Hisako Matsumoto
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View article: Sputum symptoms and microbiome in type 2 airway diseases with mucus plugs on computed tomography
Sputum symptoms and microbiome in type 2 airway diseases with mucus plugs on computed tomography Open
View article: Sarcoidosis With Pulmonary and Bone Marrow Involvement Following Chemotherapy in a Cancer Patient
Sarcoidosis With Pulmonary and Bone Marrow Involvement Following Chemotherapy in a Cancer Patient Open
Sarcoidosis is a multisystem granulomatous disease that rarely involves the bone marrow and is particularly uncommon during chemotherapy. A 56‐year‐old Japanese woman with stage IIIc fallopian tube carcinoma developed persistent high‐grade…
View article: Clinical and pathophysiological roles of lower lobe–dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis
Clinical and pathophysiological roles of lower lobe–dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis Open
View article: Clinical and Healthcare Cost Characteristics of Severe Asthma Patients with Long-Term Control on Omalizumab: A Comparative Analysis with Patients Who Switched to Other Biologics
Clinical and Healthcare Cost Characteristics of Severe Asthma Patients with Long-Term Control on Omalizumab: A Comparative Analysis with Patients Who Switched to Other Biologics Open
Patients with nonsevere type-2 inflammation and a high BMI can achieve effective asthma control with OML, reducing treatment costs. Identifying this phenotype can improve the cost-effectiveness of biologic therapies for patients with sever…
View article: Body Composition Changes in Hospitalized Patients with Community-Acquired Pneumonia
Body Composition Changes in Hospitalized Patients with Community-Acquired Pneumonia Open
Background: The influence of hospitalization owing to pneumonia on changes in body composition has not been specifically reported. We conducted a prospective cohort study of patients with community-acquired pneumonia (CAP) requiring hospit…
View article: Potential Protective Role of Galectin‐3 in Airway Dilatation in Obstructive Airway Diseases
Potential Protective Role of Galectin‐3 in Airway Dilatation in Obstructive Airway Diseases Open
View article: From mucus plugging to airway dilatation in chronic airway diseases: A perspective on the contribution of the airway microbiome and inflammation
From mucus plugging to airway dilatation in chronic airway diseases: A perspective on the contribution of the airway microbiome and inflammation Open
Airway mucus plugs are the main pathological and computed tomography (CT) findings that affect clinical outcomes in patients with asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap. Despite the introduction of bi…
View article: Independent association of a 17q21 variant with exacerbations in type 2–low adult asthma
Independent association of a 17q21 variant with exacerbations in type 2–low adult asthma Open
The rs7216389 TT variant on 17q21 may be an independent risk factor for exacerbations in adults with type 2-low asthma, highlighting the role of GSDMB in its pathophysiology.
View article: Exploring factors associated with clinical remission in patients with severe asthma receiving anti-IL-4Rα, anti-IL-5/5R, or anti-IgE treatment
Exploring factors associated with clinical remission in patients with severe asthma receiving anti-IL-4Rα, anti-IL-5/5R, or anti-IgE treatment Open
Anti-IL-4Rα treatment may be effective for patients with severe asthma who have chronic rhinosinusitis or high FeNO levels at baseline.
View article: Clinical Characteristics of Difficult‐To‐Treat Allergic Bronchopulmonary Aspergillosis and Its Prediction Score
Clinical Characteristics of Difficult‐To‐Treat Allergic Bronchopulmonary Aspergillosis and Its Prediction Score Open
Background and Objective Administration of oral corticosteroids and/or azole antifungals for 4–6 months remains the standard treatment for allergic bronchopulmonary aspergillosis (ABPA). This study investigated the clinical characteristics…
View article: Importance of sputum and computed tomography assessments of airway neutrophil inflammation and mucus plugging in bronchiectasis management
Importance of sputum and computed tomography assessments of airway neutrophil inflammation and mucus plugging in bronchiectasis management Open
Sputum myeloperoxidase quantification and computed tomography scoring of mucus plugs in central airways deepen understanding of relationships between airway neutrophilic inflammation, mucus plugging and disease severity in patients with…
View article: Real-world usage and response to gefapixant in refractory chronic cough
Real-world usage and response to gefapixant in refractory chronic cough Open
Background The real-world efficacy of the P2X3 antagonist gefapixant, a new class of antitussive for refractory chronic cough, is not yet fully understood. This study aimed to evaluate the real-world usage and response to gefapixant in pat…
View article: A Case Report of Smear-positive Pulmonary Tuberculosis with False-negative Loop-mediated Isothermal Amplification and T-SPOT.<i>TB</i> Assays
A Case Report of Smear-positive Pulmonary Tuberculosis with False-negative Loop-mediated Isothermal Amplification and T-SPOT.<i>TB</i> Assays Open
Rapid molecular and immunological assays for tuberculosis, including loop-mediated isothermal amplification (LAMP) and T-SPOT. TB assays, may yield false-negative results. We herein report a 62-year-old immunocompetent man with a productiv…
View article: Exploring the roles of airway dipeptidyl peptidase 1 in obstructive airway disease
Exploring the roles of airway dipeptidyl peptidase 1 in obstructive airway disease Open
Background Dipeptidyl peptidase 1 (DPP1) exacerbates airway neutrophilic inflammation in bronchiectasis, which is characterised by airway dysfunction and dilation and chronic bacterial infection. However, little is known about the pathogen…
View article: Refractory phenotype of Aspergillus-sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis
Refractory phenotype of Aspergillus-sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis Open
The refractory phenotype with persistent mucus plugs was identified in Aspergillus-sensitized refractory asthma with bronchiectasis and ABPA. Mucus plug prevention is warranted.
View article: III. Asthma and Non-cystic Fibrosis Bronchiectasis
III. Asthma and Non-cystic Fibrosis Bronchiectasis Open
View article: 18. Future Asthma Treatment from the Perspective of Cytokine Regulation
18. Future Asthma Treatment from the Perspective of Cytokine Regulation Open
View article: <i>IL1RL1</i>variant may affect the response to type 2 biologics in patients with severe asthma
<i>IL1RL1</i>variant may affect the response to type 2 biologics in patients with severe asthma Open
Background Asthma is a heterogeneous disease with variable response to treatment. Genetic backgrounds are involved in the severity of type 2 asthma, but their effects on responses to biologics remain unknown. This study aimed to clarify th…
View article: Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap
Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap Open
The associations between mucus plugging and the microbiome in ACO differed from those in COPD and asthma. Greater relative abundances of the phylum Proteobacteria and genus Haemophilus may be involved in mucus plugging in patients with ACO…
View article: Diagnosis, Pathology and New Therapeutic Strategies of Bronchiecasis
Diagnosis, Pathology and New Therapeutic Strategies of Bronchiecasis Open
View article: Enhanced diaphragm excursion and exercise tolerance in COPD patients through inspiratory muscle training after standardised pulmonary rehabilitation: randomised controlled trial
Enhanced diaphragm excursion and exercise tolerance in COPD patients through inspiratory muscle training after standardised pulmonary rehabilitation: randomised controlled trial Open
Objective Inspiratory muscle training (IMT) is used to improve inspiratory muscle strength in patients with COPD. However, the effect of IMT on diaphragmatic function has not yet been thoroughly evaluated. This study aimed to evaluate the …
View article: Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
Exploring Definitions and Predictors of Response to Biologics for Severe Asthma Open
View article: Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults
Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults Open
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify t…
View article: Prevalence and causes of chronic cough in Japan
Prevalence and causes of chronic cough in Japan Open
We confirmed that the main causes of chronic cough were cough variant asthma, SBS, atopic cough, and their complications. We also showed that complicated GER-associated cough was more likely to become refractory. This is the first nationwi…
View article: Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma
Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma Open
Higher FeNO may reflect the inflammation and remodeling of relatively peripheral airways in asthma in both former smokers and nonsmokers.
View article: 18. Future Asthma Treatment from the Perspective of Cytokine Regulation
18. Future Asthma Treatment from the Perspective of Cytokine Regulation Open
View article: Improvement of diaphragmatic excursion in the supine position in a patient with idiopathic pleuroparenchymal fibroelastosis: A case report
Improvement of diaphragmatic excursion in the supine position in a patient with idiopathic pleuroparenchymal fibroelastosis: A case report Open
Idiopathic pleuroparenchymal fibroelastosis (iPPFE) is a rare form of idiopathic interstitial pneumonia. We report a case of a patient with iPPFE in whom postural changes improved diaphragmatic excursion (DE) and exercise tolerance. Chest …
View article: Clinical characteristics of allergic bronchopulmonary mycosis caused by <i>Schizophyllum commune</i>
Clinical characteristics of allergic bronchopulmonary mycosis caused by <i>Schizophyllum commune</i> Open
Background Allergic bronchopulmonary mycosis (ABPM) is an allergic disease caused by type I and type III hypersensitivity to environmental fungi. Schizophyllum commune , a basidiomycete fungus, is one of the most common fungi that causes n…
View article: Increased blood eosinophils and airflow obstruction as new-onset asthma predictors in the elderly: The Nagahama study
Increased blood eosinophils and airflow obstruction as new-onset asthma predictors in the elderly: The Nagahama study Open
Eosinophilic inflammation and airflow obstruction may predict subsequent new-onset asthma after the age of 65 years. Revealing the characteristics of new-onset asthma in the elderly can aid in the prevention of underdiagnosed asthma.
View article: Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap
Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap Open