2023-04-03
Data from Y-box Binding Protein-1 Contributes to Both HER2/ErbB2 Expression and Lapatinib Sensitivity in Human Gastric Cancer Cells
2023-04-03 • Tomohiro Shibata, Hitoshi Kan, Yûichi Murakami, Hiroki Ureshino, Kosuke Watari, Akihiko Kawahara, Masayoshi Kage, Satoshi Hattori, Mayumi Ono, Mich...
<div>Abstract<p>Gene amplification of <i>HER2/ErbB2</i> occurs in gastric cancer and the therapeutic efficacy of the HER2-targeted antibody, trastuzumab, has recently been improved against HER2-positive advanced stomach cancer. Here, we examined whether Y-box-binding protein-1 (YB-1) could selectively control <i>HER2</i> gene expression and cellular sensitivity to EGF receptor (EGFR) family protein-targeted drugs in human gastric cancer cells. HER2 expression was specifically do…