Hitoshi Fujiwara
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View article: Minimally Invasive Esophagectomy for Esophageal Cancer: Current Evidence and Future Perspectives
Minimally Invasive Esophagectomy for Esophageal Cancer: Current Evidence and Future Perspectives Open
Aim Esophageal cancer is a highly aggressive malignancy with regional variations in histological subtypes. Adenocarcinoma predominates in Western countries, whereas squamous cell carcinoma is more common in Asia. Despite advances in multim…
View article: Incidental rib hotspots on 99mTc-pyrophosphate scintigraphy in a patient with transthyretin cardiac amyloidosis: cough-induced fractures unveiled
Incidental rib hotspots on 99mTc-pyrophosphate scintigraphy in a patient with transthyretin cardiac amyloidosis: cough-induced fractures unveiled Open
View article: Cardiac Beriberi After Gastrectomy Presenting With Peripheral Neuropathy and Mimicking Tachycardia-Induced Cardiomyopathy: A Case Report
Cardiac Beriberi After Gastrectomy Presenting With Peripheral Neuropathy and Mimicking Tachycardia-Induced Cardiomyopathy: A Case Report Open
View article: Positive lymph node ratio as a nodal staging system to avoid stage migration between remnant and primary proximal gastric cancers
Positive lymph node ratio as a nodal staging system to avoid stage migration between remnant and primary proximal gastric cancers Open
Nodal staging of gastric cancer (GC) based on the number of positive lymph nodes (PLNs) is a robust prognostic factor. However, the number of retrieved lymph nodes in remnant GC (RGC) may be lower than in primary GC owing to variations in …
View article: Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer
Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer Open
Recent studies indicate that reduced levels of certain tumor-suppressing microRNAs (miRNAs) circulating in the blood are linked to tumor progression and poor prognosis across various types of malignancies. Identified from a comprehensive a…
View article: Worldwide survey on the transcervical approach for minimally invasive treatment of esophageal cancer: results of questionnaire of the international collaborative group on transCervical Minimally Invasive Esophagectomy
Worldwide survey on the transcervical approach for minimally invasive treatment of esophageal cancer: results of questionnaire of the international collaborative group on transCervical Minimally Invasive Esophagectomy Open
Summary Minimally invasive esophagectomy has emerged over open surgery, showing important advantages on the short time and comparable oncological outcomes, though concerns persist about pulmonary complications. The avoidance of the thoraci…
View article: An Unusual Case of Transthyretin Cardiac Amyloidosis Presenting as Heart Failure With Improved Ejection Fraction Without Left Ventricular Hypertrophy
An Unusual Case of Transthyretin Cardiac Amyloidosis Presenting as Heart Failure With Improved Ejection Fraction Without Left Ventricular Hypertrophy Open
Heart failure with preserved ejection fraction (EF) and left ventricular (LV) hypertrophy (LVH) are typical phenotypes of transthyretin cardiac amyloidosis (ATTR-CA). Extracardiac manifestations, such as carpal tunnel syndrome, lumbar spin…
View article: Effectiveness of a low-glycaemic-index formula on post-gastrectomy hypoglycaemia in patients with gastric cancer: randomized crossover study
Effectiveness of a low-glycaemic-index formula on post-gastrectomy hypoglycaemia in patients with gastric cancer: randomized crossover study Open
Background Patients undergoing gastrectomy often experience postprandial hypoglycaemia, late dumping syndrome, and night-time hypoglycaemia. However, countermeasures for post-gastrectomy hypoglycaemia rely on the patients’ own efforts. We …
View article: Re-examining the optimal extent of lymph node dissection for colon cancer using the lymphadenectomy index
Re-examining the optimal extent of lymph node dissection for colon cancer using the lymphadenectomy index Open
The optimal extent of lymph node dissection in colon cancer surgery is specified in guidelines based on the results of past analyses. However, with advances in surgical techniques and multidisciplinary treatments, the clinical significance…
View article: Transthyretin Cardiac Amyloidosis in a Very Elderly Patient With a History of Inferior Myocardial Infarction: A Case Report
Transthyretin Cardiac Amyloidosis in a Very Elderly Patient With a History of Inferior Myocardial Infarction: A Case Report Open
View article: Prognostic value of liver metastasis in patients with esophageal squamous cell carcinoma treated with nivolumab
Prognostic value of liver metastasis in patients with esophageal squamous cell carcinoma treated with nivolumab Open
Nivolumab has been approved for unresectable recurrent advanced esophageal cancer. The present study aimed to provide real-world data on diverse patient profiles, including the elderly and those with poor performance status, while explorin…
View article: Overexpression of SHANK2 contributes malignant outcomes as a Hippo pathway regulator in gastric cancer
Overexpression of SHANK2 contributes malignant outcomes as a Hippo pathway regulator in gastric cancer Open
These findings suggest that SHANK2 plays a crucial role in tumor malignant potential through the Hippo pathway suppression and highlight its usefulness as a prognostic factor and potential therapeutic target in GC.
View article: Neoadjuvant Chemotherapy Followed by Laparoscopic and Endoscopic Cooperative Surgery for Locally Advanced Duodenal Gastrointestinal Stromal Tumor: A Case Report
Neoadjuvant Chemotherapy Followed by Laparoscopic and Endoscopic Cooperative Surgery for Locally Advanced Duodenal Gastrointestinal Stromal Tumor: A Case Report Open
Neoadjuvant imatinib effectively downsized a locally advanced D-GIST, enabling safe, minimally invasive resection via D-LECS. This case highlights the potential of NAC and D-LECS as a less invasive alternative to PD in anatomically challen…
View article: An Atypical Case of Licorice-Induced Pseudoaldosteronism Presenting With Decreased Urine Potassium Excretion in the Presence of Severe Hypokalemia in a Very Elderly Patient
An Atypical Case of Licorice-Induced Pseudoaldosteronism Presenting With Decreased Urine Potassium Excretion in the Presence of Severe Hypokalemia in a Very Elderly Patient Open
Most herbal medicines contain licorice, which may inhibit 11-beta-hydroxysteroid dehydrogenase type 2 (11βHSD2). When licorice inhibits 11βHSD2, accumulated cortisol binds excessively to the mineralocorticoid receptor (MR) instead of aldos…
View article: Association between surgical difficulty and tumor location based on subsegments of the Glisson branches in laparoscopic liver resection
Association between surgical difficulty and tumor location based on subsegments of the Glisson branches in laparoscopic liver resection Open
Background Laparoscopic liver resection has a steep learning curve, and multiple difficulty‐scoring systems have been proposed to support safe implementation. Though the IWATE scoring system is widely used, the rationale for its tumor loca…
View article: X‐Raying Neutral Density Disturbances in the Mesosphere and Lower Thermosphere Induced by the 2022 Hunga‐Tonga Volcano Eruption‐Explosion
X‐Raying Neutral Density Disturbances in the Mesosphere and Lower Thermosphere Induced by the 2022 Hunga‐Tonga Volcano Eruption‐Explosion Open
We present X‐ray observations of the upper atmospheric density disturbance caused by the explosive eruption of the Hunga Tonga‐Hunga Ha'apai (HTHH) volcano on 15 January 2022. From 14 January to 16 January, the Chinese X‐ray astronomy sate…
View article: Re-examining the Optimal Extent of Lymph Node Dissection for Colon Cancer using the Lymphadenectomy Index
Re-examining the Optimal Extent of Lymph Node Dissection for Colon Cancer using the Lymphadenectomy Index Open
The optimal extent of lymph node dissection in colon cancer surgery is specified in guidelines based on the results of past analyses. However, with advances in surgical techniques and multidisciplinary treatments, the clinical significance…
View article: Efficacy of Sacubitril/Valsartan in a Patient With Heart Failure and Impaired Secretion of Atrial Natriuretic Peptide Due to Long-Standing Persistent Atrial Fibrillation
Efficacy of Sacubitril/Valsartan in a Patient With Heart Failure and Impaired Secretion of Atrial Natriuretic Peptide Due to Long-Standing Persistent Atrial Fibrillation Open
View article: Patients with T4N0 and T1‑3N1 colon cancer and a high preoperative carcinoembryonic antigen level benefit from adjuvant chemotherapy with oxaliplatin for 6 months
Patients with T4N0 and T1‑3N1 colon cancer and a high preoperative carcinoembryonic antigen level benefit from adjuvant chemotherapy with oxaliplatin for 6 months Open
A shorter duration of oxaliplatin adjuvant chemotherapy has recently emerged as a potential option for patients with high-risk stage II and low-risk stage III (T1-3N1) colon cancer (CC). The present study aimed to elucidate the risk factor…
View article: X-Raying Neutral Density Disturbances in the Mesosphere and Lower Thermosphere induced by the 2022 Hunga-Tonga Volcano Eruption-Explosion
X-Raying Neutral Density Disturbances in the Mesosphere and Lower Thermosphere induced by the 2022 Hunga-Tonga Volcano Eruption-Explosion Open
We present X-ray observations of the upper atmospheric density disturbance caused by the explosive eruption of the Hunga Tonga-Hunga Ha'apai (HTHH) volcano on 15 January 2022. From 14 January to 16 January, the Chinese X-ray astronomy sate…
View article: Recurrent Thrombosis in a Very Elderly Patient With Dementia, Atrial Fibrillation, and Idiopathic Thrombocytopenic Purpura on Eltrombopag Treatment
Recurrent Thrombosis in a Very Elderly Patient With Dementia, Atrial Fibrillation, and Idiopathic Thrombocytopenic Purpura on Eltrombopag Treatment Open
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder, leading to an increased bruising and bleeding tendency. Eltrombopag, a thrombopoietin receptor agonist, is an effective treatment option even in elderly patients with ITP…
View article: Deep pelvis and low visceral fat mass as risk factors for neurogenic bladder after rectal cancer surgery
Deep pelvis and low visceral fat mass as risk factors for neurogenic bladder after rectal cancer surgery Open
Lower VFA, older age, and prolonged surgery are independent risk factors for developing PONB. Additionally, a deep pelvis is an independent risk factor for severe PONB. Delicate surgical techniques should consider the risk of nerve injury …
View article: 260. LOW BLOOD LEVEL OF TUMOR SUPPRESSOR MIR-3619 AS A TARGET OF NUCLEIC ACID THERAPY TO PIM-1 IN ESOPHAGEAL CANCER
260. LOW BLOOD LEVEL OF TUMOR SUPPRESSOR MIR-3619 AS A TARGET OF NUCLEIC ACID THERAPY TO PIM-1 IN ESOPHAGEAL CANCER Open
Background Numerous studies have attempted to understand the molecular mechanisms of tumorigenesis and identify clinical biomarkers and molecular targets for esophageal squamous cell carcinoma (ESCC). However, there are still only a few bi…
View article: Extracellular glypican‐1 affects tumor progression and prognosis in esophageal cancer
Extracellular glypican‐1 affects tumor progression and prognosis in esophageal cancer Open
Introduction Cells are covered with a glycan surface layer that is referred to as the glycocalyx (GCX). It has been reported that the formation of the GCX is promoted on cancer cells and is associated with tumor growth and metastasis. Hepa…
View article: 557. POTENTIAL THERAPEUTIC TARGETS OF TRPV2 AND SLC12A2 IN ESOPHAGEAL ADENOCARCINOMA CANCER STEM CELLS
557. POTENTIAL THERAPEUTIC TARGETS OF TRPV2 AND SLC12A2 IN ESOPHAGEAL ADENOCARCINOMA CANCER STEM CELLS Open
Background Cancer stem cells (CSCs) are resistant to current anticancer drugs and radiation. The membrane transporters have recently been reported to play crucial roles for Esophageal adenocarcinoma (EA) CSCs. The aim of our study was to i…
View article: 478. OVERVIEW ON USE OF THE TRANSCERVICAL MEDIASTINOSCOPIC APPROACH FOR MINIMALLY INVASIVE TREATMENT OF ESOPHAGEAL CANCER: ESTABLISHMENT OF INTERNATIONAL COLLABORATIVE GROUP
478. OVERVIEW ON USE OF THE TRANSCERVICAL MEDIASTINOSCOPIC APPROACH FOR MINIMALLY INVASIVE TREATMENT OF ESOPHAGEAL CANCER: ESTABLISHMENT OF INTERNATIONAL COLLABORATIVE GROUP Open
Background Minimally invasive esophagectomy has emerged as a promising alternative to open surgery, demonstrating reduced postoperative complications and comparable oncological outcomes. Despite advancements, pulmonary complications and an…
View article: 350. CONTINUOUS INTRAOPERATIVE NERVE MONITORING TO REDUCE THE LEFT RECURRENT LARYNGEAL NERVE PARALYSIS IN TRANSMEDIASTINAL ESOPHAGECTOMY
350. CONTINUOUS INTRAOPERATIVE NERVE MONITORING TO REDUCE THE LEFT RECURRENT LARYNGEAL NERVE PARALYSIS IN TRANSMEDIASTINAL ESOPHAGECTOMY Open
Introduction Transmediastinal esophagectomy (TME) is a curative option for esophageal cancer, and can achieve total mediastinal lymph node dissection (LND) with transcervical and transhiatal procedures. With the transcervical procedure, th…
View article: 428. MIDDLE MEDIASTINAL LYMPHADENECTOMY IN MEDIASTINOSCOPIC ESOPHAGECTOMY FOR ESCC
428. MIDDLE MEDIASTINAL LYMPHADENECTOMY IN MEDIASTINOSCOPIC ESOPHAGECTOMY FOR ESCC Open
(Introduction) In mediastinoscopic esophagectomy, it is necessary to secure a view of the deep middle mediastinum. Although tracheal carina lymph nodes can be stably dissected using a cervical approach, but they are dissected using a hiata…
View article: 559. SURGICAL PROCEDURE AND CLINICAL OUTCOME OF TRANSMEDIASTINAL ESOPHAGECTOMY FOR ESOPHAGEAL CANCER
559. SURGICAL PROCEDURE AND CLINICAL OUTCOME OF TRANSMEDIASTINAL ESOPHAGECTOMY FOR ESOPHAGEAL CANCER Open
Background We started performing esophagectomy by a laparoscopic transhiatal approach in 2009, and 577 patients had undergone to date. Furthermore, we started performing single-port mediastinoscopic cervical approach in 2014, and developed…
View article: A Case Report of Wet Beriberi Due to Excessive White Rice Consumption in an Elderly Male Patient: A Potentially Forgotten and Underrecognized Disease
A Case Report of Wet Beriberi Due to Excessive White Rice Consumption in an Elderly Male Patient: A Potentially Forgotten and Underrecognized Disease Open
Thiamine deficiency can cause various clinical manifestations. Wet beriberi, a phenotype of thiamine deficiency, is often underdiagnosed in clinical practice due to the nonspecificity of symptoms. An 83-year-old man presented to a primary …