Hisao Yamada
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View article: Aging-related changes of miR-23b-3p expression in extracellular vesicles from mesenchymal stromal cells affect TGFBR3 signaling
Aging-related changes of miR-23b-3p expression in extracellular vesicles from mesenchymal stromal cells affect TGFBR3 signaling Open
Extracellular vesicles (EVs), which carry biological mediators such as microRNAs (miRNAs) and cytokines, play a crucial role in regulating recipient tissues and are considered a key mechanism of action in cell therapy. However, it has been…
View article: Epigenetic Clocks and EpiScore for Preventive Medicine: Risk Stratification and Intervention Models for Age-Related Diseases
Epigenetic Clocks and EpiScore for Preventive Medicine: Risk Stratification and Intervention Models for Age-Related Diseases Open
Aging is the primary risk factor for chronic diseases such as cardiovascular disease, cancer, and dementia. However, chronological age alone fails to capture individual variability in aging trajectories and disease susceptibility. Recent a…
View article: Epigenetic Clocks and EpiScore for Preventive Medicine: Risk Stratification and Intervention Models for Age-Related Diseases
Epigenetic Clocks and EpiScore for Preventive Medicine: Risk Stratification and Intervention Models for Age-Related Diseases Open
Background: Recent advances in aging research have enabled quantification of biological age through epigenetic clocks and the emergence of EpiScore, reshaping our understanding of aging and health. Methods: This review synthesizes key stud…
View article: Cytoplasmic Polyadenylation Element-Binding Protein 1 Post-transcriptionally Regulates Fragile X Mental Retardation 1 Expression Through 3′ Untranslated Region in Central Nervous System Neurons
Cytoplasmic Polyadenylation Element-Binding Protein 1 Post-transcriptionally Regulates Fragile X Mental Retardation 1 Expression Through 3′ Untranslated Region in Central Nervous System Neurons Open
Fragile X syndrome (FXS) is an inherited intellectual disability caused by a deficiency in Fragile X mental retardation 1 ( Fmr1 ) gene expression. Recent studies have proposed the importance of cytoplasmic polyadenylation element-binding …
View article: <i>Cpeb1</i> expression is post‐transcriptionally regulated by AUF1, CPEB1, and microRNAs
<i>Cpeb1</i> expression is post‐transcriptionally regulated by AUF1, CPEB1, and microRNAs Open
Cytoplasmic polyadenylation element binding protein 1 (CPEB1) regulates the translation of numerous mRNAs. We previously showed that AU‐rich binding factor 1 (AUF1) regulates Cpeb1 expression through the 3’ untranslated region (3’UTR). To …
View article: GATA4/6 regulate DHH transcription in rat adrenocortical autografts
GATA4/6 regulate DHH transcription in rat adrenocortical autografts Open
Adrenal cortex autotransplantation with ACTH stimulation may be an alternative therapy for patients with bilateral adrenalectomy to avoid adrenal crisis, but its underlying mechanism has not been elucidated. Previously, we detected Dhh upr…
View article: Hedgehog signaling pathway in the adrenal gland
Hedgehog signaling pathway in the adrenal gland Open
われわれは，最新の組織化学的手法を駆使したラット副腎皮質自家移植片再生過程の解析によって，これまで明らかとなっていなかった副腎皮質自家移植片再生のカギとなりうるシグナル経路を同定した．新規in situ hybridizationであるRNA scopeによって，移植片再生過程におけるDesert hedgehog（Dhh）の一過性発現上昇とSonic hedgehog（Shh）の発現低下を明らかとした．DHHは性腺に限局した発現を示すヘッジホッグファミリータンパクとされて…
View article: Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription
Involvement of PLAGL1/ZAC1 in hypocretin/orexin transcription Open
The hypocretin/orexin neuropeptide system coordinates the regulation of various physiological processes. Our previous study reported that a reduction in the expression of pleomorphic adenoma gene‑like 1 (Plagl1), which encodes a C2H2 zinc‑…
View article: BS2.3 - Chain-shaped plasmonic crystal for highly sensitive label-free biosensor
BS2.3 - Chain-shaped plasmonic crystal for highly sensitive label-free biosensor Open
In this study, we designed and fabricated plasmonic crystal (PC) which has chain-shaped periodic metal nanostructures for excitation of the localized surface plasmon resonance (LSPR) at two different wavelength by changing polarization of …
View article: Hypothalamo-hypophysial system in rats with autotransplantation of the adrenal cortex
Hypothalamo-hypophysial system in rats with autotransplantation of the adrenal cortex Open
Patients with bilateral pheochromocytoma often require an adrenalectomy. Autotransplantation of the adrenal cortex is an alternative therapy that could potentially be performed instead of receiving glucocorticoid replacement following adre…
View article: A Device for Ribbon Collection for Array Tomography with Scanning Electron Microscopy
A Device for Ribbon Collection for Array Tomography with Scanning Electron Microscopy Open
"Array tomography" is a method used to observe the fine structure of cells and tissues in a three-dimensional view. In this method, serial ultrathin sections in the ribbon state (ribbons) are mounted on a solid substrate and observed by sc…
View article: Anti-Tribbles Pseudokinase 2 (TRIB2)-Immunization Modulates Hypocretin/Orexin Neuronal Functions
Anti-Tribbles Pseudokinase 2 (TRIB2)-Immunization Modulates Hypocretin/Orexin Neuronal Functions Open
Our results suggest that the general activation of the immune system modulates the functions of hypocretin neurons. The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in…