Hiroto Furuhashi, Yosuke Tsuji , et al. · 2025

The multi-loop traction device (MLTD) facilitates optimal visualization of the submucosa throughout endoscopic submucosal dissection (ESD). This trial aimed to assess the efficacy of MLTD for colorectal ESD. We conducted a multicenter, ope…

Microbiome and Colorectal Cancer in Humans: A Review of Recent Studies Open

Hiroyuki Takamaru, Cynthia Tsay, Satoshi Shiba, Shinichi Yachida, Yutaka Saito · 2025

The tumor microenvironment has recently been well-studied in various gastrointestinal cancers, including colorectal cancer (CRC). The gut microbiota, a collection of microorganisms in the human gastrointestinal tract, is one of the microen…

Endoscopic Characteristics of Squamous Epithelial Lesions and Squamous Cell Carcinoma in the Anal Canal Open

Takeshi Uozumi, Reona Kawamura, Yasuhiko Mizuguchi, Ryoji Ichijima, Naoya Toyoshima , et al. · 2025

Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies Open

Shoko Ikuta, Yutaka Saito, So Takata, Yoichiro Nakatani, Izumi Nagatomo , et al. · 2024

Detection response of the active components of the SciBar Cosmic Ray Telescope at Sierra Negra Open

F. Monterde-Andrade, L. X. González, Jose F. Valdés Galicia, Oscar G. Morales-Olivares, Maria A. Sergeeva , et al. · 2024

The Scibar Cosmic-Ray Telescope (SciCRT) is the most promising detector of the Sierra Negra Cosmic Rays Observatory (SN-CRO). At this location, being a target and a tracker of secondary cosmic rays, the SciCRT offers a high probability of …

Microbiome spectra and prevalent colibactin-associated mutational process in Japanese colorectal cancer Open

Tatsuhiro Shibata, Satoshi Shiba, Shinichi Yachida, Sayaka Mizutani, Yasushi Totoki , et al. · 2024

The recent rapid increase in colorectal cancer (CRC) cases, particularly among young patients, poses a significant public health concern in Japan and other countries. The association between the gut microbiota and CRC has been well establi…

Fusobacterium species are distinctly associated with patients with Lynch syndrome colorectal cancer Open

Felix Salim, Sayaka Mizutani, Satoshi Shiba, Hiroyuki Takamaru, Masayoshi Yamada , et al. · 2024

Comparison of Effective Imaging Modalities for Detecting Gastric Neoplasms: A Randomized 3-Arm Phase II Trial Open

Tomohiro Kadota, Seiichiro Abe, Noriya Uedo, Hisashi Doyama, Yasuaki Furue , et al. · 2024

INTRODUCTION: The early detection of gastric neoplasms (GNs) leads to favorable treatment outcomes. The latest endoscopic system, EVIS X1, includes third-generation narrow-band imaging (3G-NBI), texture and color enhancement imaging (TXI),…

Chronological Trend of Opportunistic Endoscopic Screening for Gastric Cancer and Atrophic Gastritis Open

Keiko Nakamura, Yasuo Kakukgawa, Masau Sekiguchi, Eriko So Tsuruki, Minori Matsumoto , et al. · 2024

The gastric cancer detection rate and atrophic gastritis prevalence have decreased over time. However, continuing endoscopic screening is important, especially for those at a high risk of developing gastric cancer complicated by severe atr…

Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan Open

Ken Yamashita, Shiro Oka, Takeshi Yamada, Keigo Mitsui, Hironori Yamamoto , et al. · 2024

Background The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, remain undetermined due to its rarity in Japan. Methods We analyzed 354 patients with 358 PSBAs, between Jan…

Comparison of the efficacy and tolerability of elobixibat plus sodium picosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, randomised, controlled E-PLUS trial Open

Kinichi Hotta, Yosuke Otake, Daisuke Yamaguchi, Yuichi Shimodate, Norihiro Hanabata , et al. · 2024

Background Sodium picosulfate (SP)/magnesium citrate (MC) and polyethylene glycol (PEG) plus ascorbic acid are recommended by Western guidelines as laxative solutions for bowel preparation. Clinically, SP/MC has a slower post-dose defaecat…

Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study Open

Yoshitaka Nishikawa, Takahiro Horimatsu, Shiro Oka, Takeshi Yamada, Keigo Mitsui , et al. · 2024

PURPOSE Limited information is available regarding the characteristics and outcomes of stage IV small bowel adenocarcinoma (SBA) in Japan. This study examined the clinical and pathological characteristics and outcomes according to the trea…

Small-scale Cosmic-Ray Anisotropy Observed by the GRAPES-3 Experiment at TeV Energies Open

M. Chakraborty, S. Ahmad, Anuj Chandra, S. R. Dugad, Umananda Dev Goswami , et al. · 2024

GRAPES-3 is a mid-altitude (2200 m) and near-equatorial (11.°4N) air shower array, overlapping in its field of view for cosmic-ray observations with experiments that are located in the Northern and Southern Hemispheres. We analyze a sample…

Endoscopist‐related factors affecting adenoma detection during colonoscopy: Data from the J‐SCOUT study Open

Takuji Kawamura, Masau Sekiguchi, Hiroyuki Takamaru, Yasuhiko Mizuguchi, Go Horiguchi , et al. · 2023

Objectives Colonoscopy withdrawal times are associated with the adenoma detection rate (ADR). However, the relationship between ADR and cecal insertion time has been inadequately characterized. We aimed to evaluate endoscopist‐related fact…

Small-scale cosmic ray anisotropy observed by the GRAPES-3 experiment at TeV energies Open

M. Chakraborty, Shakeel Ahmad, Anuj Chandra, S. R. Dugad, Umananda Dev Goswami , et al. · 2023

GRAPES-3 is a mid-altitude (2200 m) and near equatorial ($11.4^{\circ}$ North) air shower array, overlapping in its field of view for cosmic ray observations with experiments that are located in Northern and Southern hemispheres. We analyz…

Dynamics of the gut microbiome in FAP patients undergoing intensive endoscopic removal of polyps Open

Shinichi Yachida, Sayaka Mizutani, Satoshi Shiba, Felix Salim, Masayoshi Yamada , et al. · 2023

To elucidate the intestinal environment in patients with familial adenomatous polyposis (FAP) and any association of the microbiome with high-risk factors for developing colorectal cancer, we performed shotgun metagenomic sequencing and me…

Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development Open

Kana Shimomura, Naoko Hattori, Naoko Iida, Yukari Muranaka, Kotomi Sato , et al. · 2023

Proton penetration efficiency over a high altitude observatory in Mexico Open

Shoko Miyake, T. Koi, Y. Muraki, Y. Matsubara, S. Masuda , et al. · 2023

In association with a large solar flare on November 7, 2004, the solar neutron detectors located at Mt. Chacaltaya (5,250 m) in Bolivia and Mt. Sierra Negra (4,600 m) in Mexico recorded very interesting events. In order to explain these ev…

Proton Penetration Efficiency over Sierra Negra (Mexico) and Oulu (Finland) Open

Y. Muraki, Shoko Miyake, T. Koi, Y. Matsubara, S. Masuda , et al. · 2023

On November 7, 2004, a large solar flare was observed, which had a notable impact on the solar neutron detectors located at Mt. Chacaltaya (5,250 m) in Bolivia and Mt. Sierra Negra (4,600 m) in Mexico. In addition, the neutron monitor at O…

The 48 year data analysis of Nagoya muon telescope - Discovery of (125+-45) day periodicity Open

Y. Muraki, S. Shibata, Hiroyuki Takamaru, A. Oshima · 2023

We analyzed 48 years of the data from the Nagoya muon telescope\nwithout using the East minus West method.\nThe results confirm the existence of\n(1) one-year periodic oscillations, and\n(2) winter (4~10) day variations.\n(3) A new (125+-4…

Effectiveness of endoscopic resection for colorectal neoplasms in ulcerative colitis: a multicenter registration study Open

Minami Hirai, Shunichi Yanai, Reiko Kunisaki, Masafumi Nishio, Kenji Watanabe , et al. · 2023

Difficult colorectal polypectomy: Technical tips and recent advances Open

Sukit Pattarajierapan, Hiroyuki Takamaru, Supakij Khomvilai · 2023

Colonoscopy has been shown to be an effective modality to prevent colorectal cancer (CRC) development. CRC reduction is achieved by detecting and removing adenomas, which are precursors of CRC. Most colorectal polyps are small and do not p…

Supplementary Figure S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors Open

Seiko Kamimae, Eiichiro Yamamoto, Hiro‐o Yamano, Masanori Nojima, Hiromu Suzuki , et al. · 2023

Supplementary Figure S2 from Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors

Supplementary Table 3 from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer Open

Hiroyuki Takamaru, Eiichiro Yamamoto, Hiromu Suzuki, Masanori Nojima, Reo Maruyama , et al. · 2023

XLS file - 78K, Genes hypermethylated in background gastric mucosae from patients with diffuse type GC

Supplementary Table 4 from Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer Open

Hiroyuki Takamaru, Eiichiro Yamamoto, Hiromu Suzuki, Masanori Nojima, Reo Maruyama , et al. · 2023

XLS file - 80K, Genes commonly methylated in background gastric mucosa from patients with intestinal type GC or diffuse type GC

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