Hisashi Fujioka
YOU?
Author Swipe
View article: Loss of mouse C19orf12 homolog disturbs tubular ER homeostasis and leads to neuroaxonal dystrophy
Loss of mouse C19orf12 homolog disturbs tubular ER homeostasis and leads to neuroaxonal dystrophy Open
Neurodegeneration with brain iron accumulation (NBIA) is a group of rare diseases associated with genetic mutations in several genes including C19orf12. To explore the underlying mechanism of NBIA pathogenesis, we investigated a mouse homo…
View article: Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury
Inhibiting 15-PGDH blocks blood–brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury Open
Alzheimer’s disease (AD) and traumatic brain injury (TBI) are currently untreatable neurodegenerative disorders afflicting millions of people worldwide. These conditions are pathologically related, and TBI is one of the greatest risk facto…
View article: Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes
Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes Open
Background Activation of mitochondrial fission and quality control occur early in the onset of insulin resistance in human skeletal muscle. We hypothesized that differences in mitochondrial dynamics, structure and bioenergetics in humans w…
View article: Deterioration of neuronal primary cilia in Alzheimer’s disease
Deterioration of neuronal primary cilia in Alzheimer’s disease Open
Background Emerging evidence links Alzheimer’s disease (AD) to dysfunction of the primary cilium, a historically overlooked organelle that serves as the neuron’s antenna. All neurons harbor a single primary cilium that projects from the me…
View article: Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury
Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury Open
Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurod…
View article: Intraneuronal β-amyloid impaired mitochondrial proteostasis through the impact on LONP1
Intraneuronal β-amyloid impaired mitochondrial proteostasis through the impact on LONP1 Open
Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease (AD). Mitochondrial proteostasis regulated by chaperones and proteases in each compartment of mitochondria is critical for mitochondrial function, a…
View article: Intermittent Ex Vivo Lung Perfusion in a Porcine Model for Prolonged Lung Preservation
Intermittent Ex Vivo Lung Perfusion in a Porcine Model for Prolonged Lung Preservation Open
Background. Ex vivo lung perfusion expands the lung transplant donor pool and extends preservation time beyond cold static preservation. We hypothesized that repeated regular ex vivo lung perfusion would better maintain lung grafts. Method…
View article: Bezafibrate confers neuroprotection in the 5xFAD mouse model of Alzheimer's disease
Bezafibrate confers neuroprotection in the 5xFAD mouse model of Alzheimer's disease Open
View article: Fluorescent Nanoparticle Uptake by Myzocytosis and Endocytosis in Colpodella sp. ATCC 50594
Fluorescent Nanoparticle Uptake by Myzocytosis and Endocytosis in Colpodella sp. ATCC 50594 Open
Colpodella sp. (ATCC 50594) is a free-living biflagellate predator closely related to pathogenic Apicomplexa such as Plasmodium, Cryptosporidium and Toxoplasma gondii. Colpodella sp. (ATCC 50594) obtain nutrients by preying on Parabodo cau…
View article: Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain
Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain Open
Loss of synapses is the most robust pathological correlate of Alzheimer’s disease (AD)-associated cognitive deficits, although the underlying mechanism remains incompletely understood. Synaptic terminals have abundant mitochondria which pl…
View article: α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention
α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention Open
Γ-Crystallins play a major role in age-related lens transparency. Their destabilization by mutations and physical chemical insults are associated with cataract formation. Therefore, drugs that increase their stability should have anticatar…
View article: Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease Open
View article: Ultrastructure of Myzocytosis and Cyst Formation, and the Role of Actin in Tubular Tether Formation in Colpodella sp. (ATCC 50594)
Ultrastructure of Myzocytosis and Cyst Formation, and the Role of Actin in Tubular Tether Formation in Colpodella sp. (ATCC 50594) Open
Free-living relatives of the Apicomplexa such as Colpodella species, Alphamonas species, and Voromonas pontica are predators that prey on ciliate, bodonid, and algal prey using the process of myzocytosis. During myzocytosis, the pseudocono…
View article: Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control
Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control Open
Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organell…
View article: Mitochondrial Fusion Suppresses Tau Pathology-Induced Neurodegeneration and Cognitive Decline
Mitochondrial Fusion Suppresses Tau Pathology-Induced Neurodegeneration and Cognitive Decline Open
Background: Abnormalities of mitochondrial fission and fusion, dynamic processes known to be essential for various aspects of mitochondrial function, have repeatedly been reported to be altered in Alzheimer’s disease (AD). Neurofibrillary …
View article: Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics
Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics Open
View article: Translational regulation in the brain by TDP-43 phase separation
Translational regulation in the brain by TDP-43 phase separation Open
The in vivo physiological function of liquid–liquid phase separation (LLPS) that governs non–membrane-bound structures remains elusive. Among LLPS-prone proteins, TAR DNA-binding protein of 43 kD (TDP-43) is under intense investigation bec…
View article: Colpodella sp. (ATCC 50594) Life Cycle: Myzocytosis and Possible Links to the Origin of Intracellular Parasitism
Colpodella sp. (ATCC 50594) Life Cycle: Myzocytosis and Possible Links to the Origin of Intracellular Parasitism Open
Colpodella species are free living bi-flagellated protists that prey on algae and bodonids in a process known as myzocytosis. Colpodella species are phylogenetically related to Apicomplexa. We investigated the life cycle of Colpodella sp. …
View article: The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering <i>in vivo</i>
The role of Mfn2 in the structure and function of endoplasmic reticulum-mitochondrial tethering <i>in vivo</i> Open
Mitochondria-endoplasmic reticulum contacts (MERCs) play an essential role in multiple cell physiological processes. Although Mfn2 was the first protein implicated in the formation of MERCs, there is debate as to whether it acts as a tethe…
View article: Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans Open
View article: <i>VPS35</i> D620N knockin mice recapitulate cardinal features of Parkinson’s disease
<i>VPS35</i> D620N knockin mice recapitulate cardinal features of Parkinson’s disease Open
D620N mutation in the vacuolar protein sorting 35 ortholog (VPS35) gene causes late‐onset, autosomal dominant familial Parkinson's disease (PD) and contributes to idiopathic PD. However, how D620N mutation leads to PD‐related deficits in v…
View article: Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease Open
The Drp1-HK1-NLRP3 axis is a key mechanism of oligodendrocyte damage and white matter degeneration in AD.
View article: P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition
P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition Open
Significance Chronic neurodegeneration, a major cause of the long-term disabilities that afflict survivors of traumatic brain injury (TBI), is linked to an increased risk for late-life neurodegenerative disorders, including Alzheimer’s dis…
View article: Massive Release of CD9+ Microvesicles in Human Immunodeficiency Virus Infection, Regardless of Virologic Control
Massive Release of CD9+ Microvesicles in Human Immunodeficiency Virus Infection, Regardless of Virologic Control Open
Background The role of extracellular vesicles (EVs) in human immunodeficiency virus (HIV) pathogenesis is unknown. We examine the cellular origin of plasma microvesicles (MVs), a type of ectocytosis-derived EV, the presence of mitochondria…
View article: BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control Open
Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long-term weight control. This is due, in part, to difficulties in identifying tolerab…
View article: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease Open
Alzheimer’s disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates …
View article: Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death
Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death Open
It is believed that mitochondrial fragmentation cause mitochondrial dysfunction and neuronal deficits in Alzheimer’s disease. We recently reported that constitutive knockout of the mitochondria fusion protein mitofusin2 (Mfn2) in the mouse…
View article: DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1 Open
Significance Endoplasmic reticulum (ER) and mitochondria form close associations that serve as a critical signaling platform. Loss-of-function mutations in DJ-1 are associated with autosomal recessive early onset Parkinson’s disease (PD). …
View article: PTBP2-dependent alternative splicing regulates protein transport and mitochondria morphology in post-meiotic germ cells.
PTBP2-dependent alternative splicing regulates protein transport and mitochondria morphology in post-meiotic germ cells. Open
The RNA binding protein PTBP2 (polypyrimidine tract binding protein 2) is a key regulator of tissue-specific alternative RNA splicing. In the testis, PTBP2 is expressed in meiotic and post-meiotic germ cells (spermatocytes and spermatids, …
View article: Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity
Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity Open
Aim The subsarcolemmal ( SSM ) and interfibrillar ( IFM ) mitochondria in skeletal muscle appear to have distinct biochemical properties affecting metabolism in health and disease. The isolation of mitochondrial subpopulations has been a l…