Hishan Tharmaseelan
YOU?
Author Swipe
View article: Early Free Light‐Chain Suppression as a Prognostic Marker in Relapsed and Refractory Myeloma Patients Treated With BCMA‐Directed CAR‐T Cells
Early Free Light‐Chain Suppression as a Prognostic Marker in Relapsed and Refractory Myeloma Patients Treated With BCMA‐Directed CAR‐T Cells Open
Background Relapsed/refractory multiple myeloma (RRMM) remains difficult to treat despite advances in therapy. B‐cell maturation antigen (BCMA)‐directed chimeric antigen receptor T‐cell (CAR‐T) therapies, such as idecabtagene vicleucel (id…
View article: Sequential BCMA CAR T-cell therapy in refractory multiple myeloma
Sequential BCMA CAR T-cell therapy in refractory multiple myeloma Open
Multiple myeloma (MM) relapsing after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell treatment remains a therapeutic challenge. Data on re-exposure to CAR T-cell therapy targeting the same antigen are scar…
View article: 828 | TRIAL IN PROGRESS: PEMBROLIZUMAB IN COMBINATION WITH SALVAGE CHEMOTHERAPY FOR FIRST‐RELAPSED OR REFRACTORY CLASSICAL HODGKIN LYMPHOMA (PEMBRO‐CORE)
828 | TRIAL IN PROGRESS: PEMBROLIZUMAB IN COMBINATION WITH SALVAGE CHEMOTHERAPY FOR FIRST‐RELAPSED OR REFRACTORY CLASSICAL HODGKIN LYMPHOMA (PEMBRO‐CORE) Open
View article: 358 | PD‐1‐BASED SALVAGE THERAPY FOR RELAPSED AND REFRACTORY HODGKIN LYMPHOMA: A MULTICENTER REAL‐WORLD ANALYSIS
358 | PD‐1‐BASED SALVAGE THERAPY FOR RELAPSED AND REFRACTORY HODGKIN LYMPHOMA: A MULTICENTER REAL‐WORLD ANALYSIS Open
View article: 356 | METABOLIC TUMOR VOLUME IN OLDER PATIENTS WITH ADVANCED‐STAGE CLASSIC HODGKIN LYMPHOMA: RESULTS FROM THE GHSG HD21 TRIAL
356 | METABOLIC TUMOR VOLUME IN OLDER PATIENTS WITH ADVANCED‐STAGE CLASSIC HODGKIN LYMPHOMA: RESULTS FROM THE GHSG HD21 TRIAL Open
View article: Correction: Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials
Correction: Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials Open
View article: Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials
Correlation of progression-free survival and overall survival after treatment for relapsed Hodgkin lymphoma: individual patient data analysis of randomized German Hodgkin Study Group (GHSG) Trials Open
View article: Post-transplant-cyclophosphamide plus everolimus as GvHD prophylaxis in refractory T- and B-cell lymphoma
Post-transplant-cyclophosphamide plus everolimus as GvHD prophylaxis in refractory T- and B-cell lymphoma Open
View article: Comparison of diagnostic accuracy of radiomics parameter maps and standard reconstruction for the detection of liver lesions in computed tomography
Comparison of diagnostic accuracy of radiomics parameter maps and standard reconstruction for the detection of liver lesions in computed tomography Open
Background The liver is a frequent location of metastatic disease in various malignant tumor entities. Computed tomography (CT) is the most frequently employed modality for initial diagnosis. However, liver metastases may only be delineate…
View article: Post-Transplant-Cyclophosphamide and short-term Everolimus as Graft-versus-Host-Prophylaxis in a real –world cohort of patients with refractory T- and B-cell Lymphoma
Post-Transplant-Cyclophosphamide and short-term Everolimus as Graft-versus-Host-Prophylaxis in a real –world cohort of patients with refractory T- and B-cell Lymphoma Open
Background: A growing array of therapies exists for aggressive lymphomas. However, for refractory lymphomas following CAR-T cell treatment, prospects are grim, often leaving allogeneic bone marrow transplantation (aHSCT) as the sole curati…
View article: Textural heterogeneity of liver lesions in CT imaging - comparison of colorectal and pancreatic metastases
Textural heterogeneity of liver lesions in CT imaging - comparison of colorectal and pancreatic metastases Open
Purpose Tumoral heterogeneity poses a challenge for personalized cancer treatments. Especially in metastasized cancer, it remains a major limitation for successful targeted therapy, often leading to drug resistance due to tumoral escape me…
View article: Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan
Uncertainty-aware deep-learning model for prediction of supratentorial hematoma expansion from admission non-contrast head computed tomography scan Open
Hematoma expansion (HE) is a modifiable risk factor and a potential treatment target in patients with intracerebral hemorrhage (ICH). We aimed to train and validate deep-learning models for high-confidence prediction of supratentorial ICH …
View article: Analysis of Epicardial Adipose Tissue Texture in Relation to Coronary Artery Calcification in PCCT: The EAT Signature!
Analysis of Epicardial Adipose Tissue Texture in Relation to Coronary Artery Calcification in PCCT: The EAT Signature! Open
(1) Background: Epicardial adipose tissue influences cardiac biology in physiological and pathological terms. As it is suspected to be linked to coronary artery calcification, identifying improved methods of diagnostics for these patients …
View article: Correction: Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment
Correction: Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment Open
Correction to: Imaging-based characterization of tumoral heterogeneity for personalized cancer treatmentRofo 2024; 196(03): 262-272DOI: 10.1055/a-2175-4622
View article: Computed tomography imaging phenotypes of hepatoblastoma identified from radiomics signatures are associated with the efficacy of neoadjuvant chemotherapy
Computed tomography imaging phenotypes of hepatoblastoma identified from radiomics signatures are associated with the efficacy of neoadjuvant chemotherapy Open
Background Though neoadjuvant chemotherapy has been widely used in the treatment of hepatoblastoma, there still lacks an effective way to predict its effect. Objective To characterize hepatoblastoma based on radiomics image features and id…
View article: Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment
Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment Open
With personalized tumor therapy, understanding and addressing the heterogeneity of malignant tumors is becoming increasingly important. Heterogeneity can be found within one lesion (intralesional) and between several tumor lesions emerging…
View article: Pericoronary radiomics texture features associated with hypercholesterolemia on a photon-counting-CT
Pericoronary radiomics texture features associated with hypercholesterolemia on a photon-counting-CT Open
Introduction Pericoronary adipose tissue (PCAT) stands in complex bidirectional interaction with the surrounding arteries and is known to be connected to many cardiovascular diseases involving vascular inflammation. PCAT texture may be inf…
View article: Tumor classification of gastrointestinal liver metastases using CT-based radiomics and deep learning
Tumor classification of gastrointestinal liver metastases using CT-based radiomics and deep learning Open
Objectives The goal of this study is to demonstrate the performance of radiomics and CNN-based classifiers in determining the primary origin of gastrointestinal liver metastases for visually indistinguishable lesions. Methods In this retro…
View article: Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study
Clinical implications of Peri-hematomal edema microperfusion fraction in intracerebral hemorrhage intravoxel incoherent motion imaging – A pilot study Open
View article: Radiomic markers of intracerebral hemorrhage expansion on non-contrast CT: independent validation and comparison with visual markers
Radiomic markers of intracerebral hemorrhage expansion on non-contrast CT: independent validation and comparison with visual markers Open
Objective To devise and validate radiomic signatures of impending hematoma expansion (HE) based on admission non-contrast head computed tomography (CT) of patients with intracerebral hemorrhage (ICH). Methods Utilizing a large multicentric…
View article: Periaortic adipose radiomics texture features associated with increased coronary calcium score—first results on a photon-counting-CT
Periaortic adipose radiomics texture features associated with increased coronary calcium score—first results on a photon-counting-CT Open
Background Cardiovascular diseases remain the world’s primary cause of death. The identification and treatment of patients at risk of cardiovascular events thus are as important as ever. Adipose tissue is a classic risk factor for cardiova…
View article: Phantom-based radiomics feature test–retest stability analysis on photon-counting detector CT
Phantom-based radiomics feature test–retest stability analysis on photon-counting detector CT Open
View article: Evaluation of radiomics feature stability in abdominal monoenergetic photon counting CT reconstructions
Evaluation of radiomics feature stability in abdominal monoenergetic photon counting CT reconstructions Open
View article: The Potential and Emerging Role of Quantitative Imaging Biomarkers for Cancer Characterization
The Potential and Emerging Role of Quantitative Imaging Biomarkers for Cancer Characterization Open
Similar to the transformation towards personalized oncology treatment, emerging techniques for evaluating oncologic imaging are fostering a transition from traditional response assessment towards more comprehensive cancer characterization …
View article: Myocardial Radiomics Texture Features Associated with Increased Coronary Calcium Score—First Results of a Photon-Counting CT
Myocardial Radiomics Texture Features Associated with Increased Coronary Calcium Score—First Results of a Photon-Counting CT Open
The coronary artery calcium score is an independent risk factor of the development of adverse cardiac events. The severity of coronary artery calcification may influence the myocardial texture. Due to higher spatial resolution and signal-t…
View article: Influence of local aortic calcification on periaortic adipose tissue radiomics texture features—a primary analysis on PCCT
Influence of local aortic calcification on periaortic adipose tissue radiomics texture features—a primary analysis on PCCT Open
View article: Comparison Study of Myocardial Radiomics Feature Properties on Energy-Integrating and Photon-Counting Detector CT
Comparison Study of Myocardial Radiomics Feature Properties on Energy-Integrating and Photon-Counting Detector CT Open
The implementation of radiomics-based, quantitative imaging parameters is hampered by a lack of stability and standardization. Photon-counting computed tomography (PCCT), compared to energy-integrating computed tomography (EICT), does rely…
View article: Identification of CT Imaging Phenotypes of Colorectal Liver Metastases from Radiomics Signatures—Towards Assessment of Interlesional Tumor Heterogeneity
Identification of CT Imaging Phenotypes of Colorectal Liver Metastases from Radiomics Signatures—Towards Assessment of Interlesional Tumor Heterogeneity Open
(1) Background: Tumoral heterogeneity (TH) is a major challenge in the treatment of metastatic colorectal cancer (mCRC) and is associated with inferior response. Therefore, the identification of TH would be beneficial for treatment plannin…
View article: The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volume
The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volume Open
Background Among prognostic imaging variables, the hematoma volume on admission computed tomography (CT) has long been considered the strongest predictor of outcome and mortality in intracerebral hemorrhage. Aims To examine whether differe…
View article: Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH‐2 trial intracerebral hemorrhage population
Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH‐2 trial intracerebral hemorrhage population Open
Background and purpose Radiomics provides a framework for automated extraction of high‐dimensional feature sets from medical images. We aimed to determine radiomics signature correlates of admission clinical severity and medium‐term outcom…